JPS54109975A - Thienohydantoin derivative - Google Patents

Thienohydantoin derivative

Info

Publication number
JPS54109975A
JPS54109975A JP444379A JP444379A JPS54109975A JP S54109975 A JPS54109975 A JP S54109975A JP 444379 A JP444379 A JP 444379A JP 444379 A JP444379 A JP 444379A JP S54109975 A JPS54109975 A JP S54109975A
Authority
JP
Japan
Prior art keywords
thienohydantoin
derivative
thienohydantoin derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP444379A
Other languages
English (en)
Other versions
JPS612067B2 (ja
Inventor
Saajizu Reinhaado
Kooguren Shiyunuaa Rodonii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of JPS54109975A publication Critical patent/JPS54109975A/ja
Publication of JPS612067B2 publication Critical patent/JPS612067B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP444379A 1978-01-18 1979-01-17 Thienohydantoin derivative Granted JPS54109975A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/870,542 US4127665A (en) 1978-01-18 1978-01-18 Thienohydantoin derivatives

Publications (2)

Publication Number Publication Date
JPS54109975A true JPS54109975A (en) 1979-08-29
JPS612067B2 JPS612067B2 (ja) 1986-01-22

Family

ID=25355609

Family Applications (1)

Application Number Title Priority Date Filing Date
JP444379A Granted JPS54109975A (en) 1978-01-18 1979-01-17 Thienohydantoin derivative

Country Status (11)

Country Link
US (1) US4127665A (ja)
JP (1) JPS54109975A (ja)
BE (1) BE873500A (ja)
DE (1) DE2901477C2 (ja)
DK (1) DK151260C (ja)
FR (1) FR2415112A1 (ja)
GB (1) GB2012759B (ja)
IE (1) IE47726B1 (ja)
IT (1) IT1110007B (ja)
LU (1) LU80795A1 (ja)
NL (1) NL176459B (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018104454A (ja) * 2009-12-04 2018-07-05 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 多環式化合物及びその使用方法
US10815249B2 (en) 2018-02-16 2020-10-27 Sunovion Pharmaceuticals Inc. Salts, crystal forms, and production methods thereof
US11129807B2 (en) 2017-02-16 2021-09-28 Sunovion Pharmaceuticals Inc. Methods of treating schizophrenia
US11738002B2 (en) 2020-04-14 2023-08-29 Sunovion Pharmaceuticals Inc. Methods of treating neurological and psychiatric disorders

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4147797A (en) * 1978-08-11 1979-04-03 Pfizer Inc. Spiro-furanohydantoin derivatives
US4181728A (en) * 1978-11-16 1980-01-01 Pfizer Inc. Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) * 1979-03-21 1980-01-01 Pfizer Inc. Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4210667A (en) * 1979-04-19 1980-07-01 Pfizer Inc. Pharmaceutical preparations containing coumarin carboxylic acid derivatives
US4490381A (en) * 1979-11-13 1984-12-25 Imperial Chemical Industries Plc 1'-Substituted spiro[imidazolidine-4,3'-indoline]2,2',5-triones
EP0065393B1 (en) * 1981-05-12 1984-12-27 Imperial Chemical Industries Plc Pyrrole derivatives
US4464385A (en) * 1982-04-15 1984-08-07 Alcon Laboratories, Inc. Treatment of diabetic complications with hydantoins
US4540700A (en) * 1982-04-15 1985-09-10 Alcon Laboratories, Inc. Treatment of diabetic complications with certain spiro-imidazolidine-diones
US4436745A (en) 1982-04-15 1984-03-13 Alcon Laboratories, Inc. Method of inhibiting aldose reductase activity
US4438272A (en) 1982-04-15 1984-03-20 Alcon Laboratories, Inc. Spiro-(fluoren-9,4'-imidazolidine)-2',5'-diones
US5070100A (en) * 1983-09-14 1991-12-03 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives
US4864028A (en) * 1983-09-14 1989-09-05 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives
US4537892A (en) * 1983-09-14 1985-08-27 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
US5153211A (en) * 1983-09-14 1992-10-06 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
US4680306A (en) * 1984-07-20 1987-07-14 Pfizer Inc. Sprio-imidazolones for treatment of diabetes complications
US4966911A (en) * 1984-11-20 1990-10-30 Washington Research Foundation Immunoregulatory agents
US5340829A (en) * 1984-11-20 1994-08-23 Washington Research Foundation Immunoregulatory agents
JP2708507B2 (ja) * 1988-04-07 1998-02-04 株式会社三和化学研究所 （ｄ）‐６‐フルオロ‐２，３‐ジヒドロ‐２’，５’‐ジオキソ‐スピロ［４Ｈ‐１‐ベンゾピラン‐４，４’‐イミダゾリジン］‐２‐カルボキサミド誘導体、これらの製法及び用途
JPH05508386A (ja) * 1989-02-10 1993-11-25 ワシントン　リサーチ　ファンデション 免疫調整剤
KR20190065246A (ko) 2016-07-29 2019-06-11 선오비온 파마슈티컬스 인코포레이티드 화합물 및 조성물 및 이들의 용도
IL264446B1 (en) 2016-07-29 2024-05-01 Pgi Drug Discovery Llc Compounds and compositions and their use
EP3661929B1 (en) 2017-08-02 2021-07-14 Sunovion Pharmaceuticals Inc. Isochroman compounds and uses thereof
AU2020236225A1 (en) 2019-03-14 2021-09-16 Sunovion Pharmaceuticals Inc. Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB796069A (en) * 1955-12-23 1958-06-04 Ici Ltd Substituted hydantoins
DE1135915B (de) * 1961-06-29 1962-09-06 Asta Werke Ag Chem Fab Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine
CA1088945A (en) * 1976-10-18 1980-11-04 Pfizer Limited Hydantoin derivatives as therapeutic agents

