NL1006764C2 - Bereiding van preparaten die hoge concentraties vitamine B12 bevatten. - Google Patents
Bereiding van preparaten die hoge concentraties vitamine B12 bevatten. Download PDFInfo
- Publication number
- NL1006764C2 NL1006764C2 NL1006764A NL1006764A NL1006764C2 NL 1006764 C2 NL1006764 C2 NL 1006764C2 NL 1006764 A NL1006764 A NL 1006764A NL 1006764 A NL1006764 A NL 1006764A NL 1006764 C2 NL1006764 C2 NL 1006764C2
- Authority
- NL
- Netherlands
- Prior art keywords
- vitamin
- preparation
- natural vitamin
- lysate
- microbial cells
- Prior art date
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- 229930003779 Vitamin B12 Natural products 0.000 title claims description 134
- 235000019163 vitamin B12 Nutrition 0.000 title claims description 134
- 239000011715 vitamin B12 Substances 0.000 title claims description 134
- 238000002360 preparation method Methods 0.000 title claims description 44
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 title claims 13
- 238000000034 method Methods 0.000 claims description 38
- 230000000813 microbial effect Effects 0.000 claims description 19
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- 239000007791 liquid phase Substances 0.000 claims description 10
- OAJLVMGLJZXSGX-NDSREFPTSA-L (2r,3s,4s,5r)-2-(6-aminopurin-9-yl)-5-methanidyloxolane-3,4-diol;cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12 Chemical compound [Co+3].O[C@H]1[C@H](O)[C@@H]([CH2-])O[C@H]1N1C2=NC=NC(N)=C2N=C1.C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O OAJLVMGLJZXSGX-NDSREFPTSA-L 0.000 claims description 9
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- JEWJRMKHSMTXPP-BYFNXCQMSA-M methylcobalamin Chemical compound C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O JEWJRMKHSMTXPP-BYFNXCQMSA-M 0.000 claims description 9
- 238000011282 treatment Methods 0.000 claims description 9
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- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 122
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/42—Cobalamins, i.e. vitamin B12, LLD factor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polymers & Plastics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Animal Husbandry (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96202254 | 1996-08-12 | ||
| EP96202254 | 1996-08-12 | ||
| EP97200054 | 1997-01-14 | ||
| EP97200054 | 1997-01-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NL1006764A1 NL1006764A1 (nl) | 1997-09-10 |
| NL1006764C2 true NL1006764C2 (nl) | 1997-11-18 |
Family
ID=26143080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL1006764A NL1006764C2 (nl) | 1996-08-12 | 1997-08-12 | Bereiding van preparaten die hoge concentraties vitamine B12 bevatten. |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US5955321A (de) |
| EP (1) | EP0824152B1 (de) |
| KR (1) | KR20000029904A (de) |
| CN (1) | CN1229440A (de) |
| AR (1) | AR022986A1 (de) |
| AT (1) | ATE228171T1 (de) |
| AU (1) | AU730618B2 (de) |
| BE (1) | BE1010976A5 (de) |
| BR (1) | BR9710884A (de) |
| CA (1) | CA2261286A1 (de) |
| DE (1) | DE69717207T2 (de) |
| DK (1) | DK0824152T3 (de) |
