DK165877C - 1,4-DIHYDRO-6-FLUORO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID DERIVATIVES AND SALTS THEREOF, ANTIBACTERIAL PREPARATIONS CONTAINING SUCH COMPOUNDS - Google Patents
1,4-DIHYDRO-6-FLUORO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID DERIVATIVES AND SALTS THEREOF, ANTIBACTERIAL PREPARATIONS CONTAINING SUCH COMPOUNDSInfo
- Publication number
- DK165877C DK165877C DK185685A DK185685A DK165877C DK 165877 C DK165877 C DK 165877C DK 185685 A DK185685 A DK 185685A DK 185685 A DK185685 A DK 185685A DK 165877 C DK165877 C DK 165877C
- Authority
- DK
- Denmark
- Prior art keywords
- naphthyridine
- dihydro
- oxo
- fluoro
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8496384 | 1984-04-26 | ||
JP59084963A JPS60228479A (en) | 1984-04-26 | 1984-04-26 | 1,4-dihydro-4-oxonaphthyridine derivative and salt thereof |
Publications (4)
Publication Number | Publication Date |
---|---|
DK185685D0 DK185685D0 (en) | 1985-04-25 |
DK185685A DK185685A (en) | 1985-10-27 |
DK165877B DK165877B (en) | 1993-02-01 |
DK165877C true DK165877C (en) | 1993-06-21 |
Family
ID=13845280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK185685A DK165877C (en) | 1984-04-26 | 1985-04-25 | 1,4-DIHYDRO-6-FLUORO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID DERIVATIVES AND SALTS THEREOF, ANTIBACTERIAL PREPARATIONS CONTAINING SUCH COMPOUNDS |
Country Status (30)
Country | Link |
---|---|
JP (1) | JPS60228479A (en) |
KR (1) | KR870001693B1 (en) |
AR (1) | AR241911A1 (en) |
AT (2) | AT389698B (en) |
AU (2) | AU565087B2 (en) |
BE (1) | BE902279A (en) |
CH (1) | CH673458A5 (en) |
CS (1) | CS250684B2 (en) |
DD (1) | DD238795A5 (en) |
DE (2) | DE3546658C2 (en) |
DK (1) | DK165877C (en) |
EG (1) | EG17339A (en) |
ES (2) | ES8700256A1 (en) |
FI (1) | FI80453C (en) |
FR (2) | FR2563521B1 (en) |
GB (2) | GB2158825B (en) |
HU (2) | HU197571B (en) |
ID (1) | ID21142A (en) |
IL (1) | IL75021A (en) |
IT (1) | IT1209953B (en) |
LU (1) | LU85871A1 (en) |
NL (2) | NL187314C (en) |
NO (1) | NO162238C (en) |
NZ (1) | NZ211895A (en) |
PH (3) | PH22801A (en) |
PL (1) | PL147392B1 (en) |
PT (1) | PT80349B (en) |
RO (2) | RO95509B (en) |
SE (2) | SE463102B (en) |
ZA (1) | ZA853102B (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6172753A (en) * | 1984-09-18 | 1986-04-14 | Dainippon Pharmaceut Co Ltd | Pyridyl ketone derivative |
AU576657B2 (en) * | 1985-01-23 | 1988-09-01 | Toyama Chemical Co. Ltd. | Naphthyridine and pyridine derivatives |
AT392789B (en) * | 1985-01-23 | 1991-06-10 | Toyama Chemical Co Ltd | METHOD FOR PRODUCING 1-SUBSTITUTED ARYL-1,4-DIHYDRO-4-OXONAPHTHYRIDINE DERIVATIVES |
DE3525108A1 (en) * | 1985-06-07 | 1986-12-11 | Bayer Ag, 5090 Leverkusen | ANTIBACTERIAL EFFECT OF CHINOLON CARBON ACID ESTERS |
EP0207420B1 (en) * | 1985-06-26 | 1992-05-06 | Daiichi Pharmaceutical Co., Ltd. | Pyridonecarboxylic acid derivatives |
US4962112A (en) * | 1987-08-04 | 1990-10-09 | Abbott Laboratories | 7-(2-methyl-4-aminopyrrolidinyl)naphthryidine and quinoline compounds |
IE62600B1 (en) * | 1987-08-04 | 1995-02-22 | Abbott Lab | Naphtyridine antianaerobic compounds |
US4859776A (en) * | 1988-03-11 | 1989-08-22 | Abbott Laboratories | (S)-7-(3-aminopyrrolidin-1-yl)-1-(ortho, para-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid and method for its preparation |
JP2844079B2 (en) * | 1988-05-23 | 1999-01-06 | 塩野義製薬株式会社 | Pyridonecarboxylic acid antibacterial agent |
DE3934082A1 (en) * | 1989-10-12 | 1991-04-18 | Bayer Ag | CHINOLON CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS AN ANTIVIRAL AGENT |
