NO155771B - Analogifremgangsmaate for fremstilling av terapeutisk aktive aminopropanolderivater. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive aminopropanolderivater. Download PDF

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NO155771B
NO155771B NO823161A NO823161A NO155771B NO 155771 B NO155771 B NO 155771B NO 823161 A NO823161 A NO 823161A NO 823161 A NO823161 A NO 823161A NO 155771 B NO155771 B NO 155771B
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drill
radical
sleeve
alkyl
preparation
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NO823161L (no
NO155771C (no
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Albrecht Franke
Josef Mueller
Helmut Lietz
Walter-Wielant Wiersdorff
Hans-Guenther Hege
Claus D Mueller
Josef Gries
Dieter Lenke
Gerda Von Philipsborn
Manfred Raschack
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Basf Ag
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
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    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
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    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/73—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
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    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
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    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
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    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Farmakologisk aktive aminopropanolderivater med formel I:. hvor. R 1 og R 2 betyr hydrogenatomer, alkyl-, cykloalkyl-, alkenyl-, alkynyl- eller hydroksyalkyl-rester, alkoksyalky1-, alkyltio-alkyl- eller dialkylaminoalkyl-rester, eller fenylalkyl- eller fenoksyalkyl-rester hvor fenylresten eventuelt er substituert med alkyl eller alkoksy, eller. 1 2. R og R sammen med nitrogenatomet som forbinder dem, danner. en 5- til 7-leddet mettet heterocyklisk ring som eventuelt kan være substituert og kan inneholde et ytterligere oksygen- eller ndtrogenatom som heteroatom i ringen,. R^ er et hydrogenatom, en alkylrest, et halogenatom, en hydroksygruppe eller en alkoksygruppe,. Rer et hydrogenatom, en alkylrest, et halogenatom, en alkoksyrest eller resten NR^R6, hvor R^ og R^ er like eller forskjellige og utgjør alkylrester eller sammen med det nitrogenatom som de er bundet til, danner en heterocyklisk ring, idet restene 13 4 2. R , R og R ikke samtidig kan være hydrogenatomer derscm R utgjør en alkylrest med 3-4 C-atomer, og. n er 1, 2 eller 3.Forbindelsene er særlig egnet som antiarytmika. Fremstilling av forbindelsene er beskrevet.

