FR2614620B1 - 1,4-DIHYDRO-4-OXONAPHTYRIDINE DERIVATIVES AND SALTS THEREOF, PROCESS FOR THEIR PRODUCTION AND ANTI-BACTERIAL AGENTS CONTAINING THEM - Google Patents

1,4-DIHYDRO-4-OXONAPHTYRIDINE DERIVATIVES AND SALTS THEREOF, PROCESS FOR THEIR PRODUCTION AND ANTI-BACTERIAL AGENTS CONTAINING THEM

Info

Publication number
FR2614620B1
FR2614620B1 FR888808836A FR8808836A FR2614620B1 FR 2614620 B1 FR2614620 B1 FR 2614620B1 FR 888808836 A FR888808836 A FR 888808836A FR 8808836 A FR8808836 A FR 8808836A FR 2614620 B1 FR2614620 B1 FR 2614620B1
Authority
FR
France
Prior art keywords
oxonaphtyridine
dihydro
derivatives
salts
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR888808836A
Other languages
French (fr)
Other versions
FR2614620A1 (en
Inventor
Hirokazu Narita
Yoshinori Konishi
Jun Nitta
Hideyoshi Nagaki
Isao Kitayama
Yoriko Kobayashi
Mikako Shinagawa
Yasuho Watanabe
Akira Yotsuji
Shinzaburo Minami
Isamu Saikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13845280&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2614620(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of FR2614620A1 publication Critical patent/FR2614620A1/en
Application granted granted Critical
Publication of FR2614620B1 publication Critical patent/FR2614620B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FR888808836A 1984-04-26 1988-06-30 1,4-DIHYDRO-4-OXONAPHTYRIDINE DERIVATIVES AND SALTS THEREOF, PROCESS FOR THEIR PRODUCTION AND ANTI-BACTERIAL AGENTS CONTAINING THEM Expired - Lifetime FR2614620B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59084963A JPS60228479A (en) 1984-04-26 1984-04-26 1,4-dihydro-4-oxonaphthyridine derivative and salt thereof

Publications (2)

Publication Number Publication Date
FR2614620A1 FR2614620A1 (en) 1988-11-04
FR2614620B1 true FR2614620B1 (en) 1990-03-09

Family

ID=13845280

Family Applications (2)

Application Number Title Priority Date Filing Date
FR858506327A Expired FR2563521B1 (en) 1984-04-26 1985-04-25 1,4-DIHYDRO-4-OXONAPHTYRIDINE DERIVATIVES AND THEIR SALTS, PROCESS FOR THEIR PRODUCTION AND ANTIBACTERIAL AGENTS CONTAINING THEM
FR888808836A Expired - Lifetime FR2614620B1 (en) 1984-04-26 1988-06-30 1,4-DIHYDRO-4-OXONAPHTYRIDINE DERIVATIVES AND SALTS THEREOF, PROCESS FOR THEIR PRODUCTION AND ANTI-BACTERIAL AGENTS CONTAINING THEM

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR858506327A Expired FR2563521B1 (en) 1984-04-26 1985-04-25 1,4-DIHYDRO-4-OXONAPHTYRIDINE DERIVATIVES AND THEIR SALTS, PROCESS FOR THEIR PRODUCTION AND ANTIBACTERIAL AGENTS CONTAINING THEM

Country Status (30)

