JP2008074872A - ヘルペスを処置するための医薬組成物 - Google Patents
ヘルペスを処置するための医薬組成物 Download PDFInfo
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Abstract
【解決手段】第一構成成分として第四級アンモニウム化合物および/または第二構成成分として抗ウイルス剤および/または第三構成成分として植物抽出物を薬学的に許容される基剤に含み、該3構成成分は相互に和合している、ヘルペス単純ウイルス感染の処置のための医薬組成物により解決される。
【選択図】なし
Description
1.構成成分の抗ウイルス活性
この実施例ではAmerican Type Culture Collection(受付番号CCL26)からのVERO細胞を用いた。VERO細胞は、Earle’s塩および5%子牛血清と共に培地199(Gibco)中で培養した。ウイルス源としてヘルペス単純ウイルス1(HSV−1、臨床分離株)を用い、100μg/mlペニシリン、100μg/mlストレプトマイシンおよび2%子牛血清と共に培養した。
同様に、実施例1で調製した試験混合物の抗ウイルス活性を測定した。15分間25℃における軟膏の殺ウイルス活性の結果を表3に示す。
表3から、軟膏は25℃で希釈1/100までHSVについての殺ウイルス活性を発揮することが分かる。セトリミドも25℃ですら完全な活性を保持する。
抗菌活性
個々の構成成分および最終産物の抗菌活性を試験微生物Candida albicans(ATTC 10231)、Escherichia coli(ATTC 8739),Pseudomonas aeruginosa(ATTC 15442)およびStaphylococcus aureus(ATTC 6538)で測定した。用いた培地はトリプチカーゼ醤油肉汁(TSB)、トリプチカーゼ醤油寒天(TSA)および無菌リン酸緩衝液(PBS)である。
最小阻止濃度(MIC)を測定するために、一夜培養物を37℃でTSB中各微生物について調製した。使用する試験物質のTSBにおいて1/2希釈系を同様につくった。各希釈100μlをミクロタイター・プレートに入れた。一夜培養物をTSB中1/1000に希釈した。同様に細菌懸濁液100μlを物質に加えた。無菌性の対照として、細菌を加えない物質希釈液および物質希釈液を加えない細菌希釈液を用いた。ミクロタイター・プレートを湿室内で24時間37℃でインキュベートした。細菌生育を懸濁液の混濁性をもとに調べた。MIC価は、微生物の正常な生育を阻止し得る、すなわちいかなる懸濁をももたらさない最小の物質濃度である。
実施例1に記載したように、別々の3軟膏を調製した。そのロット番号は94A12、94D21および94E05である。プラセボとしてセトリミドを除外した同じ組成物を調製した。このプラセボは94D27と呼ぶ。対照として無菌蒸留水中の1%セトリミドを用いた。すべての試験サンプルは室温で保存した。
最小阻止濃度は、細菌がもはや生育しない試験物質の濃度である。用いた最も高い濃度(1/10希釈)は、無菌蒸留水9ml中に軟膏1gを懸濁することにより調製した。希釈液を細菌に加え、24時間培養した。用いた微生物は、容量105 Candida albicans(Ca)、106 Escherichia coli(Ec)、105 Pseudomonas aeruginosa(Pa)および106 Staphylococcus aureus(Sa)であった。
表5は、細菌の生育が阻止される希釈度を示す。
抗菌活性をCandida albicans(105)、Escherichia coli(106)、Pseudomonas aeruginosa(105)およびStaphylococcus aureus(106)で調べる。抗菌活性は、ヨーロッパ薬局方の記載に従って測定する。試験する物質を微生物と混じ、ある時間インキュベートし、この混合物を希釈し、どの希釈度でなお微生物の生育が起きるかを測定する。
抗真菌活性を測定するために、試験微生物Epidermophyton floccosum(RV 69635)およびTrichophyton rubrum(RV58124)を用いた。抗真菌活性は抗菌活性と同じ方法で測定した。
殺ウイルス活性をD.Vanden Berghe et al.in “Methods in Plant Biochemistry”,Vol.6“Assays for Bioactivity”,p.49-67,Academic Press Limited 1991記載のミクロ方法に従って測定した。物質希釈液300μlに非希釈ウイルス懸濁液300μlを加えた。混合物を34℃で15秒間インキュベートした。希釈チューブにウイルス用の冷却培養培地0.9mlを加え、氷浴に入れた。インキュベート混合物100μlを希釈チューブに入れた。それから1/10希釈系を調製した。これらの希釈液200μlをVERO細胞上に入れた。対照は非処置ウイルス(ウイルス対照)および非処置細胞(細胞対照)である。プレートを37℃で湿培養器中5−7日間インキュベートした。細胞毒性および細胞病理学的効果について顕微鏡で細胞を調べた。結果は低下因数(Rf)で表す。低下因数は、最初のウイルス濃度に対する残留ウイルス濃度の比である。この試験は3回実施された。Rfで表された結果を表8に示す。
インビボ活性試験
試験群は、口唇にコールド・ソアがある15人の患者からなる。彼等は以下の組成を有する軟膏で処置された。
Claims (10)
- 第一構成成分として第四級アンモニウム化合物および/または第二構成成分として抗ウイルス剤および/または第三構成成分として植物抽出物を薬学的に許容される基剤に含み、該3構成成分は相互に和合している、ヘルペス単純ウイルス感染の処置のための医薬組成物。
- 第一構成成分がセトリミド、塩化ベンザルコニウムからなる群より選ばれることを特徴とする請求項1の医薬組成物。
- 第二構成成分がアシクロビル、ブロモビニルデソクスウリジン(BVDU)、3−フルオロチミジン(3FT)、イドクスウリジン、プロピル・ガレート、エチル・ガレート、プロアントシアニド、グルコサミンからなる群より選ばれることを特徴とする請求項1または2の医薬組成物。
