NL9500216A - Farmaceutische samenstelling voor de behandeling van herpes. - Google Patents
Farmaceutische samenstelling voor de behandeling van herpes. Download PDFInfo
- Publication number
- NL9500216A NL9500216A NL9500216A NL9500216A NL9500216A NL 9500216 A NL9500216 A NL 9500216A NL 9500216 A NL9500216 A NL 9500216A NL 9500216 A NL9500216 A NL 9500216A NL 9500216 A NL9500216 A NL 9500216A
- Authority
- NL
- Netherlands
- Prior art keywords
- pharmaceutical composition
- component
- composition according
- cetrimide
- activity
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 22
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 title claims abstract description 10
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims abstract description 44
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims abstract description 31
- 229960002798 cetrimide Drugs 0.000 claims abstract description 31
- 239000000473 propyl gallate Substances 0.000 claims abstract description 22
- 235000010388 propyl gallate Nutrition 0.000 claims abstract description 22
- 229940075579 propyl gallate Drugs 0.000 claims abstract description 22
- 239000000419 plant extract Substances 0.000 claims abstract description 14
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims abstract description 13
- 208000015181 infectious disease Diseases 0.000 claims abstract description 10
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims abstract description 9
- 208000009889 Herpes Simplex Diseases 0.000 claims abstract description 8
- 229960004150 aciclovir Drugs 0.000 claims abstract description 8
- 229960000686 benzalkonium chloride Drugs 0.000 claims abstract description 7
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000003443 antiviral agent Substances 0.000 claims abstract description 6
- 229960004716 idoxuridine Drugs 0.000 claims abstract description 3
- LDACMRNPUIXQHN-XLPZGREQSA-N 3-fluoro-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound O=C1N(F)C(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 LDACMRNPUIXQHN-XLPZGREQSA-N 0.000 claims abstract 3
- -1 acyclovir Chemical compound 0.000 claims abstract 3
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims abstract 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims abstract 2
- 229960002442 glucosamine Drugs 0.000 claims abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 11
- 239000000284 extract Substances 0.000 claims description 9
- VFPFQHQNJCMNBZ-UHFFFAOYSA-N ethyl gallate Chemical compound CCOC(=O)C1=CC(O)=C(O)C(O)=C1 VFPFQHQNJCMNBZ-UHFFFAOYSA-N 0.000 claims description 8
- 240000001432 Calendula officinalis Species 0.000 claims description 6
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims description 6
- 244000042664 Matricaria chamomilla Species 0.000 claims description 6
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims description 6
- 229940119217 chamomile extract Drugs 0.000 claims description 6
- 235000020221 chamomile extract Nutrition 0.000 claims description 6
- 240000005528 Arctium lappa Species 0.000 claims description 5
- 235000003130 Arctium lappa Nutrition 0.000 claims description 5
- 229960000541 cetyl alcohol Drugs 0.000 claims description 5
- 235000002020 sage Nutrition 0.000 claims description 5
- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 claims description 4
- 235000003880 Calendula Nutrition 0.000 claims description 4
- 235000006693 Cassia laevigata Nutrition 0.000 claims description 4
- 244000025596 Cassia laevigata Species 0.000 claims description 4
- 239000004262 Ethyl gallate Substances 0.000 claims description 4
- 244000274883 Urtica dioica Species 0.000 claims description 4
- 235000009108 Urtica dioica Nutrition 0.000 claims description 4
- ISAOCJYIOMOJEB-UHFFFAOYSA-N benzoin Chemical compound C=1C=CC=CC=1C(O)C(=O)C1=CC=CC=C1 ISAOCJYIOMOJEB-UHFFFAOYSA-N 0.000 claims description 4
- 235000014134 echinacea Nutrition 0.000 claims description 4
- 235000019277 ethyl gallate Nutrition 0.000 claims description 4
- 229940124513 senna glycoside Drugs 0.000 claims description 4