Description

Selvborende plugghylse.
Den foreliggende oppfinnelse angår en innretning som tjener til meisling eller boring av hull i murverk, særlig hardt murverk som betong og lignende, og som dess-uten kan tjene som plugghylse til fasthol-delse av bygningsdeler som plater, kroker og lignende på muren.
Det har allerede vært foreslått å an-vende en pluggmeisel som en del av en plugg. Ved anvendelse av disse innretnin-ger har man imidlertid måttet fjerne mei-selen fra boringen etterat plugghullet var fremstilt, for å sette inn et gjenget klemstykke i forenden av boret, hvoretter dette igjen kunne settes inn i borhullet. Der-etter ble festeskruen skrudd inn i klem-stykkets gjenger, hvorved borhylsen ble ekspandert i nærheten av borkronen.
Det nye og fordelaktige ved den kom-binerte plugg og meisel ifølge oppfinnelsen i forhold til slike kjente anordninger av lignende art som er nevnt ovenfor, ligger i at det parti som bærer borhodet, kan ekspanderes ved kilevirkning ved hjelp av et klemstykke som kan føres inn utenfra, og som samvirker med fremspring i borhylsens indre. Klemstykket kan f. eks. ha form av en kjegle, en kule eller en sylinder og kiles inn på det parti av borhylsen som bærer borkronen, idet der i borhylsen er tildannet fremspring, ribber, innpresnin-ger eller lignende som reduserer innerdia-meteren av borhylsen i nærheten av borkronen. Borhylsen kan ha lukket tverr-snitt eller være helt eller delvis oppslisset. Videre er det fordelaktig å utforme en skruebolt i slagborverktøyet helt eller delvis hul, foråt borstøvet også skal kunne opptas i det indre av skruebolten. Når verk-tøyet fjernes fra borhylsen, vil borstøvet som følge av verktøyets dreie- og slagbe-vegelse lett falle ut av hulrommet. For sentrering av boret er det fordelaktig å utforme borkronens tenner forskjellige lange, idet diametralt overfor hinannen lig-gende tenner dog gjøres like lange.
På tegningen er der vist en eksempel-vis utførelsesform av oppfinnelsen. Fig. 1 viser en utførelsesform med innvendige ribber som medfører at borkronen utvides ved innsetning av et klemstykke i borhylsen. Fig. 2 er et grunnriss av borhylsen på
fig. 1.
Fig. 3 viser en pluggmeisel som er inn-satt i veggen, og hvis borkrone er utvidet ved hjelp av klemstykket, samt en festeskrue til befestigelse av bygningsdeler.
Borhylsen 1 har i sitt bakre parti innvendige gjenger 2 og ved sin fremre ende en borkrone 3. Borhylsen oppviser videre en sliss som tjener til å lette ekspansjonen av den indre ende av borhylsen i borhullet. Som følge av sin spesielle utformning og forskjellige lange tenner 3a trenger borhylsen lett inn i muren 8. Fig. 2 viser borhylsens stilling etterat hullet er ferdigbo-ret.
For å holde borhylsen fast i muren blir et klemstykke 11" satt inn i hylsen 1. Klemstykket 11" består av en eneste, gra-natformet del (sammensatt av en kjegle og en sylinder), og borhylsen 1 er forsynt med innvendige langsgående ribber 12. Disse langsgående ribber 12 medfører at borhylsens forreste del, som bærer borkronen, presses utover når klemstykket 11" drives inn, så der fås en fast forankring i muren. På fig. 3 er taormeiselen vist i bruks-stiiling, idet der etterat borhylsen 1 er fast forankret i muren 8, er innskrudd en festeskrue 13 i borhylsens innvendige gjenger 2. Denne festeskrue holder en bygnings-plate 14 og klemmer den fast mot muren.
Som følge av det klogrep som den forreste del av borhylsen får i muren ved fastkilingen, kan den som pluggmeisel ut-formede plugg tåle store belastninger. Montasjen er så enkel som vel mulig, og det er ikke nødvendig å fjerne bormeiselen fra hullet etterat dette er tildannet, noe som ofte kunne føre til uønskede utvidelser av borhullet og forsinke arbeidet.

Claims (2)

1. Selvborende og fortrinnsvis slisset plugghylse med gjenger i hylsens bakre del, karakterisert ved at det parti som bærer borhodet (3, 3a) kan ekspanderes ved kilevirkning ved hjelp av et klemstykke (11") som kan føres inn utenfra, og som samvirker med fremspring (12) i borhylsens indre.
2. Plugghylse som angitt i påstand 1, karakterisert ved at tennene (3, 3a) i borkronen er ulike lange, men sym-metrisk anordnet.
NO823161A 1981-09-18 1982-09-17 Analogifremgangsmaate for fremstilling av terapeutisk aktive aminopropanolderivater. NO155771C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3137178 1981-09-18
DE19823226863 DE3226863A1 (de) 1981-09-18 1982-07-17 Aminopropanolderivate von 2-hydroxy-ss-phenyl-propiophenonen, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel

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NO823161L NO823161L (no) 1983-03-21
NO155771B true NO155771B (no) 1987-02-16
NO155771C NO155771C (no) 1987-05-27

