NL300142I1 - Monoclonaal antilichaam tegen een cytotoxine, hybridoma cellijn, die dat uitdrukt en werkwijze voor de bereiding van het gezuiverde cytotoxine. - Google Patents

Monoclonaal antilichaam tegen een cytotoxine, hybridoma cellijn, die dat uitdrukt en werkwijze voor de bereiding van het gezuiverde cytotoxine.

Info

Publication number
NL300142I1
NL300142I1 NL300142C NL300142C NL300142I1 NL 300142 I1 NL300142 I1 NL 300142I1 NL 300142 C NL300142 C NL 300142C NL 300142 C NL300142 C NL 300142C NL 300142 I1 NL300142 I1 NL 300142I1
Authority
NL
Netherlands
Prior art keywords
cytotoxin
expresses
preparation
cell line
monoclonal antibody
Prior art date
Application number
NL300142C
Other languages
English (en)
Other versions
NL300142I2 (nl
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11055557&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL300142(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of NL300142I1 publication Critical patent/NL300142I1/nl
Publication of NL300142I2 publication Critical patent/NL300142I2/nl

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • G01N33/56972White blood cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52Assays involving cytokines
    • G01N2333/525Tumor necrosis factor [TNF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
NL300142C 1984-12-20 2004-02-12 Monoclonaal antilichaam tegen een cytotoxine, hybridoma cellijn, die dat uitdrukt en werkwijze voor de bereiding van het gezuiverde cytotoxine. NL300142I2 (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL73883A IL73883A (en) 1984-12-20 1984-12-20 Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha

Publications (2)

Publication Number Publication Date
NL300142I1 true NL300142I1 (nl) 2004-04-01
NL300142I2 NL300142I2 (nl) 2005-08-01

Family

ID=11055557

Family Applications (1)

Application Number Title Priority Date Filing Date
NL300142C NL300142I2 (nl) 1984-12-20 2004-02-12 Monoclonaal antilichaam tegen een cytotoxine, hybridoma cellijn, die dat uitdrukt en werkwijze voor de bereiding van het gezuiverde cytotoxine.

Country Status (9)

