NL2023863B1

NL2023863B1 - Protein particles and uses thereof

Protein particles and uses thereof Download PDF

Info

Publication number: NL2023863B1
Authority: NL; Netherlands
Prior art keywords: protein; amino acid; acid sequence; crm; particle
Prior art date: 2019-09-20

Application number

NL2023863A

Other languages

English (en)

Dutch (nl)

Inventor

Helmut Adam Rehm Bernd

Chen Shuxiong

Original Assignee

Univ Griffith

Priority date

2019-09-20

Filing date

2019-09-20

Publication date

2021-05-25

2019-09-20 Application filed by Univ Griffith filed Critical Univ Griffith

2019-09-20 Priority to NL2023863A priority Critical patent/NL2023863B1/en

2020-09-21 Priority to CN202080080056.6A priority patent/CN115175696A/zh

2020-09-21 Priority to JP2022517738A priority patent/JP2022549791A/ja

2020-09-21 Priority to EP20866415.1A priority patent/EP4031170A4/en

2020-09-21 Priority to US17/761,744 priority patent/US20220378894A1/en

2020-09-21 Priority to PCT/AU2020/000107 priority patent/WO2021051153A1/en

2020-09-21 Priority to AU2020349589A priority patent/AU2020349589A1/en

2021-05-25 Application granted granted Critical

2021-05-25 Publication of NL2023863B1 publication Critical patent/NL2023863B1/en

Links

108090000623 proteins and genes Proteins 0.000 title claims abstract description 723
102000004169 proteins and genes Human genes 0.000 title claims abstract description 704
239000002245 particle Substances 0.000 title claims abstract description 433
125000003275 alpha amino acid group Chemical group 0.000 claims abstract description 404
238000000034 method Methods 0.000 claims abstract description 203
102000016607 Diphtheria Toxin Human genes 0.000 claims abstract description 144
108010053187 Diphtheria Toxin Proteins 0.000 claims abstract description 144
239000000427 antigen Substances 0.000 claims abstract description 133
108091007433 antigens Proteins 0.000 claims abstract description 131
102000036639 antigens Human genes 0.000 claims abstract description 131
230000028993 immune response Effects 0.000 claims abstract description 83
239000000463 material Substances 0.000 claims abstract description 47
210000004027 cell Anatomy 0.000 claims description 194
230000002163 immunogen Effects 0.000 claims description 179
239000012634 fragment Substances 0.000 claims description 131
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 64
239000003795 chemical substances by application Substances 0.000 claims description 62
108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims description 58
210000003000 inclusion body Anatomy 0.000 claims description 47
206010028980 Neoplasm Diseases 0.000 claims description 45
244000052769 pathogen Species 0.000 claims description 41
238000011282 treatment Methods 0.000 claims description 39
241000186359 Mycobacterium Species 0.000 claims description 36
241000700605 Viruses Species 0.000 claims description 35
201000010099 disease Diseases 0.000 claims description 35
230000001717 pathogenic effect Effects 0.000 claims description 35
208000035475 disorder Diseases 0.000 claims description 29
201000011510 cancer Diseases 0.000 claims description 27
230000030788 protein refolding Effects 0.000 claims description 25
244000045947 parasite Species 0.000 claims description 23
102000037865 fusion proteins Human genes 0.000 claims description 22
108020001507 fusion proteins Proteins 0.000 claims description 22
241000187479 Mycobacterium tuberculosis Species 0.000 claims description 21
241000894006 Bacteria Species 0.000 claims description 20
238000005516 engineering process Methods 0.000 claims description 19
241000711549 Hepacivirus C Species 0.000 claims description 18
241000725619 Dengue virus Species 0.000 claims description 16
241000282414 Homo sapiens Species 0.000 claims description 16
230000001681 protective effect Effects 0.000 claims description 14
241000186366 Mycobacterium bovis Species 0.000 claims description 13
238000001338 self-assembly Methods 0.000 claims description 13
241000233866 Fungi Species 0.000 claims description 10
241000124008 Mammalia Species 0.000 claims description 10
241000193996 Streptococcus pyogenes Species 0.000 claims description 10
108010034055 CRM45 fragment of diphtheria toxin Proteins 0.000 claims description 9
101710088334 Diacylglycerol acyltransferase/mycolyltransferase Ag85B Proteins 0.000 claims description 9
241000710781 Flaviviridae Species 0.000 claims description 9
239000013566 allergen Substances 0.000 claims description 9
241000588724 Escherichia coli Species 0.000 claims description 8
101710144111 Non-structural protein 3 Proteins 0.000 claims description 8
210000001236 prokaryotic cell Anatomy 0.000 claims description 8
108020004511 Recombinant DNA Proteins 0.000 claims description 7
241000242678 Schistosoma Species 0.000 claims description 7
241000194017 Streptococcus Species 0.000 claims description 7
206010006187 Breast cancer Diseases 0.000 claims description 6
208000026310 Breast neoplasm Diseases 0.000 claims description 6
201000004792 malaria Diseases 0.000 claims description 6
238000002054 transplantation Methods 0.000 claims description 6
108090000565 Capsid Proteins Proteins 0.000 claims description 5
102100023321 Ceruloplasmin Human genes 0.000 claims description 5
206010009944 Colon cancer Diseases 0.000 claims description 5
241000712461 unidentified influenza virus Species 0.000 claims description 5
101710132601 Capsid protein Proteins 0.000 claims description 4
208000008839 Kidney Neoplasms Diseases 0.000 claims description 4
241000224016 Plasmodium Species 0.000 claims description 4
206010060862 Prostate cancer Diseases 0.000 claims description 4
208000000236 Prostatic Neoplasms Diseases 0.000 claims description 4
206010038389 Renal cancer Diseases 0.000 claims description 4
210000003527 eukaryotic cell Anatomy 0.000 claims description 4
201000010982 kidney cancer Diseases 0.000 claims description 4
201000007270 liver cancer Diseases 0.000 claims description 4
208000014018 liver neoplasm Diseases 0.000 claims description 4
201000001441 melanoma Diseases 0.000 claims description 4
101710091045 Envelope protein Proteins 0.000 claims description 3
241000700739 Hepadnaviridae Species 0.000 claims description 3
206010061598 Immunodeficiency Diseases 0.000 claims description 3
101710125507 Integrase/recombinase Proteins 0.000 claims description 3
241000223960 Plasmodium falciparum Species 0.000 claims description 3
241000223810 Plasmodium vivax Species 0.000 claims description 3
101710188315 Protein X Proteins 0.000 claims description 3
241000589540 Pseudomonas fluorescens Species 0.000 claims description 3
241000242683 Schistosoma haematobium Species 0.000 claims description 3
241000242677 Schistosoma japonicum Species 0.000 claims description 3
241000242680 Schistosoma mansoni Species 0.000 claims description 3
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
208000001333 Colorectal Neoplasms Diseases 0.000 claims description 2
241000194110 Bacillus sp. (in: Bacteria) Species 0.000 claims 1
208000029462 Immunodeficiency disease Diseases 0.000 claims 1
241000178948 Lactococcus sp. Species 0.000 claims 1
102100021696 Syncytin-1 Human genes 0.000 claims 1
230000003053 immunization Effects 0.000 claims 1
230000007813 immunodeficiency Effects 0.000 claims 1
150000001413 amino acids Chemical class 0.000 abstract description 42
238000002560 therapeutic procedure Methods 0.000 abstract description 7
238000002716 delivery method Methods 0.000 abstract description 3
238000002405 diagnostic procedure Methods 0.000 abstract description 3
235000018102 proteins Nutrition 0.000 description 640
108090000765 processed proteins & peptides Proteins 0.000 description 74
230000014509 gene expression Effects 0.000 description 65
239000000203 mixture Substances 0.000 description 58
150000007523 nucleic acids Chemical class 0.000 description 54
230000000875 corresponding effect Effects 0.000 description 48
229960005486 vaccine Drugs 0.000 description 48
235000001014 amino acid Nutrition 0.000 description 47
102000039446 nucleic acids Human genes 0.000 description 44
108020004707 nucleic acids Proteins 0.000 description 44
229940024606 amino acid Drugs 0.000 description 43
102000004196 processed proteins & peptides Human genes 0.000 description 35
201000008827 tuberculosis Diseases 0.000 description 30
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 26
230000004927 fusion Effects 0.000 description 26
238000004519 manufacturing process Methods 0.000 description 25
229920001184 polypeptide Polymers 0.000 description 25
108010008281 Recombinant Fusion Proteins Proteins 0.000 description 23
102000007056 Recombinant Fusion Proteins Human genes 0.000 description 23
230000000694 effects Effects 0.000 description 23
230000015572 biosynthetic process Effects 0.000 description 22
241000699670 Mus sp. Species 0.000 description 21
108010067390 Viral Proteins Proteins 0.000 description 21
230000000670 limiting effect Effects 0.000 description 20
239000013612 plasmid Substances 0.000 description 20
238000001514 detection method Methods 0.000 description 19
238000000746 purification Methods 0.000 description 19
239000000126 substance Substances 0.000 description 19
241001465754 Metazoa Species 0.000 description 18
230000002068 genetic effect Effects 0.000 description 18
238000004458 analytical method Methods 0.000 description 17
210000003491 skin Anatomy 0.000 description 17
108091028043 Nucleic acid sequence Proteins 0.000 description 16
238000006467 substitution reaction Methods 0.000 description 16
238000012360 testing method Methods 0.000 description 16
125000000539 amino acid group Chemical group 0.000 description 15
239000007983 Tris buffer Substances 0.000 description 14
238000003556 assay Methods 0.000 description 14
239000000499 gel Substances 0.000 description 14
239000008194 pharmaceutical composition Substances 0.000 description 14
238000003259 recombinant expression Methods 0.000 description 14
-1 splice sites Proteins 0.000 description 14
239000013598 vector Substances 0.000 description 14
230000027455 binding Effects 0.000 description 13
239000004202 carbamide Substances 0.000 description 13
230000004044 response Effects 0.000 description 13
239000000243 solution Substances 0.000 description 13
108020004414 DNA Proteins 0.000 description 12
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 12
241000186227 Corynebacterium diphtheriae Species 0.000 description 11
OWMVSZAMULFTJU-UHFFFAOYSA-N bis-tris Chemical compound OCCN(CCO)C(CO)(CO)CO OWMVSZAMULFTJU-UHFFFAOYSA-N 0.000 description 11
238000005119 centrifugation Methods 0.000 description 11
125000003729 nucleotide group Chemical group 0.000 description 11
238000005406 washing Methods 0.000 description 11
239000003085 diluting agent Substances 0.000 description 10
PSLWZOIUBRXAQW-UHFFFAOYSA-M dimethyl(dioctadecyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC PSLWZOIUBRXAQW-UHFFFAOYSA-M 0.000 description 10
239000013604 expression vector Substances 0.000 description 10
239000012139 lysis buffer Substances 0.000 description 10
231100000252 nontoxic Toxicity 0.000 description 10
230000003000 nontoxic effect Effects 0.000 description 10
238000002360 preparation method Methods 0.000 description 10
102000004127 Cytokines Human genes 0.000 description 9
108090000695 Cytokines Proteins 0.000 description 9
210000001744 T-lymphocyte Anatomy 0.000 description 9
239000002671 adjuvant Substances 0.000 description 9
239000013592 cell lysate Substances 0.000 description 9
239000003153 chemical reaction reagent Substances 0.000 description 9
238000000265 homogenisation Methods 0.000 description 9
210000000987 immune system Anatomy 0.000 description 9
208000015181 infectious disease Diseases 0.000 description 9
230000001404 mediated effect Effects 0.000 description 9
230000035772 mutation Effects 0.000 description 9
239000000546 pharmaceutical excipient Substances 0.000 description 9
230000001105 regulatory effect Effects 0.000 description 9
108091034117 Oligonucleotide Proteins 0.000 description 8
238000007792 addition Methods 0.000 description 8
210000004369 blood Anatomy 0.000 description 8
239000008280 blood Substances 0.000 description 8
239000007788 liquid Substances 0.000 description 8
239000002773 nucleotide Substances 0.000 description 8
230000008569 process Effects 0.000 description 8
239000006228 supernatant Substances 0.000 description 8
230000014616 translation Effects 0.000 description 8
108020004705 Codon Proteins 0.000 description 7
240000004808 Saccharomyces cerevisiae Species 0.000 description 7
235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 7
230000001580 bacterial effect Effects 0.000 description 7