Country Link
JP (1) JPS60228479A (en)
KR (1) KR870001693B1 (en)
AR (1) AR241911A1 (en)
AT (2) AT389698B (en)
AU (2) AU565087B2 (en)
BE (1) BE902279A (en)
CH (1) CH673458A5 (en)
CS (1) CS250684B2 (en)
DD (1) DD238795A5 (en)
DE (2) DE3546658C2 (en)
DK (1) DK165877C (en)
EG (1) EG17339A (en)
ES (2) ES8700256A1 (en)
FI (1) FI80453C (en)
FR (2) FR2563521B1 (en)
GB (2) GB2158825B (en)
HU (2) HU194226B (en)
ID (1) ID21142A (en)
IL (1) IL75021A (en)
IT (1) IT1209953B (en)
LU (1) LU85871A1 (en)
NL (2) NL187314C (en)
NO (1) NO162238C (en)
NZ (1) NZ211895A (en)
PH (3) PH22801A (en)
PL (1) PL147392B1 (en)
PT (1) PT80349B (en)
RO (2) RO95509B (en)
SE (2) SE463102B (en)
ZA (1) ZA853102B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6172753A (en) * 1984-09-18 1986-04-14 Dainippon Pharmaceut Co Ltd Pyridyl ketone derivative
AT392789B (en) * 1985-01-23 1991-06-10 Toyama Chemical Co Ltd METHOD FOR PRODUCING 1-SUBSTITUTED ARYL-1,4-DIHYDRO-4-OXONAPHTHYRIDINE DERIVATIVES
AU576657B2 (en) * 1985-01-23 1988-09-01 Toyama Chemical Co. Ltd. Naphthyridine and pyridine derivatives
DE3525108A1 (en) * 1985-06-07 1986-12-11 Bayer Ag, 5090 Leverkusen ANTIBACTERIAL EFFECT OF CHINOLON CARBON ACID ESTERS
EP0207420B1 (en) * 1985-06-26 1992-05-06 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives
US4962112A (en) * 1987-08-04 1990-10-09 Abbott Laboratories 7-(2-methyl-4-aminopyrrolidinyl)naphthryidine and quinoline compounds
IE62600B1 (en) * 1987-08-04 1995-02-22 Abbott Lab Naphtyridine antianaerobic compounds
US4859776A (en) * 1988-03-11 1989-08-22 Abbott Laboratories (S)-7-(3-aminopyrrolidin-1-yl)-1-(ortho, para-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid and method for its preparation
JP2844079B2 (en) * 1988-05-23 1999-01-06 塩野義製薬株式会社 Pyridonecarboxylic acid antibacterial agent
DE3934082A1 (en) * 1989-10-12 1991-04-18 Bayer Ag CHINOLON CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS AN ANTIVIRAL AGENT
CA2100242A1 (en) * 1991-01-14 1992-07-15 Soon K. Moon Quinolone compounds and processes for preparation thereof
FR2692577B1 (en) * 1992-05-26 1996-02-02 Bouchara Sa NOVEL FLUORINATED QUINOLONES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
KR940014395A (en) * 1992-12-09 1994-07-18 강박광 Novel quinolone derivatives and preparation methods thereof
KR0148277B1 (en) * 1993-01-18 1998-11-02 채영복 Novel fluoroquinolone derivatives and process for the preparation thereof
AU4272793A (en) * 1993-04-24 1994-11-21 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and process for preparing the same
KR950018003A (en) * 1993-12-09 1995-07-22 스미스클라인 비참 피엘씨 Novel quinolone derivatives and methods for their preparation
DE69531305T2 (en) * 1994-10-20 2004-05-13 Wakunaga Seiyaku K.K. PYRIDONE CARBOXYLATE DERIVATIVES OR SALTS THEREOF AND ANTIBACTERIAL COMPOSITIONS CONTAINING THEM AS AN ACTIVE COMPONENT
EP0897919B1 (en) 1996-04-19 2004-06-16 Wakunaga Pharmaceutical Co., Ltd. Novel pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents containing the same as the active ingredient
EP0935600A1 (en) * 1996-10-30 1999-08-18 Bayer Ag Method or producing naphthyridine compounds and novel intermediate products
DE19713506A1 (en) 1997-04-01 1998-10-08 Bayer Ag Process for the preparation of 2,6-dichloro-5-fluoronicotinonitrile and the chemical compound 3-cyano-2-hydroxy-5-fluoropyrid-6-one monosodium salt and its tautomers
CN1343128B (en) 1999-03-17 2010-04-21 第一制药株式会社 Medicinal compositions
US6441182B1 (en) 1999-06-10 2002-08-27 Bayer Aktiengesellschaft Method for the production of 2,6-dichloro-5-fluoro-nicotinic acid and coarse and particularly pure 2,6-dichloro-5-fluoro-nicotinic acid
WO2001017991A1 (en) 1999-09-02 2001-03-15 Wakunaga Pharmaceutical Co., Ltd. Quinolinecarboxylic acid derivative or its salt
EP1313708A1 (en) * 2000-08-29 2003-05-28 Chiron Corporation Quinoline antibacterial compounds and methods of use thereof
KR100981351B1 (en) * 2003-10-29 2010-09-10 주식회사 엘지생명과학 Process for preparing 7-chloro-1-cyclopropyl-6- fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CN101792443A (en) * 2010-03-09 2010-08-04 北京欧凯纳斯科技有限公司 Fluoro-carbostyril derivative as well as preparation method and application thereof
JOP20190045A1 (en) 2016-09-14 2019-03-14 Bayer Ag 7-substituted 1-aryl-naphthyridine-3-carboxylic acid amides and use thereof
CN114369092A (en) * 2021-12-20 2022-04-19 赤峰万泽药业股份有限公司 Tosufloxacin tosylate and preparation method thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2125310A1 (en) * 1971-05-21 1972-11-30 Sterling Drug Inc , New York, NY (V St A) 1-alkyl-1,4-dihydro-4-oxo-1,8-naphtyridine 3-carboxylic acids antibac
AR223983A1 (en) * 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co A PROCEDURE FOR PREPARING 6-HALOGEN-4-OXO-7- (1-PIPERAZINYL) -1,8-NAFTIRIDIN-3-CARBOXYLIC ACID DERIVATIVES
DE3033157A1 (en) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-AMINO-1-CYCLOPROPYL-4-OXO-1,4-DIHYDRO-NAPHTHYRIDINE-3-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM
US4382937A (en) 1981-02-27 1983-05-10 Dainippon Pharmaceutical Co., Ltd. Naphthyridine derivatives and their use as anti-bacterials
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
NZ210847A (en) * 1984-01-26 1988-02-29 Abbott Lab Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions
IL74064A (en) * 1984-01-26 1988-09-30 Abbott Lab 1,7-disubstituted-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivatives and antibacterial compositions containing them
AU576657B2 (en) * 1985-01-23 1988-09-01 Toyama Chemical Co. Ltd. Naphthyridine and pyridine derivatives
DE3525108A1 (en) * 1985-06-07 1986-12-11 Bayer Ag, 5090 Leverkusen ANTIBACTERIAL EFFECT OF CHINOLON CARBON ACID ESTERS