Country Link
US (1) US6090923A (nl)
EP (1) EP0186833B2 (nl)
JP (2) JPS61191620A (nl)
AU (1) AU601144B2 (nl)
CA (1) CA1337518C (nl)
DE (5) DE122004000007I1 (nl)
IL (1) IL73883A (nl)
NL (1) NL300142I2 (nl)
ZA (1) ZA859757B (nl)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019385A (en) * 1984-11-09 1991-05-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Novel lymphopine LK 2 and pharmaceutic compositions containing same
DE3631229A1 (de) * 1986-09-13 1988-03-24 Basf Ag Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung
JP3155961B2 (ja) * 1987-12-30 2001-04-16 煕 中島 抗ビリルビンモノクローナル抗体固定担体およびその製造方法
EP0409901A4 (en) * 1988-04-15 1991-10-30 Research Corporation Technologies, Inc Lak cell cytotoxin
IL99120A0 (en) * 1991-08-07 1992-07-15 Yeda Res & Dev Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them
DK0585705T3 (da) * 1992-08-28 1999-07-26 Bayer Ag Anvendelse af monoklone anti-TNF-antistoffer til behandling af bakteriel meningitis
ATE237808T1 (de) * 1992-10-21 2003-05-15 Stefan Miltenyi Direkte auswahl von zellen durch ein aussheidungsprodukt
US7166423B1 (en) 1992-10-21 2007-01-23 Miltenyi Biotec Gmbh Direct selection of cells by secretion product
IL114615A0 (en) 1995-07-16 1995-11-27 Yeda Res & Dev Modulators of the function of fas receptors and other proteins
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
CN1300173C (zh) 1996-02-09 2007-02-14 艾博特生物技术有限公司 结合人TNFα的人抗体
IL126024A0 (en) * 1998-03-19 1999-05-09 Yeda Res & Dev Modulators of the function of receptors of the tnf/ngf receptor family and other proteins
IL178921A0 (en) * 1998-12-24 2007-03-08 Yeda Res & Dev Caspase-8 interacting proteins
CA2385745C (en) 2001-06-08 2015-02-17 Abbott Laboratories (Bermuda) Ltd. Methods of administering anti-tnf.alpha. antibodies
US20050271663A1 (en) * 2001-06-28 2005-12-08 Domantis Limited Compositions and methods for treating inflammatory disorders
US20060073141A1 (en) * 2001-06-28 2006-04-06 Domantis Limited Compositions and methods for treating inflammatory disorders
US20050002900A1 (en) * 2001-11-06 2005-01-06 Grace Wong Method of treating estrogen responsive breast cancer
US20030206898A1 (en) 2002-04-26 2003-11-06 Steven Fischkoff Use of anti-TNFalpha antibodies and another drug
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
WO2004019861A2 (en) * 2002-08-28 2004-03-11 Pharmacia Corporation Stable ph optimized formulation of a modified antibody
US20040247588A1 (en) * 2002-08-28 2004-12-09 Johnson Robert E. Formulations of modified antibodies and methods of making the same
MY150740A (en) 2002-10-24 2014-02-28 Abbvie Biotechnology Ltd Low dose methods for treating disorders in which tnf? activity is detrimental
US7285269B2 (en) 2002-12-02 2007-10-23 Amgen Fremont, Inc. Antibodies directed to tumor necrosis factor
DK2447375T3 (da) 2004-03-31 2019-07-29 Massachusetts Gen Hospital Fremgangsmåde til bestemmelse af responsiviteten af en tumor på behandlinger med den epidermale vækstfaktor-receptor som mål
TWI439284B (zh) 2004-04-09 2014-06-01 Abbvie Biotechnology Ltd 用於治療TNFα相關失調症之多重可變劑量療法
NZ595225A (en) 2005-05-16 2013-05-31 Abbott Biotech Ltd Use of tnf inhibitor for treatment of erosive polyarthritis
NZ610566A (en) 2006-04-05 2014-09-26 Abbvie Biotechnology Ltd Antibody purification
WO2007120656A2 (en) 2006-04-10 2007-10-25 Abbott Biotechnology Ltd. Uses and compositions for treatment of rheumatoid arthritis
US9605064B2 (en) 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
EP2666472A3 (en) 2006-04-10 2014-04-02 Abbott Biotechnology Ltd Uses and compositions for treatment of psoriatic arthritis
EA018101B1 (ru) 2007-05-11 2013-05-30 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Способы лечения кожных язв
ES2540933T3 (es) 2007-05-11 2015-07-14 Thomas Jefferson University Métodos de tratamiento y prevención de enfermedades y trastornos neurodegenerativos
CN101679511A (zh) * 2007-06-06 2010-03-24 杜门蒂斯有限公司 多肽、抗体可变域和拮抗剂
US8999337B2 (en) 2007-06-11 2015-04-07 Abbvie Biotechnology Ltd. Methods for treating juvenile idiopathic arthritis by inhibition of TNFα
JP5570998B2 (ja) 2007-12-31 2014-08-13 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング TNFαに対する抗体
CN104188911A (zh) 2008-01-15 2014-12-10 Abbvie德国有限责任两合公司 粉末状蛋白质组合物及其制备方法
EP2228652A1 (en) 2009-03-11 2010-09-15 Medizinische Universität Wien Improvement of tumour treatment
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
EP3281640A1 (en) 2011-06-17 2018-02-14 President and Fellows of Harvard College Frizzled 2 as a target for therapeutic antibodies in the treatment of cancer
US20140227293A1 (en) 2011-06-30 2014-08-14 Trustees Of Boston University Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1)
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
US9334319B2 (en) 2012-04-20 2016-05-10 Abbvie Inc. Low acidic species compositions
WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
KR20150043523A (ko) 2012-09-02 2015-04-22 애브비 인코포레이티드 단백질 불균일성의 제어 방법
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
EP2830651A4 (en) 2013-03-12 2015-09-02 Abbvie Inc HUMAN ANTIBODIES THAT BIND TNF-ALPHA AND PREPARATION METHODS
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
EP2978446B1 (en) 2013-03-27 2020-03-04 The General Hospital Corporation Anti-cd33 antibody for use in treating alzheimer's disease
EP3052640A2 (en) 2013-10-04 2016-08-10 AbbVie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
EP3194581A4 (en) 2014-09-15 2018-04-25 Children's Medical Center Corporation Methods and compositions to increase somatic cell nuclear transfer (scnt) efficiency by removing histone h3-lysine trimethylation
EP4261222A1 (en) 2020-12-09 2023-10-18 HK inno.N Corporation ANTI-OX40L ANTIBODY, ANTI-OX40L/ANTI-TNFalpha BISPECIFIC ANTIBODY, AND USES THEREOF

