NL187314C - ANTIBACTERIAL PREPARATION, AND ONE IN PLACE 1 SUBSTITUTED 7- (3-AMINOPYRROLIDINO) -6-FLUORO-4-OXO-1,4-DIHYDRO-1,8-NAPHYTIDINE-3-CARBONIC ACID DERIVATIVE. - Google Patents

ANTIBACTERIAL PREPARATION, AND ONE IN PLACE 1 SUBSTITUTED 7- (3-AMINOPYRROLIDINO) -6-FLUORO-4-OXO-1,4-DIHYDRO-1,8-NAPHYTIDINE-3-CARBONIC ACID DERIVATIVE.

Info

Publication number
NL187314C
NL187314C NLAANVRAGE8501172,A NL8501172A NL187314C NL 187314 C NL187314 C NL 187314C NL 8501172 A NL8501172 A NL 8501172A NL 187314 C NL187314 C NL 187314C
Authority
NL
Netherlands
Prior art keywords
naphytidine
aminopyrrolidino
dihydro
oxo
fluoro
Prior art date
Application number
NLAANVRAGE8501172,A
Other languages
Dutch (nl)
Other versions
NL8501172A (en
Inventor
Hirokazu Narita
Yoshinori Konishi
Jun Nitta
Hideyoshi Nagaki
Isao Kitayama
Yoriko Kobayashi
Mikako Shinagawa
Yasuo Watanabe
Akira Yotsuji
Shinzaburo Minami
Isamu Saikawa
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13845280&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL187314(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of NL8501172A publication Critical patent/NL8501172A/en
Priority to NL9100647A priority Critical patent/NL192574C/en
Application granted granted Critical
Publication of NL187314C publication Critical patent/NL187314C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NLAANVRAGE8501172,A 1984-04-26 1985-04-23 ANTIBACTERIAL PREPARATION, AND ONE IN PLACE 1 SUBSTITUTED 7- (3-AMINOPYRROLIDINO) -6-FLUORO-4-OXO-1,4-DIHYDRO-1,8-NAPHYTIDINE-3-CARBONIC ACID DERIVATIVE. NL187314C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL9100647A NL192574C (en) 1984-04-26 1991-04-15 Antibacterial preparation, and a 1-substituted 7- (3-substituted-1-pyrrolidinyl) -6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid derivative.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59084963A JPS60228479A (en) 1984-04-26 1984-04-26 1,4-dihydro-4-oxonaphthyridine derivative and salt thereof
JP8496384 1984-04-26

Publications (2)

Publication Number Publication Date
NL8501172A NL8501172A (en) 1985-11-18
NL187314C true NL187314C (en) 1991-08-16

Family

ID=13845280

Family Applications (2)

Application Number Title Priority Date Filing Date
NLAANVRAGE8501172,A NL187314C (en) 1984-04-26 1985-04-23 ANTIBACTERIAL PREPARATION, AND ONE IN PLACE 1 SUBSTITUTED 7- (3-AMINOPYRROLIDINO) -6-FLUORO-4-OXO-1,4-DIHYDRO-1,8-NAPHYTIDINE-3-CARBONIC ACID DERIVATIVE.
NL9100648A NL9100648A (en) 1984-04-26 1991-04-15 ANTIBACTERIAL PREPARATION, AND ONE IN PLACE 1 SUBSTITUTED 7- (CYCLIC AMINO) -6-FLUORO-4-OXO-1,4-DIHYDRO-1,8-NAFTYRIDINE-3-CARBONIC ACID DERIVATIVE.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NL9100648A NL9100648A (en) 1984-04-26 1991-04-15 ANTIBACTERIAL PREPARATION, AND ONE IN PLACE 1 SUBSTITUTED 7- (CYCLIC AMINO) -6-FLUORO-4-OXO-1,4-DIHYDRO-1,8-NAFTYRIDINE-3-CARBONIC ACID DERIVATIVE.

Country Status (30)

