NO180677C - Anvendelse av (S)-(+)-hydroksyklorokin for fremstilling av legemidler - Google Patents
Anvendelse av (S)-(+)-hydroksyklorokin for fremstilling av legemidlerInfo
- Publication number
- NO180677C NO180677C NO933293A NO933293A NO180677C NO 180677 C NO180677 C NO 180677C NO 933293 A NO933293 A NO 933293A NO 933293 A NO933293 A NO 933293A NO 180677 C NO180677 C NO 180677C
- Authority
- NO
- Norway
- Prior art keywords
- hydroxychloroquine
- manufacture
- drugs
- treatment
- malaria
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Detergent Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/945,032 US5314894A (en) | 1992-09-15 | 1992-09-15 | (S)-(+)-hydroxychloroquine |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO933293D0 NO933293D0 (no) | 1993-09-15 |
| NO933293L NO933293L (no) | 1994-03-16 |
| NO180677B NO180677B (no) | 1997-02-17 |
| NO180677C true NO180677C (no) | 1997-05-28 |
Family
ID=25482508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO933293A NO180677C (no) | 1992-09-15 | 1993-09-15 | Anvendelse av (S)-(+)-hydroksyklorokin for fremstilling av legemidler |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5314894A (de) |
| EP (1) | EP0588430B1 (de) |
| JP (1) | JPH06199801A (de) |
| KR (1) | KR940007002A (de) |
| AT (1) | ATE166646T1 (de) |
| AU (2) | AU4732693A (de) |
| CA (1) | CA2104903A1 (de) |
| CZ (1) | CZ192393A3 (de) |
| DE (1) | DE69318783D1 (de) |
| FI (1) | FI934051L (de) |
| HU (1) | HUT70025A (de) |
| IL (1) | IL107004A0 (de) |
| MX (1) | MX9305621A (de) |
| MY (1) | MY109822A (de) |
| NO (1) | NO180677C (de) |
| NZ (1) | NZ248671A (de) |
| PH (1) | PH30153A (de) |
| SK (1) | SK98793A3 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5453431A (en) * | 1993-10-29 | 1995-09-26 | Gilman; Andrew L. | Use of hydroxychloroquine for treatment of graft-versus-host disease |
| US6512010B1 (en) * | 1996-07-15 | 2003-01-28 | Alza Corporation | Formulations for the administration of fluoxetine |
| US20040229908A1 (en) * | 1999-07-13 | 2004-11-18 | Jodi Nelson | Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias |
| US20020198231A1 (en) * | 1999-07-13 | 2002-12-26 | Jodi Nelson | Compositions and methods for the treatment of Parkinson's disease |
| US7108992B2 (en) * | 2002-11-27 | 2006-09-19 | St. Jude Children's Research Hospital | ATM kinase compositions and methods |
| US6916627B2 (en) * | 2002-11-27 | 2005-07-12 | St. Jude Children's Research Hospital | ATM kinase compositions and methods |
| WO2005062723A2 (en) * | 2003-11-24 | 2005-07-14 | Ipca Laboratories Limited | An improved process for the preparation of 7-chloro-4-(5-n-ehtyl-n-2-hydroxyethylamine)-2-pentyl] aminoquinoline and its intermediates |
| KR101115412B1 (ko) * | 2008-09-08 | 2012-06-12 | 주식회사 대희화학 | 하이드록시클로로퀸의 신규 제조방법 |
| KR101208587B1 (ko) * | 2009-06-24 | 2012-12-06 | 여오영 | 하이드록시클로로퀸을 포함하는 항암 치료를 위한 국소 투여용 주사제 조성물 |
| JP2013529627A (ja) | 2010-06-24 | 2013-07-22 | パンメド リミテッド | ヒドロキシクロロキンまたはヒドロキシクロロキンおよび抗ウイルス剤の組合せを使用するｃ型肝炎ウイルス関連疾患の処置 |
| WO2012176149A1 (en) | 2011-06-23 | 2012-12-27 | Panmed Ltd. | Treatment of hepatitis c virus |
| EP2561868A1 (de) | 2011-08-24 | 2013-02-27 | Anton Bernhard Van Oosten | Pharmazeutische Zusammensetzungen mit Hydroxychlorocin (HCQ), Curcumin, Piperin/BioPerin und Verwendungen in der Medizin |
| WO2014122537A2 (en) | 2013-02-05 | 2014-08-14 | Genoscience Sa | Pharmaceutical compositions and methods of treating hepatitis c virus infection using a combination of hydroxychloroquine and ribavirin |
| CN105693606B (zh) * | 2016-03-09 | 2017-12-05 | 西安科技大学 | 一种光学纯(r)/(s)‑羟氯喹的不对称合成方法 |
| CN105693605B (zh) * | 2016-03-09 | 2017-12-22 | 西安科技大学 | 一种光学纯(r)/(s)‑氯喹的不对称合成方法 |
| CN110283121A (zh) * | 2019-08-06 | 2019-09-27 | 华东理工大学 | 羟氯喹的合成方法 |
| CN113350343A (zh) * | 2020-03-06 | 2021-09-07 | 华南理工大学 | 右旋手性磷酸氯喹在制备治疗冠状病毒药物中的应用 |
| CN113350344A (zh) * | 2020-03-06 | 2021-09-07 | 华南理工大学 | 左旋手性磷酸氯喹在制备治疗冠状病毒药物中的应用 |