238000004587 chromatography analysis Methods 0.000 description 7
239000003599 detergent Substances 0.000 description 7
UQLDLKMNUJERMK-UHFFFAOYSA-L di(octadecanoyloxy)lead Chemical compound [Pb+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O UQLDLKMNUJERMK-UHFFFAOYSA-L 0.000 description 7
239000002158 endotoxin Substances 0.000 description 7
230000005847 immunogenicity Effects 0.000 description 7
238000011998 interferon-gamma release assay Methods 0.000 description 7
230000004048 modification Effects 0.000 description 7
238000012986 modification Methods 0.000 description 7
239000008188 pellet Substances 0.000 description 7
241000186225 Corynebacterium pseudotuberculosis Species 0.000 description 6
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
108010074328 Interferon-gamma Proteins 0.000 description 6
230000005875 antibody response Effects 0.000 description 6
230000009286 beneficial effect Effects 0.000 description 6
239000000969 carrier Substances 0.000 description 6
150000004676 glycans Chemical class 0.000 description 6
230000012010 growth Effects 0.000 description 6
230000001965 increasing effect Effects 0.000 description 6
230000003834 intracellular effect Effects 0.000 description 6
230000003211 malignant effect Effects 0.000 description 6
239000003550 marker Substances 0.000 description 6
239000012071 phase Substances 0.000 description 6
229920000642 polymer Polymers 0.000 description 6
238000003752 polymerase chain reaction Methods 0.000 description 6
108091033319 polynucleotide Proteins 0.000 description 6
102000040430 polynucleotide Human genes 0.000 description 6
239000002157 polynucleotide Substances 0.000 description 6
238000011084 recovery Methods 0.000 description 6
238000000527 sonication Methods 0.000 description 6
210000004988 splenocyte Anatomy 0.000 description 6
239000003053 toxin Substances 0.000 description 6
231100000765 toxin Toxicity 0.000 description 6
108700012359 toxins Proteins 0.000 description 6
238000001262 western blot Methods 0.000 description 6
102000014914 Carrier Proteins Human genes 0.000 description 5
108010078791 Carrier Proteins Proteins 0.000 description 5
102100025064 Cellular tumor antigen p53 Human genes 0.000 description 5
241000196324 Embryophyta Species 0.000 description 5
102000005720 Glutathione transferase Human genes 0.000 description 5
108010070675 Glutathione transferase Proteins 0.000 description 5
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 5
101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 description 5
241000701806 Human papillomavirus Species 0.000 description 5
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 5
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 5
102100034256 Mucin-1 Human genes 0.000 description 5
206010061902 Pancreatic neoplasm Diseases 0.000 description 5
108010033276 Peptide Fragments Proteins 0.000 description 5
102000007079 Peptide Fragments Human genes 0.000 description 5
239000002253 acid Substances 0.000 description 5
230000002776 aggregation Effects 0.000 description 5
238000004220 aggregation Methods 0.000 description 5
210000000612 antigen-presenting cell Anatomy 0.000 description 5
230000000890 antigenic effect Effects 0.000 description 5
210000003719 b-lymphocyte Anatomy 0.000 description 5
230000008901 benefit Effects 0.000 description 5
230000001413 cellular effect Effects 0.000 description 5
238000012217 deletion Methods 0.000 description 5
230000037430 deletion Effects 0.000 description 5
210000004443 dendritic cell Anatomy 0.000 description 5
238000011161 development Methods 0.000 description 5
230000018109 developmental process Effects 0.000 description 5
239000003814 drug Substances 0.000 description 5
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 5
230000036039 immunity Effects 0.000 description 5
230000001024 immunotherapeutic effect Effects 0.000 description 5
238000002955 isolation Methods 0.000 description 5
208000015486 malignant pancreatic neoplasm Diseases 0.000 description 5
239000003921 oil Substances 0.000 description 5
208000008443 pancreatic carcinoma Diseases 0.000 description 5
229920001282 polysaccharide Polymers 0.000 description 5
239000005017 polysaccharide Substances 0.000 description 5
238000002708 random mutagenesis Methods 0.000 description 5
238000000926 separation method Methods 0.000 description 5
238000002741 site-directed mutagenesis Methods 0.000 description 5
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 5
239000007787 solid Substances 0.000 description 5
239000012134 supernatant fraction Substances 0.000 description 5
239000000725 suspension Substances 0.000 description 5
208000024891 symptom Diseases 0.000 description 5
210000001519 tissue Anatomy 0.000 description 5
230000002588 toxic effect Effects 0.000 description 5
210000005253 yeast cell Anatomy 0.000 description 5
108010022366 Carcinoembryonic Antigen Proteins 0.000 description 4
102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 4
241000283153 Cetacea Species 0.000 description 4
241000186216 Corynebacterium Species 0.000 description 4
102100038132 Endogenous retrovirus group K member 6 Pro protein Human genes 0.000 description 4
102000004190 Enzymes Human genes 0.000 description 4
108090000790 Enzymes Proteins 0.000 description 4
101710154606 Hemagglutinin Proteins 0.000 description 4
108700039791 Hepatitis C virus nucleocapsid Proteins 0.000 description 4
241000282412 Homo Species 0.000 description 4
241000725303 Human immunodeficiency virus Species 0.000 description 4
206010020751 Hypersensitivity Diseases 0.000 description 4
102000008070 Interferon-gamma Human genes 0.000 description 4
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 4
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 4
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 4
206010058467 Lung neoplasm malignant Diseases 0.000 description 4
108700018351 Major Histocompatibility Complex Proteins 0.000 description 4
101710175625 Maltose/maltodextrin-binding periplasmic protein Proteins 0.000 description 4
108010008707 Mucin-1 Proteins 0.000 description 4
101710093908 Outer capsid protein VP4 Proteins 0.000 description 4
101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 4
101710176177 Protein A56 Proteins 0.000 description 4
206010039491 Sarcoma Diseases 0.000 description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
241001505901 Streptococcus sp. 'group A' Species 0.000 description 4
108091008874 T cell receptors Proteins 0.000 description 4
102000016266 T-Cell Antigen Receptors Human genes 0.000 description 4
239000013504 Triton X-100 Substances 0.000 description 4
229920004890 Triton X-100 Polymers 0.000 description 4
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 4
230000009471 action Effects 0.000 description 4
238000001042 affinity chromatography Methods 0.000 description 4
230000003197 catalytic effect Effects 0.000 description 4
238000011969 continuous reassessment method Methods 0.000 description 4
101150044687 crm gene Proteins 0.000 description 4
238000000326 densiometry Methods 0.000 description 4
238000009826 distribution Methods 0.000 description 4
241001493065 dsRNA viruses Species 0.000 description 4
238000009472 formulation Methods 0.000 description 4
230000006870 function Effects 0.000 description 4
230000013595 glycosylation Effects 0.000 description 4
238000006206 glycosylation reaction Methods 0.000 description 4
SHFKGANKURXVMY-LCWPZEQJSA-N hcv e2 protein Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)CC1=CC=CC=C1 SHFKGANKURXVMY-LCWPZEQJSA-N 0.000 description 4
210000002443 helper t lymphocyte Anatomy 0.000 description 4
239000000185 hemagglutinin Substances 0.000 description 4
230000002209 hydrophobic effect Effects 0.000 description 4
210000000265 leukocyte Anatomy 0.000 description 4
229920006008 lipopolysaccharide Polymers 0.000 description 4
201000005202 lung cancer Diseases 0.000 description 4
208000020816 lung neoplasm Diseases 0.000 description 4
239000012528 membrane Substances 0.000 description 4
238000000386 microscopy Methods 0.000 description 4
238000010369 molecular cloning Methods 0.000 description 4
235000019198 oils Nutrition 0.000 description 4
201000002528 pancreatic cancer Diseases 0.000 description 4
230000004481 post-translational protein modification Effects 0.000 description 4
102000005962 receptors Human genes 0.000 description 4
108020003175 receptors Proteins 0.000 description 4
206010039073 rheumatoid arthritis Diseases 0.000 description 4
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 4
230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 4
238000003786 synthesis reaction Methods 0.000 description 4
238000011144 upstream manufacturing Methods 0.000 description 4
230000003612 virological effect Effects 0.000 description 4
239000011534 wash buffer Substances 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 3
102000009062 ADP Ribose Transferases Human genes 0.000 description 3
108010049290 ADP Ribose Transferases Proteins 0.000 description 3
208000024827 Alzheimer disease Diseases 0.000 description 3
208000023275 Autoimmune disease Diseases 0.000 description 3
241000271566 Aves Species 0.000 description 3
241000193830 Bacillus <bacterium> Species 0.000 description 3
239000002028 Biomass Substances 0.000 description 3
241000283690 Bos taurus Species 0.000 description 3
241000282472 Canis lupus familiaris Species 0.000 description 3
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
241000282326 Felis catus Species 0.000 description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 3
239000004471 Glycine Substances 0.000 description 3
102000003886 Glycoproteins Human genes 0.000 description 3
108090000288 Glycoproteins Proteins 0.000 description 3
108010043121 Green Fluorescent Proteins Proteins 0.000 description 3
102000004144 Green Fluorescent Proteins Human genes 0.000 description 3
241000700721 Hepatitis B virus Species 0.000 description 3
241000238631 Hexapoda Species 0.000 description 3
108010093488 His-His-His-His-His-His Proteins 0.000 description 3
108060003951 Immunoglobulin Proteins 0.000 description 3
241000235058 Komagataella pastoris Species 0.000 description 3
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 3
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 3
241000194036 Lactococcus Species 0.000 description 3
206010025323 Lymphomas Diseases 0.000 description 3
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 3
102000000440 Melanoma-associated antigen Human genes 0.000 description 3
108050008953 Melanoma-associated antigen Proteins 0.000 description 3
241001529936 Murinae Species 0.000 description 3
108091007491 NSP3 Papain-like protease domains Proteins 0.000 description 3
208000012902 Nervous system disease Diseases 0.000 description 3
108010006232 Neuraminidase Proteins 0.000 description 3
102000005348 Neuraminidase Human genes 0.000 description 3
208000025966 Neurological disease Diseases 0.000 description 3
239000000020 Nitrocellulose Substances 0.000 description 3
108091005461 Nucleic proteins Proteins 0.000 description 3
206010030155 Oesophageal carcinoma Diseases 0.000 description 3
102000043276 Oncogene Human genes 0.000 description 3
206010033128 Ovarian cancer Diseases 0.000 description 3
229930182555 Penicillin Natural products 0.000 description 3
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 3
241000235648 Pichia Species 0.000 description 3
239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 3
241000235070 Saccharomyces Species 0.000 description 3
230000024932 T cell mediated immunity Effects 0.000 description 3
241000589886 Treponema Species 0.000 description 3
208000002495 Uterine Neoplasms Diseases 0.000 description 3
241000251539 Vertebrata <Metazoa> Species 0.000 description 3
230000001594 aberrant effect Effects 0.000 description 3
230000002159 abnormal effect Effects 0.000 description 3
239000000654 additive Substances 0.000 description 3
208000026935 allergic disease Diseases 0.000 description 3
230000007815 allergy Effects 0.000 description 3
230000002238 attenuated effect Effects 0.000 description 3
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
230000004071 biological effect Effects 0.000 description 3
239000010796 biological waste Substances 0.000 description 3
239000000872 buffer Substances 0.000 description 3
239000006285 cell suspension Substances 0.000 description 3
230000008859 change Effects 0.000 description 3
238000012512 characterization method Methods 0.000 description 3
238000003776 cleavage reaction Methods 0.000 description 3
238000010367 cloning Methods 0.000 description 3
208000029742 colonic neoplasm Diseases 0.000 description 3