Country Link
JP (1) JPS60228479A (en)
KR (1) KR870001693B1 (en)
AR (1) AR241911A1 (en)
AT (2) AT389698B (en)
AU (2) AU565087B2 (en)
BE (1) BE902279A (en)
CH (1) CH673458A5 (en)
CS (1) CS250684B2 (en)
DD (1) DD238795A5 (en)
DE (2) DE3546658C2 (en)
DK (1) DK165877C (en)
EG (1) EG17339A (en)
ES (2) ES8700256A1 (en)
FI (1) FI80453C (en)
FR (2) FR2563521B1 (en)
GB (2) GB2158825B (en)
HU (2) HU197571B (en)
ID (1) ID21142A (en)
IL (1) IL75021A (en)
IT (1) IT1209953B (en)
LU (1) LU85871A1 (en)
NL (2) NL187314C (en)
NO (1) NO162238C (en)
NZ (1) NZ211895A (en)
PH (3) PH22801A (en)
PL (1) PL147392B1 (en)
PT (1) PT80349B (en)
RO (2) RO91871B (en)
SE (2) SE463102B (en)
ZA (1) ZA853102B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6172753A (en) * 1984-09-18 1986-04-14 Dainippon Pharmaceut Co Ltd Pyridyl ketone derivative
AT392789B (en) * 1985-01-23 1991-06-10 Toyama Chemical Co Ltd METHOD FOR PRODUCING 1-SUBSTITUTED ARYL-1,4-DIHYDRO-4-OXONAPHTHYRIDINE DERIVATIVES
AU576657B2 (en) * 1985-01-23 1988-09-01 Toyama Chemical Co. Ltd. Naphthyridine and pyridine derivatives
DE3525108A1 (en) * 1985-06-07 1986-12-11 Bayer Ag, 5090 Leverkusen ANTIBACTERIAL EFFECT OF CHINOLON CARBON ACID ESTERS
DE3685157D1 (en) * 1985-06-26 1992-06-11 Daiichi Seiyaku Co PYRIDON CARBON ACID DERIVATIVES.
US4962112A (en) * 1987-08-04 1990-10-09 Abbott Laboratories 7-(2-methyl-4-aminopyrrolidinyl)naphthryidine and quinoline compounds
IE62600B1 (en) * 1987-08-04 1995-02-22 Abbott Lab Naphtyridine antianaerobic compounds
US4859776A (en) * 1988-03-11 1989-08-22 Abbott Laboratories (S)-7-(3-aminopyrrolidin-1-yl)-1-(ortho, para-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid and method for its preparation
JP2844079B2 (en) * 1988-05-23 1999-01-06 塩野義製薬株式会社 Pyridonecarboxylic acid antibacterial agent
DE3934082A1 (en) * 1989-10-12 1991-04-18 Bayer Ag CHINOLON CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS AN ANTIVIRAL AGENT
CA2100242A1 (en) * 1991-01-14 1992-07-15 Soon K. Moon Quinolone compounds and processes for preparation thereof
FR2692577B1 (en) * 1992-05-26 1996-02-02 Bouchara Sa NOVEL FLUORINATED QUINOLONES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
KR940014395A (en) * 1992-12-09 1994-07-18 강박광 Novel quinolone derivatives and preparation methods thereof
KR0148277B1 (en) * 1993-01-18 1998-11-02 채영복 Novel fluoroquinolone derivatives and process for the preparation thereof
AU4272793A (en) * 1993-04-24 1994-11-21 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and process for preparing the same
KR950018003A (en) * 1993-12-09 1995-07-22 스미스클라인 비참 피엘씨 Novel quinolone derivatives and methods for their preparation
US5910498A (en) * 1994-10-20 1999-06-08 Wakunaga Seiyaku Kabushiki Kaisha Pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents comprising the same as active ingredient
PT897919E (en) 1996-04-19 2004-11-30 Wakunaga Pharma Co Ltd NEW DERIVATIVES OF PYRIDONACARBOXYLIC ACID OR ITS SATISTS AND ANTI-BACTERIAL AGENTS CONTAINING THEM AS AN ACTIVE INGREDIENT
KR20000052892A (en) * 1996-10-30 2000-08-25 빌프리더 하이더 Method of producing naphthyridine compounds and novel intermediate products
DE19713506A1 (en) 1997-04-01 1998-10-08 Bayer Ag Process for the preparation of 2,6-dichloro-5-fluoronicotinonitrile and the chemical compound 3-cyano-2-hydroxy-5-fluoropyrid-6-one monosodium salt and its tautomers
RU2270695C2 (en) 1999-03-17 2006-02-27 Дайити Фармасьютикал Ко., Лтд. Pharmaceutical composition
US6441182B1 (en) 1999-06-10 2002-08-27 Bayer Aktiengesellschaft Method for the production of 2,6-dichloro-5-fluoro-nicotinic acid and coarse and particularly pure 2,6-dichloro-5-fluoro-nicotinic acid
JP3477466B2 (en) 1999-09-02 2003-12-10 湧永製薬株式会社 Quinolinecarboxylic acid derivatives or salts thereof
AU2001286852A1 (en) * 2000-08-29 2002-03-13 Chiron Corporation Quinoline antibacterial compounds and methods of use thereof
KR100981351B1 (en) * 2003-10-29 2010-09-10 주식회사 엘지생명과학 Process for preparing 7-chloro-1-cyclopropyl-6- fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CN101792443A (en) * 2010-03-09 2010-08-04 北京欧凯纳斯科技有限公司 Fluoro-carbostyril derivative as well as preparation method and application thereof
JOP20190045A1 (en) 2016-09-14 2019-03-14 Bayer Ag 7-substituted 1-aryl-naphthyridine-3-carboxylic acid amides and use thereof
CN114369092A (en) * 2021-12-20 2022-04-19 赤峰万泽药业股份有限公司 Tosufloxacin tosylate and preparation method thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2125310A1 (en) * 1971-05-21 1972-11-30 Sterling Drug Inc , New York, NY (V St A) 1-alkyl-1,4-dihydro-4-oxo-1,8-naphtyridine 3-carboxylic acids antibac
AR223983A1 (en) * 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co A PROCEDURE FOR PREPARING 6-HALOGEN-4-OXO-7- (1-PIPERAZINYL) -1,8-NAFTIRIDIN-3-CARBOXYLIC ACID DERIVATIVES
DE3033157A1 (en) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-AMINO-1-CYCLOPROPYL-4-OXO-1,4-DIHYDRO-NAPHTHYRIDINE-3-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM
US4382937A (en) 1981-02-27 1983-05-10 Dainippon Pharmaceutical Co., Ltd. Naphthyridine derivatives and their use as anti-bacterials
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
NZ210847A (en) * 1984-01-26 1988-02-29 Abbott Lab Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions
IL74064A (en) * 1984-01-26 1988-09-30 Abbott Lab 1,7-disubstituted-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivatives and antibacterial compositions containing them
AU576657B2 (en) * 1985-01-23 1988-09-01 Toyama Chemical Co. Ltd. Naphthyridine and pyridine derivatives
DE3525108A1 (en) * 1985-06-07 1986-12-11 Bayer Ag, 5090 Leverkusen ANTIBACTERIAL EFFECT OF CHINOLON CARBON ACID ESTERS

