NO20001322L - Nye fluorescerende reportermolekyler og deres anvendelse inkluderende analyser for "kaspaser" - Google Patents

Nye fluorescerende reportermolekyler og deres anvendelse inkluderende analyser for "kaspaser"

Info

Publication number
NO20001322L
NO20001322L NO20001322A NO20001322A NO20001322L NO 20001322 L NO20001322 L NO 20001322L NO 20001322 A NO20001322 A NO 20001322A NO 20001322 A NO20001322 A NO 20001322A NO 20001322 L NO20001322 L NO 20001322L
Authority
NO
Norway
Prior art keywords
caspase
assays
reporter molecules
fluorescent reporter
use including
Prior art date
Application number
NO20001322A
Other languages
English (en)
Other versions
NO20001322D0 (no
Inventor
Eckard Weber
Sui Xiong Cai
John F W Keana
John A Drewe
Han-Zhong Zhang
Original Assignee
Cytovia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytovia Inc filed Critical Cytovia Inc
Publication of NO20001322D0 publication Critical patent/NO20001322D0/no
Publication of NO20001322L publication Critical patent/NO20001322L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1488—Methods for deciding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20001322A 1997-10-10 2000-03-14 Nye fluorescerende reportermolekyler og deres anvendelse inkluderende analyser for "kaspaser" NO20001322L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6158297P 1997-10-10 1997-10-10
US3366198A 1998-03-03 1998-03-03
PCT/US1998/021231 WO1999018856A1 (en) 1997-10-10 1998-10-09 Novel fluorescent reporter molecules and their applications including assays for caspases

Publications (2)

Publication Number Publication Date
NO20001322D0 NO20001322D0 (no) 2000-03-14
NO20001322L true NO20001322L (no) 2000-06-13

Family

ID=26709974

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20001322A NO20001322L (no) 1997-10-10 2000-03-14 Nye fluorescerende reportermolekyler og deres anvendelse inkluderende analyser for "kaspaser"

Country Status (15)