- 244000144927 Aloe barbadensis Species 0.000 claims description 3
- 235000002961 Aloe barbadensis Nutrition 0.000 claims description 3
- 235000008078 Arctium minus Nutrition 0.000 claims description 3
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims description 3
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 3
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 claims description 3
- 235000011399 aloe vera Nutrition 0.000 claims description 3
- 241000157280 Aesculus hippocastanum Species 0.000 claims description 2
- 235000003840 Amygdalus nana Nutrition 0.000 claims description 2
- 244000296825 Amygdalus nana Species 0.000 claims description 2
- 241000046585 Aristolochia clematitis Species 0.000 claims description 2
- 241000086254 Arnica montana Species 0.000 claims description 2
- 235000005881 Calendula officinalis Nutrition 0.000 claims description 2
- 235000002567 Capsicum annuum Nutrition 0.000 claims description 2
- 240000004160 Capsicum annuum Species 0.000 claims description 2
- 240000003538 Chamaemelum nobile Species 0.000 claims description 2
- 101800004637 Communis Proteins 0.000 claims description 2
- 244000133098 Echinacea angustifolia Species 0.000 claims description 2
- 240000004530 Echinacea purpurea Species 0.000 claims description 2
- 241000531753 Geranium robertianum Species 0.000 claims description 2
- 235000016578 Geum urbanum Nutrition 0.000 claims description 2
- 235000002598 Inula helenium Nutrition 0.000 claims description 2
- 244000116484 Inula helenium Species 0.000 claims description 2
- 241000721662 Juniperus Species 0.000 claims description 2
- 244000165082 Lavanda vera Species 0.000 claims description 2
- 235000010701 Lavanda vera Nutrition 0.000 claims description 2
- 235000010663 Lavandula angustifolia Nutrition 0.000 claims description 2
- 244000208060 Lawsonia inermis Species 0.000 claims description 2
- 235000013939 Malva Nutrition 0.000 claims description 2
- 240000000982 Malva neglecta Species 0.000 claims description 2
- 235000000060 Malva neglecta Nutrition 0.000 claims description 2
- 241000131463 Marrubium Species 0.000 claims description 2
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 2
- 241001479543 Mentha x piperita Species 0.000 claims description 2
- 244000215554 Nepeta hederacea Species 0.000 claims description 2
- 235000011755 Nepeta hederacea Nutrition 0.000 claims description 2
- 240000006571 Piper sanctum Species 0.000 claims description 2
- 235000011432 Prunus Nutrition 0.000 claims description 2
- 235000009122 Rubus idaeus Nutrition 0.000 claims description 2
- 244000235659 Rubus idaeus Species 0.000 claims description 2
- 240000007164 Salvia officinalis Species 0.000 claims description 2
- 235000002912 Salvia officinalis Nutrition 0.000 claims description 2
- 241000219287 Saponaria Species 0.000 claims description 2
- 235000008981 Smilax officinalis Nutrition 0.000 claims description 2
- 240000002493 Smilax officinalis Species 0.000 claims description 2
- 241000193241 Solanum dulcamara Species 0.000 claims description 2
- 235000000336 Solanum dulcamara Nutrition 0.000 claims description 2
- 244000303286 Stachys officinalis Species 0.000 claims description 2
- 235000009225 Stachys officinalis Nutrition 0.000 claims description 2
- 244000028419 Styrax benzoin Species 0.000 claims description 2
- 235000000126 Styrax benzoin Nutrition 0.000 claims description 2
- 235000008411 Sumatra benzointree Nutrition 0.000 claims description 2
- 241000208241 Tropaeolum Species 0.000 claims description 2
- 244000225942 Viola tricolor Species 0.000 claims description 2
- 229960002130 benzoin Drugs 0.000 claims description 2
- 239000001511 capsicum annuum Substances 0.000 claims description 2
- 229960001231 choline Drugs 0.000 claims description 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims description 2
- 235000019382 gum benzoic Nutrition 0.000 claims description 2
- 235000010181 horse chestnut Nutrition 0.000 claims description 2
- 239000001771 mentha piperita Substances 0.000 claims description 2