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018104454A (ja) * 2009-12-04 2018-07-05 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 多環式化合物及びその使用方法
US10894033B2 (en) 2009-12-04 2021-01-19 Sunovion Pharmaceuticals Inc. Multicyclic compounds and methods of use thereof
US11129807B2 (en) 2017-02-16 2021-09-28 Sunovion Pharmaceuticals Inc. Methods of treating schizophrenia
US10815249B2 (en) 2018-02-16 2020-10-27 Sunovion Pharmaceuticals Inc. Salts, crystal forms, and production methods thereof
US11440921B2 (en) 2018-02-16 2022-09-13 Sunovion Pharmaceuticals Inc. Salts, crystal forms, and production methods thereof
US11738002B2 (en) 2020-04-14 2023-08-29 Sunovion Pharmaceuticals Inc. Methods of treating neurological and psychiatric disorders

Also Published As

Publication number Publication date
NL176459B (nl) 1984-11-16
BE873500A (fr) 1979-07-16
GB2012759A (en) 1979-08-01
DK151260B (da) 1987-11-16
FR2415112A1 (fr) 1979-08-17
LU80795A1 (fr) 1979-09-07
FR2415112B1 (ja) 1983-01-14
JPS612067B2 (ja) 1986-01-22
IE790088L (en) 1979-07-18
GB2012759B (en) 1982-05-26
DK19579A (da) 1979-07-19
NL7900354A (nl) 1979-07-20
IT1110007B (it) 1985-12-23
DE2901477A1 (de) 1979-07-19
DE2901477C2 (de) 1982-06-09
IE47726B1 (en) 1984-05-30
DK151260C (da) 1988-05-09
US4127665A (en) 1978-11-28
IT7919369A0 (it) 1979-01-17

Similar Documents

Publication Publication Date Title
GB2033893B (en) Tetrazolylalkoxycarbostyril derivatives
JPS54109975A (en) Thienohydantoin derivative
JPS54141798A (en) 44desacetyl vlboo33carboxyhydrazide derivative
JPS54119450A (en) 2hhbenzofurann33one derivative
JPS54132627A (en) Cumalin derivative
JPS5527193A (en) Spiroofuranohydantoin derivative
GB2022079B (en) L-leucyl-4-hydroxyanilide derivatives
JPS54151966A (en) Nnsubstituted oxobenzothiazoline derivative
GB2018757B (en) 3-phenyltetrahydropyridine derivatives
PH17055A (en) Delta4-androstenes derivative
GB2036744B (en) Eburnane derivatives
GB2017708B (en) Steroid-spirooxazolidinone derivatives
JPS54128570A (en) Arylaminoimidazoline derivative
GB2019843B (en) N-alkenylmoranoline derivatives
GB2017691B (en) 2-hydroxymethyl-pyrazine derivatives
JPS5543080A (en) 22oxazolin derivative
GB2024806B (en) Onomycin derivatives
JPS54163596A (en) Flonaphlizine derivative
JPS54109991A (en) 111alkanoyll4***deoxyy4***isonitroooleandomycin derivative
GB2013187B (en) Phenylpyrol derivatives
GB2023574B (en) N-cyano-azomethine derivatives
JPS557262A (en) Novel bettaine derivative
JPS5581835A (en) Novel pentenee22yl derivative
JPS54122232A (en) Phenylnitramine derivative
JPS54151967A (en) Nnsubstituted oxobenzothiazoline derivative