NL1028624A1 - Alfa-aryl- of -heteroarylmethyl-bèta-piperidinopropaan-zuurverbindingen als ORL1-receptorantagonisten. - Google Patents

Alfa-aryl- of -heteroarylmethyl-bèta-piperidinopropaan-zuurverbindingen als ORL1-receptorantagonisten.

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Publication number
NL1028624A1
NL1028624A1 NL1028624A NL1028624A NL1028624A1 NL 1028624 A1 NL1028624 A1 NL 1028624A1 NL 1028624 A NL1028624 A NL 1028624A NL 1028624 A NL1028624 A NL 1028624A NL 1028624 A1 NL1028624 A1 NL 1028624A1
Authority
NL
Netherlands
Prior art keywords
heteroarylmethyl
beta
aryl
alpha
receptor antagonists
Prior art date
Application number
NL1028624A
Other languages
English (en)
Other versions
NL1028624C2 (nl
Inventor
Yoshinobu Hashizume
Masako Hirota
Sachiko Mihara
Hiroshi Nakamura
Hiroki Koike
Yukari Matsumoto
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NL1028624A1 publication Critical patent/NL1028624A1/nl
Application granted granted Critical
Publication of NL1028624C2 publication Critical patent/NL1028624C2/nl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

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NL1028624A 2004-03-29 2005-03-24 Alfa-aryl- of -heteroarylmethyl-bèta-piperidinopropaan-zuurverbindingen als ORL1-receptorantagonisten. NL1028624C2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55759804P 2004-03-29 2004-03-29
US55759804 2004-03-29

Publications (2)

Publication Number Publication Date
NL1028624A1 true NL1028624A1 (nl) 2005-10-03
NL1028624C2 NL1028624C2 (nl) 2006-02-21

Family

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NL1028624A NL1028624C2 (nl) 2004-03-29 2005-03-24 Alfa-aryl- of -heteroarylmethyl-bèta-piperidinopropaan-zuurverbindingen als ORL1-receptorantagonisten.

Country Status (13)

Country Link
US (2) US7354925B2 (nl)
EP (2) EP1732928A2 (nl)
JP (2) JP2007530653A (nl)
AR (1) AR048340A1 (nl)
BR (2) BRPI0509307A (nl)
CA (2) CA2563164A1 (nl)
DO (1) DOP2005000046A (nl)
MX (1) MXPA06011265A (nl)
NL (1) NL1028624C2 (nl)
PA (1) PA8627801A1 (nl)
TW (1) TW200533641A (nl)
UY (1) UY28823A1 (nl)
WO (2) WO2005092858A2 (nl)

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UY28823A1 (es) 2005-10-31
US20050277659A1 (en) 2005-12-15
EP1732893A2 (en) 2006-12-20
DOP2005000046A (es) 2005-11-30
CA2561488A1 (en) 2005-10-06
US20070197500A1 (en) 2007-08-23
WO2005092895A3 (en) 2006-03-02
AR048340A1 (es) 2006-04-19
PA8627801A1 (es) 2006-05-16
NL1028624C2 (nl) 2006-02-21
JP2007530653A (ja) 2007-11-01
TW200533641A (en) 2005-10-16
WO2005092895A2 (en) 2005-10-06
WO2005092858A3 (en) 2006-03-02
EP1732928A2 (en) 2006-12-20
JP2007530656A (ja) 2007-11-01
US7354925B2 (en) 2008-04-08
BRPI0509377A (pt) 2007-09-11
US7279486B2 (en) 2007-10-09
MXPA06011265A (es) 2006-12-15
WO2005092858A2 (en) 2005-10-06
BRPI0509307A (pt) 2007-09-04

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