WO1992012155A1 (en) * | 1991-01-14 | 1992-07-23 | Hanmi Pharmaceutical Co., Ltd. | Novel quinolone compounds and processes for preparation thereof |
FR2692577B1 (en) * | 1992-05-26 | 1996-02-02 | Bouchara Sa | NOVEL FLUORINATED QUINOLONES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. |
KR940014395A (en) * | 1992-12-09 | 1994-07-18 | 강박광 | Novel quinolone derivatives and preparation methods thereof |
KR0148277B1 (en) * | 1993-01-18 | 1998-11-02 | 채영복 | Novel fluoroquinolone derivatives and process for the preparation thereof |
WO1994025464A1 (en) * | 1993-04-24 | 1994-11-10 | Korea Research Institute Of Chemical Technology | Novel quinolone carboxylic acid derivatives and process for preparing the same |
KR950018003A (en) * | 1993-12-09 | 1995-07-22 | 스미스클라인 비참 피엘씨 | Novel quinolone derivatives and methods for their preparation |
EP0787720B1 (en) * | 1994-10-20 | 2003-07-16 | Wakunaga Seiyaku Kabushiki Kaisha | Pyridonecarboxylate derivative or salt thereof and antibacterial containing the same as active ingredient |
WO1997040036A1 (en) | 1996-04-19 | 1997-10-30 | Wakunaga Pharmaceutical Co., Ltd. | Novel pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents containing the same as the active ingredient |
CZ154999A3 (en) * | 1996-10-30 | 1999-08-11 | Bayer Aktiengesellschaft | Process for preparing naphthyridine compounds and novel intermediates for such preparation |
DE19713506A1 (en) | 1997-04-01 | 1998-10-08 | Bayer Ag | Process for the preparation of 2,6-dichloro-5-fluoronicotinonitrile and the chemical compound 3-cyano-2-hydroxy-5-fluoropyrid-6-one monosodium salt and its tautomers |
KR100768034B1 (en) | 1999-03-17 | 2007-10-17 | 다이이찌 세이야꾸 가부시기가이샤 | Pharmaceutical composition |
DE19926400A1 (en) | 1999-06-10 | 2000-12-14 | Bayer Ag | Improved process for the preparation of 2,6-dichloro-5-fluoro-nicotinic acid and coarse and particularly pure 2,6-dichloro-5-fluoro-nicotinic acid |
WO2001017991A1 (en) | 1999-09-02 | 2001-03-15 | Wakunaga Pharmaceutical Co., Ltd. | Quinolinecarboxylic acid derivative or its salt |
EP1313708A1 (en) * | 2000-08-29 | 2003-05-28 | Chiron Corporation | Quinoline antibacterial compounds and methods of use thereof |
KR100981351B1 (en) * | 2003-10-29 | 2010-09-10 | 주식회사 엘지생명과학 | Process for preparing 7-chloro-1-cyclopropyl-6- fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid |
CN101792443A (en) * | 2010-03-09 | 2010-08-04 | 北京欧凯纳斯科技有限公司 | Fluoro-carbostyril derivative as well as preparation method and application thereof |
JOP20190045A1 (en) | 2016-09-14 | 2019-03-14 | Bayer Ag | 7-substituted 1-aryl-naphthyridine-3-carboxylic acid amides and use thereof |
CN114369092A (en) * | 2021-12-20 | 2022-04-19 | 赤峰万泽药业股份有限公司 | Tosufloxacin tosylate and preparation method thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2125310A1 (en) * | 1971-05-21 | 1972-11-30 | Sterling Drug Inc , New York, NY (V St A) | 1-alkyl-1,4-dihydro-4-oxo-1,8-naphtyridine 3-carboxylic acids antibac |
AR223983A1 (en) * | 1978-08-25 | 1981-10-15 | Dainippon Pharmaceutical Co | A PROCEDURE FOR PREPARING 6-HALOGEN-4-OXO-7- (1-PIPERAZINYL) -1,8-NAFTIRIDIN-3-CARBOXYLIC ACID DERIVATIVES |
DE3033157A1 (en) * | 1980-09-03 | 1982-04-01 | Bayer Ag, 5090 Leverkusen | 7-AMINO-1-CYCLOPROPYL-4-OXO-1,4-DIHYDRO-NAPHTHYRIDINE-3-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM |
US4382937A (en) * | 1981-02-27 | 1983-05-10 | Dainippon Pharmaceutical Co., Ltd. | Naphthyridine derivatives and their use as anti-bacterials |
