NO121344B - - Google Patents
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- Publication number
- NO121344B NO121344B NO1742/68A NO174268A NO121344B NO 121344 B NO121344 B NO 121344B NO 1742/68 A NO1742/68 A NO 1742/68A NO 174268 A NO174268 A NO 174268A NO 121344 B NO121344 B NO 121344B
- Authority
- NO
- Norway
- Prior art keywords
- diethyl
- dibenzofuranyl
- malonate
- equimolecular
- compound
- Prior art date
Links
- OIFBSDVPJOWBCH-UHFFFAOYSA-N Diethyl carbonate Chemical compound CCOC(=O)OCC OIFBSDVPJOWBCH-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- -1 ethyl 2-dibenzofuranyl acetate Chemical compound 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 claims description 3
- 230000001225 therapeutic effect Effects 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 description 6
- 230000003110 anti-inflammatory effect Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- PTJNLAJKMMXRNQ-UHFFFAOYSA-N diethyl 2-dibenzofuran-2-ylpropanedioate Chemical compound C(C)OC(C(C(=O)OCC)C1=CC2=C(OC3=C2C=CC=C3)C=C1)=O PTJNLAJKMMXRNQ-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 201000003068 rheumatic fever Diseases 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012434 Dermatitis allergic Diseases 0.000 description 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 206010018691 Granuloma Diseases 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920003091 Methocel™ Polymers 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012259 ether extract Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/76—Dibenzothiophenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB22258/67A GB1175996A (en) | 1967-05-12 | 1967-05-12 | Diethyl-alpha-(2-Dibenzofuranyl)malonate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO121344B true NO121344B (fr) | 1971-02-15 |
Family
ID=10176453
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO1742/68A NO121344B (fr) | 1967-05-12 | 1968-05-04 | |
| NO1756/68A NO121502B (fr) | 1967-05-12 | 1968-05-06 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO1756/68A NO121502B (fr) | 1967-05-12 | 1968-05-06 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US3567742A (fr) |
| AT (1) | AT277988B (fr) |
| BE (2) | BE714816A (fr) |
| CH (2) | CH483420A (fr) |
| DE (2) | DE1768370B1 (fr) |
| DK (2) | DK122322B (fr) |
| ES (2) | ES353802A1 (fr) |
| FI (3) | FI47662C (fr) |
| FR (4) | FR1583848A (fr) |
| GB (1) | GB1175996A (fr) |
| IL (2) | IL29837A (fr) |
| LU (2) | LU56045A1 (fr) |
| NL (3) | NL6805924A (fr) |
| NO (2) | NO121344B (fr) |
| SE (2) | SE331100B (fr) |
| YU (2) | YU31950B (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1217689A (en) * | 1967-08-14 | 1970-12-31 | Guppo Lepetit S P A | Ethyl esters of fluro-acetic acids |
| DE2223391C3 (de) * | 1972-05-13 | 1982-02-11 | Merck Patent Gmbh, 6100 Darmstadt | Dibenzofuranderivate, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen enthaltend diese Verbindungen |
| NL7305520A (fr) * | 1972-05-13 | 1973-11-15 | ||
| US3928602A (en) * | 1972-11-01 | 1975-12-23 | Astra Laekemedel Ab | Substituted phenoxymalonic acids, esters thereof and hypolipaemic agents containing the same for lowering lipid levels |
-
1967
- 1967-05-12 GB GB22258/67A patent/GB1175996A/en not_active Expired
-
1968
- 1968-04-16 IL IL29837A patent/IL29837A/xx unknown
- 1968-04-16 IL IL29838A patent/IL29838A/en unknown
- 1968-04-23 CH CH597168A patent/CH483420A/fr not_active IP Right Cessation
- 1968-04-23 CH CH597268A patent/CH484034A/fr not_active IP Right Cessation
- 1968-04-25 NL NL6805924A patent/NL6805924A/xx unknown
- 1968-04-25 NL NL686805923A patent/NL149171B/xx unknown
- 1968-05-02 DK DK202368AA patent/DK122322B/da unknown
- 1968-05-03 US US726557A patent/US3567742A/en not_active Expired - Lifetime
- 1968-05-04 NO NO1742/68A patent/NO121344B/no unknown
- 1968-05-06 NO NO1756/68A patent/NO121502B/no unknown
- 1968-05-06 FI FI681267A patent/FI47662C/fi active
- 1968-05-06 FI FI01268/68A patent/FI48576B/fi active
- 1968-05-06 FI FI681268A patent/FI48576C/fi active
- 1968-05-07 DE DE19681768370 patent/DE1768370B1/de not_active Withdrawn
- 1968-05-07 DK DK209868A patent/DK133093C/da active
- 1968-05-07 DE DE19681768371 patent/DE1768371B2/de active Granted
- 1968-05-08 BE BE714816D patent/BE714816A/xx unknown
- 1968-05-08 BE BE714815D patent/BE714815A/xx unknown
- 1968-05-09 FR FR1583848D patent/FR1583848A/fr not_active Expired
- 1968-05-09 LU LU56045A patent/LU56045A1/xx unknown
- 1968-05-09 LU LU56044A patent/LU56044A1/xx unknown
- 1968-05-10 YU YU1109/68A patent/YU31950B/xx unknown
- 1968-05-10 YU YU1108/68A patent/YU32183B/xx unknown
- 1968-05-10 SE SE06363/68A patent/SE331100B/xx unknown
- 1968-05-10 FR FR1583853D patent/FR1583853A/fr not_active Expired
- 1968-05-10 SE SE06364/68A patent/SE353313B/xx unknown
- 1968-05-10 AT AT455068A patent/AT277988B/de not_active IP Right Cessation
- 1968-05-11 ES ES353802A patent/ES353802A1/es not_active Expired
- 1968-05-11 ES ES353801A patent/ES353801A1/es not_active Expired
- 1968-07-25 FR FR160601A patent/FR8082M/fr not_active Expired
- 1968-08-08 FR FR162347A patent/FR7708M/fr not_active Expired
-
1971
- 1971-03-12 NL NL7103372A patent/NL7103372A/xx unknown
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