- 235000014774 prunus Nutrition 0.000 claims description 2
- 235000009467 Carica papaya Nutrition 0.000 claims 1
- 240000006432 Carica papaya Species 0.000 claims 1
- 208000037952 HSV-1 infection Diseases 0.000 claims 1
- 241001168280 Hypera meles Species 0.000 claims 1
- 235000002725 Olea europaea Nutrition 0.000 claims 1
- 240000007817 Olea europaea Species 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 34
- 238000000034 method Methods 0.000 abstract description 6
- 150000001875 compounds Chemical class 0.000 abstract description 3
- 238000010790 dilution Methods 0.000 description 36
- 239000012895 dilution Substances 0.000 description 36
- 239000000047 product Substances 0.000 description 30
- 238000012360 testing method Methods 0.000 description 30
- 241000700605 Viruses Species 0.000 description 28
- 239000002674 ointment Substances 0.000 description 20
- 230000003253 viricidal effect Effects 0.000 description 20
- 230000000844 anti-bacterial effect Effects 0.000 description 16
- 230000000694 effects Effects 0.000 description 15
- 230000000840 anti-viral effect Effects 0.000 description 13
- 241000700588 Human alphaherpesvirus 1 Species 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 244000005700 microbiome Species 0.000 description 9
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 8
- 239000012153 distilled water Substances 0.000 description 8
- 210000003501 vero cell Anatomy 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 7
- 239000001974 tryptic soy broth Substances 0.000 description 7
- 108010050327 trypticase-soy broth Proteins 0.000 description 7
- 241000700584 Simplexvirus Species 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000000855 fungicidal effect Effects 0.000 description 6
- 238000011534 incubation Methods 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 229940068196 placebo Drugs 0.000 description 6
- 239000000902 placebo Substances 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 5
- 230000000120 cytopathologic effect Effects 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 5
- 239000011777 magnesium Substances 0.000 description 5
- 230000036407 pain Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 4
- 208000004898 Herpes Labialis Diseases 0.000 description 4
- 206010019973 Herpes virus infection Diseases 0.000 description 4
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000000645 desinfectant Substances 0.000 description 4
- 210000000609 ganglia Anatomy 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 239000006150 trypticase soy agar Substances 0.000 description 4
- 208000035143 Bacterial infection Diseases 0.000 description 3
- ODZBBRURCPAEIQ-DJLDLDEBSA-N Brivudine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C=CBr)=C1 ODZBBRURCPAEIQ-DJLDLDEBSA-N 0.000 description 3
- 241000222122 Candida albicans Species 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 206010067152 Oral herpes Diseases 0.000 description 3
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 208000022362 bacterial infectious disease Diseases 0.000 description 3
- 244000052616 bacterial pathogen Species 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 244000309466 calf Species 0.000 description 3
- 229940095731 candida albicans Drugs 0.000 description 3
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000003902 lesion Effects 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 230000029812 viral genome replication Effects 0.000 description 3
- WQZGKKKJIJFFOK-SVZMEOIVSA-N (+)-Galactose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-SVZMEOIVSA-N 0.000 description 2
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 description 2
- 235000019743 Choline chloride Nutrition 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000208690 Hamamelis Species 0.000 description 2
- 208000001688 Herpes Genitalis Diseases 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 229940121357 antivirals Drugs 0.000 description 2