- 第三構成成分が Aesculus hippocastanum L; Aloe vera L; Anagallis arvensis L; Anthemis nobilis L; Arctium lappa L; Aristolochia clematitis L; Arnica montana L; Betonica officinalis L; Calendula officinalis L; Capsicum annuum (tetraqonum); Carica papaya L; Carlina acaulis L; Caryophyllus aromaticus L; Cynoglossum officinale L; Echinacea angustifolia; Echinacea purpurea L; Eupatorium cannabinum L; Geranium robertianum; Geum urbanum L; Glechoma hederacea L; Hamamelis virginiana L; Hypericum perforatum L; Inula helenium L; Juglans regia L; Juniperus oxycedrus L; Lavandula officinalis; Lawsonia alba L; Lysimachia nummeralia L; Lythrum salicaria L; Malva sylvestris; Marrubium vulgare L; Matricaria chamomilla L; Mentha piperita L; Myroxylon balsamum L; Myrtus communis L; Olea europaea L; Prunus amygdalus; Pyrus cydonia L; Quercus robur L; Quillaja saponaria; Rubus idaeus L; Salvia officinalis L; Saponaria officinalis L; Smilax officinalis; Solanum dulcamara L; Solidago virga aurea L; Styrax tonkinensis; Styrax benzoides; Styrax benzoin; Symphytum officinale L; Trigonella foenum-graecum L; Tropaeolum majus L; Urtica urens L; Urtica dioica L; Viola tricolor L.の抽出物からなる群より選ばれることを特徴とする請求項1、2または3の医薬組成物。
- 第一構成成分がセトリミドの場合に第三構成成分がカミツレ、キンセンカ、サルビア、ゴボウ類およびセンナの植物抽出物からなる群より選ばれることを特徴とする請求項1、2または3の医薬組成物。
- 第一構成成分が塩化ベンザルコニウムの場合に第三構成成分がカミツレ、キレセンカ、センナの抽出物からなる群より選ばれることを特徴とする請求項1、2または3の医薬組成物。
- 第四級アンモニウム塩0.1−5%、抗ウイルス剤0.01−3%および植物抽出物1−20%を薬学的に許容される担体中に含む、請求項1−6のいずれかの医薬組成物。
- HSV−1感染の処置のための請求項1−8のいずれかの医薬組成物の使用。
- HSV−2感染の処置のための請求項1−8のいずれかの医薬組成物の使用。
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NL9500216A NL9500216A (nl) | 1995-02-06 | 1995-02-06 | Farmaceutische samenstelling voor de behandeling van herpes. |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8524159A Division JPH10513193A (ja) | 1995-02-06 | 1996-01-23 | ヘルペスを処置するための医薬組成物 |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2008074872A true JP2008074872A (ja) | 2008-04-03 |
Family
ID=19865548
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8524159A Withdrawn JPH10513193A (ja) | 1995-02-06 | 1996-01-23 | ヘルペスを処置するための医薬組成物 |
JP2007319836A Pending JP2008074872A (ja) | 1995-02-06 | 2007-12-11 | ヘルペスを処置するための医薬組成物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8524159A Withdrawn JPH10513193A (ja) | 1995-02-06 | 1996-01-23 | ヘルペスを処置するための医薬組成物 |
Country Status (12)
Country | Link |
---|---|
US (1) | US6284289B1 (ja) |
EP (1) | EP0808168B1 (ja) |
JP (2) | JPH10513193A (ja) |
CN (1) | CN1121232C (ja) |
AT (1) | ATE226081T1 (ja) |
AU (1) | AU712744B2 (ja) |
CA (1) | CA2211802C (ja) |
DE (1) | DE69624340T2 (ja) |
DK (1) | DK0808168T3 (ja) |
ES (1) | ES2185760T3 (ja) |
NL (1) | NL9500216A (ja) |
WO (1) | WO1996024367A1 (ja) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6348503B1 (en) | 1996-02-12 | 2002-02-19 | Meryl J. Squires | Method and topical treatment composition for herpesvirus hominis |
US6355684B1 (en) | 1990-10-11 | 2002-03-12 | Meryl J. Squires | Antimicrobial treatment for herpes simplex virus and other infectious diseases |
US6350784B1 (en) | 1996-02-12 | 2002-02-26 | Meryl J. Squires | Antimicrobial prevention and treatment of human immunedeficiency virus and other infectious diseases |
US8173709B2 (en) * | 1999-09-22 | 2012-05-08 | Quadex Pharmaceuticals, Llc | Anti-infective methods for treating pathogen-induced disordered tissues |
ATE312189T1 (de) * | 2000-01-21 | 2005-12-15 | Biovex Ltd | Virusstämme für die onkolytische behandlung von krebs |
