NL8600317A - Vaccinsysteem. - Google Patents
Vaccinsysteem. Download PDFInfo
- Publication number
- NL8600317A NL8600317A NL8600317A NL8600317A NL8600317A NL 8600317 A NL8600317 A NL 8600317A NL 8600317 A NL8600317 A NL 8600317A NL 8600317 A NL8600317 A NL 8600317A NL 8600317 A NL8600317 A NL 8600317A
- Authority
- NL
- Netherlands
- Prior art keywords
- vaccine
- oil
- adjuvant
- live
- water
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims description 69
- 239000002671 adjuvant Substances 0.000 claims description 22
- 238000002255 vaccination Methods 0.000 claims description 19
- 239000003921 oil Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 235000019198 oils Nutrition 0.000 claims description 11
- 241000271566 Aves Species 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 239000012071 phase Substances 0.000 claims description 9
- 244000005700 microbiome Species 0.000 claims description 8
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 230000002238 attenuated effect Effects 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 239000003995 emulsifying agent Substances 0.000 claims description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 239000008346 aqueous phase Substances 0.000 claims description 4
- 239000007764 o/w emulsion Substances 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 241000124008 Mammalia Species 0.000 claims description 2
- 235000019483 Peanut oil Nutrition 0.000 claims description 2
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 235000005687 corn oil Nutrition 0.000 claims description 2
- 239000002285 corn oil Substances 0.000 claims description 2
- 239000002480 mineral oil Substances 0.000 claims description 2
- 235000010446 mineral oil Nutrition 0.000 claims description 2
- 239000000312 peanut oil Substances 0.000 claims description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
- 229920000136 polysorbate Polymers 0.000 claims description 2
- 229920000053 polysorbate 80 Polymers 0.000 claims description 2
- 239000008159 sesame oil Substances 0.000 claims description 2
- 235000011803 sesame oil Nutrition 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- 241000251468 Actinopterygii Species 0.000 claims 1
- 241000498849 Chlamydiales Species 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000007975 buffered saline Substances 0.000 claims 1
- 238000004945 emulsification Methods 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000003549 soybean oil Substances 0.000 claims 1
- 235000012424 soybean oil Nutrition 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 239000000839 emulsion Substances 0.000 description 21
- 230000036039 immunity Effects 0.000 description 16
- 239000000427 antigen Substances 0.000 description 13
- 102000036639 antigens Human genes 0.000 description 13
- 108091007433 antigens Proteins 0.000 description 13
- 241001465754 Metazoa Species 0.000 description 12
- 229940031551 inactivated vaccine Drugs 0.000 description 10
- 208000015181 infectious disease Diseases 0.000 description 9
- 208000010359 Newcastle Disease Diseases 0.000 description 8
- 230000003053 immunization Effects 0.000 description 7
- 230000008901 benefit Effects 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- 241000700605 Viruses Species 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 230000002458 infectious effect Effects 0.000 description 5
- 239000007762 w/o emulsion Substances 0.000 description 5
- 201000006082 Chickenpox Diseases 0.000 description 4
- 241000287828 Gallus gallus Species 0.000 description 4
- 235000013330 chicken meat Nutrition 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- 241000700662 Fowlpox virus Species 0.000 description 3
- 206010046980 Varicella Diseases 0.000 description 3
- 239000002158 endotoxin Substances 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 244000144977 poultry Species 0.000 description 3
- 235000013594 poultry meat Nutrition 0.000 description 3
- 238000010254 subcutaneous injection Methods 0.000 description 3
- 239000007929 subcutaneous injection Substances 0.000 description 3
- JDRAOGVAQOVDEB-KTKRTIGZSA-N (3-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl) (z)-octadec-9-enoate Chemical compound OC1COC2C(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC21 JDRAOGVAQOVDEB-KTKRTIGZSA-N 0.000 description 2
- 241000711404 Avian avulavirus 1 Species 0.000 description 2
- 208000000666 Fowlpox Diseases 0.000 description 2
- 206010022095 Injection Site reaction Diseases 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 206010006451 bronchitis Diseases 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 230000035931 haemagglutination Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 229920006008 lipopolysaccharide Polymers 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 229920005862 polyol Polymers 0.000 description 2