230000021615 conjugation Effects 0.000 description 3
238000010276 construction Methods 0.000 description 3
210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 3
206010013023 diphtheria Diseases 0.000 description 3
229960003983 diphtheria toxoid Drugs 0.000 description 3
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
238000011143 downstream manufacturing Methods 0.000 description 3
239000000839 emulsion Substances 0.000 description 3
238000001976 enzyme digestion Methods 0.000 description 3
210000003743 erythrocyte Anatomy 0.000 description 3
244000053095 fungal pathogen Species 0.000 description 3
239000008103 glucose Substances 0.000 description 3
239000005090 green fluorescent protein Substances 0.000 description 3
230000001900 immune effect Effects 0.000 description 3
102000018358 immunoglobulin Human genes 0.000 description 3
238000010348 incorporation Methods 0.000 description 3
230000001939 inductive effect Effects 0.000 description 3
230000003993 interaction Effects 0.000 description 3
229960003130 interferon gamma Drugs 0.000 description 3
238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 3
238000005259 measurement Methods 0.000 description 3
238000002703 mutagenesis Methods 0.000 description 3
231100000350 mutagenesis Toxicity 0.000 description 3
229920001220 nitrocellulos Polymers 0.000 description 3
230000002018 overexpression Effects 0.000 description 3
229940049954 penicillin Drugs 0.000 description 3
239000002953 phosphate buffered saline Substances 0.000 description 3
230000009145 protein modification Effects 0.000 description 3
238000001742 protein purification Methods 0.000 description 3
108010014186 ras Proteins Proteins 0.000 description 3
102000016914 ras Proteins Human genes 0.000 description 3
230000002829 reductive effect Effects 0.000 description 3
238000011160 research Methods 0.000 description 3
108091008146 restriction endonucleases Proteins 0.000 description 3
230000007017 scission Effects 0.000 description 3
238000004062 sedimentation Methods 0.000 description 3
210000002966 serum Anatomy 0.000 description 3
239000002904 solvent Substances 0.000 description 3
125000006850 spacer group Chemical group 0.000 description 3
241000894007 species Species 0.000 description 3
230000002269 spontaneous effect Effects 0.000 description 3
PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 3
230000000638 stimulation Effects 0.000 description 3
231100000331 toxic Toxicity 0.000 description 3
238000012546 transfer Methods 0.000 description 3
238000004627 transmission electron microscopy Methods 0.000 description 3
208000027930 type IV hypersensitivity disease Diseases 0.000 description 3
206010046766 uterine cancer Diseases 0.000 description 3
238000002255 vaccination Methods 0.000 description 3
239000012130 whole-cell lysate Substances 0.000 description 3
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 description 2
241000219496 Alnus Species 0.000 description 2
201000003076 Angiosarcoma Diseases 0.000 description 2
241000272517 Anseriformes Species 0.000 description 2
239000004475 Arginine Substances 0.000 description 2
235000003261 Artemisia vulgaris Nutrition 0.000 description 2
240000006891 Artemisia vulgaris Species 0.000 description 2
244000075850 Avena orientalis Species 0.000 description 2
208000003950 B-cell lymphoma Diseases 0.000 description 2
241000194107 Bacillus megaterium Species 0.000 description 2
244000063299 Bacillus subtilis Species 0.000 description 2
235000014469 Bacillus subtilis Nutrition 0.000 description 2
241000238658 Blattella Species 0.000 description 2
102100025570 Cancer/testis antigen 1 Human genes 0.000 description 2
201000009030 Carcinoma Diseases 0.000 description 2
206010008342 Cervix carcinoma Diseases 0.000 description 2
102000019034 Chemokines Human genes 0.000 description 2
108010012236 Chemokines Proteins 0.000 description 2
244000281762 Chenopodium ambrosioides Species 0.000 description 2
235000000509 Chenopodium ambrosioides Nutrition 0.000 description 2
235000005490 Chenopodium botrys Nutrition 0.000 description 2
241000606153 Chlamydia trachomatis Species 0.000 description 2
102000011022 Chorionic Gonadotropin Human genes 0.000 description 2
108010062540 Chorionic Gonadotropin Proteins 0.000 description 2
241000223203 Coccidioides Species 0.000 description 2
108700010070 Codon Usage Proteins 0.000 description 2
108010035532 Collagen Proteins 0.000 description 2
102000008186 Collagen Human genes 0.000 description 2
108010047041 Complementarity Determining Regions Proteins 0.000 description 2
241000711573 Coronaviridae Species 0.000 description 2
241001125840 Coryphaenidae Species 0.000 description 2
240000005109 Cryptomeria japonica Species 0.000 description 2
241000209210 Dactylis Species 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
102000001301 EGF receptor Human genes 0.000 description 2
108060006698 EGF receptor Proteins 0.000 description 2
241000709661 Enterovirus Species 0.000 description 2
101000906736 Escherichia phage Mu DNA circularization protein N Proteins 0.000 description 2
241000711950 Filoviridae Species 0.000 description 2
108010000916 Fimbriae Proteins Proteins 0.000 description 2
241000710831 Flavivirus Species 0.000 description 2
108091072337 GAGE family Proteins 0.000 description 2
102000040452 GAGE family Human genes 0.000 description 2
102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 2
108060003393 Granulin Proteins 0.000 description 2
241000606768 Haemophilus influenzae Species 0.000 description 2
208000001258 Hemangiosarcoma Diseases 0.000 description 2
101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 description 2
101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 2
101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 2
241000713772 Human immunodeficiency virus 1 Species 0.000 description 2
241000712431 Influenza A virus Species 0.000 description 2
102100037850 Interferon gamma Human genes 0.000 description 2
241000721662 Juniperus Species 0.000 description 2
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 2
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 2
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 2
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
241000589248 Legionella Species 0.000 description 2
208000007764 Legionnaires' Disease Diseases 0.000 description 2
241000713666 Lentivirus Species 0.000 description 2
241000270322 Lepidosauria Species 0.000 description 2
239000006137 Luria-Bertani broth Substances 0.000 description 2
239000004472 Lysine Substances 0.000 description 2
102000018697 Membrane Proteins Human genes 0.000 description 2
108010052285 Membrane Proteins Proteins 0.000 description 2
208000031998 Mycobacterium Infections Diseases 0.000 description 2
JDHILDINMRGULE-LURJTMIESA-N N(pros)-methyl-L-histidine Chemical compound CN1C=NC=C1C[C@H](N)C(O)=O JDHILDINMRGULE-LURJTMIESA-N 0.000 description 2
206010029260 Neuroblastoma Diseases 0.000 description 2
102000007999 Nuclear Proteins Human genes 0.000 description 2
108010089610 Nuclear Proteins Proteins 0.000 description 2
241000795633 Olea <sea slug> Species 0.000 description 2
206010061535 Ovarian neoplasm Diseases 0.000 description 2
102000036673 PRAME Human genes 0.000 description 2
108060006580 PRAME Proteins 0.000 description 2
241001631646 Papillomaviridae Species 0.000 description 2
241000701945 Parvoviridae Species 0.000 description 2
241001494479 Pecora Species 0.000 description 2
108091005804 Peptidases Proteins 0.000 description 2
108091093037 Peptide nucleic acid Proteins 0.000 description 2
201000005702 Pertussis Diseases 0.000 description 2
241001127637 Plantago Species 0.000 description 2
206010035226 Plasma cell myeloma Diseases 0.000 description 2
241000223821 Plasmodium malariae Species 0.000 description 2
241001505293 Plasmodium ovale Species 0.000 description 2
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
239000004365 Protease Substances 0.000 description 2
108010076504 Protein Sorting Signals Proteins 0.000 description 2
108700020978 Proto-Oncogene Proteins 0.000 description 2
102000052575 Proto-Oncogene Human genes 0.000 description 2
241000125945 Protoparvovirus Species 0.000 description 2
241000589516 Pseudomonas Species 0.000 description 2
241000700159 Rattus Species 0.000 description 2
101001039269 Rattus norvegicus Glycine N-methyltransferase Proteins 0.000 description 2
102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 2
241000607142 Salmonella Species 0.000 description 2
229920002125 Sokalan® Polymers 0.000 description 2
235000011684 Sorghum saccharatum Nutrition 0.000 description 2
244000062793 Sorghum vulgare Species 0.000 description 2
241000713675 Spumavirus Species 0.000 description 2
208000005718 Stomach Neoplasms Diseases 0.000 description 2
244000057717 Streptococcus lactis Species 0.000 description 2
235000014897 Streptococcus lactis Nutrition 0.000 description 2
241000193998 Streptococcus pneumoniae Species 0.000 description 2
101000764570 Streptomyces phage phiC31 Probable tape measure protein Proteins 0.000 description 2
241000282887 Suidae Species 0.000 description 2
238000003917 TEM image Methods 0.000 description 2
240000001068 Thogoto virus Species 0.000 description 2
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 2
239000004473 Threonine Substances 0.000 description 2
241000218636 Thuja Species 0.000 description 2
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 2
102000044209 Tumor Suppressor Genes Human genes 0.000 description 2
108700025716 Tumor Suppressor Genes Proteins 0.000 description 2
208000024780 Urticaria Diseases 0.000 description 2
208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 2
206010046865 Vaccinia virus infection Diseases 0.000 description 2
108010003533 Viral Envelope Proteins Proteins 0.000 description 2
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
230000021736 acetylation Effects 0.000 description 2
238000006640 acetylation reaction Methods 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
230000004913 activation Effects 0.000 description 2
230000000996 additive effect Effects 0.000 description 2
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
229910021502 aluminium hydroxide Inorganic materials 0.000 description 2
ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 2
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 2
229960000723 ampicillin Drugs 0.000 description 2
238000010171 animal model Methods 0.000 description 2
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
125000003118 aryl group Chemical group 0.000 description 2
235000003704 aspartic acid Nutrition 0.000 description 2
208000006673 asthma Diseases 0.000 description 2
208000010668 atopic eczema Diseases 0.000 description 2
239000011324 bead Substances 0.000 description 2
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
238000009534 blood test Methods 0.000 description 2
210000004556 brain Anatomy 0.000 description 2
OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
239000002775 capsule Substances 0.000 description 2
210000002421 cell wall Anatomy 0.000 description 2
230000007969 cellular immunity Effects 0.000 description 2
230000036755 cellular response Effects 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
235000010980 cellulose Nutrition 0.000 description 2
201000010881 cervical cancer Diseases 0.000 description 2
230000003196 chaotropic effect Effects 0.000 description 2
229940038705 chlamydia trachomatis Drugs 0.000 description 2
229920001436 collagen Polymers 0.000 description 2
239000002299 complementary DNA Substances 0.000 description 2
238000013270 controlled release Methods 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical class NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 description 2
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
235000018417 cysteine Nutrition 0.000 description 2
210000000805 cytoplasm Anatomy 0.000 description 2
230000003412 degenerative effect Effects 0.000 description 2
238000004925 denaturation Methods 0.000 description 2
230000036425 denaturation Effects 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
229960000633 dextran sulfate Drugs 0.000 description 2
230000029087 digestion Effects 0.000 description 2
FOOBQHKMWYGHCE-UHFFFAOYSA-N diphthamide Chemical compound C[N+](C)(C)C(C(N)=O)CCC1=NC=C(CC(N)C([O-])=O)N1 FOOBQHKMWYGHCE-UHFFFAOYSA-N 0.000 description 2
231100000676 disease causative agent Toxicity 0.000 description 2
239000006185 dispersion Substances 0.000 description 2
239000002552 dosage form Substances 0.000 description 2
239000003937 drug carrier Substances 0.000 description 2
238000002296 dynamic light scattering Methods 0.000 description 2
