NO125680B - - Google Patents
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- Publication number
- NO125680B NO125680B NO4783/69A NO478369A NO125680B NO 125680 B NO125680 B NO 125680B NO 4783/69 A NO4783/69 A NO 4783/69A NO 478369 A NO478369 A NO 478369A NO 125680 B NO125680 B NO 125680B
- Authority
- NO
- Norway
- Prior art keywords
- carbon atoms
- general formula
- phenyl
- denotes
- benzoic acid
- Prior art date
Links
- 239000002253 acid Substances 0.000 claims description 9
- 125000004432 carbon atom Chemical group C* 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- -1 alkyl radical Chemical group 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 150000007522 mineralic acids Chemical class 0.000 claims description 4
- 150000007524 organic acids Chemical class 0.000 claims description 4
- 229910052801 chlorine Inorganic materials 0.000 claims description 3
- 239000000460 chlorine Substances 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 2
- AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 claims description 2
- 235000005985 organic acids Nutrition 0.000 claims description 2
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 9
- 230000003480 fibrinolytic effect Effects 0.000 description 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- YUKQRDCYNOVPGJ-UHFFFAOYSA-N thioacetamide Chemical compound CC(N)=S YUKQRDCYNOVPGJ-UHFFFAOYSA-N 0.000 description 5
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 102000005686 Serum Globulins Human genes 0.000 description 2
- 108010045362 Serum Globulins Proteins 0.000 description 2
- QIOZLISABUUKJY-UHFFFAOYSA-N Thiobenzamide Chemical compound NC(=S)C1=CC=CC=C1 QIOZLISABUUKJY-UHFFFAOYSA-N 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000020764 fibrinolysis Effects 0.000 description 2
- 239000003527 fibrinolytic agent Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- KAOGWKRVOAXQDX-UHFFFAOYSA-N 3,4-dimethoxybenzenecarbothioamide Chemical compound COC1=CC=C(C(N)=S)C=C1OC KAOGWKRVOAXQDX-UHFFFAOYSA-N 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 108010023197 Streptokinase Proteins 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 125000005805 dimethoxy phenyl group Chemical group 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 229940083124 ganglion-blocking antiadrenergic secondary and tertiary amines Drugs 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229960005202 streptokinase Drugs 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB59720/68A GB1248070A (en) | 1968-12-16 | 1968-12-16 | Thiazolyl-benzoic acid derivatives and process for preparing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO125680B true NO125680B (de) | 1972-10-16 |
Family
ID=10484296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO4783/69A NO125680B (de) | 1968-12-16 | 1969-12-03 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US3821237A (de) |
| JP (1) | JPS4615935B1 (de) |
| AT (1) | AT289108B (de) |
| BE (1) | BE743152A (de) |
| BR (1) | BR6915142D0 (de) |
| CH (1) | CH518300A (de) |
| DK (1) | DK122965B (de) |
| ES (1) | ES374549A1 (de) |
| FR (1) | FR2026216B1 (de) |
| GB (1) | GB1248070A (de) |
| IL (1) | IL33500A (de) |
| NL (1) | NL141878B (de) |
| NO (1) | NO125680B (de) |
| SE (1) | SE362077B (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1308028A (en) * | 1970-06-12 | 1973-02-21 | Science Union & Cie | Thiazolylbenzoic acid derivatives and a process for their manufactur |
