NO179975C - Analogifremgangsmåte for fremstilling av heterocykliske derivater - Google Patents

Analogifremgangsmåte for fremstilling av heterocykliske derivater

Info

Publication number
NO179975C
NO179975C NO913378A NO913378A NO179975C NO 179975 C NO179975 C NO 179975C NO 913378 A NO913378 A NO 913378A NO 913378 A NO913378 A NO 913378A NO 179975 C NO179975 C NO 179975C
Authority
NO
Norway
Prior art keywords
alkyl
preparation
csnq1q2
conq1q2
indolyl
Prior art date
Application number
NO913378A
Other languages
English (en)
Norwegian (no)
Other versions
NO913378L (no
NO179975B (no
NO913378D0 (no
Inventor
Andre Bernat
Jean-Marc Herbert
Gerard Valette
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of NO913378D0 publication Critical patent/NO913378D0/no
Publication of NO913378L publication Critical patent/NO913378L/no
Publication of NO179975B publication Critical patent/NO179975B/no
Publication of NO179975C publication Critical patent/NO179975C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
NO913378A 1989-12-29 1991-08-28 Analogifremgangsmåte for fremstilling av heterocykliske derivater NO179975C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8917491A FR2656610B1 (fr) 1989-12-29 1989-12-29 Derives d'amino-2 phenyl-4 thiazole, leur procede de preparation et leur application therapeutique.
PCT/FR1990/000970 WO1991009857A1 (fr) 1989-12-29 1990-12-28 Derives heterocycliques, leur procede de preparation et leur application therapeutique

Publications (4)

Publication Number Publication Date
NO913378D0 NO913378D0 (no) 1991-08-28
NO913378L NO913378L (no) 1991-10-28
NO179975B NO179975B (no) 1996-10-14
NO179975C true NO179975C (no) 1997-01-22

Family

ID=9389177

Family Applications (1)

Application Number Title Priority Date Filing Date
NO913378A NO179975C (no) 1989-12-29 1991-08-28 Analogifremgangsmåte for fremstilling av heterocykliske derivater

Country Status (31)

Country Link
US (5) US5470855A (pl)
EP (1) EP0462264B1 (pl)
JP (1) JP2758077B2 (pl)
KR (1) KR0159517B1 (pl)
CN (1) CN1028757C (pl)
AT (1) ATE119160T1 (pl)
AU (1) AU627103B2 (pl)
BR (1) BR1100202A (pl)
CA (1) CA2046883C (pl)
CZ (1) CZ280803B6 (pl)
DE (1) DE69017443T2 (pl)
DK (1) DK0462264T3 (pl)
ES (1) ES2069276T3 (pl)
FI (1) FI95380C (pl)
FR (1) FR2656610B1 (pl)
HK (1) HK1000011A1 (pl)
HU (2) HU213230B (pl)
IE (1) IE67322B1 (pl)
IL (1) IL96811A (pl)
LV (1) LV5803B4 (pl)
MX (1) MX9203019A (pl)
NO (1) NO179975C (pl)
NZ (1) NZ236678A (pl)
PL (1) PL167101B1 (pl)
PT (1) PT96368B (pl)
RU (1) RU2049784C1 (pl)
SK (1) SK627790A3 (pl)
TW (1) TW215921B (pl)
UA (1) UA35546C2 (pl)
WO (1) WO1991009857A1 (pl)
ZA (1) ZA9010447B (pl)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9127304D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
FR2692893B1 (fr) * 1992-06-24 1994-09-02 Sanofi Elf Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
GB9312893D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
FR2714059B1 (fr) * 1993-12-21 1996-03-08 Sanofi Elf Dérivés amino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
FR2728901B1 (fr) * 1994-12-28 1997-03-28 Sanofi Sa Derives de phenyl-4-thiazoles substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
US5795905A (en) * 1995-06-06 1998-08-18 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
FR2735777B1 (fr) * 1995-06-21 1997-09-12 Sanofi Sa Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
PL327582A1 (en) 1995-12-29 1998-12-21 Boehringer Ingelheim Pharma Derivatives of phenylthiazole exhibiting antiviral properties against herpes virues
US6288091B1 (en) 1995-12-29 2001-09-11 Boehringer Ingelheim Ltd. Antiherpes virus compounds and methods for their preparation and use
ZA9756B (en) * 1996-01-16 1997-07-17 Warner Lambert Co Process for preparing 4,6-disubstituted pyrido[3,4-d]-pyrimidines
WO1997041097A2 (en) * 1996-12-31 1997-11-06 Dr. Reddy's Research Foundation Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
FR2754258B1 (fr) * 1996-10-08 1998-12-31 Sanofi Sa Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
DE69812623T2 (de) * 1997-06-24 2004-02-19 Janssen Pharmaceutica N.V. Angiogenesis hemmende thiadiazolypyridazine derivaten
US6057340A (en) * 1998-02-03 2000-05-02 American Home Products Corporation Oxazole derivatives as serotonin-1A receptor agonists
FR2776925B3 (fr) * 1998-04-07 2000-05-26 Sanofi Sa Utilisation de derives d'aminothiazole pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation
CN1158075C (zh) * 1998-12-01 2004-07-21 诺沃挪第克公司 新药物组合物及其制备方法
US6242448B1 (en) 1998-12-17 2001-06-05 American Home Products Corporation Trisubstituted-oxazole derivatives as serotonin ligands
US6417360B1 (en) * 1999-03-03 2002-07-09 Hoffmann-La Roche Inc. Heterocyclic sulfonamides
AR035016A1 (es) * 1999-08-25 2004-04-14 Takeda Chemical Industries Ltd Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima.
RU2259827C2 (ru) * 1999-10-29 2005-09-10 Орион Корпорейшн Лечение или предупреждение гипотензии и шока
WO2002083863A2 (en) 2001-04-17 2002-10-24 Sepracor, Inc. Thiazole and other heterocyclic ligands and use thereof
US6670071B2 (en) * 2002-01-15 2003-12-30 Quallion Llc Electric storage battery construction and method of manufacture
CN1946703A (zh) * 2004-04-20 2007-04-11 特兰斯泰克制药公司 取代的噻唑和嘧啶衍生物作为黑素细胞皮质激素受体调节剂
JP5260507B2 (ja) 2006-10-19 2013-08-14 武田薬品工業株式会社 インドール化合物
TWI443090B (zh) 2007-05-25 2014-07-01 Abbvie Deutschland 作為代謝性麩胺酸受體2(mglu2 受體)之正向調節劑之雜環化合物
WO2010025142A1 (en) * 2008-08-29 2010-03-04 Transtech Pharma, Inc. Substituted aminothiazole derivatives, pharmaceutical compositions, and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE471555A (pl) * 1943-06-22
DE3486009T2 (de) * 1983-09-09 1993-04-15 Takeda Chemical Industries Ltd 5-pyridyl-1,3-thiazol-derivate, ihre herstellung und anwendung.
FR2612187B1 (fr) * 1987-03-12 1989-07-21 Sanofi Sa Derives du thiazole actifs sur le systeme cholinergique, leur procede de preparation et compositions pharmaceutiques en contenant