| ES (1) | ES2187720T3 (de) |
| HU (1) | HUP9903580A3 (de) |
| IL (1) | IL128032A0 (de) |
| IT (1) | IT1293968B1 (de) |
| NL (1) | NL1006764C2 (de) |
| NO (1) | NO990653L (de) |
| NZ (1) | NZ333821A (de) |
| PL (1) | PL331514A1 (de) |
| PT (1) | PT824152E (de) |
| WO (1) | WO1998006868A2 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5739313A (en) | 1995-11-13 | 1998-04-14 | Regents Of The University Of Minnesota | Radionuclide labeling of vitamin B12 and coenzymes thereof |
| GB9806444D0 (en) * | 1998-03-25 | 1998-05-27 | Mars Uk Ltd | Food |
| AU3042500A (en) | 1998-12-18 | 2000-07-12 | Dsm N.V. | Improved process for the production of vitamin b12 |
| US6806363B1 (en) * | 1999-04-16 | 2004-10-19 | Mayo Foundation For Medical Education & Research | Cobalamin conjugates useful as antitumor agents |
| US7314732B2 (en) * | 2000-02-17 | 2008-01-01 | Tfk Inc. | Drug and manufacturing method of same |
| AU2002243438A1 (en) * | 2000-10-25 | 2002-07-24 | Mayo Foundation For Medical Education And Research | Transcobalamin binding conjugates useful for treating abnormal cellular proliferation |
| US20030018009A1 (en) * | 2001-06-20 | 2003-01-23 | Collins Douglas A. | Adenosyl-cobalamin fortified compositions |
| TWI328612B (en) | 2002-07-25 | 2010-08-11 | Dsm Ip Assets Bv | Genes and their encoded polypeptides involved in the biosynthetic pathway of vitamin b12, vectors and host cells comprising the genes, and process for producing vitamin b12 |
| EP1575382A2 (de) * | 2002-11-14 | 2005-09-21 | DSM IP Assets B.V. | Zusammensetzungen enthaltend vitamin b12, ihre herstellung und verwendung |
| ATE509624T1 (de) | 2005-12-23 | 2011-06-15 | Nutricia Nv | Zusammensetzung enthaltend mehrfach ungesättigte fettsäuren, proteine, mangan und/oder molybden und nukleotide/nukleoside, zur behandlung von demenz |
| DE102010023324A1 (de) * | 2010-06-10 | 2011-12-15 | Thomas Schütz | Verwendung von Corrinoiden zur kosmetischen Anwendung bei gesundem Fell bzw. gesunder Haut, sowie zur kosmetischen Pflege bei Fell- und Hauterkrankungen bei Klein- und Groß-Tieren (warm- und kaltblütig), (z.B. bei Fischen, Vögeln, Pferden, Rindern, Kamelen, Hunden Katzen, Reptilien) |
| FR2973700B1 (fr) * | 2011-04-05 | 2013-04-26 | Oreal | Nouvel actif derivant d'une bacterie appartenant au genre vitreoscilla sp. utile pour prevenir et/ou traiter les etats pelliculaires du cuir chevelu |
| US20170232047A1 (en) * | 2012-01-16 | 2017-08-17 | Elizabeth McKenna | Control of Cellular Redox Levels |
| KR20200106088A (ko) | 2012-01-16 | 2020-09-10 | 엘라자베스 맥켄나 | 간 질환들 및 장애들의 치료를 위한 조성물들 및 방법들 |
| WO2014047588A1 (en) | 2012-09-21 | 2014-03-27 | Elizabeth Mckenna | Naturally occurring cpg oligonucleotide compositions and therapeutic applications thereof |
| DE102013008336A1 (de) | 2013-01-29 | 2014-07-31 | Erdinger Weissbräu Franz Brombach e.K. | Verfahren zur Herstellung eines Malzes sowie damit hergestelltes Malz, Verfahren zur Herstellung eines Weichwassers sowie damit hergestelltes Weichwasser; Verwendung von Milchsäurebakterien |
