NL176459B - Farmaceutisch preparaat met remmende werking op aldose-reductase, alsmede tricyclisch, gecondenseerd heterocyclisch imide. - Google Patents

Farmaceutisch preparaat met remmende werking op aldose-reductase, alsmede tricyclisch, gecondenseerd heterocyclisch imide.

Info

Publication number
NL176459B
NL176459B NLAANVRAGE7900354,A NL7900354A NL176459B NL 176459 B NL176459 B NL 176459B NL 7900354 A NL7900354 A NL 7900354A NL 176459 B NL176459 B NL 176459B
Authority
NL
Netherlands
Prior art keywords
pharmaceutical preparation
aldose reductase
condensed heterocyclic
tricyclic condensed
heterocyclic imide
Prior art date
Application number
NLAANVRAGE7900354,A
Other languages
English (en)
Other versions
NL7900354A (nl
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NL7900354A publication Critical patent/NL7900354A/nl
Publication of NL176459B publication Critical patent/NL176459B/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NLAANVRAGE7900354,A 1978-01-18 1979-01-17 Farmaceutisch preparaat met remmende werking op aldose-reductase, alsmede tricyclisch, gecondenseerd heterocyclisch imide. NL176459B (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/870,542 US4127665A (en) 1978-01-18 1978-01-18 Thienohydantoin derivatives

Publications (2)

Publication Number Publication Date
NL7900354A NL7900354A (nl) 1979-07-20
NL176459B true NL176459B (nl) 1984-11-16

Family

ID=25355609

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7900354,A NL176459B (nl) 1978-01-18 1979-01-17 Farmaceutisch preparaat met remmende werking op aldose-reductase, alsmede tricyclisch, gecondenseerd heterocyclisch imide.

Country Status (11)

Country Link
US (1) US4127665A (nl)
JP (1) JPS54109975A (nl)
BE (1) BE873500A (nl)
DE (1) DE2901477C2 (nl)
DK (1) DK151260C (nl)
FR (1) FR2415112A1 (nl)
GB (1) GB2012759B (nl)
IE (1) IE47726B1 (nl)
IT (1) IT1110007B (nl)
LU (1) LU80795A1 (nl)
NL (1) NL176459B (nl)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4147797A (en) * 1978-08-11 1979-04-03 Pfizer Inc. Spiro-furanohydantoin derivatives
US4181728A (en) * 1978-11-16 1980-01-01 Pfizer Inc. Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) * 1979-03-21 1980-01-01 Pfizer Inc. Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4210667A (en) * 1979-04-19 1980-07-01 Pfizer Inc. Pharmaceutical preparations containing coumarin carboxylic acid derivatives
AU532110B2 (en) * 1979-11-13 1983-09-15 Ici Ltd. Spiro(imidazolidine-4,3:-indoline)-2,2:5-trione derivatives
EP0065393B1 (en) * 1981-05-12 1984-12-27 Imperial Chemical Industries Plc Pyrrole derivatives
US4436745A (en) 1982-04-15 1984-03-13 Alcon Laboratories, Inc. Method of inhibiting aldose reductase activity
US4540700A (en) * 1982-04-15 1985-09-10 Alcon Laboratories, Inc. Treatment of diabetic complications with certain spiro-imidazolidine-diones
US4438272A (en) 1982-04-15 1984-03-20 Alcon Laboratories, Inc. Spiro-(fluoren-9,4'-imidazolidine)-2',5'-diones
US4464385A (en) * 1982-04-15 1984-08-07 Alcon Laboratories, Inc. Treatment of diabetic complications with hydantoins
US5070100A (en) * 1983-09-14 1991-12-03 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives
US4864028A (en) * 1983-09-14 1989-09-05 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives
US4537892A (en) * 1983-09-14 1985-08-27 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
US5153211A (en) * 1983-09-14 1992-10-06 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
HU198212B (en) * 1984-07-20 1989-08-28 Pfizer Process for production of spiro-imidasolones
US4966911A (en) * 1984-11-20 1990-10-30 Washington Research Foundation Immunoregulatory agents
US5340829A (en) * 1984-11-20 1994-08-23 Washington Research Foundation Immunoregulatory agents
JP2708507B2 (ja) * 1988-04-07 1998-02-04 株式会社三和化学研究所 （ｄ）‐６‐フルオロ‐２，３‐ジヒドロ‐２’，５’‐ジオキソ‐スピロ［４Ｈ‐１‐ベンゾピラン‐４，４’‐イミダゾリジン］‐２‐カルボキサミド誘導体、これらの製法及び用途
EP0536119A4 (en) * 1989-02-10 1993-08-04 Washington Research Foundation Immunoregulatory agents
SG10201510665WA (en) 2009-12-04 2016-01-28 Sunovion Pharmaceuticals Inc Multicycle Compounds And Pharmaceutical Compositions Useful For The Treatment Of Neurological Disorders
MA45795A (fr) 2016-07-29 2019-06-05 Sunovion Pharmaceuticals Inc Composés et compositions, et utilisations associées
IL264446B1 (en) 2016-07-29 2024-05-01 Pgi Drug Discovery Llc Compounds and compositions and their use
IL268694B2 (en) 2017-02-16 2023-10-01 Sunovion Pharmaceuticals Inc Treatment of schizophrenia
BR112020001433A2 (pt) 2017-08-02 2020-07-28 Sunovion Pharmaceuticals Inc. compostos de isocromano e usos dos mesmos
KR20200122345A (ko) 2018-02-16 2020-10-27 선오비온 파마슈티컬스 인코포레이티드 염, 결정 형태 및 이들의 제조 방법
CA3130849A1 (en) 2019-03-14 2020-09-17 Sunovion Pharmaceuticals Inc. Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
KR20230003503A (ko) 2020-04-14 2023-01-06 선오비온 파마슈티컬스 인코포레이티드 신경학적 및 정신의학적 장애의 치료를 위한 (S)-(4,5-디히드로-7H-티에노[2,3-c]피란-7-일)-N-메틸메탄아민