Also Published As

Publication number Publication date
MX9203019A (es) 1992-08-01
US5891893A (en) 1999-04-06
AU7055591A (en) 1991-07-24
NO913378L (no) 1991-10-28
FR2656610B1 (fr) 1992-05-07
JPH04504863A (ja) 1992-08-27
FR2656610A1 (fr) 1991-07-05
KR0159517B1 (ko) 1998-12-01
BR1100202A (pt) 1999-11-09
LV5803A4 (lv) 1997-02-20
CZ280803B6 (cs) 1996-04-17
DE69017443D1 (de) 1995-04-06
NO179975B (no) 1996-10-14
CZ627790A3 (en) 1996-01-17
PL167101B1 (pl) 1995-07-31
FI95380B (fi) 1995-10-13
IE67322B1 (en) 1996-03-20
CN1028757C (zh) 1995-06-07
CA2046883A1 (en) 1991-06-30
SK278810B6 (sk) 1998-03-04
WO1991009857A1 (fr) 1991-07-11
NZ236678A (en) 1992-06-25
HU213230B (en) 1997-03-28
FI95380C (fi) 1996-01-25
IL96811A (en) 1995-03-15
IE904721A1 (en) 1991-07-17
US5780468A (en) 1998-07-14
PT96368B (pt) 1998-06-30
LV5803B4 (lv) 1997-08-20
JP2758077B2 (ja) 1998-05-25
HUT61761A (en) 1993-03-01
US5891894A (en) 1999-04-06
FI914058A0 (fi) 1991-08-28
HK1000011A1 (en) 1997-10-03
EP0462264A1 (fr) 1991-12-27
HU912819D0 (en) 1992-02-28
TW215921B (pl) 1993-11-11
NO913378D0 (no) 1991-08-28
CA2046883C (en) 2000-08-15
SK627790A3 (en) 1998-03-04
CN1053064A (zh) 1991-07-17
PT96368A (pt) 1991-09-30
RU2049784C1 (ru) 1995-12-10
UA35546C2 (uk) 2001-04-16
AU627103B2 (en) 1992-08-13
US6057318A (en) 2000-05-02
DE69017443T2 (de) 1995-10-12
DK0462264T3 (da) 1995-05-22
EP0462264B1 (fr) 1995-03-01
ATE119160T1 (de) 1995-03-15
US5470855A (en) 1995-11-28
IL96811A0 (en) 1991-09-16
KR920701202A (ko) 1992-08-11
ZA9010447B (en) 1992-08-26
ES2069276T3 (es) 1995-05-01

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