| DE102013008335A1 (de) | 2013-01-29 | 2014-07-31 | Erdinger Weissbräu Franz Brombach e.K. | Verfahren zur Herstellung eines Nahrungsmittels sowie das damit hergestellte Nahrungsmittel und Verwendung von Milchsäurebakterien, eines Sauerguts, einer Maische, einer Würze, eines Getränks oder eines Konzentrats |
| DE102013100891A1 (de) | 2013-01-29 | 2014-07-31 | Erdinger Weissbräu Franz Brombach e.K. | Verfahren zur Herstellung eines Sauergutes, einer Maische oder Würze, eines Getränks, eines Konzentrats sowie die damit hergestellten Erzeugnisse und Verwendung von Milchsäurebakterien, eines Sauerguts, einer Maische, einer Würze oder eines Konzentrats |
| DE102014110182A1 (de) | 2014-07-18 | 2016-01-21 | Erdinger Weißbräu Werner Brombach GmbH & Co. KG | Verfahren zur Herstellung eines Nahrungsmittels oder einer Vorstufe desselben, Nahrungsmittel oder eine Vorstufe desselben und entsprechende Verwendung |
| DE102017120283A1 (de) | 2017-09-04 | 2019-03-07 | Erdinger Weißbräu Werner Brombach GmbH & Co. KG | Verfahren zur Herstellung eines Nahrungsmittels oder einer Vorstufe desselben, Nahrungsmittel oder eine Vorstufe desselben und eine entsprechende Verwendung |
| CN110759959B (zh) * | 2018-07-28 | 2023-04-07 | 广济药业（孟州）有限公司 | 一种从发酵液中分离提取维生素b12的方法 |
| US10791755B1 (en) * | 2019-04-11 | 2020-10-06 | Goli Nutrition Inc. | Apple cider vinegar nutritional supplement |
| WO2021171294A1 (en) * | 2020-02-27 | 2021-09-02 | Hinoman Ltd. | Bacterial cultures for increasing vitamin b12 in plants |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3146165A (en) * | 1960-08-26 | 1964-08-25 | Distillers Co Yeast Ltd | Composition containing cobalamin and glutathione and process of employing same |
| US4383110A (en) * | 1980-11-29 | 1983-05-10 | Nippon Oil Company, Ltd. | Process for purifying and separating vitamin B12 |
| EP0087920B1 (de) * | 1982-02-26 | 1987-06-24 | Nippon Oil Co. Ltd. | Verfahren zur Herstellung von Vitamin B12 mittels Fermentationstechnik und Vitamin B12 herstellender Mikroorganismus |
| JPH03244376A (ja) * | 1982-02-26 | 1991-10-31 | Nippon Oil Co Ltd | ビタミンｂ↓１↓２生産菌 |
| EP0131456A3 (de) * | 1983-07-08 | 1986-07-23 | Kureha Kagaku Kogyo Kabushiki Kaisha | Herstellung von Vitamin B12 durch Verwendung eines fusionierten Zellhybrids |
| HU188955B (en) * | 1983-09-16 | 1986-05-28 | Richter Gedeon Vegyeszeti Gyar Rt,Hu | Process for preparing a fermentation broth for the production of coenzyme b down 12 |
| RU2001953C1 (ru) * | 1990-10-30 | 1993-10-30 | Всесоюзный научно-исследовательский технологический институт антибиотиков и ферментов медицинского назначени | Способ получени препарата витамина @ |
| US5098691A (en) * | 1991-05-06 | 1992-03-24 | Colgate-Palmolive Company | Composition for disclosing dental plaque |
| JP3085320B2 (ja) * | 1991-09-17 | 2000-09-04 | 日石三菱株式会社 | ヒドロキソコバラミンの製造方法 |
| CN1087522A (zh) * | 1992-09-14 | 1994-06-08 | 韦斯塔药品有限公司 | 用于治疗和预防婴儿代谢紊乱的组合物 |
| EP0647717A1 (de) * | 1993-10-06 | 1995-04-12 | Takeda Chemical Industries, Ltd. | Verfahren zur Herstellung von Vitamin B12 |
| DE4344141C1 (de) * | 1993-12-20 | 1995-07-13 | Coiffeur Consulting Team Elect | Kosmetisches Produkt zur spezifischen Haarpflege |