- 229960003178 choline chloride Drugs 0.000 description 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 201000004946 genital herpes Diseases 0.000 description 2
- 229910001385 heavy metal Inorganic materials 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 235000019799 monosodium phosphate Nutrition 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 2
- 229940057838 polyethylene glycol 4000 Drugs 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
- DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- CTKBCQCRHRCICI-UHFFFAOYSA-N 2-[[2-fluoro-4-[3-(trifluoromethoxy)phenyl]phenyl]carbamoyl]cyclopentene-1-carboxylic acid Chemical compound C1CCC(C(=O)O)=C1C(=O)NC1=CC=C(C=2C=C(OC(F)(F)F)C=CC=2)C=C1F CTKBCQCRHRCICI-UHFFFAOYSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 235000014649 Carica monoica Nutrition 0.000 description 1
- 244000132069 Carica monoica Species 0.000 description 1
- 235000005882 Carlina acaulis Nutrition 0.000 description 1
- 240000001789 Carlina acaulis Species 0.000 description 1
- 235000009917 Crataegus X brevipes Nutrition 0.000 description 1
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 description 1
- 235000009685 Crataegus X maligna Nutrition 0.000 description 1
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 description 1
- 235000009486 Crataegus bullatus Nutrition 0.000 description 1
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 description 1
- 235000009682 Crataegus limnophila Nutrition 0.000 description 1
- 240000000171 Crataegus monogyna Species 0.000 description 1
- 235000004423 Crataegus monogyna Nutrition 0.000 description 1
- 235000002313 Crataegus paludosa Nutrition 0.000 description 1
- 235000009840 Crataegus x incaedua Nutrition 0.000 description 1
- 230000004543 DNA replication Effects 0.000 description 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 241001473317 Eupatorium cannabinum Species 0.000 description 1
- 206010017964 Gastrointestinal infection Diseases 0.000 description 1
- 235000017309 Hypericum perforatum Nutrition 0.000 description 1
- 244000141009 Hypericum perforatum Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010021531 Impetigo Diseases 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 235000010654 Melissa officinalis Nutrition 0.000 description 1
- 244000062730 Melissa officinalis Species 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000035415 Reinfection Diseases 0.000 description 1
- 240000003946 Saponaria officinalis Species 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- 244000172533 Viola sororia Species 0.000 description 1
- 108020005202 Viral DNA Proteins 0.000 description 1
- 241000405119 Virga Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 150000001449 anionic compounds Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical group O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 1
- 231100000086 high toxicity Toxicity 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 229910001412 inorganic anion Inorganic materials 0.000 description 1
- 206010023332 keratitis Diseases 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 150000002731 mercury compounds Chemical class 0.000 description 1
- 150000002736 metal compounds Chemical class 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 description 1
- 230000007433 nerve pathway Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 231100000028 nontoxic concentration Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 150000002891 organic anions Chemical class 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000010583 slow cooling Methods 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 229940054269 sodium pyruvate Drugs 0.000 description 1
- 229940074404 sodium succinate Drugs 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 231100000378 teratogenic Toxicity 0.000 description 1
- 230000003390 teratogenic effect Effects 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 230000007733 viral latency Effects 0.000 description 1
- 239000012873 virucide Substances 0.000 description 1