| US4153703A (en) * | 1977-06-30 | 1979-05-08 | Uniroyal, Inc. | Method of controlling insects and acarids with certain aryl-substituted thiazoles |
| US4197306A (en) * | 1977-06-30 | 1980-04-08 | Uniroyal, Inc. | Aryl-substituted thiazoles |
| CA2036192A1 (en) | 1990-02-13 | 1991-08-14 | Nicholas Meanwell | Heterocyclic carboxylic acids and esters |
| US5077305A (en) * | 1990-02-13 | 1991-12-31 | Bristol-Myers Squibb Co. | Thiazole carboxylic acids and esters |
| CA2074933C (en) * | 1990-11-30 | 2002-12-03 | Masatoshi Chihiro | Thiazole derivatives as active superoxide radical inhibitors |
| US5639770A (en) * | 1992-05-29 | 1997-06-17 | Otsuka Pharmaceutical Co., Ltd. | Thiazole derivatives |
| AU4298997A (en) * | 1996-08-26 | 1998-03-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Thiazole derivatives useful as selective inhibitors of pde-iv |
| MY128323A (en) * | 1996-09-30 | 2007-01-31 | Otsuka Pharma Co Ltd | Thiazole derivatives for inhibition of cytokine production and of cell adhesion |
| JP2000281664A (ja) * | 1999-03-30 | 2000-10-10 | Otsuka Pharmaceut Co Ltd | チアゾール誘導体 |
| WO2005028426A1 (ja) * | 2003-09-19 | 2005-03-31 | Chugai Seiyaku Kabushiki Kaisha | 新規４−フェニルアミノ−ベンズアルドオキシム誘導体並びにそのmek阻害剤としての使用 |
| TWI361066B (en) * | 2004-07-26 | 2012-04-01 | Chugai Pharmaceutical Co Ltd | 5-substituted-2-phenylamino benzamides as mek inhibitors |
| EP1815206B1 (de) | 2004-10-13 | 2016-04-06 | PTC Therapeutics, Inc. | Verbindungen zur nonsense-unterdrückung und verfahren zu deren verwendung |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1743083A (en) * | 1928-02-03 | 1930-01-07 | Winthrop Chem Co | Catechol thiazoles and process of making the same |
-
1968
- 1968-12-16 GB GB59720/68A patent/GB1248070A/en not_active Expired
-
1969
- 1969-11-26 CH CH1757869A patent/CH518300A/fr not_active IP Right Cessation
- 1969-12-01 NL NL696917991A patent/NL141878B/xx unknown
- 1969-12-02 US US00881590A patent/US3821237A/en not_active Expired - Lifetime
- 1969-12-03 NO NO4783/69A patent/NO125680B/no unknown
- 1969-12-08 IL IL33500A patent/IL33500A/en unknown
- 1969-12-11 SE SE17161/69A patent/SE362077B/xx unknown
- 1969-12-11 FR FR696942891A patent/FR2026216B1/fr not_active Expired
- 1969-12-13 ES ES374549A patent/ES374549A1/es not_active Expired
- 1969-12-15 BR BR215142/69A patent/BR6915142D0/pt unknown
- 1969-12-15 BE BE743152D patent/BE743152A/xx unknown
- 1969-12-15 JP JP10018869A patent/JPS4615935B1/ja active Pending
- 1969-12-16 DK DK663769AA patent/DK122965B/da unknown
- 1969-12-16 AT AT1170069A patent/AT289108B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2026216A1 (de) | 1970-09-18 |
| IL33500A0 (en) | 1970-02-19 |
| JPS4615935B1 (de) | 1971-04-30 |
| DE1962493A1 (de) | 1970-06-18 |
| NL141878B (nl) | 1974-04-16 |
| BE743152A (de) | 1970-06-15 |
| US3821237A (en) | 1974-06-28 |
| FR2026216B1 (de) | 1973-07-13 |
| NL6917991A (de) | 1970-06-18 |
| SE362077B (de) | 1973-11-26 |
| AT289108B (de) | 1971-04-13 |
| BR6915142D0 (pt) | 1973-04-19 |
| GB1248070A (en) | 1971-09-29 |
| IL33500A (en) | 1973-01-30 |
| DK122965B (da) | 1972-05-01 |
| ES374549A1 (es) | 1972-01-01 |
| CH518300A (fr) | 1972-01-31 |
| DE1962493B2 (de) | 1976-06-10 |
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