NI200600063A - Proceso para la sintesis de 3-(3-fluoro-4-hidroxifenil)-7-hidroxinaftonitrilo - Google Patents

Proceso para la sintesis de 3-(3-fluoro-4-hidroxifenil)-7-hidroxinaftonitrilo

Info

Publication number
NI200600063A
NI200600063A NI200600063A NI200600063A NI200600063A NI 200600063 A NI200600063 A NI 200600063A NI 200600063 A NI200600063 A NI 200600063A NI 200600063 A NI200600063 A NI 200600063A NI 200600063 A NI200600063 A NI 200600063A
Authority
NI
Nicaragua
Prior art keywords
hydroxinaftonitrile
hydroxyphenyl
fluoro
synthesis
compounds
Prior art date
Application number
NI200600063A
Other languages
English (en)
Inventor
Yanzhong Wu
Jianxin Ren
Mousumi Ghosh
Mahmut Levent
Karen Southerland
Panolil Raveendranath
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34312297&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NI200600063(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NI200600063A publication Critical patent/NI200600063A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/24—Preparation of ethers by reactions not forming ether-oxygen bonds by elimination of halogens, e.g. elimination of HCl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procedimiento para hacer un compuesto de la fórmula I, en donde R1 es CN, F o Cl; R2 es H o Br; y R3 y R4 son cada uno independientemente H o F. Estos compuestos son útiles en el tratamiento de enfermedades inflamatorias crónicas, tales como artritis reumatoide.
NI200600063A 2003-09-09 2006-03-08 Proceso para la sintesis de 3-(3-fluoro-4-hidroxifenil)-7-hidroxinaftonitrilo NI200600063A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50170003P 2003-09-09 2003-09-09

Publications (1)

Publication Number Publication Date
NI200600063A true NI200600063A (es) 2006-06-21

Family

ID=34312297

Family Applications (1)

Application Number Title Priority Date Filing Date
NI200600063A NI200600063A (es) 2003-09-09 2006-03-08 Proceso para la sintesis de 3-(3-fluoro-4-hidroxifenil)-7-hidroxinaftonitrilo

Country Status (26)

Country Link
US (1) US7557237B2 (es)
EP (1) EP1663929A2 (es)
JP (1) JP2007505119A (es)
KR (1) KR20060088876A (es)
CN (1) CN1894185A (es)
AR (1) AR045613A1 (es)
AU (1) AU2004272571A1 (es)
BR (1) BRPI0413724A (es)
CA (1) CA2536768A1 (es)
CO (1) CO5670331A2 (es)
CR (1) CR8263A (es)
EC (1) ECSP066416A (es)
GT (1) GT200400179A (es)
IL (1) IL173922A0 (es)
MX (1) MXPA06002450A (es)
NI (1) NI200600063A (es)
NO (1) NO20061117L (es)
NZ (1) NZ569134A (es)
PA (1) PA8611901A1 (es)
PE (1) PE20050947A1 (es)
RU (1) RU2006105916A (es)
SG (1) SG146646A1 (es)
TW (1) TW200510280A (es)
UA (1) UA84166C2 (es)
WO (1) WO2005026105A2 (es)
ZA (1) ZA200601986B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104114521A (zh) * 2012-02-17 2014-10-22 旭硝子株式会社 含氟芳香族化合物及其制造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5554621A (en) 1995-06-07 1996-09-10 Bristol-Myers Squibb Company Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives
JP2001500155A (ja) 1996-09-13 2001-01-09 アルベマール・コーポレーシヨン ６―ブロモ―２―ナフトール及びその誘導体の製造
US5840996A (en) 1997-05-08 1998-11-24 Albemarle Corporation Production of brominated methoxynaphthalene compounds
TWI306450B (en) 2001-12-13 2009-02-21 Wyeth Corp Substituted phenyl naphthalenes as estrogenic agents

Also Published As

Publication number Publication date
NO20061117L (no) 2006-03-22
GT200400179A (es) 2005-04-18
NZ569134A (en) 2009-10-30
IL173922A0 (en) 2006-07-05
PA8611901A1 (es) 2006-06-02
KR20060088876A (ko) 2006-08-07
TW200510280A (en) 2005-03-16
US20050054870A1 (en) 2005-03-10
UA84166C2 (ru) 2008-09-25
RU2006105916A (ru) 2007-10-20
CA2536768A1 (en) 2005-03-24
AU2004272571A1 (en) 2005-03-24
PE20050947A1 (es) 2005-12-13
CN1894185A (zh) 2007-01-10
WO2005026105A3 (en) 2005-06-23
JP2007505119A (ja) 2007-03-08
CR8263A (es) 2006-10-06
SG146646A1 (en) 2008-10-30
CO5670331A2 (es) 2006-08-31
ZA200601986B (en) 2009-09-30
BRPI0413724A (pt) 2006-10-17
MXPA06002450A (es) 2006-06-20
WO2005026105A2 (en) 2005-03-24
US7557237B2 (en) 2009-07-07
EP1663929A2 (en) 2006-06-07
AR045613A1 (es) 2005-11-02
ECSP066416A (es) 2006-09-18

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