Also Published As

Publication number Publication date
JPS6320828B2 (en) 1988-04-30
AR241911A1 (en) 1993-01-29
IL75021A0 (en) 1985-08-30
GB2191776B (en) 1990-03-28
PL147392B1 (en) 1989-05-31
NO162238C (en) 1989-12-06
AT389698B (en) 1990-01-10
AU8180487A (en) 1988-03-24
CS250684B2 (en) 1987-05-14
AU565087B2 (en) 1987-09-03
KR870001693B1 (en) 1987-09-24
IL75021A (en) 1994-01-25
HU197571B (en) 1989-04-28
DK185685A (en) 1985-10-27
RO95509A (en) 1988-09-30
FR2563521B1 (en) 1989-02-03
KR850007596A (en) 1985-12-07
FI80453B (en) 1990-02-28
IT8548002A0 (en) 1985-04-26
SE501412C2 (en) 1995-02-13
FR2563521A1 (en) 1985-10-31
HU194226B (en) 1988-01-28
NL9100648A (en) 1991-08-01
NO162238B (en) 1989-08-21
RO95509B (en) 1988-10-01
EG17339A (en) 1989-06-30
HUT38634A (en) 1986-06-30
ATA267888A (en) 1989-09-15
GB2158825A (en) 1985-11-20
SE8804586D0 (en) 1988-12-20
PL253108A1 (en) 1985-12-17
LU85871A1 (en) 1985-12-16
SE8502017D0 (en) 1985-04-25
DK185685D0 (en) 1985-04-25
ES8700256A1 (en) 1986-09-16
CH673458A5 (en) 1990-03-15
GB8716897D0 (en) 1987-08-26
BE902279A (en) 1985-10-25
PH25228A (en) 1991-03-27
DK165877C (en) 1993-06-21
RO91871A (en) 1987-07-30
DK165877B (en) 1993-02-01
FI80453C (en) 1990-06-11
NL187314C (en) 1991-08-16
NO851643L (en) 1985-10-28
DE3546658C2 (en) 1992-04-02
SE8502017L (en) 1985-10-27
ES8706673A1 (en) 1987-07-01
GB2191776A (en) 1987-12-23
ES551538A0 (en) 1987-07-01
PH25046A (en) 1991-01-28
ATA122485A (en) 1989-06-15
PH22801A (en) 1988-12-12
NZ211895A (en) 1988-07-28
PT80349A (en) 1985-05-01
GB2158825B (en) 1989-01-25
DE3514076C2 (en) 1989-03-30
DE3514076A1 (en) 1985-10-31
JPS60228479A (en) 1985-11-13
SE8804586L (en) 1988-12-20
ES542584A0 (en) 1986-09-16
PT80349B (en) 1987-09-30
IT1209953B (en) 1989-08-30
AU612993B2 (en) 1991-07-25
AT390258B (en) 1990-04-10
GB8510297D0 (en) 1985-05-30
FI851637L (en) 1985-10-27
NL8501172A (en) 1985-11-18
FR2614620A1 (en) 1988-11-04
DD238795A5 (en) 1986-09-03
SE463102B (en) 1990-10-08
ZA853102B (en) 1986-12-30
ID21142A (en) 1999-04-29
FI851637A0 (en) 1985-04-25
AU4165085A (en) 1985-10-31
RO91871B (en) 1987-07-31

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