NI201000124A - Derivados de carboxamidas azabicíclicas, su preparación y su aplicación en terapéutica - Google Patents

Derivados de carboxamidas azabicíclicas, su preparación y su aplicación en terapéutica

Info

Publication number
NI201000124A
NI201000124A NI201000124A NI201000124A NI201000124A NI 201000124 A NI201000124 A NI 201000124A NI 201000124 A NI201000124 A NI 201000124A NI 201000124 A NI201000124 A NI 201000124A NI 201000124 A NI201000124 A NI 201000124A
Authority
NI
Nicaragua
Prior art keywords
therapeutics
preparation
nitrogen atom
azabicyclic
carboxamides
Prior art date
Application number
NI201000124A
Other languages
English (en)
Inventor
Dubois Laurent
Evanno Yannick
Malanda André
Machnik David
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NI201000124A publication Critical patent/NI201000124A/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención se refiere a los compuestos de fórmula general (I) en la que X1, X2, X3, y X4 representan, independientemente el uno del otro, un átomo de nitrógeno o un grupo C-R1 ; Z1, Z2, Z3 y Z4 representan, independientemente el uno del otro, un átomo de nitrógeno o un grupo C-R2 ; Ra y Rb forman junto con los átomos de carbono a los que están unidos un ciclo de cinco eslabones, conteniendo este ciclo un átomo de nitrógeno y átomos de carbono, estando este ciclo parcialmente saturado o insaturado y estando sustituido opcionalmente con uno o varios sustituyentes R3 ; W representa un átomo de oxígeno o de azufre ; n es igual a 0, 1, 2 ó 3 ; Y representa un arilo o un heteroarilo sustituido opcionalmente ; en el estado de base o de sal de adición a un ácido, así como en el estado de hidrato o de solvato. Procedimiento de preparación y aplicación en terapéutica.
NI201000124A 2008-01-22 2010-07-21 Derivados de carboxamidas azabicíclicas, su preparación y su aplicación en terapéutica NI201000124A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0800308A FR2926554B1 (fr) 2008-01-22 2008-01-22 Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
NI201000124A true NI201000124A (es) 2010-12-17

Family

ID=39843820

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201000124A NI201000124A (es) 2008-01-22 2010-07-21 Derivados de carboxamidas azabicíclicas, su preparación y su aplicación en terapéutica

Country Status (29)

Country Link
US (1) US8354425B2 (es)
EP (1) EP2235015B1 (es)
JP (1) JP5478512B2 (es)
KR (1) KR101593711B1 (es)
CN (1) CN101977911A (es)
AR (1) AR070206A1 (es)
AU (1) AU2009224533B2 (es)
BR (1) BRPI0907381A2 (es)
CA (1) CA2712609C (es)
CO (1) CO6280509A2 (es)
CR (1) CR11546A (es)
DO (1) DOP2010000213A (es)
EA (1) EA201070872A1 (es)
EC (1) ECSP10010337A (es)
FR (1) FR2926554B1 (es)
HN (1) HN2010001459A (es)
IL (1) IL207078A (es)
MA (1) MA32089B1 (es)
MX (1) MX2010007977A (es)
MY (1) MY150576A (es)
NI (1) NI201000124A (es)
NZ (1) NZ586938A (es)
PA (1) PA8812801A1 (es)
PE (1) PE20091320A1 (es)
TW (1) TWI428339B (es)
UA (1) UA102837C2 (es)
UY (1) UY31606A1 (es)
WO (1) WO2009112678A2 (es)
ZA (1) ZA201005202B (es)

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JO3603B1 (ar) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
EP2997019B1 (en) 2013-05-17 2018-08-08 Janssen Sciences Ireland UC Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
TR201807090T4 (tr) 2013-07-25 2018-06-21 Janssen Sciences Ireland Uc Glioksamid sübstitüeli pirrolamid deriveleri ve bunun hepatitin tedavisine yönelik ilaçlar olarak kullanımı.
JP6452119B2 (ja) 2013-10-23 2019-01-16 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー カルボキサミド誘導体およびb型肝炎の処置のための医薬品としてのその使用
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Also Published As

Publication number Publication date
AU2009224533A1 (en) 2009-09-17
EA201070872A1 (ru) 2011-02-28
JP5478512B2 (ja) 2014-04-23
NZ586938A (en) 2012-06-29
EP2235015B1 (fr) 2016-08-24
CR11546A (es) 2010-10-05
UY31606A1 (es) 2009-08-31
AR070206A1 (es) 2010-03-25
MY150576A (en) 2014-01-30
CN101977911A (zh) 2011-02-16
US8354425B2 (en) 2013-01-15
UA102837C2 (ru) 2013-08-27
CO6280509A2 (es) 2011-05-20
CA2712609C (fr) 2016-03-08
MA32089B1 (fr) 2011-02-01
FR2926554B1 (fr) 2010-03-12
KR20100105783A (ko) 2010-09-29
KR101593711B1 (ko) 2016-02-12
MX2010007977A (es) 2010-08-04
TWI428339B (zh) 2014-03-01
PA8812801A1 (es) 2009-08-26
US20110009364A1 (en) 2011-01-13
TW200936585A (en) 2009-09-01
CA2712609A1 (fr) 2009-09-17
BRPI0907381A2 (pt) 2015-07-14
EP2235015A2 (fr) 2010-10-06
IL207078A0 (en) 2010-12-30
FR2926554A1 (fr) 2009-07-24
DOP2010000213A (es) 2010-07-31
IL207078A (en) 2015-09-24
PE20091320A1 (es) 2009-09-26
JP2011510050A (ja) 2011-03-31
AU2009224533B2 (en) 2013-12-05
ZA201005202B (en) 2011-09-28
ECSP10010337A (es) 2010-08-31
HN2010001459A (es) 2013-07-29
WO2009112678A2 (fr) 2009-09-17
WO2009112678A3 (fr) 2009-12-30

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