NL8001955A - 5-aryl-1-(2-oxazolin-2-yl)-1h-1,4-benzodiazepinen en verwante verbindingen. - Google Patents
5-aryl-1-(2-oxazolin-2-yl)-1h-1,4-benzodiazepinen en verwante verbindingen. Download PDFInfo
- Publication number
- NL8001955A NL8001955A NL8001955A NL8001955A NL8001955A NL 8001955 A NL8001955 A NL 8001955A NL 8001955 A NL8001955 A NL 8001955A NL 8001955 A NL8001955 A NL 8001955A NL 8001955 A NL8001955 A NL 8001955A
- Authority
- NL
- Netherlands
- Prior art keywords
- formula
- dihydro
- chloro
- benzodiazepine
- chlorophenyl
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims description 83
- 229940049706 benzodiazepine Drugs 0.000 title claims description 34
- -1 2-OXAZOLIN-2-YL Chemical class 0.000 title claims description 22
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims description 37
- 239000001257 hydrogen Substances 0.000 claims description 26
- 229910052739 hydrogen Inorganic materials 0.000 claims description 26
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 19
- 229910052736 halogen Inorganic materials 0.000 claims description 18
- 150000002367 halogens Chemical class 0.000 claims description 18
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 17
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 150000002431 hydrogen Chemical class 0.000 claims description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 10
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 9
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 9
- 239000001301 oxygen Substances 0.000 claims description 9
- 229910052760 oxygen Inorganic materials 0.000 claims description 9
- 125000001841 imino group Chemical group [H]N=* 0.000 claims description 8
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims description 8
- 239000013543 active substance Substances 0.000 claims description 3
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- DQFQCHIDRBIESA-UHFFFAOYSA-N 1-benzazepine Chemical compound N1C=CC=CC2=CC=CC=C12 DQFQCHIDRBIESA-UHFFFAOYSA-N 0.000 claims 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/026,701 US4208327A (en) | 1979-04-03 | 1979-04-03 | 5-Aryl-1-(2-oxazolin-2-yl)-1H-1,4-benzodiazepines and related compounds |
| US2670179 | 1979-04-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8001955A true NL8001955A (nl) | 1980-10-07 |
Family
ID=21833326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8001955A NL8001955A (nl) | 1979-04-03 | 1980-04-02 | 5-aryl-1-(2-oxazolin-2-yl)-1h-1,4-benzodiazepinen en verwante verbindingen. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4208327A (enExample) |
| JP (1) | JPS55153784A (enExample) |
| AU (1) | AU5709380A (enExample) |
| BE (1) | BE882590A (enExample) |
| CA (1) | CA1134358A (enExample) |
| DE (1) | DE3012801A1 (enExample) |
| DK (1) | DK143880A (enExample) |
| ES (4) | ES8104283A1 (enExample) |
| FR (1) | FR2453173A1 (enExample) |
| GB (1) | GB2050352B (enExample) |
| IE (1) | IE49575B1 (enExample) |
| IT (1) | IT1127417B (enExample) |
| NL (1) | NL8001955A (enExample) |
| SE (1) | SE8002523L (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19538192A1 (de) * | 1995-10-13 | 1997-04-17 | Zahnradfabrik Friedrichshafen | Ölversorgungsvorrichtung |
| WO2000029410A1 (en) * | 1998-11-17 | 2000-05-25 | Shionogi & Co., Ltd. | Thiazolone derivatives having fused polycyclic heterocycle at the 2-position and pesticides containing the same as the active ingredient |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3371085A (en) * | 1959-12-10 | 1968-02-27 | Hoffmann La Roche | 5-aryl-3h-1,4-benzodiazepin-2(1h)-ones |
| US3136815A (en) * | 1959-12-10 | 1964-06-09 | Hoffmann La Roche | Amino substituted benzophenone oximes and derivatives thereof |
| US3481921A (en) * | 1965-10-22 | 1969-12-02 | Hoffmann La Roche | Benzodiazepines |
| US3812103A (en) * | 1967-04-11 | 1974-05-21 | Hoffmann La Roche | 2,3-dihydro-1,4-benzodiazepines |
| US3778433A (en) * | 1969-04-18 | 1973-12-11 | Sumitomo Chemical Co | Process for producing benzodiazepine derivatives |
| IL39413A0 (en) * | 1971-05-13 | 1972-07-26 | Sparamedica Ag | Benzodiazepine derivatives,their preparation and pharmaceutical compositions containing them |
| JPS5011999B1 (enExample) * | 1971-06-18 | 1975-05-08 |
-
1979
- 1979-04-03 US US06/026,701 patent/US4208327A/en not_active Expired - Lifetime
-
1980
- 1980-04-01 ES ES490187A patent/ES8104283A1/es not_active Expired
- 1980-04-02 IE IE674/80A patent/IE49575B1/en unknown
- 1980-04-02 BE BE0/200080A patent/BE882590A/fr not_active IP Right Cessation
- 1980-04-02 AU AU57093/80A patent/AU5709380A/en not_active Abandoned
- 1980-04-02 IT IT48322/80A patent/IT1127417B/it active
- 1980-04-02 SE SE8002523A patent/SE8002523L/xx not_active Application Discontinuation
- 1980-04-02 NL NL8001955A patent/NL8001955A/nl not_active Application Discontinuation
- 1980-04-02 DE DE19803012801 patent/DE3012801A1/de not_active Withdrawn
- 1980-04-02 DK DK143880A patent/DK143880A/da not_active Application Discontinuation
- 1980-04-03 FR FR8007601A patent/FR2453173A1/fr active Granted
- 1980-04-03 GB GB8011413A patent/GB2050352B/en not_active Expired
- 1980-04-03 JP JP4403780A patent/JPS55153784A/ja active Pending
- 1980-04-03 CA CA000349206A patent/CA1134358A/en not_active Expired
- 1980-12-16 ES ES497809A patent/ES497809A0/es active Granted
- 1980-12-16 ES ES497807A patent/ES497807A0/es active Granted
- 1980-12-16 ES ES497808A patent/ES8200889A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IE800674L (en) | 1980-10-03 |
| GB2050352A (en) | 1981-01-07 |
| ES497808A0 (es) | 1981-11-16 |
| ES490187A0 (es) | 1981-04-01 |
| ES8200890A1 (es) | 1981-11-16 |
| BE882590A (fr) | 1980-10-02 |
| GB2050352B (en) | 1982-12-08 |
| IT8048322A0 (it) | 1980-04-02 |
| DE3012801A1 (de) | 1980-10-16 |
| ES497809A0 (es) | 1981-11-16 |
| IE49575B1 (en) | 1985-10-30 |
| DK143880A (da) | 1980-10-04 |
| JPS55153784A (en) | 1980-11-29 |
| IT1127417B (it) | 1986-05-21 |
| ES8104283A1 (es) | 1981-04-01 |
| FR2453173B1 (enExample) | 1983-04-22 |
| SE8002523L (sv) | 1980-10-04 |
| US4208327A (en) | 1980-06-17 |
| FR2453173A1 (fr) | 1980-10-31 |
| ES8200888A1 (es) | 1981-11-16 |
| ES497807A0 (es) | 1981-11-16 |
| ES8200889A1 (es) | 1981-11-16 |
| AU5709380A (en) | 1980-10-09 |
| CA1134358A (en) | 1982-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BV | The patent application has lapsed |