NL1029045C2 - Pyrimidinederivaten voor de behandeling van abnormale celgroei. - Google Patents

Pyrimidinederivaten voor de behandeling van abnormale celgroei. Download PDF

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Publication number
NL1029045C2
NL1029045C2 NL1029045A NL1029045A NL1029045C2 NL 1029045 C2 NL1029045 C2 NL 1029045C2 NL 1029045 A NL1029045 A NL 1029045A NL 1029045 A NL1029045 A NL 1029045A NL 1029045 C2 NL1029045 C2 NL 1029045C2
Authority
NL
Netherlands
Prior art keywords
ylamino
methyl
trifluoromethylpyrimidine
dihydro
oxo
Prior art date
Application number
NL1029045A
Other languages
English (en)
Dutch (nl)
Other versions
NL1029045A1 (nl
Inventor
Michael Joseph Luzzio
John Charles Kath
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34966230&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL1029045(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NL1029045A1 publication Critical patent/NL1029045A1/nl
Application granted granted Critical
Publication of NL1029045C2 publication Critical patent/NL1029045C2/nl

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NL1029045A 2004-05-14 2005-05-13 Pyrimidinederivaten voor de behandeling van abnormale celgroei. NL1029045C2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57131204P 2004-05-14 2004-05-14
US57131204 2004-05-14

Publications (2)

Publication Number Publication Date
NL1029045A1 NL1029045A1 (nl) 2005-11-15
NL1029045C2 true NL1029045C2 (nl) 2006-06-02

Family

ID=34966230

Family Applications (2)

Application Number Title Priority Date Filing Date
NL1029045A NL1029045C2 (nl) 2004-05-14 2005-05-13 Pyrimidinederivaten voor de behandeling van abnormale celgroei.
NL1031845A NL1031845C2 (nl) 2004-05-14 2006-05-19 Pyrimidinederivaten voor de behandeling van abnormale celgroei.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NL1031845A NL1031845C2 (nl) 2004-05-14 2006-05-19 Pyrimidinederivaten voor de behandeling van abnormale celgroei.

Country Status (27)

Country Link
EP (1) EP1751143A1 (no)
JP (1) JP4099212B2 (no)
KR (1) KR100886990B1 (no)
CN (2) CN102127058A (no)
AP (1) AP2241A (no)
AR (1) AR049097A1 (no)
AU (2) AU2005243397A1 (no)
BR (1) BRPI0511138A (no)
CA (1) CA2566707A1 (no)
CR (1) CR8749A (no)
EA (1) EA200601796A1 (no)
EC (1) ECSP066997A (no)
GE (1) GEP20104875B (no)
GT (1) GT200500113A (no)
IL (1) IL178828A0 (no)
MA (1) MA28583B1 (no)
MX (1) MXPA06011890A (no)
NL (2) NL1029045C2 (no)
NO (1) NO20064576L (no)
NZ (1) NZ550448A (no)
PA (1) PA8632601A1 (no)
PE (1) PE20060240A1 (no)
TN (1) TNSN06370A1 (no)
TW (1) TWI303635B (no)
UY (1) UY28894A1 (no)
WO (1) WO2005111023A1 (no)
ZA (1) ZA200608394B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4812763B2 (ja) * 2004-05-18 2011-11-09 ライジェル ファーマシューティカルズ, インコーポレイテッド シクロアルキル置換ピリミジンジアミン化合物およびそれらの用途
US20070032514A1 (en) * 2005-07-01 2007-02-08 Zahn Stephan K 2,4-diamino-pyrimidines as aurora inhibitors
KR101060051B1 (ko) * 2005-12-21 2011-08-29 화이자 프로덕츠 인크. 비정상적인 세포 성장을 치료하기 위한 피리미딘 유도체
ES2593486T3 (es) * 2007-04-18 2016-12-09 Pfizer Products Inc. Derivados de sulfonil amida para el tratamiento del crecimiento celular anómalo
CN101903357A (zh) * 2007-07-17 2010-12-01 里格尔药品股份有限公司 作为pkc抑制剂的环状胺取代的嘧啶二胺
EP2231620A1 (en) * 2007-12-03 2010-09-29 Boehringer Ingelheim International GmbH Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation
HUE035029T2 (en) * 2008-05-21 2018-03-28 Ariad Pharma Inc Kinase inhibitor phosphorus derivatives
US8410126B2 (en) * 2009-05-29 2013-04-02 Boehringer Ingelheim International Gmbh Pyrimidine inhibitors of PKTK2
JP5539518B2 (ja) 2009-08-14 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 2−アミノ−5−トリフルオロメチルピリミジン誘導体の位置選択的調製
US8933227B2 (en) 2009-08-14 2015-01-13 Boehringer Ingelheim International Gmbh Selective synthesis of functionalized pyrimidines
US20120244141A1 (en) 2010-09-28 2012-09-27 Boehringer Ingelheim International Gmbh Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors
JPWO2014174745A1 (ja) * 2013-04-26 2017-02-23 国立大学法人京都大学 Eg5阻害剤
CN109608444B (zh) * 2018-11-27 2022-02-11 中国药科大学 含异吲哚啉酮的erk抑制剂及其制备方法与用途
CN111732548B (zh) * 2020-06-11 2022-06-17 浙江大学 N2-氨甲酰芳环-2-氨基嘧啶类衍生物及其医药用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9721437D0 (en) * 1997-10-10 1997-12-10 Glaxo Group Ltd Heteroaromatic compounds and their use in medicine
AR042586A1 (es) 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
WO2003030909A1 (en) 2001-09-25 2003-04-17 Bayer Pharmaceuticals Corporation 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
WO2004056807A1 (en) * 2002-12-20 2004-07-08 Pfizer Products Inc. Pyrimidine derivatives for the treatment of abnormal cell growth
UA80767C2 (en) * 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth

Also Published As

Publication number Publication date
GT200500113A (es) 2006-01-10
NL1029045A1 (nl) 2005-11-15
PE20060240A1 (es) 2006-04-01
AU2009238255A1 (en) 2009-12-03
CN1953974A (zh) 2007-04-25
EA200601796A1 (ru) 2007-04-27
GEP20104875B (en) 2010-01-11
NL1031845A1 (nl) 2006-07-31
NZ550448A (en) 2010-11-26
MA28583B1 (fr) 2007-05-02
ZA200608394B (en) 2008-05-28
KR100886990B1 (ko) 2009-03-04
WO2005111023A1 (en) 2005-11-24
UY28894A1 (es) 2005-12-30
JP4099212B2 (ja) 2008-06-11
JP2007537234A (ja) 2007-12-20
CN102127058A (zh) 2011-07-20
AP2241A (en) 2011-06-01
AR049097A1 (es) 2006-06-28
TWI303635B (en) 2008-12-01
CA2566707A1 (en) 2005-11-24
IL178828A0 (en) 2007-03-08
TNSN06370A1 (fr) 2008-02-22
ECSP066997A (es) 2007-02-28
AU2005243397A1 (en) 2005-11-24
KR20070012477A (ko) 2007-01-25
NL1031845C2 (nl) 2006-11-23
AP2006003790A0 (en) 2006-10-31
MXPA06011890A (es) 2006-12-14
PA8632601A1 (es) 2006-06-02
NO20064576L (no) 2006-11-07
TW200539871A (en) 2005-12-16
BRPI0511138A (pt) 2007-11-27
CR8749A (es) 2006-12-05
EP1751143A1 (en) 2007-02-14

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