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4843841B1 (nl) * 1969-09-06 1973-12-21
GB1541435A (en) * 1975-02-04 1979-02-28 Searle & Co Immunological materials
CA1208546A (en) * 1981-09-08 1986-07-29 Anthony Cerami Lipoprotein lipase suppression by endotoxin-induced mediator (shock assay)
US5700466A (en) * 1981-09-08 1997-12-23 The Rockefeller University Method of ameliorating or preventing septic shock using a monoclonal antibody specific to cachectin/tumor necrosis factor
JPS58138383A (ja) 1982-02-13 1983-08-17 Nippon Shinyaku Co Ltd 生理活性物質の製法
EP0117705A3 (en) * 1983-02-24 1985-09-25 The Regents Of The University Of California Monoclonal antibody specific for monocytes and blast cells
JPH0780914B2 (ja) * 1984-04-02 1995-08-30 旭化成工業株式会社 ヒト腫瘍壊死因子に対する抗体
US4879226A (en) * 1984-04-06 1989-11-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel human physiologically active polypeptide
IL75318A (en) * 1984-05-31 1994-08-26 Genentech Inc Recombinant human memotoxin and methods for its recombinant production
US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
GR851626B (nl) * 1984-07-05 1985-11-26 Genentech Inc
JPS61124392A (ja) * 1984-11-22 1986-06-12 Asahi Chem Ind Co Ltd 遺伝子組換体の産生する生理活性物質の精製法
US4684623A (en) * 1985-05-02 1987-08-04 The Board Of Trustees Of The Cetus Corporation Use of tumor necrosis factor as a weight regulator
ES2159529T5 (es) * 1993-03-05 2011-03-09 Bayer Corporation Anticuerpos monoclonales humanos anti-tnf alfa.

Also Published As

Publication number Publication date
JPS61191620A (ja) 1986-08-26
DE3586536T2 (de) 1993-02-18
EP0186833A3 (en) 1987-05-27
DE3586536T3 (de) 2002-05-08
US6090923A (en) 2000-07-18
DE122004000017I1 (de) 2005-06-16
ZA859757B (en) 1986-09-24
EP0186833A2 (en) 1986-07-09
AU5142485A (en) 1986-06-26
IL73883A0 (en) 1985-03-31
DE186833T1 (de) 1986-12-18
NL300142I2 (nl) 2005-08-01
JPH0787966A (ja) 1995-04-04
IL73883A (en) 1990-12-23
DE122004000005I1 (de) 2006-06-08
EP0186833B1 (en) 1992-08-19
AU601144B2 (en) 1990-09-06
EP0186833B2 (en) 2001-11-28
DE3586536D1 (de) 1992-09-24
CA1337518C (en) 1995-11-07
DE122004000007I1 (de) 2004-07-01

Similar Documents

Publication Publication Date Title
NL300142I2 (nl) Monoclonaal antilichaam tegen een cytotoxine, hybridoma cellijn, die dat uitdrukt en werkwijze voor de bereiding van het gezuiverde cytotoxine.
DE3689734D1 (de) Gereinigter immunoglobulinbezüglicher Faktor, monoklonale Antikörper, Hybridoma-Zellinien, Verfahren und Verwendungen.
NL192157B (nl) Werkwijze voor de vervaardiging van een inductantie-element.
NL193165B (nl) Werkwijze voor de vervaardiging van een voor warmte geïsoleerde leidingbuis.
NL194832B (nl) Werkwijze voor het vormen van een dunne-halfgeleiderfilm.
ATE143376T1 (de) Gegen die beta-kette des leukozyten-adhäsions- rezeptors gerichtete monoklonale antikörper, verfahren zu ihrer herstellung und ihre verwendung
DE3167698D1 (en) Method for the determination of antigens with the aid of two or more monoclonal antibodies
NL186831C (nl) Werkwijze voor het isoleren van een pijp.
NL191796C (nl) Werkwijze voor het verstevigen van een slappe bodem.
NL186643C (nl) Werkwijze voor het veresteren van natuurhars.
NL189373C (nl) Werkwijze voor het verzegelen van een flensverbinding.
NL188432C (nl) Werkwijze voor het vervaardigen van een mosfet.
NL7902621A (nl) Werkwijze voor het vormen van een aftakdichting.
EP0198086A4 (en) MAN-MOUSE HYBRIDOMA PRODUCING HUMAN ANTIVIRAL ANTIBODY, PREPARATION METHOD AND HUMAN ANTIVIRAL MONOCLONAL ANTIBODY.
NL190814B (nl) Werkwijze voor het bereiden van een polyacetaalcopolymeer.
NL190453C (nl) Werkwijze voor de versteviging van een geologische formatie.
NL190000C (nl) Werkwijze voor het centreren van een ruwe edelsteen.
NL184576B (nl) Werkwijze voor het bereiden van een samengesteld materiaal, bestaande uit metaalnitriden.
FI862978A0 (fi) Onkofetaalisia spesifisiä monoklonaalisia vasta-aineita, menetelmä niiden valmistamiseksi ja niiden käyttö.
NL8403069A (nl) Nieuwe werkwijze voor het bereiden van een cefalosporine, een tussenprodukt voor het cefalosporine en werkwijze voor het bereiden van het tussenprodukt.
NL186319C (nl) Werkwijze voor het zuiveren van glucosaminoglucan.
WO1992004464A3 (en) Monoclonal antibodies against tenascin
NL189254C (nl) Werkwijze voor het zuiveren van indool.
NL186619B (nl) Werkwijze voor het regenereren van een ijzer fosfaat-katalysator.
NL191009B (nl) Sigaret en werkwijze voor het wijzigen van de omtreksvormgeving van een sigaret.