NL9120006A - Verbeteringen van of verbandhoudende met organische verbindingen. - Google Patents

Verbeteringen van of verbandhoudende met organische verbindingen. Download PDF

Info

Publication number
NL9120006A
NL9120006A NL9120006A NL9120006A NL9120006A NL 9120006 A NL9120006 A NL 9120006A NL 9120006 A NL9120006 A NL 9120006A NL 9120006 A NL9120006 A NL 9120006A NL 9120006 A NL9120006 A NL 9120006A
Authority
NL
Netherlands
Prior art keywords
clozapine
ascorbic acid
radical scavenger
radical
schizophrenia
Prior art date
Application number
NL9120006A
Other languages
English (en)
Dutch (nl)
Inventor
Volker Fischer
Ronald Paul Mason
Original Assignee
Sandoz Sa
Us Commerce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa, Us Commerce filed Critical Sandoz Sa
Publication of NL9120006A publication Critical patent/NL9120006A/nl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
NL9120006A 1990-08-20 1991-08-14 Verbeteringen van of verbandhoudende met organische verbindingen. NL9120006A (nl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US56968990A 1990-08-20 1990-08-20
US56968990 1990-08-20
US71713691A 1991-06-18 1991-06-18
US71713691 1991-06-18

Publications (1)

Publication Number Publication Date
NL9120006A true NL9120006A (nl) 1992-08-03

Family

ID=27075116

Family Applications (1)

Application Number Title Priority Date Filing Date
NL9120006A NL9120006A (nl) 1990-08-20 1991-08-14 Verbeteringen van of verbandhoudende met organische verbindingen.

Country Status (30)

Country Link
US (2) US5312819A (de)
JP (1) JPH0813745B2 (de)
KR (1) KR100189349B1 (de)
AT (1) AT400522B (de)
AU (1) AU649269B2 (de)
BE (1) BE1006878A5 (de)
CA (1) CA2065421A1 (de)
CH (1) CH684162A5 (de)
CZ (1) CZ281843B6 (de)
DE (1) DE4191979T (de)
DK (1) DK51292A (de)
ES (1) ES2078838B1 (de)
FI (1) FI913888A (de)
FR (1) FR2665835B1 (de)
GB (1) GB2254252B (de)
GR (1) GR1002188B (de)
HU (1) HUT60137A (de)
IE (1) IE66121B1 (de)
IL (1) IL99224A (de)
IT (1) IT1251226B (de)
LU (1) LU88099A1 (de)
MX (1) MX9100742A (de)
MY (1) MY107976A (de)
NL (1) NL9120006A (de)
NZ (1) NZ239464A (de)
PT (1) PT98707B (de)
RU (1) RU2080860C1 (de)
SE (1) SE9201189D0 (de)
SK (1) SK279225B6 (de)
WO (1) WO1992003138A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2935292A (en) * 1991-10-31 1993-06-07 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Prevention of drug-induced agranulocytosis with free radical scavengers
US5538965A (en) * 1993-12-23 1996-07-23 Allelix Biopharmaceuticals Inc. Dopamine receptor ligands
CA2735293A1 (en) * 1995-01-17 1996-07-18 Menuco Corp. Nadh and nadph therapeutic agents for dermal administration
JP3889481B2 (ja) * 1996-08-16 2007-03-07 株式会社カネカ 医薬組成物
CN1281335A (zh) * 1997-10-27 2001-01-24 科泰克斯药物股份有限公司 用安哌克和精神安定剂治疗精神分裂症
US8753675B1 (en) * 2000-01-20 2014-06-17 Raj K. Chopra Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications
JP2003026567A (ja) * 2001-05-10 2003-01-29 Kanegafuchi Chem Ind Co Ltd 補酵素ｑを有効成分とする粘膜投与用組成物
NZ527142A (en) * 2003-07-23 2006-03-31 Douglas Pharmaceuticals Ltd A stable suspension formulation
US8173637B2 (en) * 2008-07-24 2012-05-08 Handa Pharmaceuticals, Llc Stabilized atypical antipsychotic formulation
RU2610169C2 (ru) * 2014-09-11 2017-02-08 Общество С Ограниченной Ответственностью "Валентек" ПРОИЗВОДНЫЕ 7-ФТОРО-8-ХЛОРО-5Н-ДИБЕНЗО[b, е][1, 4]ДИАЗЕПИНА И ИХ ПРИМЕНЕНИЕ

