NO178333C - Fremgangsmåte for fremstilling av mellomprodukter ved kjemisk syntese av oligonukleotider - Google Patents

Fremgangsmåte for fremstilling av mellomprodukter ved kjemisk syntese av oligonukleotider

Info

Publication number
NO178333C
NO178333C NO913626A NO913626A NO178333C NO 178333 C NO178333 C NO 178333C NO 913626 A NO913626 A NO 913626A NO 913626 A NO913626 A NO 913626A NO 178333 C NO178333 C NO 178333C
Authority
NO
Norway
Prior art keywords
chemical synthesis
oligonucleotides
intermediates
preparation
ease
Prior art date
Application number
NO913626A
Other languages
English (en)
Other versions
NO913626D0 (no
NO913626L (no
NO178333B (no
Inventor
Wolfgang Pfleiderer
Frank Bergmann
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4029244A external-priority patent/DE4029244A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO913626D0 publication Critical patent/NO913626D0/no
Publication of NO913626L publication Critical patent/NO913626L/no
Priority to NO950427A priority Critical patent/NO180751C/no
Priority to NO950428A priority patent/NO180752C/no
Priority to NO951911A priority patent/NO180419C/no
Publication of NO178333B publication Critical patent/NO178333B/no
Publication of NO178333C publication Critical patent/NO178333C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
    • C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
    • C07C309/35—Naphthalene sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
NO913626A 1990-09-14 1991-09-13 Fremgangsmåte for fremstilling av mellomprodukter ved kjemisk syntese av oligonukleotider NO178333C (no)

Priority Applications (3)

Application Number Priority Date Filing Date Title
NO950427A NO180751C (no) 1990-09-14 1995-02-06 Fremgangsmåte for kjemisk syntese av oligonukleotider, og anvendelse av forbindelsene i oligonukleotidsyntese
NO950428A NO180752C (no) 1990-09-14 1995-02-06 Fremgangsmåte for kjemisk syntese av oligonukleotider, og anvendelse av forbindelsene i oligonukleotidsyntese
NO951911A NO180419C (no) 1990-09-14 1995-05-15 Oligonukleotider og anvendelse i oligonukleotidsyntese

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4029244A DE4029244A1 (de) 1990-09-14 1990-09-14 Verfahren zur chemischen synthese von oligonukleotiden
DE4111363 1991-04-09

Publications (4)

Publication Number Publication Date
NO913626D0 NO913626D0 (no) 1991-09-13
NO913626L NO913626L (no) 1992-03-16
NO178333B NO178333B (no) 1995-11-27
NO178333C true NO178333C (no) 1996-03-06

Family

ID=25896883

Family Applications (1)

Application Number Title Priority Date Filing Date
NO913626A NO178333C (no) 1990-09-14 1991-09-13 Fremgangsmåte for fremstilling av mellomprodukter ved kjemisk syntese av oligonukleotider

Country Status (17)

Country Link
US (2) US5631362A (no)
EP (1) EP0475443B1 (no)
JP (2) JP3539978B2 (no)
KR (1) KR100228606B1 (no)
AT (1) ATE113031T1 (no)
AU (1) AU641882B2 (no)
CA (1) CA2051217C (no)
DE (1) DE59103277D1 (no)
DK (1) DK0475443T3 (no)
ES (1) ES2065595T3 (no)
FI (1) FI102072B1 (no)
HU (1) HUT63432A (no)
IE (1) IE65094B1 (no)
IL (1) IL99465A (no)
NO (1) NO178333C (no)
NZ (1) NZ239766A (no)
PT (1) PT98963B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048975A (en) * 1991-09-12 2000-04-11 Hoechst Aktiengesellschaft Process for the chemical synthesis of oligonucleotides
DE19842164B4 (de) * 1998-09-15 2004-06-03 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verfahren zur Qualitätskontrolle beim Aufbau von Oligomerrastern
CN102887841A (zh) * 2012-11-02 2013-01-23 天津希恩思生化科技有限公司 化合物丹磺酰氯的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE757863A (fr) * 1969-10-24 1971-04-22 Hoechst Ag Colorants anthraquinoniques solubles dans l'eau et leur preparation
EP0267996A1 (en) * 1986-11-20 1988-05-25 Tamir Biotechnology Ltd. New nucleotide derivatives
US4960700A (en) * 1986-12-24 1990-10-02 Genentech, Inc. Compositions and methods for the synthesis and assay of a mammalian enkephalinase
US4997928A (en) * 1988-09-15 1991-03-05 E. I. Du Pont De Nemours And Company Fluorescent reagents for the preparation of 5'-tagged oligonucleotides
WO1991004983A1 (en) * 1989-10-05 1991-04-18 University Patents, Inc. Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes

Also Published As

Publication number Publication date
KR920006305A (ko) 1992-04-27
HU912936D0 (en) 1992-01-28
US5631362A (en) 1997-05-20
NO913626D0 (no) 1991-09-13
CA2051217C (en) 2003-12-09
FI914293A0 (fi) 1991-09-12
US5945524A (en) 1999-08-31
HUT63432A (en) 1993-08-30
JP3539978B2 (ja) 2004-07-07
EP0475443B1 (de) 1994-10-19
EP0475443A2 (de) 1992-03-18
JPH05320122A (ja) 1993-12-03
FI914293A (fi) 1992-03-15
JP3983691B2 (ja) 2007-09-26
ATE113031T1 (de) 1994-11-15
IL99465A (en) 2001-04-30
NO913626L (no) 1992-03-16
FI102072B (fi) 1998-10-15
AU641882B2 (en) 1993-09-30
DK0475443T3 (da) 1995-04-03
DE59103277D1 (de) 1994-11-24
FI102072B1 (fi) 1998-10-15
JP2003292499A (ja) 2003-10-15
EP0475443A3 (en) 1992-07-08
PT98963B (pt) 1999-02-26
PT98963A (pt) 1992-08-31
NO178333B (no) 1995-11-27
KR100228606B1 (ko) 1999-11-01
IE65094B1 (en) 1995-10-04
CA2051217A1 (en) 1992-03-15
IE913250A1 (en) 1992-02-25
AU8386591A (en) 1992-03-19
ES2065595T3 (es) 1995-02-16
IL99465A0 (en) 1992-08-18
NZ239766A (en) 1994-05-26

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