Country Link
EP (1) EP1026988A4 (no)
JP (1) JP2001519368A (no)
KR (1) KR20010031056A (no)
CN (1) CN1281346A (no)
AU (1) AU754634B2 (no)
BR (1) BR9814816A (no)
CA (1) CA2308125A1 (no)
EA (1) EA200000408A1 (no)
HU (1) HUP0100079A2 (no)
IL (1) IL135365A0 (no)
IS (1) IS5414A (no)
NO (1) NO20001322L (no)
NZ (1) NZ503619A (no)
PL (1) PL341661A1 (no)
WO (1) WO1999018856A1 (no)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342611B1 (en) 1997-10-10 2002-01-29 Cytovia, Inc. Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof
WO2000004914A1 (en) 1998-07-21 2000-02-03 Cytovia, Inc. Novel fluorescence dyes and their applications for whole cell fluorescence screening assays for caspases, peptidases, proteases and other enzymes and the use thereof
JP2002539428A (ja) * 1999-03-12 2002-11-19 エヴォテック アナリティカル システムズ ゲゼルシャフト ミット ベシュレンクテル ハフツング カスパゼ活性を用いる化学感受性測定
EP1055929A1 (en) * 1999-05-26 2000-11-29 Tibotec N.V. Means and methods for drug discovery and the phenotypic characterisation of cells
EP1185644A1 (en) * 1999-05-27 2002-03-13 Merck Frosst Canada & Co. Assays for caspase activity using green fluorescent proteins
US6261794B1 (en) * 1999-10-14 2001-07-17 Saint Louis University Methods for identifying inhibitors of methionine aminopeptidases
PT1230232E (pt) 1999-11-05 2004-07-30 Cytovia Inc 4h-cromeno substituido e seus analogos como activadores de caspases e indutores de apoptose e sua utilizacao
GB9927331D0 (en) 1999-11-18 2000-01-12 Fluorescience Ltd Assay for measuring enzyme activity in vivo
WO2001079187A2 (en) 2000-04-18 2001-10-25 Cytovia, Inc. Substituted 1,4-thiazepine and analogs and their use as activators of caspases
AU2001278135A1 (en) 2000-08-03 2002-02-18 Cytovia, Inc. Method of identifying immunosuppressive agents
DE10053747C2 (de) * 2000-10-30 2002-10-24 Deutsches Krebsforsch Verfahren zur gleichzeitigen Bestimmung zweier Fluoreszenz-Emissionen mit einem Einlaser-Durchflußzytometer
EP1205540A1 (de) 2000-11-10 2002-05-15 Evotec OAI AG Verfahren zur Vitalitätsmessung an Zellen
WO2002102301A2 (en) 2000-12-07 2002-12-27 Cytovia, Inc. Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof
US6716851B2 (en) 2000-12-12 2004-04-06 Cytovia, Inc. Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof
US7256219B2 (en) 2001-03-14 2007-08-14 Cytovia, Inc. Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof
US6979530B2 (en) 2001-05-21 2005-12-27 Applera Corporation Peptide conjugates and fluorescence detection methods for intracellular caspase assay
WO2003066611A1 (en) 2002-02-01 2003-08-14 Promega Corporation Bioluminescent protease assay
AU2003241482A1 (en) 2002-05-16 2003-12-02 Cytovia, Inc. Substituted 4h-chromenes, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof
EP1509515A4 (en) 2002-05-16 2006-07-05 Cytovia Inc SUBSTITUTED 4-ARYL-4H-PYRROLO 2,3-H | CHROMENES AND ANALOGUES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THEIR USE
JP4318180B2 (ja) * 2002-07-08 2009-08-19 ジーイー・ヘルスケア・ユーケイ・リミテッド タンパク質の飽和標識用の試薬及び方法
US8252520B2 (en) * 2002-10-11 2012-08-28 Taivex Therapeutics Corporation Methods and compounds for inhibiting Hec1 activity for the treatment of proliferative diseases
US6821744B2 (en) 2002-10-29 2004-11-23 Roche Diagnostics Operations, Inc. Method, assay, and kit for quantifying HIV protease inhibitors
CN1984660B (zh) 2003-07-03 2010-12-15 美瑞德生物工程公司 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉
US7534902B2 (en) 2003-11-14 2009-05-19 Wisconsin Alumni Research Foundation Fluorescence assays with improved sensitivity
EP1704257A2 (en) 2004-01-16 2006-09-27 Applera Corporation Fluorogenic kinase assays and substrates for kinases and phosphatases
US7553632B2 (en) 2004-01-22 2009-06-30 Promega Corporation Luminogenic and nonluminogenic multiplex assay