AU2001239835A1 (en) * | 2000-02-26 | 2001-09-03 | Advanced Photodynamic Technologies, Inc. | Photodynamic cellular and acellular organism eradication utilizing a photosensitive material and surfactant |
GB0317511D0 (en) * | 2003-07-25 | 2003-08-27 | Biovex Ltd | Viral vectors |
ITMI20032287A1 (it) * | 2003-11-24 | 2005-05-25 | Indena Spa | Composizioni per il trattamento delle affezioni del cavo orale e delle prime vie respiratorie |
US7968122B2 (en) * | 2003-12-10 | 2011-06-28 | Adventrx Pharmaceuticals, Inc. | Anti-viral pharmaceutical compositions |
US7250180B2 (en) * | 2004-01-07 | 2007-07-31 | Edwin Cevallos Arellano | Anti-prostate cancer composition and therapeutic uses therefor |
US8044098B2 (en) | 2005-08-02 | 2011-10-25 | Shenghua Guangzhou Pharmaceutical Science & Technology Co., Ltd. | Use of hydroxybenzoic acids and their esters and analogues for preventing or treating virus infection |
CN100427082C (zh) * | 2005-08-02 | 2008-10-22 | 盛华(广州)医药科技有限公司 | 羟基苯甲酸酯及其类似物在制备预防和治疗病毒性感染药物中的应用 |
US7790203B2 (en) * | 2005-12-13 | 2010-09-07 | Lowder Tom R | Composition and regimen for the treatment of herpes simplex virus, herpes zoster, and herpes genitalia epidermal herpetic lesions |
JP5944325B2 (ja) * | 2009-12-18 | 2016-07-05 | エクソドス ライフ サイエンシーズ リミテッド パートナーシップ | 皮膚の炎症を治療するための方法及び組成物 |
US8247006B2 (en) * | 2010-06-22 | 2012-08-21 | Golio Dominick I | Composition and method of treating lipid encapsulated virus infections |
ES2442928T3 (es) * | 2010-07-08 | 2014-02-14 | Devirex Ag | Composiciones de polietilenglicol para controlar las recidivas de herpes labialis, herpes genitalis y herpes zoster |
US8846725B2 (en) | 2011-01-24 | 2014-09-30 | Quadex Pharmaceuticals, Llc | Highly penetrating compositions and methods for treating pathogen-induced disordered tissues |
WO2014055659A1 (en) * | 2012-10-03 | 2014-04-10 | Pharma Green Llc | Methods and compositions for production of recombinant pharmaceutical proteins in medicinal plants |
US9463180B2 (en) | 2013-03-14 | 2016-10-11 | Quadex Pharmaceuticals, Llc | Treatment of molluscum contagiosum |
US9549930B2 (en) | 2013-03-14 | 2017-01-24 | Quadex Pharmaceuticals, Llc | Combined systemic and topical treatment of disordered and/or prodromal stage tissue |
US9125911B2 (en) | 2013-03-14 | 2015-09-08 | Quadex Pharmaceuticals, Llc | Combined systemic and topical treatment of disordered tissues |
ITUB20152286A1 (it) * | 2015-07-17 | 2017-01-17 | Harven S A S | Composizione anti herpes |
US10744175B2 (en) * | 2016-02-23 | 2020-08-18 | Apurve Mehra | Herbal composition for the treatment of Herpes |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS6137729A (ja) * | 1984-07-26 | 1986-02-22 | ザ リポソ−ム カンパニ−、インコ−ポレ−テツド | 脂質小胞体中に含有された抗菌物質の混合物による抗菌活性の増高 |
JPH01163119A (ja) * | 1987-09-23 | 1989-06-27 | Atlantic Pharmaceut Prod Ltd | 第四アンモニウムフルオリドを含む,少なくとも一種の単細胞生物を抑制または駆除する組成物,及びその塩の製造方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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US4053628A (en) * | 1971-05-12 | 1977-10-11 | Fisons Limited | Composition |
AU553789B2 (en) * | 1982-06-30 | 1986-07-24 | Biorex Laboratories Ltd. | Glycyrrhetinic acid derivatives in cream compositions |
