NL178968C - Werkwijze voor het bereiden van tetramethylchroman-derivaten, alsmede voor het bereiden van tocoferolen uit deze chromanderivaten. - Google Patents

Werkwijze voor het bereiden van tetramethylchroman-derivaten, alsmede voor het bereiden van tocoferolen uit deze chromanderivaten.

Info

Publication number
NL178968C
NL178968C NLAANVRAGE7317590,A NL7317590A NL178968C NL 178968 C NL178968 C NL 178968C NL 7317590 A NL7317590 A NL 7317590A NL 178968 C NL178968 C NL 178968C
Authority
NL
Netherlands
Prior art keywords
preparing
chroman derivatives
tocoferols
tetramethyl
derivatives
Prior art date
Application number
NLAANVRAGE7317590,A
Other languages
English (en)
Other versions
NL7317590A (nl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NL7317590A publication Critical patent/NL7317590A/xx
Application granted granted Critical
Publication of NL178968C publication Critical patent/NL178968C/nl

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B5/00Preserving by using additives, e.g. anti-oxidants
    • C11B5/0021Preserving by using additives, e.g. anti-oxidants containing oxygen
    • C11B5/0035Phenols; Their halogenated and aminated derivates, their salts, their esters with carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/093Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/14Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of a —CHO group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • C07C29/80Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by distillation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/52Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/723,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K15/00Anti-oxidant compositions; Compositions inhibiting chemical change
    • C09K15/04Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
    • C09K15/06Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing oxygen
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K15/00Anti-oxidant compositions; Compositions inhibiting chemical change
    • C09K15/04Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
    • C09K15/06Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing oxygen
    • C09K15/08Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing oxygen containing a phenol or quinone moiety
    • CCHEMISTRY; METALLURGY
    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M1/00Liquid compositions essentially based on mineral lubricating oils or fatty oils; Their use as lubricants
    • C10M1/08Liquid compositions essentially based on mineral lubricating oils or fatty oils; Their use as lubricants with additives
    • CCHEMISTRY; METALLURGY
    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2207/00Organic non-macromolecular hydrocarbon compounds containing hydrogen, carbon and oxygen as ingredients in lubricant compositions
    • C10M2207/28Esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Edible Oils And Fats (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Fats And Perfumes (AREA)
NLAANVRAGE7317590,A 1972-12-22 1973-12-21 Werkwijze voor het bereiden van tetramethylchroman-derivaten, alsmede voor het bereiden van tocoferolen uit deze chromanderivaten. NL178968C (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31756672A 1972-12-22 1972-12-22

Publications (2)

Publication Number Publication Date
NL7317590A NL7317590A (nl) 1974-06-25
NL178968C true NL178968C (nl) 1986-06-16

Family

ID=23234257

Family Applications (2)

Application Number Title Priority Date Filing Date
NLAANVRAGE7317590,A NL178968C (nl) 1972-12-22 1973-12-21 Werkwijze voor het bereiden van tetramethylchroman-derivaten, alsmede voor het bereiden van tocoferolen uit deze chromanderivaten.
NL7317587A NL7317587A (nl) 1972-12-22 1973-12-21

Family Applications After (1)

Application Number Title Priority Date Filing Date
NL7317587A NL7317587A (nl) 1972-12-22 1973-12-21

Country Status (21)