- 239000002544 virustatic Substances 0.000 description 1
- 230000001790 virustatic effect Effects 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940107931 zovirax Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/264—Aristolochia (Dutchman's pipe)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/49—Fagaceae (Beech family), e.g. oak or chestnut
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/52—Juglandaceae (Walnut family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL9500216A NL9500216A (nl) | 1995-02-06 | 1995-02-06 | Farmaceutische samenstelling voor de behandeling van herpes. |
| ES96902505T ES2185760T3 (es) | 1995-02-06 | 1996-01-23 | Composicion farmaceutica para el tratamiento del herpes. |
| JP8524159A JPH10513193A (ja) | 1995-02-06 | 1996-01-23 | ヘルペスを処置するための医薬組成物 |
| US08/875,661 US6284289B1 (en) | 1995-02-06 | 1996-01-23 | Treatment of herpes infection with composition containing quaternary ammonium compound and an anti-viral agent |
| CA002211802A CA2211802C (fr) | 1995-02-06 | 1996-01-23 | Composition pharmaceutique pour le traitement de l'herpes |
| AT96902505T ATE226081T1 (de) | 1995-02-06 | 1996-01-23 | Pharmazeutische zusammensetzung zur behandlung von herpes |
| DE69624340T DE69624340T2 (de) | 1995-02-06 | 1996-01-23 | Pharmazeutische zusammensetzung zur behandlung von herpes |
| CN96191807A CN1121232C (zh) | 1995-02-06 | 1996-01-23 | 治疗疱疹的药物组合物 |
| PCT/NL1996/000038 WO1996024367A1 (fr) | 1995-02-06 | 1996-01-23 | Composition pharmaceutique pour le traitement de l'herpes |
| AU46788/96A AU712744B2 (en) | 1995-02-06 | 1996-01-23 | Pharmaceutical composition for the treatment of herpes |
| DK96902505T DK0808168T3 (da) | 1995-02-06 | 1996-01-23 | Farmaceutisk præparat til behandlingen af herpes |
| EP96902505A EP0808168B1 (fr) | 1995-02-06 | 1996-01-23 | Composition pharmaceutique pour le traitement de l'herpes |
| JP2007319836A JP2008074872A (ja) | 1995-02-06 | 2007-12-11 | ヘルペスを処置するための医薬組成物 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL9500216A NL9500216A (nl) | 1995-02-06 | 1995-02-06 | Farmaceutische samenstelling voor de behandeling van herpes. |
| NL9500216 | 1995-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL9500216A true NL9500216A (nl) | 1996-09-02 |
Family
ID=19865548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL9500216A NL9500216A (nl) | 1995-02-06 | 1995-02-06 | Farmaceutische samenstelling voor de behandeling van herpes. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6284289B1 (fr) |
| EP (1) | EP0808168B1 (fr) |
| JP (2) | JPH10513193A (fr) |
| CN (1) | CN1121232C (fr) |
| AT (1) | ATE226081T1 (fr) |
| AU (1) | AU712744B2 (fr) |
| CA (1) | CA2211802C (fr) |
| DE (1) | DE69624340T2 (fr) |
| DK (1) | DK0808168T3 (fr) |
| ES (1) | ES2185760T3 (fr) |
| NL (1) | NL9500216A (fr) |
| WO (1) | WO1996024367A1 (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6355684B1 (en) | 1990-10-11 | 2002-03-12 | Meryl J. Squires | Antimicrobial treatment for herpes simplex virus and other infectious diseases |
| US6348503B1 (en) | 1996-02-12 | 2002-02-19 | Meryl J. Squires | Method and topical treatment composition for herpesvirus hominis |
| US6350784B1 (en) | 1996-02-12 | 2002-02-26 | Meryl J. Squires | Antimicrobial prevention and treatment of human immunedeficiency virus and other infectious diseases |
| US8173709B2 (en) * | 1999-09-22 | 2012-05-08 | Quadex Pharmaceuticals, Llc | Anti-infective methods for treating pathogen-induced disordered tissues |
| AU2695101A (en) | 2000-01-21 | 2001-07-31 | Biovex Ltd | Virus strains |
| JP2003531828A (ja) * | 2000-02-26 | 2003-10-28 | アドバンスト フォトダイナミック テクノロジーズ， インコーポレイテッド | 光感光性物質および界面活性剤を使用する、光力学的な細胞および無細胞生物の根絶 |
| GB0317511D0 (en) * | 2003-07-25 | 2003-08-27 | Biovex Ltd | Viral vectors |
| ITMI20032287A1 (it) * | 2003-11-24 | 2005-05-25 | Indena Spa | Composizioni per il trattamento delle affezioni del cavo orale e delle prime vie respiratorie |
| US7968122B2 (en) * | 2003-12-10 | 2011-06-28 | Adventrx Pharmaceuticals, Inc. | Anti-viral pharmaceutical compositions |