238000004945 emulsification Methods 0.000 description 2
239000003995 emulsifying agent Substances 0.000 description 2
231100000284 endotoxic Toxicity 0.000 description 2
230000002346 endotoxic effect Effects 0.000 description 2
238000000605 extraction Methods 0.000 description 2
238000005194 fractionation Methods 0.000 description 2
206010017758 gastric cancer Diseases 0.000 description 2
238000002523 gelfiltration Methods 0.000 description 2
229930195712 glutamate Natural products 0.000 description 2
235000013922 glutamic acid Nutrition 0.000 description 2
239000004220 glutamic acid Substances 0.000 description 2
150000002332 glycine derivatives Chemical class 0.000 description 2
239000001963 growth medium Substances 0.000 description 2
229960000789 guanidine hydrochloride Drugs 0.000 description 2
PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 2
230000003394 haemopoietic effect Effects 0.000 description 2
230000036541 health Effects 0.000 description 2
229940084986 human chorionic gonadotropin Drugs 0.000 description 2
125000001165 hydrophobic group Chemical group 0.000 description 2
238000002649 immunization Methods 0.000 description 2
230000003308 immunostimulating effect Effects 0.000 description 2
230000001976 improved effect Effects 0.000 description 2
238000001727 in vivo Methods 0.000 description 2
238000011534 incubation Methods 0.000 description 2
230000002757 inflammatory effect Effects 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
230000002401 inhibitory effect Effects 0.000 description 2
229910052500 inorganic mineral Inorganic materials 0.000 description 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
238000007918 intramuscular administration Methods 0.000 description 2
238000007912 intraperitoneal administration Methods 0.000 description 2
238000001990 intravenous administration Methods 0.000 description 2
230000002427 irreversible effect Effects 0.000 description 2
229960000310 isoleucine Drugs 0.000 description 2
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 2
208000032839 leukemia Diseases 0.000 description 2
KVJWZTLXIROHIL-QDORLFPLSA-N lipid IVA Chemical compound O[C@H]1[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O[C@@H]1CO[C@H]1[C@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@H](OP(O)(O)=O)[C@@H](CO)O1 KVJWZTLXIROHIL-QDORLFPLSA-N 0.000 description 2
150000002632 lipids Chemical class 0.000 description 2
239000002502 liposome Substances 0.000 description 2
210000004324 lymphatic system Anatomy 0.000 description 2
210000004698 lymphocyte Anatomy 0.000 description 2
108020004999 messenger RNA Proteins 0.000 description 2
239000011707 mineral Substances 0.000 description 2
208000027531 mycobacterial infectious disease Diseases 0.000 description 2
201000000050 myeloid neoplasm Diseases 0.000 description 2
238000012261 overproduction Methods 0.000 description 2
230000036961 partial effect Effects 0.000 description 2
210000001322 periplasm Anatomy 0.000 description 2
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
230000026731 phosphorylation Effects 0.000 description 2
238000006366 phosphorylation reaction Methods 0.000 description 2
230000000704 physical effect Effects 0.000 description 2
229920003023 plastic Polymers 0.000 description 2
239000004033 plastic Substances 0.000 description 2
229920005862 polyol Polymers 0.000 description 2
150000003077 polyols Chemical class 0.000 description 2
230000003389 potentiating effect Effects 0.000 description 2
239000000843 powder Substances 0.000 description 2
239000002243 precursor Substances 0.000 description 2
239000000047 product Substances 0.000 description 2
230000002035 prolonged effect Effects 0.000 description 2
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
230000012846 protein folding Effects 0.000 description 2
238000011002 quantification Methods 0.000 description 2
108700042226 ras Genes Proteins 0.000 description 2
238000010188 recombinant method Methods 0.000 description 2
230000002441 reversible effect Effects 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
238000004626 scanning electron microscopy Methods 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
210000004989 spleen cell Anatomy 0.000 description 2
108010088201 squamous cell carcinoma-related antigen Proteins 0.000 description 2
241001147420 ssDNA viruses Species 0.000 description 2
238000007619 statistical method Methods 0.000 description 2
201000011549 stomach cancer Diseases 0.000 description 2
229940031000 streptococcus pneumoniae Drugs 0.000 description 2
229960005322 streptomycin Drugs 0.000 description 2
238000007920 subcutaneous administration Methods 0.000 description 2
239000000758 substrate Substances 0.000 description 2
235000000346 sugar Nutrition 0.000 description 2
239000003826 tablet Substances 0.000 description 2
101150047061 tag-72 gene Proteins 0.000 description 2
229940124597 therapeutic agent Drugs 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
231100000419 toxicity Toxicity 0.000 description 2
230000001988 toxicity Effects 0.000 description 2
238000013518 transcription Methods 0.000 description 2
230000035897 transcription Effects 0.000 description 2
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
241001430294 unidentified retrovirus Species 0.000 description 2
208000007089 vaccinia Diseases 0.000 description 2
239000004474 valine Substances 0.000 description 2
235000015112 vegetable and seed oil Nutrition 0.000 description 2
239000008158 vegetable oil Substances 0.000 description 2
239000003981 vehicle Substances 0.000 description 2
239000006226 wash reagent Substances 0.000 description 2
238000000733 zeta-potential measurement Methods 0.000 description 2
MXYRZDAGKTVQIL-IOSLPCCCSA-N (2r,3r,4s,5r)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-2-methyloxolane-3,4-diol Chemical compound C1=NC2=C(N)N=CN=C2N1[C@]1(C)O[C@H](CO)[C@@H](O)[C@H]1O MXYRZDAGKTVQIL-IOSLPCCCSA-N 0.000 description 1
ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 1
YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical compound C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 description 1
UKAUYVFTDYCKQA-UHFFFAOYSA-N -2-Amino-4-hydroxybutanoic acid Natural products OC(=O)C(N)CCO UKAUYVFTDYCKQA-UHFFFAOYSA-N 0.000 description 1
GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical compound NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 description 1
FJLUATLTXUNBOT-UHFFFAOYSA-N 1-Hexadecylamine Chemical compound CCCCCCCCCCCCCCCCN FJLUATLTXUNBOT-UHFFFAOYSA-N 0.000 description 1
LUTLAXLNPLZCOF-UHFFFAOYSA-N 1-Methylhistidine Natural products OC(=O)C(N)(C)CC1=NC=CN1 LUTLAXLNPLZCOF-UHFFFAOYSA-N 0.000 description 1
HWPZZUQOWRWFDB-UHFFFAOYSA-N 1-methylcytosine Chemical compound CN1C=CC(N)=NC1=O HWPZZUQOWRWFDB-UHFFFAOYSA-N 0.000 description 1
PYAFUXYGTYWWBP-UHFFFAOYSA-N 19-methoxynonadecane-1,2,3-triol Chemical compound COCCCCCCCCCCCCCCCCC(O)C(O)CO PYAFUXYGTYWWBP-UHFFFAOYSA-N 0.000 description 1
OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 description 1
KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 description 1
WTLKTXIHIHFSGU-UHFFFAOYSA-N 2-nitrosoguanidine Chemical compound NC(N)=NN=O WTLKTXIHIHFSGU-UHFFFAOYSA-N 0.000 description 1
MGADZUXDNSDTHW-UHFFFAOYSA-N 2H-pyran Chemical compound C1OC=CC=C1 MGADZUXDNSDTHW-UHFFFAOYSA-N 0.000 description 1
LYFYWXLKKQIOKO-UHFFFAOYSA-N 3,3-diaminopentan-1-ol Chemical compound CCC(N)(N)CCO LYFYWXLKKQIOKO-UHFFFAOYSA-N 0.000 description 1
LKKMLIBUAXYLOY-UHFFFAOYSA-N 3-Amino-1-methyl-5H-pyrido[4,3-b]indole Chemical compound N1C2=CC=CC=C2C2=C1C=C(N)N=C2C LKKMLIBUAXYLOY-UHFFFAOYSA-N 0.000 description 1
BRMWTNUJHUMWMS-UHFFFAOYSA-N 3-Methylhistidine Natural products CN1C=NC(CC(N)C(O)=O)=C1 BRMWTNUJHUMWMS-UHFFFAOYSA-N 0.000 description 1
ZLOIGESWDJYCTF-XVFCMESISA-N 4-thiouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=S)C=C1 ZLOIGESWDJYCTF-XVFCMESISA-N 0.000 description 1
102100030310 5,6-dihydroxyindole-2-carboxylic acid oxidase Human genes 0.000 description 1
101710163881 5,6-dihydroxyindole-2-carboxylic acid oxidase Proteins 0.000 description 1
UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 1
PXBWLHQLSCMJEM-IOSLPCCCSA-N 9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-methyloxolan-2-yl]-3h-purin-6-one Chemical compound C1=NC2=C(O)N=CN=C2N1[C@]1(C)O[C@H](CO)[C@@H](O)[C@H]1O PXBWLHQLSCMJEM-IOSLPCCCSA-N 0.000 description 1
PWJFNRJRHXWEPT-UHFFFAOYSA-N ADP ribose Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OCC(O)C(O)C(O)C=O)C(O)C1O PWJFNRJRHXWEPT-UHFFFAOYSA-N 0.000 description 1
208000030507 AIDS Diseases 0.000 description 1
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
229920000178 Acrylic resin Polymers 0.000 description 1
239000004925 Acrylic resin Substances 0.000 description 1
241000251468 Actinopterygii Species 0.000 description 1
102100021305 Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 Human genes 0.000 description 1
208000003200 Adenoma Diseases 0.000 description 1
241000701242 Adenoviridae Species 0.000 description 1
241000209136 Agropyron Species 0.000 description 1
241000743339 Agrostis Species 0.000 description 1
240000005611 Agrostis gigantea Species 0.000 description 1
108010088751 Albumins Proteins 0.000 description 1
102000009027 Albumins Human genes 0.000 description 1
208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
206010027654 Allergic conditions Diseases 0.000 description 1
241000700587 Alphaherpesvirinae Species 0.000 description 1
241001664176 Alpharetrovirus Species 0.000 description 1
241000710929 Alphavirus Species 0.000 description 1
241000223600 Alternaria Species 0.000 description 1
241000223602 Alternaria alternata Species 0.000 description 1
208000004881 Amebiasis Diseases 0.000 description 1
206010001980 Amoebiasis Diseases 0.000 description 1
208000037259 Amyloid Plaque Diseases 0.000 description 1
102000013455 Amyloid beta-Peptides Human genes 0.000 description 1
108010090849 Amyloid beta-Peptides Proteins 0.000 description 1
241000743857 Anthoxanthum Species 0.000 description 1
240000004178 Anthoxanthum odoratum Species 0.000 description 1
235000014251 Anthoxanthum odoratum Nutrition 0.000 description 1
241000269350 Anura Species 0.000 description 1
241000224482 Apicomplexa Species 0.000 description 1
241001533425 Aquabirnavirus Species 0.000 description 1
241000702652 Aquareovirus Species 0.000 description 1
241000712892 Arenaviridae Species 0.000 description 1
241000712891 Arenavirus Species 0.000 description 1
241000508787 Arrhenatherum Species 0.000 description 1
241000508786 Arrhenatherum elatius Species 0.000 description 1
235000003826 Artemisia Nutrition 0.000 description 1
235000004355 Artemisia lactiflora Nutrition 0.000 description 1
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
241000228212 Aspergillus Species 0.000 description 1
241001533362 Astroviridae Species 0.000 description 1
241000701061 Ateline gammaherpesvirus 2 Species 0.000 description 1
206010003645 Atopy Diseases 0.000 description 1
235000005781 Avena Nutrition 0.000 description 1
235000007319 Avena orientalis Nutrition 0.000 description 1
241000701802 Aviadenovirus Species 0.000 description 1
241000713826 Avian leukosis virus Species 0.000 description 1
241001533426 Avibirnavirus Species 0.000 description 1
241000701397 Avihepadnavirus Species 0.000 description 1
241000700663 Avipoxvirus Species 0.000 description 1
102000019260 B-Cell Antigen Receptors Human genes 0.000 description 1
108010012919 B-Cell Antigen Receptors Proteins 0.000 description 1
208000004736 B-Cell Leukemia Diseases 0.000 description 1
108091067183 BAGE family Proteins 0.000 description 1
102000039506 BAGE family Human genes 0.000 description 1
241000223836 Babesia Species 0.000 description 1
241000193738 Bacillus anthracis Species 0.000 description 1
108010077805 Bacterial Proteins Proteins 0.000 description 1
231100000699 Bacterial toxin Toxicity 0.000 description 1
206010004146 Basal cell carcinoma Diseases 0.000 description 1
241000701021 Betaherpesvirinae Species 0.000 description 1
241000219429 Betula Species 0.000 description 1
235000003932 Betula Nutrition 0.000 description 1
241000219430 Betula pendula Species 0.000 description 1
235000009109 Betula pendula Nutrition 0.000 description 1
241000219495 Betulaceae Species 0.000 description 1
241000702628 Birnaviridae Species 0.000 description 1
206010005003 Bladder cancer Diseases 0.000 description 1
241000680806 Blastobotrys adeninivorans Species 0.000 description 1
241000228405 Blastomyces dermatitidis Species 0.000 description 1
241001493069 Bluetongue virus 1 Species 0.000 description 1
241000588832 Bordetella pertussis Species 0.000 description 1
