JPS5699484A - Pterin derivative and determination of pterins - Google Patents

Pterin derivative and determination of pterins

Info

Publication number
JPS5699484A
JPS5699484A JP188480A JP188480A JPS5699484A JP S5699484 A JPS5699484 A JP S5699484A JP 188480 A JP188480 A JP 188480A JP 188480 A JP188480 A JP 188480A JP S5699484 A JPS5699484 A JP S5699484A
Authority
JP
Japan
Prior art keywords
formula
erythro
pteridine
hydroxy
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP188480A
Other languages
Japanese (ja)
Other versions
JPH0255434B2 (en
Inventor
Toshiharu Nagatsu
Takeshi Kato
Tokio Yamaguchi
Miki Akino
Sadao Matsuura
Takashi Sugimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm RI Pharma Co Ltd
Original Assignee
Fujifilm RI Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm RI Pharma Co Ltd filed Critical Fujifilm RI Pharma Co Ltd
Priority to JP188480A priority Critical patent/JPS5699484A/en
Priority to GB8021637A priority patent/GB2056459B/en
Priority to NL8003854A priority patent/NL8003854A/en
Priority to DE3025226A priority patent/DE3025226C2/en
Priority to SE8004933A priority patent/SE441529B/en
Priority to CA000355429A priority patent/CA1150243A/en
Priority to AU60106/80A priority patent/AU526214B2/en
Priority to FR8014984A priority patent/FR2460952A1/en
Priority to US06/166,519 priority patent/US4371514A/en
Publication of JPS5699484A publication Critical patent/JPS5699484A/en
Publication of JPH0255434B2 publication Critical patent/JPH0255434B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:Pterin derivatives of formula VI and formula VII (R6 and R7 are H, alkyl or hydroxyalkyl; *I is radioactive iodine).
EXAMPLE: 125I - labeled 4-hydroxy -2- [ 2-( p-hydroxyphenyl) ethyl ] amino -6- ( L- erythro-1,2-dihydroxypropyl)pteridine.
USE: A tracer for radio-immuno-assay. Diagnosis of various anenzymia by determining pterins composed mainly of biopterin [2-amino-4-hydroxy-6-(L-erythro-1,2- dihydroxypropyl)pteridine] and neopterin [2-amino-4-hydroxy-6-(L-erythro-1,2,3- trihydroxypropyl)pteridine] in a specimen such as urine, easily, in high sensitivity.
PROCESS: The compounds of formula VI and formula VII can be prepared from the compound and of formula II according to the reaction formula.
COPYRIGHT: (C)1981,JPO&Japio
JP188480A 1979-07-04 1980-01-11 Pterin derivative and determination of pterins Granted JPS5699484A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP188480A JPS5699484A (en) 1980-01-11 1980-01-11 Pterin derivative and determination of pterins
GB8021637A GB2056459B (en) 1979-07-04 1980-07-02 Pterin derivatives and an assay method for determining pterins
NL8003854A NL8003854A (en) 1979-07-04 1980-07-03 PTERIDINE DERIVATIVES AND RADIO-IMMUNOLOGICAL DETERMINATION METHOD.
DE3025226A DE3025226C2 (en) 1979-07-04 1980-07-03 Pterin derivatives and their use for the radioimmunological determination of pterins
SE8004933A SE441529B (en) 1979-07-04 1980-07-03 RADIO IMMUNO ANALYSIS OF PTERINES AND NEW PTERIN DERIVATIVES EASY FOR THIS
CA000355429A CA1150243A (en) 1979-07-04 1980-07-04 Radioimmunoassay of pterins and novel pterin derivatives useful therefor
AU60106/80A AU526214B2 (en) 1979-07-04 1980-07-04 Pteridin derivatives
FR8014984A FR2460952A1 (en) 1979-07-04 1980-07-04 METHOD FOR THE RADIOIMMUNOLOGICAL DETERMINATION OF PTERINS AND NEW PTERIN DERIVATIVES USEFUL IN THIS PROCESS
US06/166,519 US4371514A (en) 1979-07-04 1980-07-07 Radioimmunoassay of pterins and novel pterin derivatives useful therefor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP188480A JPS5699484A (en) 1980-01-11 1980-01-11 Pterin derivative and determination of pterins

Publications (2)

Publication Number Publication Date
JPS5699484A true JPS5699484A (en) 1981-08-10
JPH0255434B2 JPH0255434B2 (en) 1990-11-27

Family

ID=11513986

Family Applications (1)

Application Number Title Priority Date Filing Date
JP188480A Granted JPS5699484A (en) 1979-07-04 1980-01-11 Pterin derivative and determination of pterins

Country Status (1)

Country Link
JP (1) JPS5699484A (en)

Also Published As

Publication number Publication date
JPH0255434B2 (en) 1990-11-27

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