NL8003854A - Pteridinederivaten en radio-immunologische bepalingsmethode. - Google Patents
Pteridinederivaten en radio-immunologische bepalingsmethode. Download PDFInfo
- Publication number
- NL8003854A NL8003854A NL8003854A NL8003854A NL8003854A NL 8003854 A NL8003854 A NL 8003854A NL 8003854 A NL8003854 A NL 8003854A NL 8003854 A NL8003854 A NL 8003854A NL 8003854 A NL8003854 A NL 8003854A
- Authority
- NL
- Netherlands
- Prior art keywords
- pteridine
- group
- hydroxy
- erythro
- mixture
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 18
- CPNGPNLZQNNVQM-UHFFFAOYSA-N pteridine Chemical class N1=CN=CC2=NC=CN=C21 CPNGPNLZQNNVQM-UHFFFAOYSA-N 0.000 title claims description 18
- 150000001875 compounds Chemical class 0.000 claims description 28
- -1 5-carboxypentylamino Chemical group 0.000 claims description 27
- 229910052740 iodine Inorganic materials 0.000 claims description 22
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 20
- 239000011630 iodine Substances 0.000 claims description 20
- 230000002285 radioactive effect Effects 0.000 claims description 20
- 150000003195 pteridines Chemical class 0.000 claims description 19
- 125000004432 carbon atom Chemical group C* 0.000 claims description 12
- 125000002947 alkylene group Chemical group 0.000 claims description 6
- 125000004464 hydroxyphenyl group Chemical group 0.000 claims description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 4
- 238000010324 immunological assay Methods 0.000 claims description 3
- XMBWDFGMSWQBCA-RNFDNDRNSA-M iodine-131(1-) Chemical compound [131I-] XMBWDFGMSWQBCA-RNFDNDRNSA-M 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 47
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 30
- 239000000243 solution Substances 0.000 description 30
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- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001042 pteridinyl group Chemical group N1=C(N=CC2=NC=CN=C12)* 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000006798 ring closing metathesis reaction Methods 0.000 description 1
- 238000005185 salting out Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- FNKQXYHWGSIFBK-RPDRRWSUSA-N sapropterin Chemical compound N1=C(N)NC(=O)C2=C1NC[C@H]([C@@H](O)[C@@H](O)C)N2 FNKQXYHWGSIFBK-RPDRRWSUSA-N 0.000 description 1
- 229960004617 sapropterin Drugs 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- AWDBHOZBRXWRKS-UHFFFAOYSA-N tetrapotassium;iron(6+);hexacyanide Chemical compound [K+].[K+].[K+].[K+].[Fe+6].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] AWDBHOZBRXWRKS-UHFFFAOYSA-N 0.000 description 1
- 229960001479 tosylchloramide sodium Drugs 0.000 description 1
- 229960004441 tyrosine Drugs 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8456879A JPH0231720B2 (ja) | 1979-07-04 | 1979-07-04 | Puterinjudotaioyobiputerinruinosokuteiho |
| JP8456879 | 1979-07-04 | ||
| JP188480A JPS5699484A (en) | 1980-01-11 | 1980-01-11 | Pterin derivative and determination of pterins |
| JP188480 | 1980-07-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8003854A true NL8003854A (nl) | 1981-01-06 |
Family
ID=26335174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8003854A NL8003854A (nl) | 1979-07-04 | 1980-07-03 | Pteridinederivaten en radio-immunologische bepalingsmethode. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4371514A (OSRAM) |
| AU (1) | AU526214B2 (OSRAM) |
| CA (1) | CA1150243A (OSRAM) |
| DE (1) | DE3025226C2 (OSRAM) |
| FR (1) | FR2460952A1 (OSRAM) |
| GB (1) | GB2056459B (OSRAM) |
| NL (1) | NL8003854A (OSRAM) |
| SE (1) | SE441529B (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1076495B (de) * | 1954-08-17 | 1960-02-25 | Ing Ernst Godderidge | Rotierende Verdraengerpumpe |
| US4550109A (en) * | 1984-05-31 | 1985-10-29 | The Board Of Regents, The University Of Texas System | Lipoidal biopterin compounds |
| DE4215275A1 (de) * | 1992-05-09 | 1993-11-11 | Merck Patent Gmbh | Mittel und Verfahren zur Behandlung von Körperflüssigkeiten bei der Bestimmung von Neopterin |