241000589968 Borrelia Species 0.000 description 1
241000589969 Borreliella burgdorferi Species 0.000 description 1
108091003079 Bovine Serum Albumin Proteins 0.000 description 1
241000712462 Bovine ephemeral fever virus Species 0.000 description 1
241000714266 Bovine leukemia virus Species 0.000 description 1
238000009010 Bradford assay Methods 0.000 description 1
208000003174 Brain Neoplasms Diseases 0.000 description 1
241000209200 Bromus Species 0.000 description 1
241000743756 Bromus inermis Species 0.000 description 1
241000589562 Brucella Species 0.000 description 1
241000589567 Brucella abortus Species 0.000 description 1
241001509299 Brucella canis Species 0.000 description 1
241001148111 Brucella suis Species 0.000 description 1
241001493154 Bunyamwera virus Species 0.000 description 1
241001453380 Burkholderia Species 0.000 description 1
241000722910 Burkholderia mallei Species 0.000 description 1
241001136175 Burkholderia pseudomallei Species 0.000 description 1
125000001433 C-terminal amino-acid group Chemical group 0.000 description 1
210000004366 CD4-positive T-lymphocyte Anatomy 0.000 description 1
QCMYYKRYFNMIEC-UHFFFAOYSA-N COP(O)=O Chemical class COP(O)=O QCMYYKRYFNMIEC-UHFFFAOYSA-N 0.000 description 1
241000244203 Caenorhabditis elegans Species 0.000 description 1
101100005789 Caenorhabditis elegans cdk-4 gene Proteins 0.000 description 1
241000714198 Caliciviridae Species 0.000 description 1
241000222120 Candida <Saccharomycetales> Species 0.000 description 1
241000282465 Canis Species 0.000 description 1
241000700664 Capripoxvirus Species 0.000 description 1
208000005623 Carcinogenesis Diseases 0.000 description 1
208000009458 Carcinoma in Situ Diseases 0.000 description 1
241000710190 Cardiovirus Species 0.000 description 1
102100026548 Caspase-8 Human genes 0.000 description 1
108090000538 Caspase-8 Proteins 0.000 description 1
241000242722 Cestoda Species 0.000 description 1
241000723437 Chamaecyparis Species 0.000 description 1
101710163595 Chaperone protein DnaK Proteins 0.000 description 1
241001502567 Chikungunya virus Species 0.000 description 1
241000606161 Chlamydia Species 0.000 description 1
241001647372 Chlamydia pneumoniae Species 0.000 description 1
108010009685 Cholinergic Receptors Proteins 0.000 description 1
208000006332 Choriocarcinoma Diseases 0.000 description 1
241001533399 Circoviridae Species 0.000 description 1
241000193403 Clostridium Species 0.000 description 1
241000193155 Clostridium botulinum Species 0.000 description 1
241000193449 Clostridium tetani Species 0.000 description 1
108091026890 Coding region Proteins 0.000 description 1
241000204955 Colorado tick fever virus Species 0.000 description 1
241000702669 Coltivirus Species 0.000 description 1
208000035473 Communicable disease Diseases 0.000 description 1
241000777300 Congiopodidae Species 0.000 description 1
108010060123 Conjugate Vaccines Proteins 0.000 description 1
206010010741 Conjunctivitis Diseases 0.000 description 1
241001445332 Coxiella <snail> Species 0.000 description 1
241000606678 Coxiella burnetii Species 0.000 description 1
201000007336 Cryptococcosis Diseases 0.000 description 1
241000221204 Cryptococcus neoformans Species 0.000 description 1
241000223935 Cryptosporidium Species 0.000 description 1
241000723198 Cupressus Species 0.000 description 1
244000301850 Cupressus sempervirens Species 0.000 description 1
201000000077 Cysticercosis Diseases 0.000 description 1
241000701022 Cytomegalovirus Species 0.000 description 1
102000012410 DNA Ligases Human genes 0.000 description 1
108010061982 DNA Ligases Proteins 0.000 description 1
206010012289 Dementia Diseases 0.000 description 1
241000710827 Dengue virus 1 Species 0.000 description 1
241000710815 Dengue virus 2 Species 0.000 description 1
241000710872 Dengue virus 3 Species 0.000 description 1
241000710844 Dengue virus 4 Species 0.000 description 1
201000004624 Dermatitis Diseases 0.000 description 1
241000238710 Dermatophagoides Species 0.000 description 1
241000238713 Dermatophagoides farinae Species 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
206010012735 Diarrhoea Diseases 0.000 description 1
BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
241000725618 Duck hepatitis B virus Species 0.000 description 1
241001115402 Ebolavirus Species 0.000 description 1
206010014096 Echinococciasis Diseases 0.000 description 1
208000009366 Echinococcosis Diseases 0.000 description 1
241000508725 Elymus repens Species 0.000 description 1
241000710188 Encephalomyocarditis virus Species 0.000 description 1
206010014733 Endometrial cancer Diseases 0.000 description 1
206010014759 Endometrial neoplasm Diseases 0.000 description 1
241000991587 Enterovirus C Species 0.000 description 1
101710121417 Envelope glycoprotein Proteins 0.000 description 1
241001455610 Ephemerovirus Species 0.000 description 1
241001446318 Epizootic haematopoietic necrosis virus Species 0.000 description 1
241000283086 Equidae Species 0.000 description 1
241000710803 Equine arteritis virus Species 0.000 description 1
208000000461 Esophageal Neoplasms Diseases 0.000 description 1
102100038595 Estrogen receptor Human genes 0.000 description 1
108700024394 Exon Proteins 0.000 description 1
241000282324 Felis Species 0.000 description 1
241000234642 Festuca Species 0.000 description 1
241000234645 Festuca pratensis Species 0.000 description 1
208000004262 Food Hypersensitivity Diseases 0.000 description 1
241000710198 Foot-and-mouth disease virus Species 0.000 description 1
241000807592 Fowl adenovirus Species 0.000 description 1
241000700662 Fowlpox virus Species 0.000 description 1
241000223218 Fusarium Species 0.000 description 1
102100039713 G antigen 6 Human genes 0.000 description 1
101710092269 G antigen 6 Proteins 0.000 description 1
101710113436 GTPase KRas Proteins 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
241000701046 Gammaherpesvirinae Species 0.000 description 1
241001663880 Gammaretrovirus Species 0.000 description 1
201000003741 Gastrointestinal carcinoma Diseases 0.000 description 1
206010017993 Gastrointestinal neoplasms Diseases 0.000 description 1
239000001828 Gelatine Substances 0.000 description 1
108700028146 Genetic Enhancer Elements Proteins 0.000 description 1
241000224466 Giardia Species 0.000 description 1
102000006395 Globulins Human genes 0.000 description 1
108010044091 Globulins Proteins 0.000 description 1
102000008214 Glutamate decarboxylase Human genes 0.000 description 1
108091022930 Glutamate decarboxylase Proteins 0.000 description 1
108010051815 Glutamyl endopeptidase Proteins 0.000 description 1
108010015899 Glycopeptides Proteins 0.000 description 1
102000002068 Glycopeptides Human genes 0.000 description 1
208000009329 Graft vs Host Disease Diseases 0.000 description 1
241000057766 Gymnostoma chamaecyparis Species 0.000 description 1
241000150562 Hantaan orthohantavirus Species 0.000 description 1
101710178376 Heat shock 70 kDa protein Proteins 0.000 description 1
101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 description 1
241000589989 Helicobacter Species 0.000 description 1
241000590002 Helicobacter pylori Species 0.000 description 1
241000893570 Hendra henipavirus Species 0.000 description 1
241000711557 Hepacivirus Species 0.000 description 1
241000724675 Hepatitis E virus Species 0.000 description 1
241000724709 Hepatitis delta virus Species 0.000 description 1
241000709715 Hepatovirus Species 0.000 description 1
241000709721 Hepatovirus A Species 0.000 description 1
241001122120 Hepeviridae Species 0.000 description 1
241000700586 Herpesviridae Species 0.000 description 1
241000226709 Hesperocyparis arizonica Species 0.000 description 1
241001290232 Hesperocyparis macrocarpa Species 0.000 description 1
241000228404 Histoplasma capsulatum Species 0.000 description 1
208000017604 Hodgkin disease Diseases 0.000 description 1
208000021519 Hodgkin lymphoma Diseases 0.000 description 1
208000010747 Hodgkins lymphoma Diseases 0.000 description 1
241000744855 Holcus Species 0.000 description 1
240000003857 Holcus lanatus Species 0.000 description 1
241001272567 Hominoidea Species 0.000 description 1
101001042227 Homo sapiens Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 Proteins 0.000 description 1
101000710072 Homo sapiens Cilia- and flagella-associated protein 97 Proteins 0.000 description 1
101001014223 Homo sapiens MAPK/MAK/MRK overlapping kinase Proteins 0.000 description 1
101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 description 1
101001005716 Homo sapiens Melanoma-associated antigen 11 Proteins 0.000 description 1
101001005720 Homo sapiens Melanoma-associated antigen 4 Proteins 0.000 description 1
101000623901 Homo sapiens Mucin-16 Proteins 0.000 description 1
101000623904 Homo sapiens Mucin-17 Proteins 0.000 description 1
101000871708 Homo sapiens Proheparin-binding EGF-like growth factor Proteins 0.000 description 1
108010048209 Human Immunodeficiency Virus Proteins Proteins 0.000 description 1
108091006905 Human Serum Albumin Proteins 0.000 description 1
102000008100 Human Serum Albumin Human genes 0.000 description 1
241000598171 Human adenovirus sp. Species 0.000 description 1
241000700588 Human alphaherpesvirus 1 Species 0.000 description 1
241000701085 Human alphaherpesvirus 3 Species 0.000 description 1
241001479210 Human astrovirus Species 0.000 description 1
241000701024 Human betaherpesvirus 5 Species 0.000 description 1
241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
241000701027 Human herpesvirus 6 Species 0.000 description 1
241000711920 Human orthopneumovirus Species 0.000 description 1
101000767631 Human papillomavirus type 16 Protein E7 Proteins 0.000 description 1
241000726041 Human respirovirus 1 Species 0.000 description 1
241000710130 Human rhinovirus 1A Species 0.000 description 1
241001135958 Human type D retrovirus Species 0.000 description 1
AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 1
108010043496 Immunoglobulin Idiotypes Proteins 0.000 description 1
241000702626 Infectious bursal disease virus Species 0.000 description 1
241000710921 Infectious pancreatic necrosis virus Species 0.000 description 1
241000713196 Influenza B virus Species 0.000 description 1
241000713297 Influenza C virus Species 0.000 description 1
241001500351 Influenzavirus A Species 0.000 description 1
241001500350 Influenzavirus B Species 0.000 description 1
241001500343 Influenzavirus C Species 0.000 description 1
UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
229930010555 Inosine Natural products 0.000 description 1
108090001061 Insulin Proteins 0.000 description 1
102100023915 Insulin Human genes 0.000 description 1
108010050904 Interferons Proteins 0.000 description 1
102000014150 Interferons Human genes 0.000 description 1
102000000589 Interleukin-1 Human genes 0.000 description 1
108010002352 Interleukin-1 Proteins 0.000 description 1
102000013462 Interleukin-12 Human genes 0.000 description 1
108010065805 Interleukin-12 Proteins 0.000 description 1
102000000588 Interleukin-2 Human genes 0.000 description 1
108010002350 Interleukin-2 Proteins 0.000 description 1
102000015696 Interleukins Human genes 0.000 description 1
108010063738 Interleukins Proteins 0.000 description 1
108091092195 Intron Proteins 0.000 description 1
241000701377 Iridoviridae Species 0.000 description 1
241000721668 Juniperus ashei Species 0.000 description 1
241000592238 Juniperus communis Species 0.000 description 1
241000588747 Klebsiella pneumoniae Species 0.000 description 1
241001138401 Kluyveromyces lactis Species 0.000 description 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
125000000998 L-alanino group Chemical group [H]N([*])[C@](C([H])([H])[H])([H])C(=O)O[H] 0.000 description 1
150000008575 L-amino acids Chemical class 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
FSBIGDSBMBYOPN-VKHMYHEASA-N L-canavanine Chemical compound OC(=O)[C@@H](N)CCONC(N)=N FSBIGDSBMBYOPN-VKHMYHEASA-N 0.000 description 1
102100031413 L-dopachrome tautomerase Human genes 0.000 description 1
101710093778 L-dopachrome tautomerase Proteins 0.000 description 1
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
UKAUYVFTDYCKQA-VKHMYHEASA-N L-homoserine Chemical compound OC(=O)[C@@H](N)CCO UKAUYVFTDYCKQA-VKHMYHEASA-N 0.000 description 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 description 1
125000000510 L-tryptophano group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C(C([H])([H])[C@@]([H])(C(O[H])=O)N([H])[*])C2=C1[H] 0.000 description 1
206010065048 Latent tuberculosis Diseases 0.000 description 1
241000222722 Leishmania <genus> Species 0.000 description 1
101000839464 Leishmania braziliensis Heat shock 70 kDa protein Proteins 0.000 description 1
