NO135748B - - Google Patents
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- Publication number
- NO135748B NO135748B NO2993/70A NO299370A NO135748B NO 135748 B NO135748 B NO 135748B NO 2993/70 A NO2993/70 A NO 2993/70A NO 299370 A NO299370 A NO 299370A NO 135748 B NO135748 B NO 135748B
- Authority
- NO
- Norway
- Prior art keywords
- methyl
- group
- hydrogen atom
- formula
- acid
- Prior art date
Links
- 239000002253 acid Substances 0.000 claims description 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 14
- 150000001875 compounds Chemical class 0.000 claims description 13
- 150000002148 esters Chemical class 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 8
- 150000001408 amides Chemical class 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 150000007513 acids Chemical class 0.000 claims description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 231100000252 nontoxic Toxicity 0.000 claims description 2
- 230000003000 nontoxic effect Effects 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 22
- -1 hydrocarbon alcohols Chemical class 0.000 description 19
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
- 239000003208 petroleum Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000011734 sodium Substances 0.000 description 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 6
- 238000010992 reflux Methods 0.000 description 6
- MQMLSRLJPKVUFB-UHFFFAOYSA-M sodium;2-ethyl-2-methoxycarbonylbutanoate Chemical compound [Na+].CCC(CC)(C([O-])=O)C(=O)OC MQMLSRLJPKVUFB-UHFFFAOYSA-M 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 6
- 238000001704 evaporation Methods 0.000 description 5
- 230000008020 evaporation Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- QGCPSHFCQNUANM-UHFFFAOYSA-N (3-bromo-2-methyl-1-phenylprop-1-enyl)benzene Chemical compound C=1C=CC=CC=1C(=C(CBr)C)C1=CC=CC=C1 QGCPSHFCQNUANM-UHFFFAOYSA-N 0.000 description 4
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- OYHDPMVVANDTBQ-UHFFFAOYSA-N 2,4-dimethyl-5,5-diphenylpent-4-enoic acid Chemical compound C=1C=CC=CC=1C(=C(C)CC(C)C(O)=O)C1=CC=CC=C1 OYHDPMVVANDTBQ-UHFFFAOYSA-N 0.000 description 3
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 3
- 239000012965 benzophenone Substances 0.000 description 3
- 230000001076 estrogenic effect Effects 0.000 description 3
- 150000004702 methyl esters Chemical class 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 2
- BBMCTIGTTCKYKF-UHFFFAOYSA-N 1-heptanol Chemical compound CCCCCCCO BBMCTIGTTCKYKF-UHFFFAOYSA-N 0.000 description 2
- AUQTWQKQFQORGZ-UHFFFAOYSA-N 2-methyl-3,3-diphenylprop-2-en-1-ol Chemical compound C=1C=CC=CC=1C(=C(CO)C)C1=CC=CC=C1 AUQTWQKQFQORGZ-UHFFFAOYSA-N 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 239000012280 lithium aluminium hydride Substances 0.000 description 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 2
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 description 2
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000010626 work up procedure Methods 0.000 description 2
- NYZAKYKCCUVKJT-UHFFFAOYSA-N (2-bromo-3-methyl-1-phenylbut-1-enyl)benzene Chemical compound C=1C=CC=CC=1C(=C(Br)C(C)C)C1=CC=CC=C1 NYZAKYKCCUVKJT-UHFFFAOYSA-N 0.000 description 1
- OZDCBKYPNBVRSA-UHFFFAOYSA-N (4,4-dimethoxycyclohexa-1,5-dien-1-yl)-phenylmethanone Chemical compound C1=CC(OC)(OC)CC=C1C(=O)C1=CC=CC=C1 OZDCBKYPNBVRSA-UHFFFAOYSA-N 0.000 description 1
- SWFHGTMLYIBPPA-UHFFFAOYSA-N (4-methoxyphenyl)-phenylmethanone Chemical compound C1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 SWFHGTMLYIBPPA-UHFFFAOYSA-N 0.000 description 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 description 1