- 150000003077 polyols Chemical class 0.000 description 2
- 230000037452 priming Effects 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229940021648 varicella vaccine Drugs 0.000 description 2
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- 206010003274 Arthritis viral Diseases 0.000 description 1
- 241000193738 Bacillus anthracis Species 0.000 description 1
- 241001148106 Brucella melitensis Species 0.000 description 1
- 208000027312 Bursal disease Diseases 0.000 description 1
- 241000606161 Chlamydia Species 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 206010061043 Clostridial infection Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 208000004575 Infectious Arthritis Diseases 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- 241000186359 Mycobacterium Species 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 241000204022 Mycoplasma gallisepticum Species 0.000 description 1
- 241000606856 Pasteurella multocida Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 206010037742 Rabies Diseases 0.000 description 1
- 241000220010 Rhode Species 0.000 description 1
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 206010044302 Tracheitis Diseases 0.000 description 1
- 241000700647 Variola virus Species 0.000 description 1
- 206010051511 Viral diarrhoea Diseases 0.000 description 1
- LUXUAZKGQZPOBZ-SAXJAHGMSA-N [(3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (Z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O LUXUAZKGQZPOBZ-SAXJAHGMSA-N 0.000 description 1
- 206010000210 abortion Diseases 0.000 description 1
- 231100000176 abortion Toxicity 0.000 description 1
- 229940024546 aluminum hydroxide gel Drugs 0.000 description 1
- SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 229940065181 bacillus anthracis Drugs 0.000 description 1
- 229940038698 brucella melitensis Drugs 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 150000001720 carbohydrates Chemical group 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- -1 etc.) Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 229940124452 immunizing agent Drugs 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 229940047122 interleukins Drugs 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 201000009837 laryngotracheitis Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 229940051027 pasteurella multocida Drugs 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 1
- 239000001570 sorbitan monopalmitate Substances 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 239000002512 suppressor factor Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL7428985 | 1985-02-10 | ||
| IL74289A IL74289A (en) | 1985-02-10 | 1985-02-10 | Vaccine system comprising a live-non-virulent vaccine and an adjuvant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8600317A true NL8600317A (nl) | 1986-09-01 |
Family
ID=11055665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8600317A NL8600317A (nl) | 1985-02-10 | 1986-02-10 | Vaccinsysteem. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4795635A (es) |
| DE (1) | DE3604109A1 (es) |
| ES (1) | ES8802209A1 (es) |
| FR (1) | FR2577139B1 (es) |
| GB (1) | GB2170708B (es) |
| IL (1) | IL74289A (es) |
| NL (1) | NL8600317A (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK189788D0 (da) * | 1988-04-07 | 1988-04-07 | Wolf Watz Hans | Vaccine |
| FR2649012B1 (fr) * | 1989-07-03 | 1991-10-25 | Seppic Sa | Emulsions multiphasiques injectables |
| FR2649013B1 (fr) * | 1989-07-03 | 1991-10-25 | Seppic Sa | Vaccins et vecteurs de principes actifs fluides contenant une huile metabolisable |
| US5565205A (en) * | 1990-08-16 | 1996-10-15 | Solvay Animal Health, Inc. | Inactivated Mycoplasma hypopneumoniae bacterin and method of use thereof |
| ES2053402B1 (es) * | 1993-01-15 | 1995-02-01 | Hipra Lab Sa | Metodo de preparacion de vacunas inactivadas y vacunas vivas adyuvantadas asi como las vacunas obtenidas por dicho metodo. |
| WO1995011700A1 (en) * | 1993-10-29 | 1995-05-04 | Pharmos Corp. | Submicron emulsions as vaccine adjuvants |
| US5961970A (en) * | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
| US5538733A (en) * | 1994-07-07 | 1996-07-23 | Willmar Poultry Company, Inc. | Method of priming an immune response in a one-day old animal |
| US5989805A (en) * | 1995-10-27 | 1999-11-23 | Board Of Trustees Operating Michigan State University | Immortal avian cell line to grow avian and animal viruses to produce vaccines |
| US5780448A (en) | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
| ZA978434B (en) * | 1996-09-27 | 1998-03-26 | Akzo Nobel Nv | Inactivated vaccines. |
| DE69730152T2 (de) * | 1996-09-30 | 2005-11-03 | University Of Arkansas, Fayetteville | Verfahren zur erzeugung aktiver immunität durch vakzinkonjugate |
