NO166083C - Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyridazodiazepinderivater. - Google Patents

Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyridazodiazepinderivater.

Info

Publication number
NO166083C
NO166083C NO875200A NO875200A NO166083C NO 166083 C NO166083 C NO 166083C NO 875200 A NO875200 A NO 875200A NO 875200 A NO875200 A NO 875200A NO 166083 C NO166083 C NO 166083C
Authority
NO
Norway
Prior art keywords
preparation
therapeutically active
analogy procedure
pyridazodiazepine
derivatives
Prior art date
Application number
NO875200A
Other languages
English (en)
Norwegian (no)
Other versions
NO875200L (no
NO166083B (no
NO875200D0 (no
Inventor
Geoffrey Lawton
Sally Redshaw
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO875200D0 publication Critical patent/NO875200D0/no
Publication of NO875200L publication Critical patent/NO875200L/no
Publication of NO166083B publication Critical patent/NO166083B/no
Publication of NO166083C publication Critical patent/NO166083C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO875200A 1986-12-15 1987-12-14 Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyridazodiazepinderivater. NO166083C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868629875A GB8629875D0 (en) 1986-12-15 1986-12-15 Pyridazodiazepine derivatives

Publications (4)

Publication Number Publication Date
NO875200D0 NO875200D0 (no) 1987-12-14
NO875200L NO875200L (no) 1988-06-16
NO166083B NO166083B (no) 1991-02-18
NO166083C true NO166083C (no) 1991-05-29

Family

ID=10609005

Family Applications (1)

Application Number Title Priority Date Filing Date
NO875200A NO166083C (no) 1986-12-15 1987-12-14 Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyridazodiazepinderivater.

Country Status (17)

Country Link
US (2) US4757069A (ja)
EP (1) EP0271795A3 (ja)
JP (1) JPS63162693A (ja)
KR (1) KR880007538A (ja)
AU (1) AU602546B2 (ja)
CA (1) CA1291478C (ja)
DK (1) DK628087A (ja)
FI (1) FI85482C (ja)
GB (1) GB8629875D0 (ja)
HU (1) HU198492B (ja)
IL (1) IL84765A (ja)
MC (1) MC1879A1 (ja)
NO (1) NO166083C (ja)
NZ (1) NZ222825A (ja)
PH (1) PH23813A (ja)
PT (1) PT86365B (ja)
ZA (1) ZA879229B (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
DK0534363T3 (da) * 1991-09-27 1997-09-22 Merrell Pharma Inc 2-substituerede indan-2-mercaptoacetylamid-forbindelse med inhiberende virkning på enkephalinase og ACE.
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
CA2130116C (en) * 1992-02-14 1998-04-07 Gary A. Flynn Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
ATE182892T1 (de) * 1992-05-15 1999-08-15 Merrell Pharma Inc Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
CA2146238C (en) * 1992-10-30 2001-03-13 Gary A. Flynn Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace
CN1142831A (zh) * 1994-02-14 1997-02-12 默里尔药物公司 用作脑啡肽酶和ace抑制剂的新的2-取代的1，2-二氢化茚-2-巯基乙酰胺二硫化物衍生物
ATE177098T1 (de) * 1994-02-14 1999-03-15 Merrell Pharma Inc Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren
WO1995021840A1 (en) * 1994-02-14 1995-08-17 Merrell Pharmaceuticals Inc. Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
PT750631E (pt) * 1994-02-14 2000-07-31 Merrell Pharma Inc Novos derivados de dissulfureto de mercapto-aacetilamido-1,3,4,5-tetra-hidro-benzo¬c)azepin-3-ona uteis como inibidores de encefalinase e ace
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
JPH10503468A (ja) * 1994-03-24 1998-03-31 メリル・フアーマシユウテイカルズ・インコーポレイテツド 低コレステロール血性、抗アテローム性動脈硬化性および低トリグリセライド血性のメルカプトアセチルアミドジスルフィド誘導体
DE69514912T2 (de) * 1994-03-24 2000-10-05 Merrell Pharmaceuticals Inc., Cincinnati Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten
WO2001060879A1 (fr) * 2000-02-17 2001-08-23 China Petroleum & Chemical Corporation Copolymere multisequence et son procede de preparation
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
IE20070935A1 (en) * 2007-12-21 2009-06-24 Trinity College Dublin Guanidine based compounds and their use in the treatment of mental and neurological disorders.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4092438A (en) * 1977-04-29 1978-05-30 Carnation Company Non-dairy coffee whitener containing acetate salt
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
GB8320764D0 (en) * 1983-08-02 1983-09-01 Rhodes Joseph Ltd Bending machines
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
EP0187037A3 (en) * 1984-12-21 1988-03-23 Takeda Chemical Industries, Ltd. Piperidine derivatives, their production and use

Also Published As

Publication number Publication date
MC1879A1 (fr) 1989-01-24
US4757069A (en) 1988-07-12
FI875483A (fi) 1988-06-16
IL84765A0 (en) 1988-05-31
AU8225487A (en) 1988-06-16
JPS63162693A (ja) 1988-07-06
ZA879229B (en) 1988-06-15
NO875200L (no) 1988-06-16
NZ222825A (en) 1990-11-27
NO166083B (no) 1991-02-18
DK628087A (da) 1988-06-16
PT86365A (en) 1988-01-01
GB8629875D0 (en) 1987-01-28
FI85482C (fi) 1992-04-27
CA1291478C (en) 1991-10-29
FI85482B (fi) 1992-01-15
HUT47279A (en) 1989-02-28
DK628087D0 (da) 1987-11-30
AU602546B2 (en) 1990-10-18
PT86365B (pt) 1990-11-20
US4782149A (en) 1988-11-01
EP0271795A2 (de) 1988-06-22
KR880007538A (ko) 1988-08-27
HU198492B (en) 1989-10-30
IL84765A (en) 1991-06-30
FI875483A0 (fi) 1987-12-14
EP0271795A3 (de) 1989-08-09
PH23813A (en) 1989-11-23
NO875200D0 (no) 1987-12-14

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