| US7250180B2 (en) * | 2004-01-07 | 2007-07-31 | Edwin Cevallos Arellano | Anti-prostate cancer composition and therapeutic uses therefor |
| CN100427082C (zh) * | 2005-08-02 | 2008-10-22 | 盛华（广州）医药科技有限公司 | 羟基苯甲酸酯及其类似物在制备预防和治疗病毒性感染药物中的应用 |
| US8044098B2 (en) | 2005-08-02 | 2011-10-25 | Shenghua Guangzhou Pharmaceutical Science & Technology Co., Ltd. | Use of hydroxybenzoic acids and their esters and analogues for preventing or treating virus infection |
| US7790203B2 (en) * | 2005-12-13 | 2010-09-07 | Lowder Tom R | Composition and regimen for the treatment of herpes simplex virus, herpes zoster, and herpes genitalia epidermal herpetic lesions |
| WO2011075654A1 (fr) * | 2009-12-18 | 2011-06-23 | Exodos Life Sciences Limited Partnership | Procédés et compositions pour traiter l'inflammation de la peau |
| US8247006B2 (en) * | 2010-06-22 | 2012-08-21 | Golio Dominick I | Composition and method of treating lipid encapsulated virus infections |
| JP5858994B2 (ja) * | 2010-07-08 | 2016-02-10 | デヴィレックス アーゲー | 口唇ヘルペス、性器ヘルペス、および帯状疱疹の再発を抑制するためのポリエチレングリコール組成物 |
| US8846725B2 (en) | 2011-01-24 | 2014-09-30 | Quadex Pharmaceuticals, Llc | Highly penetrating compositions and methods for treating pathogen-induced disordered tissues |
| WO2014055659A1 (fr) * | 2012-10-03 | 2014-04-10 | Pharma Green Llc | Procédés et compositions pour la production de protéines recombinantes pharmaceutiques dans des plantes médicinales |
| US9125911B2 (en) | 2013-03-14 | 2015-09-08 | Quadex Pharmaceuticals, Llc | Combined systemic and topical treatment of disordered tissues |
| US9463180B2 (en) | 2013-03-14 | 2016-10-11 | Quadex Pharmaceuticals, Llc | Treatment of molluscum contagiosum |
| US9549930B2 (en) | 2013-03-14 | 2017-01-24 | Quadex Pharmaceuticals, Llc | Combined systemic and topical treatment of disordered and/or prodromal stage tissue |
| ITUB20152286A1 (it) * | 2015-07-17 | 2017-01-17 | Harven S A S | Composizione anti herpes |
| US10744175B2 (en) * | 2016-02-23 | 2020-08-18 | Apurve Mehra | Herbal composition for the treatment of Herpes |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0308210A1 (fr) * | 1987-09-16 | 1989-03-22 | Patrick A. Beauchamp | Traitement topique des troubles de la peau malade |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4053628A (en) * | 1971-05-12 | 1977-10-11 | Fisons Limited | Composition |
| AU553789B2 (en) * | 1982-06-30 | 1986-07-24 | Biorex Laboratories Ltd. | Glycyrrhetinic acid derivatives in cream compositions |
| US4478818A (en) * | 1982-12-27 | 1984-10-23 | Alza Corporation | Ocular preparation housing steroid in two different therapeutic forms |
| US4902720A (en) * | 1983-01-10 | 1990-02-20 | Baldone Joseph A | Treatment of virus infections with quaternary ammonium compounds |
| JPH0655676B2 (ja) * | 1984-07-26 | 1994-07-27 | ザ リポソ−ム カンパニ−、インコ−ポレ−テツド | 脂質小胞体中に含有された抗菌物質の混合物による抗菌活性の増高 |
| US4895727A (en) * | 1985-05-03 | 1990-01-23 | Chemex Pharmaceuticals, Inc. | Pharmaceutical vehicles for exhancing penetration and retention in the skin |
| MY102648A (en) * | 1986-12-03 | 1992-08-17 | Rudov David | Pharmacological / cosmetic preparation |
| ATE78396T1 (de) * | 1987-09-23 | 1992-08-15 | Atlantic Pharma Prod | Zusammensetzung zur hemmung oder vernichtung mindestens eines einzelligen lebewesens, enthaltend ein quaternaeres ammoniumfluorid, und verfahren zur herstellung dieses salzes. |
| JP2862951B2 (ja) * | 1990-04-23 | 1999-03-03 | 花王株式会社 | 殺菌消毒剤組成物 |
| FR2687314A1 (fr) * | 1992-02-18 | 1993-08-20 | Oreal | Dispersion de vesicules lipidiques, composition cosmetique et/ou pharmaceutique la contenant et procede de preparation de ladite dispersion. |
| US5229423A (en) * | 1992-03-06 | 1993-07-20 | Albert Einstein College Of Medicine Of Yeshiva University | Use of butylurea as a contraceptive agent |
| US5455033A (en) * | 1993-05-21 | 1995-10-03 | Degree/Silverman M.D. Inc. | Medicinal composition for treatment of inflammation |
-
1995
- 1995-02-06 NL NL9500216A patent/NL9500216A/nl not_active Application Discontinuation
-
1996
