NL161429C - Werkwijze voor de bereiding van preparaten met antineop- lastische werking, waarin op de 9-plaats door een carbo- cyclische groep gesubstitueerde 3,7-dimethylnonatetraeen- verbindingen aanwezig zijn, gevormde preparaten, alsmede voor de bereiding van in de preparaten bruikbare polyeen- verbindingen. - Google Patents

Werkwijze voor de bereiding van preparaten met antineop- lastische werking, waarin op de 9-plaats door een carbo- cyclische groep gesubstitueerde 3,7-dimethylnonatetraeen- verbindingen aanwezig zijn, gevormde preparaten, alsmede voor de bereiding van in de preparaten bruikbare polyeen- verbindingen.

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Publication number
NL161429C
NL161429C NL7404324.A NL7404324A NL161429C NL 161429 C NL161429 C NL 161429C NL 7404324 A NL7404324 A NL 7404324A NL 161429 C NL161429 C NL 161429C
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NL
Netherlands
Prior art keywords
preparations
prepared
dimethylnonatetraene
preparates
carbo
Prior art date
Application number
NL7404324.A
Other languages
English (en)
Dutch (nl)
Other versions
NL161429B (nl
NL7404324A (ja
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Hoffmann La Roche
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Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NL7404324A publication Critical patent/NL7404324A/xx
Publication of NL161429B publication Critical patent/NL161429B/xx
Application granted granted Critical
Publication of NL161429C publication Critical patent/NL161429C/xx

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/093Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/12Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the ring of aromatic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/093Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/26Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/32Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by introduction of halogenated alkyl groups into ring compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/02Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
    • C07C317/10Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/205Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/515Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/52Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/42Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C07C57/48Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid having unsaturation outside the aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/58Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/54Quaternary phosphonium compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/54Quaternary phosphonium compounds
    • C07F9/5428Acyclic unsaturated phosphonium compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
NL7404324.A 1973-03-30 1974-03-29 Werkwijze voor de bereiding van preparaten met antineop- lastische werking, waarin op de 9-plaats door een carbo- cyclische groep gesubstitueerde 3,7-dimethylnonatetraeen- verbindingen aanwezig zijn, gevormde preparaten, alsmede voor de bereiding van in de preparaten bruikbare polyeen- verbindingen. NL161429C (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH460373A CH585166A5 (ja) 1973-03-30 1973-03-30

Publications (3)

Publication Number Publication Date
NL7404324A NL7404324A (ja) 1974-10-02
NL161429B NL161429B (nl) 1979-09-17
NL161429C true NL161429C (nl) 1980-02-15

Family

ID=4279174

Family Applications (2)

Application Number Title Priority Date Filing Date
NL7404324.A NL161429C (nl) 1973-03-30 1974-03-29 Werkwijze voor de bereiding van preparaten met antineop- lastische werking, waarin op de 9-plaats door een carbo- cyclische groep gesubstitueerde 3,7-dimethylnonatetraeen- verbindingen aanwezig zijn, gevormde preparaten, alsmede voor de bereiding van in de preparaten bruikbare polyeen- verbindingen.
NL930081C NL930081I2 (nl) 1973-03-30 1993-06-17 Werkwijze voor de bereiding van preparaten met antineoplastische werking, waarin op de 9-plaats dooreen carbocyclische groep gesubstitueerde 3,7-dime thylnonatetraeen verbindingen aanwezig zijn, gevormde preparaten, alsmede voor de bereiding van in de preparaten bruikbare polyeenverbindingen.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NL930081C NL930081I2 (nl) 1973-03-30 1993-06-17 Werkwijze voor de bereiding van preparaten met antineoplastische werking, waarin op de 9-plaats dooreen carbocyclische groep gesubstitueerde 3,7-dime thylnonatetraeen verbindingen aanwezig zijn, gevormde preparaten, alsmede voor de bereiding van in de preparaten bruikbare polyeenverbindingen.

Country Status (32)