241000700563 Leporipoxvirus Species 0.000 description 1
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
208000009829 Lewy Body Disease Diseases 0.000 description 1
201000002832 Lewy body dementia Diseases 0.000 description 1
241000186781 Listeria Species 0.000 description 1
241000186779 Listeria monocytogenes Species 0.000 description 1
241000209082 Lolium Species 0.000 description 1
240000004296 Lolium perenne Species 0.000 description 1
239000006142 Luria-Bertani Agar Substances 0.000 description 1
208000016604 Lyme disease Diseases 0.000 description 1
241000701043 Lymphocryptovirus Species 0.000 description 1
241000712899 Lymphocytic choriomeningitis mammarenavirus Species 0.000 description 1
241000711828 Lyssavirus Species 0.000 description 1
102100031520 MAPK/MAK/MRK overlapping kinase Human genes 0.000 description 1
108010010995 MART-1 Antigen Proteins 0.000 description 1
102000016200 MART-1 Antigen Human genes 0.000 description 1
241000282567 Macaca fascicularis Species 0.000 description 1
241001480512 Mammalian orthoreovirus 3 Species 0.000 description 1
241001115401 Marburgvirus Species 0.000 description 1
241000713821 Mason-Pfizer monkey virus Species 0.000 description 1
241000701244 Mastadenovirus Species 0.000 description 1
241000712079 Measles morbillivirus Species 0.000 description 1
102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 description 1
102100025083 Melanoma-associated antigen 11 Human genes 0.000 description 1
102100025077 Melanoma-associated antigen 4 Human genes 0.000 description 1
241000721578 Melopsittacus Species 0.000 description 1
206010027480 Metastatic malignant melanoma Diseases 0.000 description 1
241000243190 Microsporidia Species 0.000 description 1
102000013967 Monokines Human genes 0.000 description 1
108010050619 Monokines Proteins 0.000 description 1
241000712045 Morbillivirus Species 0.000 description 1
241000713333 Mouse mammary tumor virus Species 0.000 description 1
208000003445 Mouth Neoplasms Diseases 0.000 description 1
102100023123 Mucin-16 Human genes 0.000 description 1
102100023125 Mucin-17 Human genes 0.000 description 1
102100034263 Mucin-2 Human genes 0.000 description 1
108010008705 Mucin-2 Proteins 0.000 description 1
108010063954 Mucins Proteins 0.000 description 1
102000015728 Mucins Human genes 0.000 description 1
241000711386 Mumps virus Species 0.000 description 1
241000701029 Murid betaherpesvirus 1 Species 0.000 description 1
241000714177 Murine leukemia virus Species 0.000 description 1
241000701034 Muromegalovirus Species 0.000 description 1
101100394237 Mus musculus Hand1 gene Proteins 0.000 description 1
101100346932 Mus musculus Muc1 gene Proteins 0.000 description 1
108010021466 Mutant Proteins Proteins 0.000 description 1
102000008300 Mutant Proteins Human genes 0.000 description 1
101710135898 Myc proto-oncogene protein Proteins 0.000 description 1
102100038895 Myc proto-oncogene protein Human genes 0.000 description 1
241000187474 Mycobacterium asiaticum Species 0.000 description 1
241000186367 Mycobacterium avium Species 0.000 description 1
241000187482 Mycobacterium avium subsp. paratuberculosis Species 0.000 description 1
241001646019 Mycobacterium immunogenum Species 0.000 description 1
241000186364 Mycobacterium intracellulare Species 0.000 description 1
241000186362 Mycobacterium leprae Species 0.000 description 1
101100051113 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Rv2658c gene Proteins 0.000 description 1
101100445609 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) espC gene Proteins 0.000 description 1
101100389765 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) esxS gene Proteins 0.000 description 1
241000204031 Mycoplasma Species 0.000 description 1
241000204048 Mycoplasma hominis Species 0.000 description 1
241000202934 Mycoplasma pneumoniae Species 0.000 description 1
102000047918 Myelin Basic Human genes 0.000 description 1
101710107068 Myelin basic protein Proteins 0.000 description 1
241000700562 Myxoma virus Species 0.000 description 1
FFDGPVCHZBVARC-UHFFFAOYSA-N N,N-dimethylglycine Chemical compound CN(C)CC(O)=O FFDGPVCHZBVARC-UHFFFAOYSA-N 0.000 description 1
BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 description 1
GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
241000588653 Neisseria Species 0.000 description 1
241000588652 Neisseria gonorrhoeae Species 0.000 description 1
241000588650 Neisseria meningitidis Species 0.000 description 1
241000244206 Nematoda Species 0.000 description 1
DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical group NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
241000526636 Nipah henipavirus Species 0.000 description 1
208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
241000714209 Norwalk virus Species 0.000 description 1
102000008297 Nuclear Matrix-Associated Proteins Human genes 0.000 description 1
108010035916 Nuclear Matrix-Associated Proteins Proteins 0.000 description 1
101710163270 Nuclease Proteins 0.000 description 1
239000004677 Nylon Substances 0.000 description 1
FSBIGDSBMBYOPN-UHFFFAOYSA-N O-guanidino-DL-homoserine Natural products OC(=O)C(N)CCON=C(N)N FSBIGDSBMBYOPN-UHFFFAOYSA-N 0.000 description 1
REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 description 1
241000320412 Ogataea angusta Species 0.000 description 1
108700020796 Oncogene Proteins 0.000 description 1
108700026244 Open Reading Frames Proteins 0.000 description 1
241000702259 Orbivirus Species 0.000 description 1
241000700635 Orf virus Species 0.000 description 1
241000713112 Orthobunyavirus Species 0.000 description 1
241000150452 Orthohantavirus Species 0.000 description 1
241000700732 Orthohepadnavirus Species 0.000 description 1
241000712464 Orthomyxoviridae Species 0.000 description 1
241000700629 Orthopoxvirus Species 0.000 description 1
241000702244 Orthoreovirus Species 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
239000002033 PVDF binder Substances 0.000 description 1
102100034640 PWWP domain-containing DNA repair factor 3A Human genes 0.000 description 1
108050007154 PWWP domain-containing DNA repair factor 3A Proteins 0.000 description 1
241000526686 Paracoccidioides brasiliensis Species 0.000 description 1
241001480233 Paragonimus Species 0.000 description 1
241000935974 Paralichthys dentatus Species 0.000 description 1
241000711504 Paramyxoviridae Species 0.000 description 1
241000700639 Parapoxvirus Species 0.000 description 1
241000721464 Parietaria officinalis Species 0.000 description 1
241001330453 Paspalum Species 0.000 description 1
241001330451 Paspalum notatum Species 0.000 description 1
235000019483 Peanut oil Nutrition 0.000 description 1
102000035195 Peptidases Human genes 0.000 description 1
241000150350 Peribunyaviridae Species 0.000 description 1
241000710778 Pestivirus Species 0.000 description 1
206010057249 Phagocytosis Diseases 0.000 description 1
102100029251 Phagocytosis-stimulating peptide Human genes 0.000 description 1
241000745991 Phalaris Species 0.000 description 1
244000081757 Phalaris arundinacea Species 0.000 description 1
241000286209 Phasianidae Species 0.000 description 1
241000746981 Phleum Species 0.000 description 1
241000746983 Phleum pratense Species 0.000 description 1
241000709664 Picornaviridae Species 0.000 description 1
108010064851 Plant Proteins Proteins 0.000 description 1
206010035501 Plasmodium malariae infection Diseases 0.000 description 1
206010035502 Plasmodium ovale infection Diseases 0.000 description 1
241000142787 Pneumocystis jirovecii Species 0.000 description 1
241000711904 Pneumoviridae Species 0.000 description 1
241000711902 Pneumovirus Species 0.000 description 1
241000209048 Poa Species 0.000 description 1
241000136254 Poa compressa Species 0.000 description 1
241000209049 Poa pratensis Species 0.000 description 1
229920000954 Polyglycolide Polymers 0.000 description 1
241001631648 Polyomaviridae Species 0.000 description 1
241001505332 Polyomavirus sp. Species 0.000 description 1
108010076039 Polyproteins Proteins 0.000 description 1
229920001213 Polysorbate 20 Polymers 0.000 description 1
241000700625 Poxviridae Species 0.000 description 1
108010007288 PrPSc Proteins Proteins 0.000 description 1
108091000054 Prion Proteins 0.000 description 1
102000029797 Prion Human genes 0.000 description 1
208000024777 Prion disease Diseases 0.000 description 1
102100033762 Proheparin-binding EGF-like growth factor Human genes 0.000 description 1
241000186429 Propionibacterium Species 0.000 description 1
XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
102100035703 Prostatic acid phosphatase Human genes 0.000 description 1
241000589517 Pseudomonas aeruginosa Species 0.000 description 1
241000219492 Quercus Species 0.000 description 1
244000274906 Quercus alba Species 0.000 description 1
235000009137 Quercus alba Nutrition 0.000 description 1
239000012979 RPMI medium Substances 0.000 description 1
241000711798 Rabies lyssavirus Species 0.000 description 1
241000701382 Ranavirus Species 0.000 description 1
208000015634 Rectal Neoplasms Diseases 0.000 description 1
241000702247 Reoviridae Species 0.000 description 1
108091081062 Repeated sequence (DNA) Proteins 0.000 description 1
241000712907 Retroviridae Species 0.000 description 1
241000711931 Rhabdoviridae Species 0.000 description 1
241000701037 Rhadinovirus Species 0.000 description 1
206010039085 Rhinitis allergic Diseases 0.000 description 1
108091028664 Ribonucleotide Proteins 0.000 description 1
102000002278 Ribosomal Proteins Human genes 0.000 description 1
108010000605 Ribosomal Proteins Proteins 0.000 description 1
108010039491 Ricin Proteins 0.000 description 1
235000003846 Ricinus Nutrition 0.000 description 1
241000322381 Ricinus <louse> Species 0.000 description 1
240000000528 Ricinus communis Species 0.000 description 1
235000004443 Ricinus communis Nutrition 0.000 description 1
241000606701 Rickettsia Species 0.000 description 1
241000606695 Rickettsia rickettsii Species 0.000 description 1
241000122129 Roseolovirus Species 0.000 description 1
241000702670 Rotavirus Species 0.000 description 1
108700031314 Rotavirus VP6 Proteins 0.000 description 1
241000710799 Rubella virus Species 0.000 description 1
241000710801 Rubivirus Species 0.000 description 1
241001533467 Rubulavirus Species 0.000 description 1
108091079747 SCP family Proteins 0.000 description 1
108091077753 SSX family Proteins 0.000 description 1
102000042330 SSX family Human genes 0.000 description 1
102000051619 SUMO-1 Human genes 0.000 description 1
108700038981 SUMO-1 Proteins 0.000 description 1
244000004774 Sabina virginiana Species 0.000 description 1
235000008691 Sabina virginiana Nutrition 0.000 description 1
241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
241000235347 Schizosaccharomyces pombe Species 0.000 description 1
241000209056 Secale Species 0.000 description 1
244000082988 Secale cereale Species 0.000 description 1
235000007238 Secale cereale Nutrition 0.000 description 1
238000012300 Sequence Analysis Methods 0.000 description 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
241000287231 Serinus Species 0.000 description 1
241000270295 Serpentes Species 0.000 description 1
241000700665 Sheeppox virus Species 0.000 description 1
241000607768 Shigella Species 0.000 description 1
241000607764 Shigella dysenteriae Species 0.000 description 1
101710173693 Short transient receptor potential channel 1 Proteins 0.000 description 1
101710173694 Short transient receptor potential channel 2 Proteins 0.000 description 1
241000700584 Simplexvirus Species 0.000 description 1
241000710960 Sindbis virus Species 0.000 description 1
208000000453 Skin Neoplasms Diseases 0.000 description 1
208000021712 Soft tissue sarcoma Diseases 0.000 description 1
241000256251 Spodoptera frugiperda Species 0.000 description 1
108010092505 SpyTag peptide Proteins 0.000 description 1
241000191940 Staphylococcus Species 0.000 description 1
241000191967 Staphylococcus aureus Species 0.000 description 1
241000191963 Staphylococcus epidermidis Species 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
241000193985 Streptococcus agalactiae Species 0.000 description 1
241000194019 Streptococcus mutans Species 0.000 description 1
241000194025 Streptococcus oralis Species 0.000 description 1
241000193991 Streptococcus parasanguinis Species 0.000 description 1
241000193990 Streptococcus sp. 'group B' Species 0.000 description 1
101000815632 Streptococcus suis (strain 05ZYH33) Rqc2 homolog RqcH Proteins 0.000 description 1
241001312524 Streptococcus viridans Species 0.000 description 1
241000700568 Suipoxvirus Species 0.000 description 1