- LTMRRSWNXVJMBA-UHFFFAOYSA-L 2,2-diethylpropanedioate Chemical compound CCC(CC)(C([O-])=O)C([O-])=O LTMRRSWNXVJMBA-UHFFFAOYSA-L 0.000 description 1
- NZRDAYVRTXKVMO-UHFFFAOYSA-N 3,3-bis(4-methoxyphenyl)-2-methylprop-2-enoic acid Chemical compound C1=CC(OC)=CC=C1C(=C(C)C(O)=O)C1=CC=C(OC)C=C1 NZRDAYVRTXKVMO-UHFFFAOYSA-N 0.000 description 1
- FHJCCQOFMHARRW-UHFFFAOYSA-N 4-benzhydrylidene-2-methylhexanoic acid Chemical compound C=1C=CC=CC=1C(=C(CC(C)C(O)=O)CC)C1=CC=CC=C1 FHJCCQOFMHARRW-UHFFFAOYSA-N 0.000 description 1
- FVLWLSLBCCFBQQ-UHFFFAOYSA-N 4-methyl-2,5,5-triphenylpent-4-enoic acid Chemical compound C1(=CC=CC=C1)C(C(=O)O)CC(=C(C1=CC=CC=C1)C1=CC=CC=C1)C FVLWLSLBCCFBQQ-UHFFFAOYSA-N 0.000 description 1
- AMARXJFXWNSKRH-UHFFFAOYSA-N 5-(4-methoxyphenyl)-2,4-dimethyl-5-phenylpent-4-enoic acid Chemical compound C1=CC(OC)=CC=C1C(=C(C)CC(C)C(O)=O)C1=CC=CC=C1 AMARXJFXWNSKRH-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 208000017657 Menopausal disease Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- TVNOJSOOOHBLMR-UHFFFAOYSA-N [2-(bromomethyl)-1-phenylbut-1-enyl]benzene Chemical compound C1(=CC=CC=C1)C(=C(CC)CBr)C1=CC=CC=C1 TVNOJSOOOHBLMR-UHFFFAOYSA-N 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 150000001447 alkali salts Chemical group 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 229940124558 contraceptive agent Drugs 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000006114 decarboxylation reaction Methods 0.000 description 1
- 239000012024 dehydrating agents Substances 0.000 description 1
- 150000005690 diesters Chemical class 0.000 description 1
- VQAZCUCWHIIFGE-UHFFFAOYSA-N diethyl 2-ethylpropanedioate Chemical compound CCOC(=O)C(CC)C(=O)OCC VQAZCUCWHIIFGE-UHFFFAOYSA-N 0.000 description 1
- UPQZOUHVTJNGFK-UHFFFAOYSA-N diethyl 2-methylpropanedioate Chemical compound CCOC(=O)C(C)C(=O)OCC UPQZOUHVTJNGFK-UHFFFAOYSA-N 0.000 description 1
- LXQXGFPPYLKKSD-UHFFFAOYSA-L disodium;2,2-diethylpropanedioate Chemical compound [Na+].[Na+].CCC(CC)(C([O-])=O)C([O-])=O LXQXGFPPYLKKSD-UHFFFAOYSA-L 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- XIMFCGSNSKXPBO-UHFFFAOYSA-N ethyl 2-bromobutanoate Chemical compound CCOC(=O)C(Br)CC XIMFCGSNSKXPBO-UHFFFAOYSA-N 0.000 description 1
- ORSIRXYHFPHWTN-UHFFFAOYSA-N ethyl 2-bromopentanoate Chemical compound CCCC(Br)C(=O)OCC ORSIRXYHFPHWTN-UHFFFAOYSA-N 0.000 description 1
- ARFLASKVLJTEJD-UHFFFAOYSA-N ethyl 2-bromopropanoate Chemical compound CCOC(=O)C(C)Br ARFLASKVLJTEJD-UHFFFAOYSA-N 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- RMGJCSHZTFKPNO-UHFFFAOYSA-M magnesium;ethene;bromide Chemical compound [Mg+2].[Br-].[CH-]=C RMGJCSHZTFKPNO-UHFFFAOYSA-M 0.000 description 1
- 150000002690 malonic acid derivatives Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910052987 metal hydride Inorganic materials 0.000 description 1
- 150000004681 metal hydrides Chemical class 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000012260 resinous material Substances 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 229910001923 silver oxide Inorganic materials 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000002130 sulfonic acid ester group Chemical group 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3912369 | 1969-08-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO135748B true NO135748B (pt) | 1977-02-14 |
| NO135748C NO135748C (pt) | 1977-05-25 |
Family
ID=10407759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO2993/70A NO135748C (pt) | 1969-08-05 | 1970-08-03 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US3736347A (pt) |