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US (1) US4571409A (no)
EP (1) EP0075207B1 (no)
CA (1) CA1175831A (no)
CS (1) CS236489B2 (no)
DE (2) DE3226863A1 (no)
DK (1) DK164699C (no)
ES (1) ES8305684A1 (no)
FI (1) FI77224C (no)
HU (1) HU186576B (no)
IL (1) IL66783A0 (no)
NO (1) NO155771C (no)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3309595A1 (de) * 1983-03-17 1984-09-20 Basf Ag, 6700 Ludwigshafen Neue aminopropanolderivate von 1-(2-hydroxy-phenyl)-3-phenyl-propanolen, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
DE3348170C2 (no) * 1983-07-21 1993-03-11 Helopharm W. Petrik Gmbh & Co Kg, 1000 Berlin, De
DE3343671A1 (de) * 1983-12-02 1985-06-20 Basf Ag, 6700 Ludwigshafen Aminopropanolderivate von substituierten 2-hydroxy-propiophenonen, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
DE3424685A1 (de) * 1984-07-05 1986-02-06 Beiersdorf Ag, 2000 Hamburg Neue substituierte phenylpiperazinyl-propanole, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
DE3429667A1 (de) * 1984-08-11 1986-02-20 Knoll Ag, 6700 Ludwigshafen Verfahren zur herstellung von substituierten aryl-alkylketonen
DE3773188D1 (de) * 1987-03-26 1991-10-24 Helopharm Petrik Co Kg Verfahren zur herstellung von 5-hydroxydiprafenon und seiner salze mit saeuren.
EP0296264A1 (de) * 1987-06-23 1988-12-28 Helopharm W. Petrik GmbH & Co.KG. Aminopropanolderivate von 3-(2-Hydroxyphenyl)-1-propanonderivaten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0296265A1 (de) * 1987-06-23 1988-12-28 Helopharm W. Petrik GmbH & Co.KG. Aminopropanolderivate von 3-(3-Hydroxyphenyl)-1-propanon-derivaten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0296592B1 (de) * 1987-06-23 1992-02-12 Helopharm W. Petrik GmbH & Co.KG. Aminopropanolderivate von 3-(2-Hydroxyphenyl)-1-propanon-Verbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3725273A1 (de) * 1987-07-30 1989-02-09 Basf Ag Verfahren zur synthese von enantiomeren des propafenons sowie diese enthaltende therapeutische mittel
DE3834132A1 (de) * 1988-10-07 1990-04-12 Knoll Ag Hydroxypropafenonglyceride
DE4000213A1 (de) * 1990-01-05 1991-07-11 Helopharm Petrik Co Kg O-hydroxy-ss-(1-naphthyl)-propiophenonderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ES2152310T3 (es) * 1993-03-29 2001-02-01 Basf Ag Derivados de 1-amino-3-fenoxipropano como moduladores de la resistencia a multiples a farmacos.
AT401726B (de) * 1993-05-17 1996-11-25 Gerhard Dr Ecker O-acylaryloxypropanolamine mit tertiärem oder quartärem stickstoff als reversionsmodulatoren für p-glykoprotein mediierte multidrug-resistenz
CN104262178A (zh) * 2014-09-28 2015-01-07 常州瑞明药业有限公司 盐酸普罗帕酮的合成方法

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US3812129A (en) * 1966-06-24 1974-05-21 Hoffmann La Roche Piperazinyl substituted alkoxy benzophenones
DE2001431C3 (de) 1970-01-06 1974-12-12 Helopharm W. Petrik & Co Kg, 1000 Berlin 2-(2'-Hydroxy-3'-alkylaminopropoxy)-Omega-phenyl-propiophenone und Verfahren zur Herstellung derselben
DE3133814C2 (de) * 1981-08-25 1983-12-22 Helopharm W. Petrik & Co Kg, 1000 Berlin 2-[2'-Hydroxy-3'-(1,1-dimethylpropylamino)-propoxy]-β-phenylpropiophenon, seine Säureadditionssalze und Arzneimittel

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DK164699B (da) 1992-08-03
NO823161L (no) 1983-03-21
FI823217A0 (fi) 1982-09-17
EP0075207B1 (de) 1986-02-05
CA1175831A (en) 1984-10-09
CS236489B2 (en) 1985-05-15
HU186576B (en) 1985-08-28
EP0075207A2 (de) 1983-03-30
DK416082A (da) 1983-03-19
ES515788A0 (es) 1983-05-01
FI77224C (fi) 1989-02-10
FI77224B (fi) 1988-10-31
FI823217L (fi) 1983-03-19
EP0075207A3 (en) 1984-05-16
DK164699C (da) 1992-12-21
IL66783A0 (en) 1982-12-31
ES8305684A1 (es) 1983-05-01
DE3268963D1 (en) 1986-03-20
DE3226863A1 (de) 1983-04-07
NO155771C (no) 1987-05-27
US4571409A (en) 1986-02-18

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