241000700565 Swinepox virus Species 0.000 description 1
108700005078 Synthetic Genes Proteins 0.000 description 1
108010008038 Synthetic Vaccines Proteins 0.000 description 1
206010042971 T-cell lymphoma Diseases 0.000 description 1
208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
241001523006 Talaromyces marneffei Species 0.000 description 1
108010017842 Telomerase Proteins 0.000 description 1
208000024313 Testicular Neoplasms Diseases 0.000 description 1
206010057644 Testis cancer Diseases 0.000 description 1
206010043376 Tetanus Diseases 0.000 description 1
BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical class OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 description 1
102000009843 Thyroglobulin Human genes 0.000 description 1
108010034949 Thyroglobulin Proteins 0.000 description 1
208000033781 Thyroid carcinoma Diseases 0.000 description 1
208000024770 Thyroid neoplasm Diseases 0.000 description 1
241000710924 Togaviridae Species 0.000 description 1
241000711517 Torovirus Species 0.000 description 1
206010044269 Toxocariasis Diseases 0.000 description 1
241000223996 Toxoplasma Species 0.000 description 1
101710150448 Transcriptional regulator Myc Proteins 0.000 description 1
101800001690 Transmembrane protein gp41 Proteins 0.000 description 1
241000869417 Trematodes Species 0.000 description 1
241000589884 Treponema pallidum Species 0.000 description 1
241000223231 Trichosporon beigelii Species 0.000 description 1
235000021307 Triticum Nutrition 0.000 description 1
241000209140 Triticum Species 0.000 description 1
244000098338 Triticum aestivum Species 0.000 description 1
LVTKHGUGBGNBPL-UHFFFAOYSA-N Trp-P-1 Chemical compound N1C2=CC=CC=C2C2=C1C(C)=C(N)N=C2C LVTKHGUGBGNBPL-UHFFFAOYSA-N 0.000 description 1
GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
108010084754 Tuftsin Proteins 0.000 description 1
102000018594 Tumour necrosis factor Human genes 0.000 description 1
108050007852 Tumour necrosis factor Proteins 0.000 description 1
102000003425 Tyrosinase Human genes 0.000 description 1
108060008724 Tyrosinase Proteins 0.000 description 1
101710155955 U4/U6.U5 tri-snRNP-associated protein 1 Proteins 0.000 description 1
102100027244 U4/U6.U5 tri-snRNP-associated protein 1 Human genes 0.000 description 1
208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
208000008385 Urogenital Neoplasms Diseases 0.000 description 1
241000700618 Vaccinia virus Species 0.000 description 1
241000711975 Vesicular stomatitis virus Species 0.000 description 1
241000711970 Vesiculovirus Species 0.000 description 1
241000607598 Vibrio Species 0.000 description 1
241000607626 Vibrio cholerae Species 0.000 description 1
108010015780 Viral Core Proteins Proteins 0.000 description 1
241000726445 Viroids Species 0.000 description 1
241000710886 West Nile virus Species 0.000 description 1
238000000333 X-ray scattering Methods 0.000 description 1
241000235015 Yarrowia lipolytica Species 0.000 description 1
241000710772 Yellow fever virus Species 0.000 description 1
241000607734 Yersinia <bacteria> Species 0.000 description 1
241000607479 Yersinia pestis Species 0.000 description 1
UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 description 1
150000001242 acetic acid derivatives Chemical class 0.000 description 1
102000034337 acetylcholine receptors Human genes 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
229920006243 acrylic copolymer Polymers 0.000 description 1
239000012190 activator Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
208000009956 adenocarcinoma Diseases 0.000 description 1
108700010877 adenoviridae proteins Proteins 0.000 description 1
230000002411 adverse Effects 0.000 description 1
239000000443 aerosol Substances 0.000 description 1
238000000246 agarose gel electrophoresis Methods 0.000 description 1
235000004279 alanine Nutrition 0.000 description 1
125000003158 alcohol group Chemical group 0.000 description 1
239000000783 alginic acid Substances 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
229960001126 alginic acid Drugs 0.000 description 1
150000004781 alginic acids Chemical class 0.000 description 1
230000000172 allergic effect Effects 0.000 description 1
201000010105 allergic rhinitis Diseases 0.000 description 1
102000013529 alpha-Fetoproteins Human genes 0.000 description 1
108010026331 alpha-Fetoproteins Proteins 0.000 description 1
229940037003 alum Drugs 0.000 description 1
229940001007 aluminium phosphate Drugs 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 1
239000000730 antalgic agent Substances 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000003302 anti-idiotype Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 description 1
238000013459 approach Methods 0.000 description 1
235000009052 artemisia Nutrition 0.000 description 1
230000003286 arthritogenic effect Effects 0.000 description 1
235000009582 asparagine Nutrition 0.000 description 1
229960001230 asparagine Drugs 0.000 description 1
229940009098 aspartate Drugs 0.000 description 1
244000309743 astrovirus Species 0.000 description 1
238000004630 atomic force microscopy Methods 0.000 description 1
230000003190 augmentative effect Effects 0.000 description 1
WXNRAKRZUCLRBP-UHFFFAOYSA-N avridine Chemical compound CCCCCCCCCCCCCCCCCCN(CCCN(CCO)CCO)CCCCCCCCCCCCCCCCCC WXNRAKRZUCLRBP-UHFFFAOYSA-N 0.000 description 1
229950010555 avridine Drugs 0.000 description 1
201000008680 babesiosis Diseases 0.000 description 1
229940065181 bacillus anthracis Drugs 0.000 description 1
244000052616 bacterial pathogen Species 0.000 description 1
239000000688 bacterial toxin Substances 0.000 description 1
201000009036 biliary tract cancer Diseases 0.000 description 1
208000020790 biliary tract neoplasm Diseases 0.000 description 1
230000000975 bioactive effect Effects 0.000 description 1
238000004166 bioassay Methods 0.000 description 1
229960000074 biopharmaceutical Drugs 0.000 description 1
229960002685 biotin Drugs 0.000 description 1
235000020958 biotin Nutrition 0.000 description 1
239000011616 biotin Substances 0.000 description 1
229920001400 block copolymer Polymers 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
206010006007 bone sarcoma Diseases 0.000 description 1
150000003842 bromide salts Chemical class 0.000 description 1
229940056450 brucella abortus Drugs 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
239000008366 buffered solution Substances 0.000 description 1
229940074375 burkholderia mallei Drugs 0.000 description 1
235000011132 calcium sulphate Nutrition 0.000 description 1
230000036952 cancer formation Effects 0.000 description 1
239000007894 caplet Substances 0.000 description 1
210000000234 capsid Anatomy 0.000 description 1
229910002091 carbon monoxide Inorganic materials 0.000 description 1
229940096529 carboxypolymethylene Drugs 0.000 description 1
231100000504 carcinogenesis Toxicity 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
125000002091 cationic group Chemical group 0.000 description 1
238000004113 cell culture Methods 0.000 description 1
230000030833 cell death Effects 0.000 description 1
230000024245 cell differentiation Effects 0.000 description 1
239000008004 cell lysis buffer Substances 0.000 description 1
210000000170 cell membrane Anatomy 0.000 description 1
230000012292 cell migration Effects 0.000 description 1
230000004663 cell proliferation Effects 0.000 description 1
239000002458 cell surface marker Substances 0.000 description 1
230000004700 cellular uptake Effects 0.000 description 1
210000001175 cerebrospinal fluid Anatomy 0.000 description 1
238000007385 chemical modification Methods 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
238000002512 chemotherapy Methods 0.000 description 1
235000013330 chicken meat Nutrition 0.000 description 1
238000011210 chromatographic step Methods 0.000 description 1
238000011097 chromatography purification Methods 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
229910017052 cobalt Inorganic materials 0.000 description 1
239000010941 cobalt Substances 0.000 description 1
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
238000004440 column chromatography Methods 0.000 description 1
238000004891 communication Methods 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
230000000536 complexating effect Effects 0.000 description 1
238000004590 computer program Methods 0.000 description 1
229940031670 conjugate vaccine Drugs 0.000 description 1
239000000470 constituent Substances 0.000 description 1
238000012864 cross contamination Methods 0.000 description 1
239000012228 culture supernatant Substances 0.000 description 1
238000012258 culturing Methods 0.000 description 1
230000009089 cytolysis Effects 0.000 description 1
231100000433 cytotoxic Toxicity 0.000 description 1
230000001472 cytotoxic effect Effects 0.000 description 1
231100000135 cytotoxicity Toxicity 0.000 description 1
230000003013 cytotoxicity Effects 0.000 description 1
238000002784 cytotoxicity assay Methods 0.000 description 1
231100000263 cytotoxicity test Toxicity 0.000 description 1
230000006378 damage Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
239000005547 deoxyribonucleotide Substances 0.000 description 1
125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
238000000151 deposition Methods 0.000 description 1
210000003595 dermal dendritic cell Anatomy 0.000 description 1
229960002086 dextran Drugs 0.000 description 1
206010012601 diabetes mellitus Diseases 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
108700003601 dimethylglycine Proteins 0.000 description 1
229960001188 diphtheria antitoxin Drugs 0.000 description 1
229940079593 drug Drugs 0.000 description 1
241001492478 dsDNA viruses, no RNA stage Species 0.000 description 1
239000000428 dust Substances 0.000 description 1
239000012636 effector Substances 0.000 description 1
238000001493 electron microscopy Methods 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
210000002889 endothelial cell Anatomy 0.000 description 1
239000003623 enhancer Substances 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
210000002919 epithelial cell Anatomy 0.000 description 1
201000004101 esophageal cancer Diseases 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
108010038795 estrogen receptors Proteins 0.000 description 1
231100000776 exotoxin Toxicity 0.000 description 1
239000002095 exotoxin Substances 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000000284 extract Substances 0.000 description 1
239000012894 fetal calf serum Substances 0.000 description 1
102000036072 fibronectin binding proteins Human genes 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
238000000684 flow cytometry Methods 0.000 description 1
238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
108091006047 fluorescent proteins Proteins 0.000 description 1
102000034287 fluorescent proteins Human genes 0.000 description 1
235000020932 food allergy Nutrition 0.000 description 1
235000013376 functional food Nutrition 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
230000002538 fungal effect Effects 0.000 description 1
229940044627 gamma-interferon Drugs 0.000 description 1
150000002270 gangliosides Chemical class 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
238000001502 gel electrophoresis Methods 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
210000004602 germ cell Anatomy 0.000 description 1
239000011521 glass Substances 0.000 description 1
208000005017 glioblastoma Diseases 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 1
125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
208000024908 graft versus host disease Diseases 0.000 description 1
239000008187 granular material Substances 0.000 description 1
201000009277 hairy cell leukemia Diseases 0.000 description 1
201000010536 head and neck cancer Diseases 0.000 description 1
201000003911 head and neck carcinoma Diseases 0.000 description 1
208000014829 head and neck neoplasm Diseases 0.000 description 1
229940037467 helicobacter pylori Drugs 0.000 description 1
244000000013 helminth Species 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
150000002410 histidine derivatives Chemical class 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
210000005260 human cell Anatomy 0.000 description 1
230000028996 humoral immune response Effects 0.000 description 1
150000003840 hydrochlorides Chemical class 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
229920001600 hydrophobic polymer Polymers 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
230000009610 hypersensitivity Effects 0.000 description 1
238000003384 imaging method Methods 0.000 description 1
238000003119 immunoblot Methods 0.000 description 1