Country Link
JP (1) JPS5724333B2 (ja)
AR (1) AR207004A1 (ja)
AT (1) AT340397B (ja)
AU (1) AU472475B2 (ja)
BE (1) BE813002A (ja)
BR (1) BR7402525D0 (ja)
CA (1) CA1030975A (ja)
CH (4) CH585166A5 (ja)
CU (1) CU34050A (ja)
DD (1) DD111368A5 (ja)
DE (1) DE2414619C2 (ja)
DK (1) DK155043C (ja)
ES (1) ES424750A1 (ja)
FI (1) FI62280C (ja)
FR (1) FR2223037B1 (ja)
GB (2) GB1468401A (ja)
HK (1) HK28780A (ja)
HU (1) HU172655B (ja)
IE (1) IE39098B1 (ja)
IL (1) IL44368A (ja)
KE (1) KE3047A (ja)
LU (2) LU69733A1 (ja)
MX (1) MX152550A (ja)
MY (1) MY8100064A (ja)
NL (2) NL161429C (ja)
NO (2) NO143426C (ja)
PH (1) PH13081A (ja)
PL (1) PL96105B1 (ja)
SE (1) SE419752B (ja)
SU (1) SU613718A3 (ja)
YU (1) YU40253B (ja)
ZA (1) ZA741580B (ja)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH604705A5 (ja) * 1974-09-24 1978-09-15 Hoffmann La Roche
CH619437A5 (en) * 1975-08-22 1980-09-30 Hoffmann La Roche Process for the preparation of polyene compounds.
US4321209A (en) 1975-11-14 1982-03-23 Hoffmann-La Roche Inc. Fluorinated aromatic polyenes
US4266073A (en) * 1975-11-14 1981-05-05 Hoffmann-La Roche Inc. Fluorinated aromatic polyenes
US4395575A (en) 1975-11-14 1983-07-26 Hoffmann-La Roche, Inc. 5(Halophenyl)-2-fluoro-pentadienals
US4299995A (en) 1979-05-10 1981-11-10 Hoffmann-La Roche Inc. Fluorinated polyenes
US4335248A (en) 1975-11-14 1982-06-15 Hoffmann-La Roche Inc. Fluorinated polyenes
US4338253A (en) 1975-11-14 1982-07-06 Hoffmann-La Roche Inc. Fluorinated aromatic polyenes
US4169100A (en) * 1975-11-14 1979-09-25 Hoffmann-La Roche Inc. Fluorinated aromatic polyenes
CH624373A5 (en) * 1975-11-14 1981-07-31 Hoffmann La Roche Process for the preparation of polyene compounds
US4201727A (en) 1976-11-14 1980-05-06 Hoffmann-La Roche Inc. Fluorinated aromatic polyenes
US4375563A (en) 1975-11-14 1983-03-01 Hoffmann-La Roche Inc. Fluorinated aromatic polyenes
US4137246A (en) * 1976-09-13 1979-01-30 Hoffmann-La Roche Inc. Fluorinated aromatic polyenes
CA1111441A (en) 1976-12-20 1981-10-27 Werner Bollag Polyene compounds
US4200647A (en) * 1977-12-21 1980-04-29 Hoffmann-La Roche Inc. Vitamin A compositions to treat rheumatic disease
US4642318A (en) * 1982-11-17 1987-02-10 Klaus Wolff Method for decreasing radiation load in PUVA therapy
CH661516A5 (de) * 1983-12-08 1987-07-31 Hoffmann La Roche Phenylnonatetraenoylzuckerderivate.
ZA854828B (en) * 1984-07-27 1986-03-26 Hoffmann La Roche Phenyl nonatetraenoic acid derivatives
US5250562A (en) * 1988-02-24 1993-10-05 Hoffmann-La Roche Inc. Stilbene derivatives
JPH10158192A (ja) * 1996-10-03 1998-06-16 Eisai Co Ltd 移植片対宿主疾患(gvhd)の治療および臓器移植時の移植片拒絶反応抑制のための医薬組成物
JP4584384B2 (ja) * 1999-09-28 2010-11-17 扶桑薬品工業株式会社 新規抗腫瘍剤
DE102008002302A1 (de) 2007-06-13 2008-12-18 Basf Se Verfahren zur Hestellung von Etretinat
ES2619365T3 (es) * 2007-12-28 2017-06-26 Bridgestone Corporation Método para fabricar polímeros funcionalizados de hidroxiarilo

Also Published As

Publication number Publication date
FI62280B (fi) 1982-08-31
ES424750A1 (es) 1976-06-01
ATA260174A (de) 1977-04-15
NO1994004I1 (no) 1994-07-07
SE7404312L (ja) 1974-10-01
YU40253B (en) 1985-10-31
IE39098L (en) 1974-09-30
NL161429B (nl) 1979-09-17
SE419752B (sv) 1981-08-24
SU613718A3 (ru) 1978-06-30
HU172655B (hu) 1978-11-28
GB1468401A (en) 1977-03-23
IL44368A0 (en) 1974-06-30
NL930081I1 (nl) 1993-09-16
GB1468402A (en) 1977-03-23
AU6656674A (en) 1975-09-18
PL96105B1 (pl) 1977-12-31
YU88374A (en) 1983-01-21
CU34050A (es) 1981-09-09
BE813002A (fr) 1974-09-30
KE3047A (en) 1980-06-06
ZA741580B (en) 1975-02-26
FR2223037B1 (ja) 1978-07-21
FR2223037A1 (ja) 1974-10-25
IL44368A (en) 1978-07-31
DK155043C (da) 1989-07-03
AT340397B (de) 1977-12-12
AU472475B2 (en) 1976-05-27
BR7402525D0 (pt) 1974-11-19
NO143426B (no) 1980-11-03
IE39098B1 (en) 1978-08-02
DD111368A5 (ja) 1975-02-12
CH616135A5 (en) 1980-03-14
JPS49126637A (ja) 1974-12-04
LU88313I2 (de) 1994-09-09
DE2414619A1 (de) 1974-10-17
FI62280C (fi) 1982-12-10
DE2414619C2 (de) 1983-06-01
AR207004A1 (es) 1976-09-09
NO143426C (no) 1981-02-25
MX152550A (es) 1985-08-23
DK155043B (da) 1989-01-30
NO741144L (no) 1974-10-01
MY8100064A (en) 1981-12-31
NL7404324A (ja) 1974-10-02
CH616134A5 (en) 1980-03-14
NL930081I2 (nl) 1994-05-02
CH616136A5 (en) 1980-03-14
CH585166A5 (ja) 1977-02-28
LU69733A1 (ja) 1976-02-04
JPS5724333B2 (ja) 1982-05-24
CA1030975A (en) 1978-05-09
HK28780A (en) 1980-05-30
PH13081A (en) 1979-11-23

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