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB796069A (en) * 1955-12-23 1958-06-04 Ici Ltd Substituted hydantoins
DE1135915B (de) * 1961-06-29 1962-09-06 Asta Werke Ag Chem Fab Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine
CA1088945A (en) * 1976-10-18 1980-11-04 Pfizer Limited Hydantoin derivatives as therapeutic agents

Also Published As

Publication number Publication date
IT7919369A0 (it) 1979-01-17
GB2012759A (en) 1979-08-01
DK19579A (da) 1979-07-19
NL7900354A (nl) 1979-07-20
FR2415112A1 (fr) 1979-08-17
IT1110007B (it) 1985-12-23
LU80795A1 (fr) 1979-09-07
BE873500A (fr) 1979-07-16
DK151260B (da) 1987-11-16
JPS54109975A (en) 1979-08-29
JPS612067B2 (nl) 1986-01-22
DE2901477A1 (de) 1979-07-19
IE47726B1 (en) 1984-05-30
US4127665A (en) 1978-11-28
DE2901477C2 (de) 1982-06-09
FR2415112B1 (nl) 1983-01-14
IE790088L (en) 1979-07-18
GB2012759B (en) 1982-05-26
DK151260C (da) 1988-05-09

Similar Documents

Publication Publication Date Title
NL176459B (nl) Farmaceutisch preparaat met remmende werking op aldose-reductase, alsmede tricyclisch, gecondenseerd heterocyclisch imide.
NL980035I2 (nl) Benzimidazolen, de bereiding daarvan en deze verbindingen bevattende geneesmiddelen.
FI872862A (fi) Foerfarande foer modifiering av substratmaterial foer anvaendning i roekningsartiklar och produkt framstaelld daermed.
NL930029I2 (nl) Enzymederivaten en bereiding daarvan.
NL7605499A (nl) Heupgewrichtsprotese.
IT7924811A0 (it) Acidi 2-pirrolidincarbossilici 5-sostituiti, antiipertensivi.
NL175016C (nl) Veldhakselaar.
NL7805814A (nl) Spiro-aminederivaten, de bereiding ervan, alsmede der- gelijke derivaten bevattende farmacologische prepara- ten.
NL190519B (nl) 4-gesubstitueerde fenylazijnzuurverbindingen, alsmede farmaceutische preparaten.
NL7900104A (nl) Axiale borging.
IT7927614A0 (it) 1,2,4,5-tetra-alchil-4-arilpiperidi ne e relative formulazioni farmaceutiche.
NL7902333A (nl) 3-acetoxy-9beta,11beta-epoxy-trienen en -dienen en de bereiding van de overeenkomstige 6alpha-halogeen-1,4- -dieen-3-onen en 6alpha-halogeen-4-een-3-onen.
NL7903769A (nl) Di-o-n-alkylglycerolderivaten en farmaceutische preparaten daarvan.
NL7902726A (nl) Sulfonato-organosilanolverbindingen en preparaten, welke deze bevatten.
NO793590L (no) Fremgangsmaate til fremstilling av klordioksyd, alkalilut og eventuelt klor.
NL7902863A (nl) 7alpha-methoxycefalosporine verbindingen, hun gebruik en bereiding.
IT7925387A0 (it) 2-amminoetil-1-fenil-indoline, loro preparazione e loro applicazione come medicamenti.
ATE8256T1 (de) Phenyliminomethyl-3-pyridin-derivate, ihre herstellung und verwendung.
ATE4563T1 (de) Sicherheitsanordnung.
ES244212Y (es) Llavero y recipiente combinados.
NL7903973A (nl) 1,2,4-triazolidinonen-3 en thionen-3.
NO152971C (no) Analogifremgangsmaate for fremstilling av n-(1-metyl-2-pyrrolidinyl-metyl)-2,3-dimetoksy-5-metylsulfamoyl-benzamid og derivater derav.
NL190120C (nl) 2,3-dihydro-4h-1-benzopyran-4-on-0-carbamoyloximen alsmede farmaceutisch preparaat daarvan.
IT7923000A0 (it) Arilalchil-e arilossialchil-fosfonati e loro preparazione.
IT8020503A0 (it) Derivati della 1,1'-bifenil-2-ilalchilammina ad azione farmaceutica.

Legal Events

Date Code Title Description
A1A A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
A85 Still pending on 85-01-01
V1 Lapsed because of non-payment of the annual fee