| DE4308739C1 (de) * | 1993-03-19 | 1994-06-23 | Henning Berlin Gmbh | Pterinderivate, ihre Herstellung und ihre Verwendung |
| US5525711A (en) * | 1994-05-18 | 1996-06-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Pteridine nucleotide analogs as fluorescent DNA probes |
| US6562969B1 (en) * | 1996-12-24 | 2003-05-13 | Research Development Foundation | Ricin inhibitors and methods for use thereof |
| ZA9711548B (en) * | 1996-12-24 | 1999-06-23 | Res Dev Foundation | Ricin inhibitors and methods for use thereof |
| HUE029533T2 (en) * | 2003-11-17 | 2017-03-28 | Biomarin Pharm Inc | Treatment of phenylketonuria with BH4 |
| EP2436379A1 (en) | 2004-11-17 | 2012-04-04 | BioMarin Pharmaceutical Inc. | Stable tablet formulation |
| US20120115244A1 (en) * | 2010-11-09 | 2012-05-10 | Abbott Laboratories | Materials and methods for immunoassay of pterins |
| US9216178B2 (en) | 2011-11-02 | 2015-12-22 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB785353A (en) * | 1953-01-30 | 1957-10-30 | Merck & Co Inc | Substituted pteridine derivatives |
| GB785352A (en) * | 1953-10-21 | 1957-10-30 | Merck & Co Inc | Preparation of pteridine derivatives |
| GB1458978A (en) * | 1973-12-11 | 1976-12-22 | Radiochemical Centre Ltd | Saturation analysis |
| US4202976A (en) * | 1973-09-11 | 1980-05-13 | Bayly Russell J | Selenium-75 labelled derivatives of folates |
| US3972991A (en) * | 1974-03-18 | 1976-08-03 | Case Western Reserve University | Radioisotopic assay and binder therefor |
| US3989812A (en) * | 1974-08-09 | 1976-11-02 | Smithkline Instruments, Inc. | Folic acid derivatives and use in radio-assay |
| US3988431A (en) * | 1974-12-12 | 1976-10-26 | Becton, Dickinson And Company | Radioassay of folates |
| CA1078827A (en) * | 1975-02-20 | 1980-06-03 | Nathan Lewin | Isotopically labeled derivatives of folic acid |
| IL49283A0 (en) * | 1975-03-31 | 1976-05-31 | Rosen I | A process for the radioassay of folates and novel 125 iodinated folic acid derivatives used therein |
| US4028465A (en) * | 1975-11-10 | 1977-06-07 | Bio-Rad Laboratories | Assay method for serum folate |
| US4276280A (en) * | 1976-09-29 | 1981-06-30 | Becton, Dickinson And Company | Radiolabeled derivatives of folic acid |
| US4146602A (en) * | 1977-01-27 | 1979-03-27 | Becton, Dickinson & Company | Simultaneous radioassay of folate and vitamin B12 |
| US4136159A (en) * | 1977-02-28 | 1979-01-23 | New England Nuclear Corporation | Radioassay of folates |
| US4135880A (en) * | 1977-08-19 | 1979-01-23 | Bio-Rad Laboratories, Inc. | Folate assay with ion exchange resin bound-free separation |
| DE2967143D1 (en) * | 1978-12-18 | 1984-08-30 | Wachter Helmut | Diagnostic method, especially for the early recognition of malignant tumors and/or viral diseases, and means to carry it out |
-
1980
- 1980-07-02 GB GB8021637A patent/GB2056459B/en not_active Expired
- 1980-07-03 NL NL8003854A patent/NL8003854A/nl active Search and Examination
- 1980-07-03 SE SE8004933A patent/SE441529B/sv not_active IP Right Cessation
- 1980-07-03 DE DE3025226A patent/DE3025226C2/de not_active Expired
- 1980-07-04 FR FR8014984A patent/FR2460952A1/fr active Granted
- 1980-07-04 CA CA000355429A patent/CA1150243A/en not_active Expired
- 1980-07-04 AU AU60106/80A patent/AU526214B2/en not_active Ceased
- 1980-07-07 US US06/166,519 patent/US4371514A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| GB2056459A (en) | 1981-03-18 |
| FR2460952B1 (OSRAM) | 1983-05-20 |
| DE3025226A1 (de) | 1981-01-22 |
| AU6010680A (en) | 1981-10-29 |
| CA1150243A (en) | 1983-07-19 |
| SE8004933L (sv) | 1981-01-05 |
| AU526214B2 (en) | 1982-12-23 |
| SE441529B (sv) | 1985-10-14 |
| US4371514A (en) | 1983-02-01 |
| FR2460952A1 (fr) | 1981-01-30 |
| DE3025226C2 (de) | 1982-07-22 |
| GB2056459B (en) | 1983-03-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BATV | A request for search has been withdrawn | ||
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| A85 | Still pending on 85-01-01 | ||
| BN | A decision not to publish the application has become irrevocable |