NO20012473L - Kinolin-4-karboksamidderivater som NK-3 og NK-2 reseptorantagonister - Google Patents

Kinolin-4-karboksamidderivater som NK-3 og NK-2 reseptorantagonister

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Publication number
NO20012473L
NO20012473L NO20012473A NO20012473A NO20012473L NO 20012473 L NO20012473 L NO 20012473L NO 20012473 A NO20012473 A NO 20012473A NO 20012473 A NO20012473 A NO 20012473A NO 20012473 L NO20012473 L NO 20012473L
Authority
NO
Norway
Prior art keywords
quinoline
receptor antagonists
carboxamide derivatives
carboxamide
derivatives
Prior art date
Application number
NO20012473A
Other languages
English (en)
Norwegian (no)
Other versions
NO20012473D0 (no
Inventor
Carlo Farina
Giuseppe Arnaldo Mari Giardina
Mario Grugni
Luca Francesco Raveglia
Marcel Morvan
Guy Marguerite Marie Ge Nadler
Original Assignee
Smithkline Beecham Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9825553.2A external-priority patent/GB9825553D0/en
Priority claimed from GBGB9825552.4A external-priority patent/GB9825552D0/en
Application filed by Smithkline Beecham Lab filed Critical Smithkline Beecham Lab
Publication of NO20012473D0 publication Critical patent/NO20012473D0/no
Publication of NO20012473L publication Critical patent/NO20012473L/no

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO20012473A 1998-11-20 2001-05-18 Kinolin-4-karboksamidderivater som NK-3 og NK-2 reseptorantagonister NO20012473L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9825553.2A GB9825553D0 (en) 1998-11-20 1998-11-20 Novel Compounds
GBGB9825552.4A GB9825552D0 (en) 1998-11-20 1998-11-20 Novel compounds
PCT/EP1999/009115 WO2000031037A1 (fr) 1998-11-20 1999-11-19 Derives de quinoline-4-carboxamide utilises comme antagonistes des recepteurs nk-3 et nk-2

Publications (2)

Publication Number Publication Date
NO20012473D0 NO20012473D0 (no) 2001-05-18
NO20012473L true NO20012473L (no) 2001-07-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
NO20012473A NO20012473L (no) 1998-11-20 2001-05-18 Kinolin-4-karboksamidderivater som NK-3 og NK-2 reseptorantagonister

Country Status (18)

Country Link
EP (1) EP1131295A1 (fr)
JP (1) JP2002530377A (fr)
KR (1) KR20010075726A (fr)
CN (1) CN1406225A (fr)
AR (2) AR021354A1 (fr)
AU (1) AU768708B2 (fr)
BR (1) BR9915475A (fr)
CA (1) CA2351865A1 (fr)
CO (1) CO5150149A1 (fr)
HK (1) HK1041257A1 (fr)
HU (1) HUP0104959A3 (fr)
IL (1) IL143137A0 (fr)
MX (1) MXPA01005095A (fr)
NO (1) NO20012473L (fr)
NZ (1) NZ511777A (fr)
PL (1) PL347721A1 (fr)
TR (1) TR200101412T2 (fr)
WO (1) WO2000031037A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7037922B1 (en) 2000-03-10 2006-05-02 Neurogen Corporation Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands
GB0027701D0 (en) * 2000-11-13 2000-12-27 Smithkline Beecham Spa Novel compounds
EP1334089A1 (fr) * 2000-11-13 2003-08-13 GlaxoSmithKline S.p.A. Derives de la quinoline en tant qu'antagonistes de nk-3 et nk-2
GB0028964D0 (en) * 2000-11-28 2001-01-10 Smithkline Beecham Spa Novel compounds
EP1351953A1 (fr) * 2000-11-28 2003-10-15 GlaxoSmithKline S.p.A. Derives de quinoline utilises comme antagonistes de nk-3
EP1337253A1 (fr) * 2000-11-28 2003-08-27 GlaxoSmithKline S.p.A. Composes
CA2443868C (fr) 2001-04-10 2011-01-25 Ortho-Mcneil Pharmaceutical, Inc. Derives de 1,3,8-triazaspiro[4.5]decan-4-one utiles dans le traitement de troubles induits par le recepteur orl-1
DE60208178T2 (de) * 2001-04-11 2006-08-24 Glaxosmithkline S.P.A. Chinolin-4-carboxamidderivate als nk-3 und nk-2 rezeptor antagonisten
GB0109122D0 (en) * 2001-04-11 2001-05-30 Smithkline Beecham Spa Novel compounds
MY134211A (en) * 2001-05-18 2007-11-30 Smithkline Beecham Corp Novel use
JPWO2004002484A1 (ja) * 2002-06-26 2005-10-27 協和醗酵工業株式会社 ホスホジエステラーゼ阻害剤
EP1601674B1 (fr) 2002-09-09 2012-08-08 Janssen Pharmaceutica NV Dérivés de 1,3,8-triazaspiro[4.5]décan-4-one à substitution hydroxyalkyle utiles pour traiter des maladies associées au recepteur ORL-1
GB0303086D0 (en) * 2003-02-11 2003-03-19 Merck Sharp & Dohme New compounds
WO2005000247A2 (fr) * 2003-06-25 2005-01-06 Smithkline Beecham Corporation Nouveaux composes
GB0419192D0 (en) 2004-08-27 2004-09-29 Merck Sharp & Dohme Therapeutic agents
GB0425076D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0509405D0 (en) * 2005-05-10 2005-06-15 Merck Sharp & Dohme Therapeutic compounds
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CA2351865A1 (fr) 2000-06-02
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JP2002530377A (ja) 2002-09-17
IL143137A0 (en) 2002-04-21
KR20010075726A (ko) 2001-08-09
AU1777000A (en) 2000-06-13
MXPA01005095A (es) 2002-04-24
EP1131295A1 (fr) 2001-09-12
HK1041257A1 (zh) 2002-07-05
CN1406225A (zh) 2003-03-26
PL347721A1 (en) 2002-04-22
CO5150149A1 (es) 2002-04-29
BR9915475A (pt) 2001-12-18
WO2000031037A1 (fr) 2000-06-02
NZ511777A (en) 2003-12-19
AR021354A1 (es) 2002-07-17
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HUP0104959A2 (hu) 2002-04-29
NO20012473D0 (no) 2001-05-18

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