| EP4135673A4 (de) * | 2020-04-14 | 2024-05-08 | Glanis Pharmaceuticals, Inc. | System zur transdermalen und/oder topischen verabreichung mit hydroxychlorquin und/oder chloroquin |
| US20230139565A1 (en) * | 2020-04-20 | 2023-05-04 | Glanis Pharmaceuticals, Inc. | Oral delivery system comprising hydroxychloroquine and/or chloroquine |
| TWI845802B (zh) * | 2020-04-21 | 2024-06-21 | 健亞生物科技股份有限公司 | 硫酸羥氯喹之晶體 |
| WO2021217574A1 (en) * | 2020-04-30 | 2021-11-04 | Waterstone Pharmaceuticals (Wuhan) Co., Ltd. | Treatment or prevention of coronaviridae infection |
| US20210369699A1 (en) | 2020-05-31 | 2021-12-02 | Genovate Biotechnology Co. Ltd. | Treatment of lupus erythematosus using s-hydroxychloroquine |
| CN111909087A (zh) * | 2020-06-15 | 2020-11-10 | 珠海润都制药股份有限公司 | 一种手性氨基氯喹啉的制备方法 |
| CN111803501B (zh) * | 2020-06-17 | 2022-10-18 | 南方科技大学 | 手性氯喹羟氯喹作为降低心脏毒性的用途 |
| CN111793026A (zh) * | 2020-07-23 | 2020-10-20 | 珠海润都制药股份有限公司 | 一种硫酸羟氯喹及其对映体的晶型和制备方法 |
| CN114057640A (zh) * | 2020-08-05 | 2022-02-18 | 凯特立斯（深圳）科技有限公司 | 一种光学纯(r)/(s)-羟氯喹侧链的不对称合成方法 |
| CN112505198A (zh) * | 2020-12-29 | 2021-03-16 | 珠海润都制药股份有限公司 | 一种s-硫酸羟氯喹异构体检验方法 |
| CN117396204A (zh) * | 2021-06-04 | 2024-01-12 | 健亚生物科技股份有限公司 | 使用s-羟氯喹治疗抗磷脂综合征 |
| CN114573464A (zh) * | 2022-03-02 | 2022-06-03 | 重庆南松凯博生物制药有限公司 | 一种羟氯喹侧链精制方法 |
| CN115089584A (zh) * | 2022-06-14 | 2022-09-23 | 广州惠善医疗技术有限公司 | 手性羟氯喹或其药学上可接受的盐在制备防诊治免疫疾病药物中的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2546658A (en) * | 1949-07-23 | 1951-03-27 | Sterling Drug Inc | 7-chloro-4-[5-(n-ethyl-n-2-hydroxyethylamino)-2-pentyl] aminoquinoline, its acid addition salts, and method of preparation |
| US5021426A (en) * | 1990-02-26 | 1991-06-04 | Merck & Co., Inc. | Method of traeting malaria with cyproheptadine derivatives |
-
1992
- 1992-09-15 US US07/945,032 patent/US5314894A/en not_active Expired - Fee Related
-
1993
- 1993-08-13 PH PH46684A patent/PH30153A/en unknown
- 1993-08-26 CA CA002104903A patent/CA2104903A1/en not_active Abandoned
- 1993-09-08 MY MYPI93001822A patent/MY109822A/en unknown
- 1993-09-11 EP EP93202641A patent/EP0588430B1/de not_active Expired - Lifetime
- 1993-09-11 AT AT93202641T patent/ATE166646T1/de not_active IP Right Cessation
- 1993-09-11 DE DE69318783T patent/DE69318783D1/de not_active Expired - Lifetime
- 1993-09-13 MX MX9305621A patent/MX9305621A/es not_active Application Discontinuation
- 1993-09-14 SK SK987-93A patent/SK98793A3/sk unknown
- 1993-09-14 JP JP5228485A patent/JPH06199801A/ja not_active Withdrawn
- 1993-09-14 IL IL107004A patent/IL107004A0/xx unknown
- 1993-09-14 AU AU47326/93A patent/AU4732693A/en not_active Abandoned
- 1993-09-15 HU HU9302613A patent/HUT70025A/hu unknown
- 1993-09-15 CZ CZ931923A patent/CZ192393A3/cs unknown
- 1993-09-15 FI FI934051A patent/FI934051L/fi not_active Application Discontinuation
- 1993-09-15 NO NO933293A patent/NO180677C/no unknown
- 1993-09-15 KR KR1019930018519A patent/KR940007002A/ko not_active Withdrawn
- 1993-09-15 NZ NZ248671A patent/NZ248671A/en unknown
-
1996
- 1996-12-20 AU AU75494/96A patent/AU7549496A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JPH06199801A (ja) | 1994-07-19 |
| AU4732693A (en) | 1994-03-24 |
| NO180677B (no) | 1997-02-17 |
| EP0588430A1 (de) | 1994-03-23 |
| FI934051A7 (fi) | 1994-03-16 |
| MY109822A (en) | 1997-08-30 |
| PH30153A (en) | 1997-01-21 |
| NO933293L (no) | 1994-03-16 |
| HUT70025A (en) | 1995-09-28 |
| FI934051A0 (fi) | 1993-09-15 |
| KR940007002A (ko) | 1994-04-26 |
| HU9302613D0 (en) | 1993-12-28 |
| FI934051L (fi) | 1994-03-16 |
| US5314894A (en) | 1994-05-24 |
| SK98793A3 (en) | 1994-09-07 |
| NO933293D0 (no) | 1993-09-15 |
| CZ192393A3 (en) | 1994-03-16 |
| MX9305621A (es) | 1994-03-31 |
| ATE166646T1 (de) | 1998-06-15 |
| CA2104903A1 (en) | 1994-03-16 |
| IL107004A0 (en) | 1993-12-28 |
| NZ248671A (en) | 1995-04-27 |
| AU7549496A (en) | 1997-04-10 |
| EP0588430B1 (de) | 1998-05-27 |
| DE69318783D1 (de) | 1998-07-02 |
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