| JP (1) | JPS4948316B1 (pt) |
| AT (1) | AT303709B (pt) |
| BE (1) | BE754469A (pt) |
| CH (1) | CH550131A (pt) |
| DE (1) | DE2038793A1 (pt) |
| DK (2) | DK135835B (pt) |
| ES (1) | ES382485A1 (pt) |
| FI (1) | FI52458C (pt) |
| FR (1) | FR2068462B1 (pt) |
| GB (1) | GB1257266A (pt) |
| IE (1) | IE34427B1 (pt) |
| IL (1) | IL35043A (pt) |
| NL (1) | NL7011407A (pt) |
| NO (1) | NO135748C (pt) |
| OA (1) | OA03669A (pt) |
| SE (1) | SE363091B (pt) |
| SU (1) | SU367596A3 (pt) |
| ZA (1) | ZA705370B (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8311678D0 (en) * | 1983-04-28 | 1983-06-02 | Ici Plc | Phenol derivatives |
| US4603145A (en) * | 1983-05-06 | 1986-07-29 | American Cyanamid Company | Antiatherosclerotic diphenyl alkanamides |
| US5182301A (en) * | 1986-03-17 | 1993-01-26 | Eisai Co., Ltd. | Diphenylethylene derivatives pharmaceutical compositions containing same and treatment methods |
| FI92189C (fi) * | 1986-03-17 | 1994-10-10 | Eisai Co Ltd | Menetelmä lääkeaineina käyttökelpoisen difenyylimetaanijohdannaisen valmistamiseksi |
| US5206403A (en) * | 1986-03-17 | 1993-04-27 | Eisai Co., Ltd. | Diphenylethylene derivatives, pharmaceutical compositions containing same and treatment methods |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH415625A (de) * | 1960-05-16 | 1966-06-30 | Bayer Ag | Ultraviolett-Schutzfilter |
-
0
- BE BE754469D patent/BE754469A/xx unknown
-
1969
- 1969-08-05 GB GB3912369A patent/GB1257266A/en not_active Expired
-
1970
- 1970-07-30 FI FI702105A patent/FI52458C/fi active
- 1970-07-30 IE IE984/70A patent/IE34427B1/xx unknown
- 1970-07-31 NL NL7011407A patent/NL7011407A/xx unknown
- 1970-08-03 NO NO2993/70A patent/NO135748C/no unknown
- 1970-08-03 IL IL35043A patent/IL35043A/xx unknown
- 1970-08-03 US US00060729A patent/US3736347A/en not_active Expired - Lifetime
- 1970-08-04 AT AT707070A patent/AT303709B/de not_active IP Right Cessation
- 1970-08-04 ZA ZA705370A patent/ZA705370B/xx unknown
- 1970-08-04 DE DE19702038793 patent/DE2038793A1/de active Pending
- 1970-08-04 FR FR7028710A patent/FR2068462B1/fr not_active Expired
- 1970-08-05 SU SU1473940A patent/SU367596A3/ru active
- 1970-08-05 CH CH1178570A patent/CH550131A/xx not_active IP Right Cessation
- 1970-08-05 DK DK403370AA patent/DK135835B/da unknown
- 1970-08-05 SE SE10784/70A patent/SE363091B/xx unknown
- 1970-08-05 ES ES382485A patent/ES382485A1/es not_active Expired
- 1970-08-05 JP JP45068606A patent/JPS4948316B1/ja active Pending
- 1970-12-04 OA OA54109A patent/OA03669A/xx unknown
-
1971
- 1971-12-23 DK DK631471AA patent/DK128414B/da unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE363091B (pt) | 1974-01-07 |
| IE34427L (en) | 1971-02-05 |
| GB1257266A (pt) | 1971-12-15 |
| DK135835C (pt) | 1977-12-05 |
| DK135835B (da) | 1977-07-04 |
| NO135748C (pt) | 1977-05-25 |
| JPS4948316B1 (pt) | 1974-12-20 |
| FR2068462B1 (pt) | 1974-02-01 |
| ZA705370B (en) | 1971-04-28 |
| SU367596A3 (pt) | 1973-01-23 |
| AT303709B (de) | 1972-12-11 |
| FI52458C (fi) | 1977-09-12 |
| US3736347A (en) | 1973-05-29 |
| ES382485A1 (es) | 1972-12-01 |
| IL35043A0 (en) | 1970-10-30 |
| BE754469A (fr) | 1971-02-05 |
| NL7011407A (pt) | 1971-02-09 |
| DK128414B (da) | 1974-04-29 |
| FI52458B (pt) | 1977-05-31 |
| OA03669A (fr) | 1971-12-24 |
| DE2038793A1 (de) | 1971-02-18 |
| FR2068462A1 (pt) | 1971-08-27 |
| CH550131A (de) | 1974-06-14 |
| IL35043A (en) | 1974-01-14 |
| IE34427B1 (en) | 1975-05-14 |
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