US4478818A (en) * | 1982-12-27 | 1984-10-23 | Alza Corporation | Ocular preparation housing steroid in two different therapeutic forms |
US4902720A (en) * | 1983-01-10 | 1990-02-20 | Baldone Joseph A | Treatment of virus infections with quaternary ammonium compounds |
US4895727A (en) * | 1985-05-03 | 1990-01-23 | Chemex Pharmaceuticals, Inc. | Pharmaceutical vehicles for exhancing penetration and retention in the skin |
MY102648A (en) * | 1986-12-03 | 1992-08-17 | Rudov David | Pharmacological / cosmetic preparation |
CA1273576A (en) * | 1987-09-16 | 1990-09-04 | Patrick A. Beauchamp | Topical treatment for diseased skin disorders |
JP2862951B2 (ja) * | 1990-04-23 | 1999-03-03 | 花王株式会社 | 殺菌消毒剤組成物 |
FR2687314A1 (fr) * | 1992-02-18 | 1993-08-20 | Oreal | Dispersion de vesicules lipidiques, composition cosmetique et/ou pharmaceutique la contenant et procede de preparation de ladite dispersion. |
US5229423A (en) * | 1992-03-06 | 1993-07-20 | Albert Einstein College Of Medicine Of Yeshiva University | Use of butylurea as a contraceptive agent |
US5455033A (en) * | 1993-05-21 | 1995-10-03 | Degree/Silverman M.D. Inc. | Medicinal composition for treatment of inflammation |
-
1995
- 1995-02-06 NL NL9500216A patent/NL9500216A/nl not_active Application Discontinuation
-
1996
- 1996-01-23 WO PCT/NL1996/000038 patent/WO1996024367A1/en active IP Right Grant
- 1996-01-23 ES ES96902505T patent/ES2185760T3/es not_active Expired - Lifetime
- 1996-01-23 JP JP8524159A patent/JPH10513193A/ja not_active Withdrawn
- 1996-01-23 AT AT96902505T patent/ATE226081T1/de active
- 1996-01-23 US US08/875,661 patent/US6284289B1/en not_active Expired - Lifetime
- 1996-01-23 CN CN96191807A patent/CN1121232C/zh not_active Expired - Lifetime
- 1996-01-23 CA CA002211802A patent/CA2211802C/en not_active Expired - Lifetime
- 1996-01-23 DE DE69624340T patent/DE69624340T2/de not_active Expired - Lifetime
- 1996-01-23 DK DK96902505T patent/DK0808168T3/da active
- 1996-01-23 AU AU46788/96A patent/AU712744B2/en not_active Expired
- 1996-01-23 EP EP96902505A patent/EP0808168B1/en not_active Expired - Lifetime
-
2007
- 2007-12-11 JP JP2007319836A patent/JP2008074872A/ja active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6137729A (ja) * | 1984-07-26 | 1986-02-22 | ザ リポソ−ム カンパニ−、インコ−ポレ−テツド | 脂質小胞体中に含有された抗菌物質の混合物による抗菌活性の増高 |
JPH01163119A (ja) * | 1987-09-23 | 1989-06-27 | Atlantic Pharmaceut Prod Ltd | 第四アンモニウムフルオリドを含む,少なくとも一種の単細胞生物を抑制または駆除する組成物,及びその塩の製造方法 |
Also Published As
Publication number | Publication date |
---|---|
EP0808168B1 (en) | 2002-10-16 |
AU4678896A (en) | 1996-08-27 |
NL9500216A (nl) | 1996-09-02 |
CN1121232C (zh) | 2003-09-17 |
DE69624340D1 (de) | 2002-11-21 |
WO1996024367A1 (en) | 1996-08-15 |
DE69624340T2 (de) | 2003-06-18 |
ATE226081T1 (de) | 2002-11-15 |
ES2185760T3 (es) | 2003-05-01 |
EP0808168A1 (en) | 1997-11-26 |
CN1173820A (zh) | 1998-02-18 |
JPH10513193A (ja) | 1998-12-15 |
DK0808168T3 (da) | 2003-02-17 |
US6284289B1 (en) | 2001-09-04 |
CA2211802C (en) | 2009-06-02 |
AU712744B2 (en) | 1999-11-18 |
CA2211802A1 (en) | 1996-08-15 |
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