| US6524592B2 (en) * | 1997-10-17 | 2003-02-25 | American Home Products Corporation | Veterinary vaccines |
| US6159472A (en) * | 1998-11-16 | 2000-12-12 | Akzo Nobel N.V. | Intradermal Avian immunization with inactivated vaccines |
| NZ512302A (en) * | 1998-12-21 | 2003-08-29 | Akzo Nobel Nv | Method to produce inactivated w/o emulsion adjuvated vaccines |
| DE29921392U1 (de) | 1999-12-06 | 2000-03-16 | Dr. Felgenträger & Co. Öko-Chem. und Pharma GmbH, 06862 Rodleben | Mykoplasma-bovis-Kombinations-Vakzine für Rinder |
| AU2002249895A1 (en) * | 2001-01-05 | 2002-07-16 | Joslin Diabetes Center, Inc. | Autoantigen composition |
| FR2824279B1 (fr) * | 2001-05-04 | 2004-05-28 | Seppic Sa | Emulsion e/h concentree |
| FR2824269B1 (fr) * | 2001-09-03 | 2012-03-02 | Seppic Sa | Composition adjuvante constituee de 1% a 15% de tensioactifs a hlb global compris entre 5 et 8 et de 85% a 99% de corps gras |
| BRPI0910185A2 (pt) * | 2008-06-26 | 2015-12-01 | Ceva Sante Animale S A | sorotipo de reovírus aviário isolado, reovírus aviário isolado, peptídeos, vacina, antisoro isolado, anticorpo isolado, método para proteção de aves, método para detecção ou quantificação de reovírus em aves, recipiente para vacinação de aves, kit para vacinação de aves, kit de diagnóstico, linhagem celular derivada da lmh |
| FR2957933B1 (fr) * | 2010-03-24 | 2012-04-27 | Seppic Sa | Vaccin vivant pour maladies aviaires |
| JP6082901B2 (ja) * | 2011-01-31 | 2017-02-22 | オリンパス株式会社 | ワクチン・アジュバント |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL269002A (es) * | 1960-09-06 | |||
| GB1080994A (en) * | 1963-10-25 | 1967-08-31 | Nat Res Dev | Injectable emulsions containing antigens |
| BE704138A (es) * | 1965-04-12 | 1968-03-21 | ||
| US3492399A (en) * | 1965-09-27 | 1970-01-27 | Samuel J Prigal | Emulsion compositions and methods |
| IL28639A (en) * | 1967-07-21 | 1972-03-28 | American Cyanamid Co | An anti-fouling agent containing salts of polyhydric metals that have undergone hydration and fatty acids |
| GB1189340A (en) * | 1967-09-13 | 1970-04-22 | American Cyanamid Co | Antigen-Adjuvant Composition |
| GB1290141A (es) * | 1968-05-31 | 1972-09-20 | ||
| LU57465A1 (es) * | 1968-12-04 | 1970-06-04 | ||
| US3983228A (en) * | 1973-08-28 | 1976-09-28 | Merck & Co., Inc. | Water-in-oil adjuvant composition |
| FR2313078A1 (fr) * | 1975-02-07 | 1976-12-31 | Anvar | Composition a base d'huile vegetale metabolisable et d'eau, utilisable notamment pour la constitution de preparations adjuvantes, ces preparations adjuvantes et leur procede d'obtention |
| US4073743A (en) * | 1975-04-17 | 1978-02-14 | Merck & Co., Inc. | Process for preparing an emulsion |
| DE2643213C2 (de) * | 1976-09-25 | 1985-02-21 | Bayer Ag, 5090 Leverkusen | Verfahren zum Abschwächen oder Inaktivieren von Mikroorganismen |
| US4310550A (en) * | 1979-10-26 | 1982-01-12 | Pfizer Inc. | Lipid amines formulated with fat or lipid emulsions as vaccine adjuvants |
| JPS5716823A (en) * | 1980-07-03 | 1982-01-28 | Green Cross Corp:The | Live mumps vaccine pharmaceutical and stabilizing method |
| US4323555A (en) * | 1980-11-03 | 1982-04-06 | The Regents Of The University Of California | Method of protecting cattle and sheep against bovine leukemia virus and vaccines for use therein |
| DE3323070A1 (de) * | 1983-06-27 | 1985-01-03 | Henkel KGaA, 4000 Düsseldorf | Aerosolverpackung |
| EP0073856A1 (en) * | 1981-08-28 | 1983-03-16 | Gist-Brocades N.V. | Infectious-bronchitis vaccines for poultry, combined infectious-bronchitis vaccines, process for preparing such vaccines, process for preventing infectious bronchitis and infectious-bronchitis virus strain |
| NL8301996A (nl) * | 1983-06-06 | 1985-01-02 | Duphar Int Res | Werkwijze ter bereiding van geadjuveerde levende vaccins en aldus verkregen geadjuveerde levende vaccins. |
-
1985
- 1985-02-10 IL IL74289A patent/IL74289A/xx not_active IP Right Cessation
-
1986
- 1986-01-29 GB GB08602175A patent/GB2170708B/en not_active Expired
- 1986-02-07 FR FR8601670A patent/FR2577139B1/fr not_active Expired
- 1986-02-07 ES ES551726A patent/ES8802209A1/es not_active Expired
- 1986-02-10 NL NL8600317A patent/NL8600317A/nl not_active Application Discontinuation
- 1986-02-10 DE DE19863604109 patent/DE3604109A1/de not_active Ceased
-
1987
- 1987-09-23 US US07/102,794 patent/US4795635A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US4795635A (en) | 1989-01-03 |
| GB2170708B (en) | 1989-02-01 |
| FR2577139B1 (fr) | 1989-09-22 |
| DE3604109A1 (de) | 1986-08-14 |
| ES8802209A1 (es) | 1988-05-01 |
| FR2577139A1 (fr) | 1986-08-14 |
| ES551726A0 (es) | 1988-05-01 |
| IL74289A0 (en) | 1985-05-31 |
| GB2170708A (en) | 1986-08-13 |
| IL74289A (en) | 1989-02-28 |
| GB8602175D0 (en) | 1986-03-05 |
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