Also Published As

Publication number Publication date
CH673458A5 (en) 1990-03-15
FR2614620A1 (en) 1988-11-04
GB8510297D0 (en) 1985-05-30
HUT38634A (en) 1986-06-30
DK165877B (en) 1993-02-01
IL75021A (en) 1994-01-25
HU194226B (en) 1988-01-28
FI80453C (en) 1990-06-11
RO95509B (en) 1988-10-01
DD238795A5 (en) 1986-09-03
NO162238C (en) 1989-12-06
DE3514076C2 (en) 1989-03-30
IT8548002A0 (en) 1985-04-26
ES8700256A1 (en) 1986-09-16
JPS6320828B2 (en) 1988-04-30
FR2563521B1 (en) 1989-02-03
SE8804586L (en) 1988-12-20
ES542584A0 (en) 1986-09-16
SE463102B (en) 1990-10-08
SE501412C2 (en) 1995-02-13
PH22801A (en) 1988-12-12
DK185685A (en) 1985-10-27
DK165877C (en) 1993-06-21
ATA267888A (en) 1989-09-15
AU612993B2 (en) 1991-07-25
RO91871B (en) 1987-07-31
ID21142A (en) 1999-04-29
FI80453B (en) 1990-02-28
AU8180487A (en) 1988-03-24
AT389698B (en) 1990-01-10
AT390258B (en) 1990-04-10
EG17339A (en) 1989-06-30
NL9100648A (en) 1991-08-01
NO162238B (en) 1989-08-21
GB2158825A (en) 1985-11-20
PT80349B (en) 1987-09-30
PL253108A1 (en) 1985-12-17
ES8706673A1 (en) 1987-07-01
GB2191776A (en) 1987-12-23
FR2563521A1 (en) 1985-10-31
PT80349A (en) 1985-05-01
SE8502017D0 (en) 1985-04-25
DK185685D0 (en) 1985-04-25
DE3514076A1 (en) 1985-10-31
RO91871A (en) 1987-07-30
IT1209953B (en) 1989-08-30
FR2614620B1 (en) 1990-03-09
JPS60228479A (en) 1985-11-13
AR241911A1 (en) 1993-01-29
DE3546658C2 (en) 1992-04-02
NL8501172A (en) 1985-11-18
ES551538A0 (en) 1987-07-01
LU85871A1 (en) 1985-12-16
PH25228A (en) 1991-03-27
SE8804586D0 (en) 1988-12-20
GB2191776B (en) 1990-03-28
NZ211895A (en) 1988-07-28
HU197571B (en) 1989-04-28
PL147392B1 (en) 1989-05-31
BE902279A (en) 1985-10-25
AU565087B2 (en) 1987-09-03
AU4165085A (en) 1985-10-31
GB8716897D0 (en) 1987-08-26
NO851643L (en) 1985-10-28
KR870001693B1 (en) 1987-09-24
GB2158825B (en) 1989-01-25
FI851637A0 (en) 1985-04-25
IL75021A0 (en) 1985-08-30
KR850007596A (en) 1985-12-07
ZA853102B (en) 1986-12-30
RO95509A (en) 1988-09-30
ATA122485A (en) 1989-06-15
CS250684B2 (en) 1987-05-14
PH25046A (en) 1991-01-28
FI851637L (en) 1985-10-27
SE8502017L (en) 1985-10-27

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Effective date: 20050423