US7416854B2 (en) * 2004-01-22 2008-08-26 Promega Corporation Luminogenic and nonluminogenic multiplex assay
DK1942898T4 (da) 2005-09-14 2014-06-02 Takeda Pharmaceutical Dipeptidylpeptidase-inhibitorer til behandling af diabetes
KR101368988B1 (ko) 2005-09-16 2014-02-28 다케다 야쿠힌 고교 가부시키가이샤 디펩티딜 펩티다제 억제제
GB2446088B (en) * 2005-12-12 2010-10-20 Innova Biosciences Ltd Production of conjugates
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
AU2008239654A1 (en) 2007-04-13 2008-10-23 Promega Corporation Luminescent live and dead cell assay
KR100909996B1 (ko) * 2007-09-19 2009-07-29 한국생명공학연구원 카스파제-3(ｃａｓｐａｓｅ-3)의 활성 검출용 융합 단백질및 이를 이용한 카스파제-3의 활성 검출방법
CN102603695B (zh) * 2012-02-10 2014-06-18 山东大学 一种氨基酸-荧光团类化合物及其应用
ES2655212T3 (es) * 2012-07-19 2018-02-19 Kingston University Higher Education Corporation Sonda fluorescente a base de rodamina para determinar la actividad coagulasa y detección de cepas bacterianas productoras de coagulasa
CN104458709A (zh) * 2013-09-12 2015-03-25 中国药科大学 一种筛选钙激活中性蛋白酶-1抑制剂高通量筛选方法
ES2806134T3 (es) 2014-07-11 2021-02-16 Univ Tokyo Sonda fluorescente para detectar dipeptidil peptidasa IV
CN104263356B (zh) * 2014-09-29 2016-02-24 辽宁大学 一种含有甲硫氨酸结构的罗丹明pH荧光探针及其应用
CN106146611B (zh) * 2015-05-14 2019-09-17 中国科学院大连化学物理研究所 一种测定二肽基肽酶iv活性的荧光探针底物及其应用
WO2017223147A1 (en) 2016-06-23 2017-12-28 Life Technologies Corporation Methods and compositions for detecting or measuring caspases or apoptosis
CA3037767A1 (en) * 2016-09-28 2018-04-05 Georgia Tech Research Corporation Methods and compositions for noninvasive detection of organ transplant rejection
CN110352196A (zh) * 2016-10-11 2019-10-18 加利福尼亚大学董事会 生物样品中降解酶和非降解酶的检测、鉴定与纯化
CN107987019A (zh) * 2018-01-08 2018-05-04 深圳市佶达德科技有限公司 一种若丹明双吡唑乙酸酯有机激光材料的制备方法
CN108129388A (zh) * 2018-01-08 2018-06-08 深圳市佶达德科技有限公司 一种若丹明双吡唑乙酸酯有机激光材料及其应用
CN108760234B (zh) * 2018-06-05 2020-05-15 哈尔滨工程大学 一种基于piv和ptv技术的流体流动与固体运动信息同步测试方法和装置
KR102138256B1 (ko) * 2018-09-13 2020-08-13 한국과학기술연구원 케스페이즈-1 활성 측정용 프로브, 이를 포함하는 염증성 질환 진단용 조성물
CN112961209B (zh) * 2021-04-07 2022-06-24 中国科学院武汉病毒研究所 caspase抑制剂及其应用
CN114107435A (zh) * 2021-11-30 2022-03-01 广东省人民医院 一种用于免疫治疗实时监测的可激活光声-荧光双模探针及应用
CN117143949B (zh) * 2023-08-31 2024-04-05 青岛海洋食品营养与健康创新研究院 一种南极磷虾源高f值寡肽及其在护肝中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4557862A (en) * 1983-10-28 1985-12-10 University Patents, Inc. Rhodamine derivatives as fluorogenic substrates for proteinases
US5587490A (en) * 1990-04-16 1996-12-24 Credit Managers Association Of California Method of inactivation of viral and bacterial blood contaminants
US5576424A (en) * 1991-08-23 1996-11-19 Molecular Probes, Inc. Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells
US5556992A (en) * 1994-09-02 1996-09-17 Universite De Montreal Novel rhodamine derivatives for photodynamic therapy of cancer and in vitro purging of the leukemias
US5798442A (en) * 1995-04-21 1998-08-25 Merck Frosst Canada, Inc. Peptidyl derivatives as inhibitors of pro-apoptotic cysteine proteinases
WO2000004914A1 (en) * 1998-07-21 2000-02-03 Cytovia, Inc. Novel fluorescence dyes and their applications for whole cell fluorescence screening assays for caspases, peptidases, proteases and other enzymes and the use thereof

Also Published As

Publication number Publication date
IS5414A (is) 2000-03-24
WO1999018856A1 (en) 1999-04-22
CN1281346A (zh) 2001-01-24
NZ503619A (en) 2001-11-30
EA200000408A1 (ru) 2000-12-25
HUP0100079A2 (hu) 2001-05-28
NO20001322D0 (no) 2000-03-14
IL135365A0 (en) 2001-05-20
KR20010031056A (ko) 2001-04-16
AU1072299A (en) 1999-05-03
JP2001519368A (ja) 2001-10-23
PL341661A1 (en) 2001-04-23
EP1026988A1 (en) 2000-08-16
AU754634B2 (en) 2002-11-21
EP1026988A4 (en) 2005-03-30
BR9814816A (pt) 2004-06-22
CA2308125A1 (en) 1999-04-22

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