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI50242C (fi) * 1969-07-18 1976-01-12 Thomae Gmbh Dr K Menetelmä valmistaa farmakologisesti aktiivisia uusia diallyyliaminoal kanoyylidibenso- tai pyridobenso-diatsepiineja ja niiden happoadditios uoloja.
US3983234A (en) * 1974-07-04 1976-09-28 Sandoz Ltd. Treatment of dyskinesias
US4028467A (en) * 1975-01-07 1977-06-07 Berger Frank M Analgesic compositions comprising levo-propoxyphene and benzo diazepine and process
GB1498857A (en) * 1975-07-03 1978-01-25 Leo Ab Antidepressant composition
DE3069716D1 (en) * 1979-10-01 1985-01-10 Sandoz Ag Dibenzazepine derivatives, their production and pharmaceutical compositions containing them
US4761411A (en) * 1983-05-18 1988-08-02 Hoechst-Roussel Pharmaceuticals Inc. Dihydrobenzopyrrolobenzodiazepines useful for treating pyschoses
DE3542309A1 (de) * 1985-11-29 1987-06-04 Cardona Federico Dr Medizinisches antioxidativum
US4973586A (en) * 1986-01-16 1990-11-27 Schering Corporation Fused benzazepines, compositions of, and medical use thereof
GB8607684D0 (en) * 1986-03-27 1986-04-30 Ici America Inc Thiazepine compounds
CA1327008C (en) * 1988-01-15 1994-02-15 Walter Merz Anti-psychotic imidazobenzodiazepine
US4996199A (en) * 1988-04-08 1991-02-26 Whitby Research, Inc. Penetration enhancers for transdermal delivery of systemic agents
JP2903318B2 (ja) * 1989-04-04 1999-06-07 日研フード株式会社 抗酸化的ストレス物

Also Published As

Publication number Publication date
CH684162A5 (de) 1994-07-29
SK279225B6 (sk) 1998-08-05
GR1002188B (en) 1996-03-13
FR2665835A1 (fr) 1992-02-21
RU2080860C1 (ru) 1997-06-10
HUT60137A (en) 1992-08-28
DE4191979T (de) 1992-10-08
IE912934A1 (en) 1992-02-26
HU9201090D0 (en) 1992-06-29
GB9206101D0 (en) 1992-06-24
MY107976A (en) 1996-07-15
MX9100742A (es) 1992-04-01
SE9201189L (sv) 1992-04-14
ES2078838B1 (es) 1997-02-01
CZ281843B6 (cs) 1997-02-12
US5563134A (en) 1996-10-08
ITMI912261A0 (it) 1991-08-20
KR920702225A (ko) 1992-09-03
WO1992003138A1 (en) 1992-03-05
IT1251226B (it) 1995-05-05
JPH0813745B2 (ja) 1996-02-14
IL99224A0 (en) 1992-07-15
CA2065421A1 (en) 1992-02-21
AU8396391A (en) 1992-03-17
FI913888A (fi) 1992-02-21
KR100189349B1 (en) 1999-06-01
GR910100361A (el) 1992-08-31
FR2665835B1 (fr) 1995-06-23
GB2254252B (en) 1994-06-01
IE66121B1 (en) 1995-12-13
AU649269B2 (en) 1994-05-19
JPH05503296A (ja) 1993-06-03
AT400522B (de) 1996-01-25
PT98707A (pt) 1992-07-31
PT98707B (pt) 1999-01-29
US5312819A (en) 1994-05-17
ITMI912261A1 (it) 1993-02-20
ES2078838A1 (es) 1995-12-16
CS55092A3 (en) 1992-08-12
FI913888A0 (fi) 1991-08-16
ATA900491A (de) 1995-06-15
DK51292D0 (da) 1992-04-15
NZ239464A (en) 1993-10-26
DK51292A (da) 1992-04-15
GB2254252A (en) 1992-10-07
IL99224A (en) 1996-01-31
SE9201189D0 (sv) 1992-04-14
LU88099A1 (de) 1992-11-16
BE1006878A5 (fr) 1995-01-17

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Legal Events

Date Code Title Description
CNR Transfer of rights (patent application after its laying open for public inspection)

Free format text: SANDOZ LTD. EN THE UNITED STATES OF AMERICA,

BB A search report has been drawn up
BC A request for examination has been filed
CNR Transfer of rights (patent application after its laying open for public inspection)

Free format text: NOVARTIS AG;THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY UNITED STATES DEPARTMENT OF COMMERCE

BV The patent application has lapsed