| US5925625A (en) * | 1994-05-13 | 1999-07-20 | Merkus; Franciscus W. H. M. | Pharmaceutical composition for the intranasal administration of hydroxocobalamin |
| FR2740973B1 (fr) * | 1995-11-15 | 1998-02-06 | Lipha | Nouvelle forme d'administration de l'hydroxocobalamine et son utilisation dans les intoxications par les cyanures |
-
1997
- 1997-08-11 AR ARP970103634A patent/AR022986A1/es not_active Application Discontinuation
- 1997-08-12 BE BE9700673A patent/BE1010976A5/nl not_active IP Right Cessation
- 1997-08-12 IL IL12803297A patent/IL128032A0/xx unknown
- 1997-08-12 CA CA002261286A patent/CA2261286A1/en not_active Abandoned
- 1997-08-12 PT PT97202466T patent/PT824152E/pt unknown
- 1997-08-12 NL NL1006764A patent/NL1006764C2/nl not_active IP Right Cessation
- 1997-08-12 AU AU42065/97A patent/AU730618B2/en not_active Ceased
- 1997-08-12 BR BR9710884A patent/BR9710884A/pt not_active Application Discontinuation
- 1997-08-12 NZ NZ333821A patent/NZ333821A/xx unknown
- 1997-08-12 EP EP97202466A patent/EP0824152B1/de not_active Expired - Lifetime
- 1997-08-12 IT IT97TO000738A patent/IT1293968B1/it active IP Right Grant
- 1997-08-12 US US08/909,715 patent/US5955321A/en not_active Expired - Lifetime
- 1997-08-12 DK DK97202466T patent/DK0824152T3/da active
- 1997-08-12 KR KR1019997001087A patent/KR20000029904A/ko not_active Application Discontinuation
- 1997-08-12 HU HU9903580A patent/HUP9903580A3/hu unknown
- 1997-08-12 CN CN97197234A patent/CN1229440A/zh active Pending
- 1997-08-12 PL PL97331514A patent/PL331514A1/xx unknown
- 1997-08-12 AT AT97202466T patent/ATE228171T1/de not_active IP Right Cessation
- 1997-08-12 ES ES97202466T patent/ES2187720T3/es not_active Expired - Lifetime
- 1997-08-12 WO PCT/EP1997/004568 patent/WO1998006868A2/en not_active Application Discontinuation
- 1997-08-12 DE DE69717207T patent/DE69717207T2/de not_active Expired - Fee Related
-
1999
- 1999-01-19 US US09/232,920 patent/US6187761B1/en not_active Expired - Lifetime
- 1999-02-11 NO NO990653A patent/NO990653L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US6187761B1 (en) | 2001-02-13 |
| CN1229440A (zh) | 1999-09-22 |
| HUP9903580A2 (hu) | 2000-03-28 |
| ES2187720T3 (es) | 2003-06-16 |
| AR022986A1 (es) | 2002-09-04 |
| NL1006764A1 (nl) | 1997-09-10 |
| ATE228171T1 (de) | 2002-12-15 |
| BR9710884A (pt) | 1999-08-17 |
| WO1998006868A2 (en) | 1998-02-19 |
| IL128032A0 (en) | 1999-11-30 |
| NO990653D0 (no) | 1999-02-11 |
| EP0824152A3 (de) | 1998-02-25 |
| ITTO970738A1 (it) | 1999-02-12 |
| KR20000029904A (ko) | 2000-05-25 |
| BE1010976A5 (nl) | 1999-03-02 |
| WO1998006868A3 (en) | 1998-03-26 |
| EP0824152B1 (de) | 2002-11-20 |
| US5955321A (en) | 1999-09-21 |
| PT824152E (pt) | 2003-04-30 |
| CA2261286A1 (en) | 1998-02-19 |
| DE69717207T2 (de) | 2003-07-24 |
| EP0824152A2 (de) | 1998-02-18 |
| AU4206597A (en) | 1998-03-06 |
| IT1293968B1 (it) | 1999-03-15 |
| NZ333821A (en) | 2000-08-25 |
| AU730618B2 (en) | 2001-03-08 |
| PL331514A1 (en) | 1999-07-19 |
| DK0824152T3 (da) | 2003-03-10 |
| NO990653L (no) | 1999-04-09 |
| HUP9903580A3 (en) | 2001-09-28 |
| DE69717207D1 (de) | 2003-01-02 |
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