IE55898B1 (en) * | 1982-09-09 | 1991-02-14 | Warner Lambert Co | Antibacterial agents |
NZ210847A (en) * | 1984-01-26 | 1988-02-29 | Abbott Lab | Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions |
IL74064A (en) * | 1984-01-26 | 1988-09-30 | Abbott Lab | 1,7-disubstituted-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivatives and antibacterial compositions containing them |
AU576657B2 (en) * | 1985-01-23 | 1988-09-01 | Toyama Chemical Co. Ltd. | Naphthyridine and pyridine derivatives |
DE3525108A1 (en) * | 1985-06-07 | 1986-12-11 | Bayer Ag, 5090 Leverkusen | ANTIBACTERIAL EFFECT OF CHINOLON CARBON ACID ESTERS |
-
1984
- 1984-04-26 JP JP59084963A patent/JPS60228479A/en active Granted
-
1985
- 1985-04-18 DE DE3546658A patent/DE3546658C2/de not_active Expired - Lifetime
- 1985-04-18 DE DE19853514076 patent/DE3514076A1/en active Granted
- 1985-04-23 NL NLAANVRAGE8501172,A patent/NL187314C/en not_active IP Right Cessation
- 1985-04-23 PH PH32174A patent/PH22801A/en unknown
- 1985-04-23 GB GB08510297A patent/GB2158825B/en not_active Expired
- 1985-04-24 IL IL7502185A patent/IL75021A/en not_active IP Right Cessation
- 1985-04-24 NZ NZ211895A patent/NZ211895A/en unknown
- 1985-04-24 AU AU41650/85A patent/AU565087B2/en not_active Expired
- 1985-04-24 RO RO126286A patent/RO95509B/en unknown
- 1985-04-24 AT AT0122485A patent/AT389698B/en not_active IP Right Cessation
- 1985-04-24 PT PT80349A patent/PT80349B/en unknown
- 1985-04-24 DD DD85275518A patent/DD238795A5/en unknown
- 1985-04-24 EG EG261/85A patent/EG17339A/en active
- 1985-04-24 RO RO118517A patent/RO91871B/en unknown
- 1985-04-24 NO NO851643A patent/NO162238C/en not_active IP Right Cessation
- 1985-04-25 ZA ZA853102A patent/ZA853102B/en unknown
- 1985-04-25 AR AR85300190A patent/AR241911A1/en active
- 1985-04-25 KR KR1019850002822A patent/KR870001693B1/en not_active IP Right Cessation
- 1985-04-25 CS CS853035A patent/CS250684B2/en not_active IP Right Cessation
- 1985-04-25 HU HU873675A patent/HU197571B/en unknown
- 1985-04-25 DK DK185685A patent/DK165877C/en not_active IP Right Cessation
- 1985-04-25 FI FI851637A patent/FI80453C/en not_active IP Right Cessation
- 1985-04-25 ES ES542584A patent/ES8700256A1/en not_active Expired
- 1985-04-25 CH CH1798/85A patent/CH673458A5/de not_active IP Right Cessation
- 1985-04-25 BE BE0/214909A patent/BE902279A/en not_active IP Right Cessation
- 1985-04-25 ID IDP980525A patent/ID21142A/en unknown
- 1985-04-25 SE SE8502017A patent/SE463102B/en not_active IP Right Cessation
- 1985-04-25 FR FR858506327A patent/FR2563521B1/en not_active Expired
- 1985-04-25 HU HU851599A patent/HU194226B/en unknown
- 1985-04-26 IT IT8548002A patent/IT1209953B/en active
- 1985-04-26 PL PL1985253108A patent/PL147392B1/en unknown
- 1985-04-26 LU LU85871A patent/LU85871A1/en unknown
-
1986
- 1986-01-31 ES ES551538A patent/ES8706673A1/en not_active Expired
-
1987
- 1987-07-17 GB GB8716897A patent/GB2191776B/en not_active Expired - Lifetime
- 1987-10-20 PH PH35958A patent/PH25046A/en unknown
- 1987-10-20 PH PH35960A patent/PH25228A/en unknown
- 1987-11-25 AU AU81804/87A patent/AU612993B2/en not_active Expired
-
1988
- 1988-06-30 FR FR888808836A patent/FR2614620B1/en not_active Expired - Lifetime
- 1988-10-31 AT AT0267888A patent/AT390258B/en not_active IP Right Cessation
- 1988-12-20 SE SE8804586A patent/SE501412C2/en not_active IP Right Cessation
-
1991
- 1991-04-15 NL NL9100648A patent/NL9100648A/en not_active Application Discontinuation
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PUP | Patent expired |