- 1996-01-23 ES ES96902505T patent/ES2185760T3/es not_active Expired - Lifetime
- 1996-01-23 AU AU46788/96A patent/AU712744B2/en not_active Expired
- 1996-01-23 JP JP8524159A patent/JPH10513193A/ja not_active Withdrawn
- 1996-01-23 CN CN96191807A patent/CN1121232C/zh not_active Expired - Lifetime
- 1996-01-23 US US08/875,661 patent/US6284289B1/en not_active Expired - Lifetime
- 1996-01-23 CA CA002211802A patent/CA2211802C/fr not_active Expired - Lifetime
- 1996-01-23 DK DK96902505T patent/DK0808168T3/da active
- 1996-01-23 WO PCT/NL1996/000038 patent/WO1996024367A1/fr active IP Right Grant
- 1996-01-23 EP EP96902505A patent/EP0808168B1/fr not_active Expired - Lifetime
- 1996-01-23 AT AT96902505T patent/ATE226081T1/de active
- 1996-01-23 DE DE69624340T patent/DE69624340T2/de not_active Expired - Lifetime
-
2007
- 2007-12-11 JP JP2007319836A patent/JP2008074872A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0308210A1 (fr) * | 1987-09-16 | 1989-03-22 | Patrick A. Beauchamp | Traitement topique des troubles de la peau malade |
Non-Patent Citations (4)
| Title |
|---|
| B. DAMERY ET AL.: "Virucidal activity against herpes and vaccinia virus of 8 antiseptic formulations.", INT. J. PHARM., vol. 49, no. 3, pages 205 - 208 * |
| J.A. SANDS: "virucidal activity of cetyltrimethylammonium bromide below the critical micelle concentration.", FEMS MICROBIOL. LETT., vol. 36, no. 2-3, pages 261 - 263 * |
| M. AMOROS ET AL.: "Effect of saponins from Anagallis arvensis on experimental herpes simplex keratitis in rabbits.", PLANTA MED., vol. 54, no. 2, pages 128 - 131 * |
| M. KUROKAWA ET AL.: "Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo.", ANTIVIR. RES., vol. 27, no. 1-2, pages 19 - 37 * |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2185760T3 (es) | 2003-05-01 |
| US6284289B1 (en) | 2001-09-04 |
| CN1121232C (zh) | 2003-09-17 |
| EP0808168A1 (fr) | 1997-11-26 |
| AU712744B2 (en) | 1999-11-18 |
| AU4678896A (en) | 1996-08-27 |
| JP2008074872A (ja) | 2008-04-03 |
| DE69624340T2 (de) | 2003-06-18 |
| CA2211802C (fr) | 2009-06-02 |
| DE69624340D1 (de) | 2002-11-21 |
| CN1173820A (zh) | 1998-02-18 |
| WO1996024367A1 (fr) | 1996-08-15 |
| JPH10513193A (ja) | 1998-12-15 |
| DK0808168T3 (da) | 2003-02-17 |
| CA2211802A1 (fr) | 1996-08-15 |
| ATE226081T1 (de) | 2002-11-15 |
| EP0808168B1 (fr) | 2002-10-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NL9500216A (nl) | Farmaceutische samenstelling voor de behandeling van herpes. | |
| DE69837474T2 (de) | Antimikrobielle vorbeugung gegen und behandlung von aids und anderer infektiöser krankheiten | |
| CA2253736C (fr) | Traitement antimicrobien du virus de l'herpes simplex et d'autres maladies infectieuses | |
| Zeina et al. | Effect of honey versus thyme on Rubella virus survival in vitro | |
| US20170258861A1 (en) | Treatment of Herpes, Pseudomonas, Staph, and Hepatitis | |
| RU2314119C2 (ru) | Нетоксические дизинфектанты слизистых оболочек, содержащие изопропиловый спирт, кунжутное масло, алоэ и лимонное масло | |
| JP2023547727A (ja) | 経鼻投与用消毒剤組成物 | |
| Bourinbaiar et al. | Synergistic effect of gramicidin and EDTA in inhibiting sperm motility and cervical mucus penetration in vitro | |
| EP4013372A1 (fr) | Système d'administration d'argile accessible au chevet, amorphe, non activée, à ph neutre, en deux parties, qui traite des infections pathogènes chez les êtres humains et les animaux | |
| RU2248212C2 (ru) | Препарат для лечения бактериального вагиноза, способ его получения и способ лечения бактериального вагиноза | |
| UA139927U (uk) | Назальний засіб у формі спрею на основі розчину колоїдного срібла з гелем алое вера | |
| UA139724U (uk) | Назальний спрей на основі розчину колоїдного срібла з екстрактом цетрарії ісландської | |
| UA122473C2 (uk) | Спрей для горла на основі розчину колоїдного срібла з екстрактами та ефірними оліями | |
| JPH11322623A (ja) | ヘルペスシンプレックスウイルスおよび他の感染病のための抗菌治療 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1B | A search report has been drawn up | ||
| BV | The patent application has lapsed |