230000017555 immunoglobulin mediated immune response Effects 0.000 description 1
239000000677 immunologic agent Substances 0.000 description 1
229940124541 immunological agent Drugs 0.000 description 1
230000006054 immunological memory Effects 0.000 description 1
239000003547 immunosorbent Substances 0.000 description 1
238000009169 immunotherapy Methods 0.000 description 1
230000001771 impaired effect Effects 0.000 description 1
239000007943 implant Substances 0.000 description 1
230000006872 improvement Effects 0.000 description 1
239000012535 impurity Substances 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000005462 in vivo assay Methods 0.000 description 1
230000001433 inducive effect Effects 0.000 description 1
230000006698 induction Effects 0.000 description 1
206010022000 influenza Diseases 0.000 description 1
208000037797 influenza A Diseases 0.000 description 1
108700010900 influenza virus proteins Proteins 0.000 description 1
208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
230000015788 innate immune response Effects 0.000 description 1
239000002054 inoculum Substances 0.000 description 1
229960003786 inosine Drugs 0.000 description 1
239000002919 insect venom Substances 0.000 description 1
238000007689 inspection Methods 0.000 description 1
229940125396 insulin Drugs 0.000 description 1
229940047124 interferons Drugs 0.000 description 1
229940117681 interleukin-12 Drugs 0.000 description 1
229940047122 interleukins Drugs 0.000 description 1
210000003535 interstitial dendritic cell Anatomy 0.000 description 1
201000002313 intestinal cancer Diseases 0.000 description 1
230000035987 intoxication Effects 0.000 description 1
231100000566 intoxication Toxicity 0.000 description 1
238000000185 intracerebroventricular administration Methods 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
238000004255 ion exchange chromatography Methods 0.000 description 1
210000004153 islets of langerhan Anatomy 0.000 description 1
BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 1
238000002334 isothermal calorimetry Methods 0.000 description 1
210000001821 langerhans cell Anatomy 0.000 description 1
208000033353 latent tuberculosis infection Diseases 0.000 description 1
231100000636 lethal dose Toxicity 0.000 description 1
239000003446 ligand Substances 0.000 description 1
208000012987 lip and oral cavity carcinoma Diseases 0.000 description 1
GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical class O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 1
230000029226 lipidation Effects 0.000 description 1
238000004811 liquid chromatography Methods 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
244000144972 livestock Species 0.000 description 1
230000033001 locomotion Effects 0.000 description 1
HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 description 1
230000036210 malignancy Effects 0.000 description 1
150000002690 malonic acid derivatives Chemical class 0.000 description 1
210000004962 mammalian cell Anatomy 0.000 description 1
238000004949 mass spectrometry Methods 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
239000002609 medium Substances 0.000 description 1
101150110704 melC2 gene Proteins 0.000 description 1
230000015654 memory Effects 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
208000021039 metastatic melanoma Diseases 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
244000005700 microbiome Species 0.000 description 1
239000004005 microsphere Substances 0.000 description 1
238000013508 migration Methods 0.000 description 1
235000021243 milk fat Nutrition 0.000 description 1
230000003278 mimic effect Effects 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
238000001823 molecular biology technique Methods 0.000 description 1
238000000302 molecular modelling Methods 0.000 description 1
210000001616 monocyte Anatomy 0.000 description 1
150000002772 monosaccharides Chemical class 0.000 description 1
101150067482 msbA gene Proteins 0.000 description 1
229940031348 multivalent vaccine Drugs 0.000 description 1
BSOQXXWZTUDTEL-ZUYCGGNHSA-N muramyl dipeptide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-ZUYCGGNHSA-N 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
239000007922 nasal spray Substances 0.000 description 1
239000013642 negative control Substances 0.000 description 1
230000009826 neoplastic cell growth Effects 0.000 description 1
230000001537 neural effect Effects 0.000 description 1
208000004235 neutropenia Diseases 0.000 description 1
210000000440 neutrophil Anatomy 0.000 description 1
208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
210000004940 nucleus Anatomy 0.000 description 1
229920001778 nylon Polymers 0.000 description 1
239000007764 o/w emulsion Substances 0.000 description 1
229920001542 oligosaccharide Polymers 0.000 description 1
150000002482 oligosaccharides Chemical class 0.000 description 1
238000001543 one-way ANOVA Methods 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
210000003463 organelle Anatomy 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
101150006608 ox gene Proteins 0.000 description 1
238000010979 pH adjustment Methods 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
230000037361 pathway Effects 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
239000000816 peptidomimetic Substances 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
230000008782 phagocytosis Effects 0.000 description 1
230000003285 pharmacodynamic effect Effects 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
150000008298 phosphoramidates Chemical class 0.000 description 1
BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 1
230000037081 physical activity Effects 0.000 description 1
244000000003 plant pathogen Species 0.000 description 1
235000021118 plant-derived protein Nutrition 0.000 description 1
210000004180 plasmocyte Anatomy 0.000 description 1
229940118768 plasmodium malariae Drugs 0.000 description 1
229920001983 poloxamer Polymers 0.000 description 1
229920001308 poly(aminoacid) Polymers 0.000 description 1
229920000747 poly(lactic acid) Polymers 0.000 description 1
230000008488 polyadenylation Effects 0.000 description 1
229920000768 polyamine Polymers 0.000 description 1
229920002704 polyhistidine Polymers 0.000 description 1
229920000656 polylysine Polymers 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229920002981 polyvinylidene fluoride Polymers 0.000 description 1
231100000683 possible toxicity Toxicity 0.000 description 1
230000001323 posttranslational effect Effects 0.000 description 1
230000002265 prevention Effects 0.000 description 1
230000037452 priming Effects 0.000 description 1
230000009465 prokaryotic expression Effects 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
229940055019 propionibacterium acne Drugs 0.000 description 1
108010043671 prostatic acid phosphatase Proteins 0.000 description 1
235000004252 protein component Nutrition 0.000 description 1
238000002331 protein detection Methods 0.000 description 1
238000000164 protein isolation Methods 0.000 description 1
238000001243 protein synthesis Methods 0.000 description 1
231100000654 protein toxin Toxicity 0.000 description 1
230000004850 protein–protein interaction Effects 0.000 description 1
230000006337 proteolytic cleavage Effects 0.000 description 1
150000003212 purines Chemical class 0.000 description 1
JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
150000003222 pyridines Chemical class 0.000 description 1
150000003230 pyrimidines Chemical class 0.000 description 1
239000000018 receptor agonist Substances 0.000 description 1
229940044601 receptor agonist Drugs 0.000 description 1
102000027426 receptor tyrosine kinases Human genes 0.000 description 1
108091008598 receptor tyrosine kinases Proteins 0.000 description 1
229940124551 recombinant vaccine Drugs 0.000 description 1
230000006798 recombination Effects 0.000 description 1
238000005215 recombination Methods 0.000 description 1
206010038038 rectal cancer Diseases 0.000 description 1
201000001275 rectum cancer Diseases 0.000 description 1
230000008439 repair process Effects 0.000 description 1
230000003362 replicative effect Effects 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
206010039083 rhinitis Diseases 0.000 description 1
239000002336 ribonucleotide Substances 0.000 description 1
125000002652 ribonucleotide group Chemical group 0.000 description 1
229940075118 rickettsia rickettsii Drugs 0.000 description 1
229920002477 rna polymer Polymers 0.000 description 1
102200018234 rs36035373 Human genes 0.000 description 1
108700004121 sarkosyl Proteins 0.000 description 1
238000001878 scanning electron micrograph Methods 0.000 description 1
201000004409 schistosomiasis Diseases 0.000 description 1
238000012216 screening Methods 0.000 description 1
230000028327 secretion Effects 0.000 description 1
238000002398 sedimentation field-flow fractionation Methods 0.000 description 1
230000037307 sensitive skin Effects 0.000 description 1
238000002864 sequence alignment Methods 0.000 description 1
230000000405 serological effect Effects 0.000 description 1
238000007493 shaping process Methods 0.000 description 1
229940007046 shigella dysenteriae Drugs 0.000 description 1
238000012868 site-directed mutagenesis technique Methods 0.000 description 1
238000001542 size-exclusion chromatography Methods 0.000 description 1
238000004513 sizing Methods 0.000 description 1
201000000849 skin cancer Diseases 0.000 description 1
231100000430 skin reaction Toxicity 0.000 description 1
150000003384 small molecules Chemical class 0.000 description 1
238000010532 solid phase synthesis reaction Methods 0.000 description 1
238000005063 solubilization Methods 0.000 description 1
230000007928 solubilization Effects 0.000 description 1
230000003381 solubilizing effect Effects 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
230000009870 specific binding Effects 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
210000000952 spleen Anatomy 0.000 description 1
229940032094 squalane Drugs 0.000 description 1
229940031439 squalene Drugs 0.000 description 1
TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
206010041823 squamous cell carcinoma Diseases 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000011476 stem cell transplantation Methods 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
229940031626 subunit vaccine Drugs 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
229940117986 sulfobetaine Drugs 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
239000013589 supplement Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
229940126577 synthetic vaccine Drugs 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
208000004441 taeniasis Diseases 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
238000010998 test method Methods 0.000 description 1
201000003120 testicular cancer Diseases 0.000 description 1
229960000814 tetanus toxoid Drugs 0.000 description 1
208000008732 thymoma Diseases 0.000 description 1
229960002175 thyroglobulin Drugs 0.000 description 1
201000002510 thyroid cancer Diseases 0.000 description 1
208000013077 thyroid gland carcinoma Diseases 0.000 description 1
241001147422 tick-borne encephalitis virus group Species 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
231100000563 toxic property Toxicity 0.000 description 1
231100000440 toxicity profile Toxicity 0.000 description 1
230000002103 transcriptional effect Effects 0.000 description 1
230000009466 transformation Effects 0.000 description 1
238000013519 translation Methods 0.000 description 1
208000003982 trichinellosis Diseases 0.000 description 1
229960001005 tuberculin Drugs 0.000 description 1
229940035670 tuftsin Drugs 0.000 description 1
IESDGNYHXIOKRW-LEOABGAYSA-N tuftsin Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](CCCNC(N)=N)C(O)=O IESDGNYHXIOKRW-LEOABGAYSA-N 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
238000000870 ultraviolet spectroscopy Methods 0.000 description 1
241000701161 unidentified adenovirus Species 0.000 description 1
241000701447 unidentified baculovirus Species 0.000 description 1
241000709655 unidentified tobacco necrosis virus Species 0.000 description 1
201000005112 urinary bladder cancer Diseases 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
229940125575 vaccine candidate Drugs 0.000 description 1
231100000611 venom Toxicity 0.000 description 1
230000035899 viability Effects 0.000 description 1
229940118696 vibrio cholerae Drugs 0.000 description 1
239000001993 wax Substances 0.000 description 1
238000002424 x-ray crystallography Methods 0.000 description 1
229940051021 yellow-fever virus Drugs 0.000 description 1