Country Link
JP (3) JPS4988876A (nl)
KR (1) KR780000008B1 (nl)
AR (1) AR200751A1 (nl)
AT (1) AT333755B (nl)
BE (2) BE808943A (nl)
CA (1) CA1022562A (nl)
CH (3) CH603617A5 (nl)
DD (1) DD109624A5 (nl)
DE (2) DE2364141A1 (nl)
ES (1) ES421683A1 (nl)
FR (2) FR2255299B1 (nl)
GB (4) GB1456830A (nl)
HU (1) HU168043B (nl)
IE (1) IE38671B1 (nl)
IL (1) IL43888A (nl)
LU (1) LU69067A1 (nl)
NL (2) NL178968C (nl)
PH (1) PH11133A (nl)
SE (1) SE406912B (nl)
SU (1) SU518135A3 (nl)
ZA (1) ZA739471B (nl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH618695A5 (en) * 1975-01-27 1980-08-15 Hoffmann La Roche Process for the preparation of chromane derivatives
DE2820861A1 (de) * 1977-05-16 1978-11-23 Hoffmann La Roche Chromanderivate
US4150050A (en) * 1978-01-30 1979-04-17 Hoffmann-La Roche Inc. 3,6-Dioxo-1,4-cyclohexadien-1-yl-butandate esters
DE2861183D1 (en) * 1978-01-30 1981-12-24 Hoffmann La Roche Process for the preparation of chromane derivatives
DE2909601A1 (de) * 1979-03-12 1980-09-25 Basf Ag Verfahren zur herstellung von chromanderivaten
DE3010505A1 (de) * 1980-03-19 1981-10-01 Basf Ag, 6700 Ludwigshafen Chromanderivate, verfahren zu ihrer herstellung, ihre verwendung als stabilisatoren von organischen materialien sowie diese stabilisatoren enthaltende organische materialien
DE3010504A1 (de) * 1980-03-19 1981-10-01 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von 2-hydroxyalkylchromanen
DE3103707A1 (de) * 1981-02-04 1982-08-19 Basf Ag, 6700 Ludwigshafen Chromanderivate
DE3103740A1 (de) * 1981-02-04 1982-08-19 Basf Ag, 6700 Ludwigshafen Chromanderivate
JPS57136582A (en) * 1981-02-19 1982-08-23 Eisai Co Ltd Preparation of optically active alpha-tocopherol
JPS57145871A (en) * 1981-03-05 1982-09-09 Eisai Co Ltd Chromanolcarboxylic derivative
DE3139238A1 (de) * 1981-10-02 1983-04-21 Basf Ag, 6700 Ludwigshafen Optisch aktive bausteine fuer die synthese der seitenkette von (r,r,r)-(alpha)-tocopherol sowie verfahren zu deren herstellung
ATE23337T1 (de) * 1982-12-23 1986-11-15 Ici America Inc Chromanverbindungen.
ZA844519B (en) * 1983-06-24 1985-02-27 Hoffmann La Roche Dihydrobenzopyran derivatives
ATE41151T1 (de) * 1986-01-23 1989-03-15 Hoffmann La Roche 3,4-dihydro-2,5,7,8-tetramethyl-2h-1benzopyranderivate und verfahren zu ihrer herstellung.
US4987231A (en) * 1989-08-04 1991-01-22 Pfizer Inc. Optical resolution method for 3R-(3-carboxybenzyl)-6-(5-fluoro-2-benzothiazolyl)methoxy-4R-chromanol
CA2082004A1 (en) * 1991-11-20 1993-05-21 David Laffan Substituted pentaalkylchromans
DE19859251A1 (de) * 1998-12-22 2000-06-29 Basf Ag Verfahren zur Herstellung von substituierten Chromanderivaten
WO2002012221A1 (fr) * 2000-08-03 2002-02-14 Kuraray Co., Ltd. Procede de resolution optique de l'acide (±)-6-hydroxy-2,5,7,8,-tetramethyle de coumarone-2-carboxylique
WO2005073212A1 (ja) * 2004-01-30 2005-08-11 Mitsubishi Gas Chemical Company, Inc. クロマン化合物の製造方法
KR101233223B1 (ko) * 2004-12-21 2013-02-14 제이엔씨 석유 화학 주식회사 크로만환을 가지는 액정 화합물, 액정 조성물 및 이 액정조성물을 함유하는 액정 표시소자
EP2522647B1 (en) * 2011-05-10 2014-04-30 DSM IP Assets B.V. Process of separating chiral isomers of chroman compounds and their derivatives and precursors
NL2010010C2 (en) 2012-12-19 2014-06-23 Sulfateq B V Compounds for protection of cells.
JPWO2021167095A1 (nl) * 2020-02-21 2021-08-26

Also Published As

Publication number Publication date
PH11133A (en) 1977-10-27
DD109624A5 (nl) 1974-11-12
ZA739471B (en) 1974-08-28
SU518135A3 (ru) 1976-06-15
AU6400973A (en) 1975-07-03
ATA1076973A (de) 1976-04-15
AR200751A1 (es) 1974-12-13
LU69067A1 (nl) 1975-08-20
CH605892A5 (nl) 1978-10-13
JPS4988876A (nl) 1974-08-24
HU168043B (nl) 1976-02-28
DE2364141A1 (de) 1974-06-27
IE38671L (en) 1974-06-22
BE808943A (fr) 1974-06-21
ES421683A1 (es) 1976-04-01
FR2284604A1 (fr) 1976-04-09
IL43888A (en) 1977-02-28
JPS6026795B2 (ja) 1985-06-25
AT333755B (de) 1976-12-10
CH603617A5 (nl) 1978-08-31
GB1456829A (en) 1976-11-24
CA1022562A (en) 1977-12-13
GB1456827A (en) 1976-11-24
GB1456830A (en) 1976-11-24
NL7317587A (nl) 1974-06-25
CH622257A5 (en) 1981-03-31
IE38671B1 (en) 1978-05-10
JPS59144780A (ja) 1984-08-18
JPS4988877A (nl) 1974-08-24
GB1456828A (en) 1976-11-24
NL7317590A (nl) 1974-06-25
FR2255299B1 (nl) 1977-06-10
SE406912B (sv) 1979-03-05
IL43888A0 (en) 1974-03-14
JPS5946233B2 (ja) 1984-11-10
FR2255299A1 (nl) 1975-07-18
FR2284604B1 (nl) 1979-05-11
KR780000008B1 (en) 1978-03-04
BE808942A (fr) 1974-06-21
DE2364165A1 (de) 1974-06-27

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Legal Events

Date Code Title Description
BC A request for examination has been filed
A85 Still pending on 85-01-01
V1 Lapsed because of non-payment of the annual fee