MY114424A - Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors,their preparation and pharmaceutical compositions containing them - Google Patents

Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors,their preparation and pharmaceutical compositions containing them

Info

Publication number
MY114424A
MY114424A MYPI96001383A MYPI19961383A MY114424A MY 114424 A MY114424 A MY 114424A MY PI96001383 A MYPI96001383 A MY PI96001383A MY PI19961383 A MYPI19961383 A MY PI19961383A MY 114424 A MY114424 A MY 114424A
Authority
MY
Malaysia
Prior art keywords
group
hydrogen
alkyl
formula
pyrazolecarboxamides
Prior art date
Application number
MYPI96001383A
Other languages
English (en)
Inventor
Bernard Labeeuw
Danielle Gully
Jean-Charles Molimard
Francis Jeanjean
Robert Boigegrain
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of MY114424A publication Critical patent/MY114424A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/22—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/63—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C255/65—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms
    • C07C255/66—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms having cyano groups and nitrogen atoms being part of hydrazine or hydrazone groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/47—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having at least one of the sulfo groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MYPI96001383A 1995-04-11 1996-04-11 Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors,their preparation and pharmaceutical compositions containing them MY114424A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9504350A FR2732967B1 (fr) 1995-04-11 1995-04-11 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant

Publications (1)

Publication Number Publication Date
MY114424A true MY114424A (en) 2002-10-31

Family

ID=9478010

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI96001383A MY114424A (en) 1995-04-11 1996-04-11 Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors,their preparation and pharmaceutical compositions containing them

Country Status (26)

Country Link
US (6) US5723483A (OSRAM)
EP (2) EP0820444A1 (OSRAM)
JP (1) JP3061644B2 (OSRAM)
KR (1) KR100366118B1 (OSRAM)
CN (1) CN1072210C (OSRAM)
AR (1) AR003940A1 (OSRAM)
AU (1) AU709119B2 (OSRAM)
CA (1) CA2220827A1 (OSRAM)
CZ (1) CZ292255B6 (OSRAM)
EE (1) EE9700264A (OSRAM)
FR (1) FR2732967B1 (OSRAM)
HU (1) HUP9801435A3 (OSRAM)
IL (1) IL117860A0 (OSRAM)
IN (1) IN185700B (OSRAM)
IS (1) IS4582A (OSRAM)
MY (1) MY114424A (OSRAM)
NO (1) NO310071B1 (OSRAM)
NZ (1) NZ307227A (OSRAM)
PL (1) PL188077B1 (OSRAM)
RU (1) RU2195455C2 (OSRAM)
SK (1) SK136797A3 (OSRAM)
TR (1) TR199701146T1 (OSRAM)
TW (1) TW411332B (OSRAM)
UA (1) UA66750C2 (OSRAM)
WO (1) WO1996032382A1 (OSRAM)
ZA (1) ZA962886B (OSRAM)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2732967B1 (fr) 1995-04-11 1997-07-04 Sanofi Sa 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant
US6506747B1 (en) * 1998-06-05 2003-01-14 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents
DE10146867A1 (de) * 2001-09-24 2003-04-24 Bayer Ag Tetrahydroisochinoline
WO2003090680A2 (en) * 2002-04-23 2003-11-06 Axys Pharmaceuticals, Inc. Novel phenyl derivatives as inducers of apoptosis
GB0225548D0 (en) * 2002-11-01 2002-12-11 Glaxo Group Ltd Compounds
FR2847160A1 (fr) * 2002-11-20 2004-05-21 Oreal Composition capillaire contenant un compose pyrasol-carboxamide, son utilisation pour stimuler la pousse des cheveux et/ou freiner leur chute
ES2265596T3 (es) 2002-11-27 2007-02-16 Boehringer Ingelheim Pharmaceuticals Inc. Derivados de 1,2,3-triazol-amida como inhibidores de citocinas.
US7078419B2 (en) 2003-03-10 2006-07-18 Boehringer Ingelheim Pharmaceuticals, Inc. Cytokine inhibitors
RU2337099C2 (ru) * 2003-04-03 2008-10-27 Мерк Патент Гмбх Карбонильные соединения
US20060079566A1 (en) * 2003-10-03 2006-04-13 Ching-Shih Chen PDK-1/Akt signaling inhibitors
GB0323584D0 (en) * 2003-10-08 2003-11-12 Glaxo Group Ltd Compounds
GB0323585D0 (en) * 2003-10-08 2003-11-12 Glaxo Group Ltd Compounds
JP2007518686A (ja) * 2003-10-17 2007-07-12 田辺製薬株式会社 高コンダクタンス型カルシウム感受性ｋチャネル開口薬
EP1692116B1 (en) 2003-12-03 2011-03-09 Boehringer Ingelheim Pharmaceuticals Inc. 1,2,3-triazole amide derivatives as inhibitors of cytokine production
KR20060131906A (ko) * 2004-02-20 2006-12-20 아스트라제네카 아베 Ｃｂ1 조절제로서 유용한 3-치환 1,5-디페닐피라졸 유도체
PT1725544E (pt) 2004-03-09 2009-07-02 Boehringer Ingelheim Pharma 3-[4-heterociclil-1,2,3-triazol-1-il]-n-aril-benzamidas como inibidores da produção de citocinas para o tratamento de doenças inflamatórias crónicas
US7285545B2 (en) 2004-05-03 2007-10-23 Boehringer Ingelheim Pharmaceuticals, Inc. Cytokine inhibitors
GB0410121D0 (en) * 2004-05-06 2004-06-09 Glaxo Group Ltd Compounds
US7485657B2 (en) * 2004-05-12 2009-02-03 Boehringer Ingelheim Pharmaceuticals, Inc. Anti-cytokine heterocyclic compounds
US7531560B2 (en) * 2004-11-10 2009-05-12 Boehringer Ingelheim Pharmaceuticals, Inc. Anti-cytokine heterocyclic compounds
WO2006067443A1 (en) * 2004-12-23 2006-06-29 Astrazeneca Ab Therapeutic agents
RU2304967C2 (ru) * 2005-05-26 2007-08-27 Государственное общеобразовательное учреждение высшего профессионального образования Казанский государственный медицинский университет Способ лечения язвенной болезни желудка и двенадцатиперстной кишки
GB0514738D0 (en) * 2005-07-19 2005-08-24 Astrazeneca Ab Therapeutic agents
KR101077366B1 (ko) * 2006-03-22 2011-10-26 에프. 호프만-라 로슈 아게 11-베타-ｈｓｄ-1로서의 피라졸
US20100113776A1 (en) * 2006-12-14 2010-05-06 Taisho Pharmaceutical Co.,Ltd. Pyrazole derivative
RU2440989C2 (ru) * 2007-07-17 2012-01-27 Ф.Хоффманн-Ля Рош Аг ИНГИБИТОРЫ 11β-ГИДРОКСИСТЕРОИДНОЙ ДЕГИДРОГЕНАЗЫ
ES2538002T3 (es) 2009-01-07 2015-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Métodos para el tratamiento, la evaluación pronóstica y la detección de cáncer de mama
JPWO2011007819A1 (ja) 2009-07-17 2012-12-27 塩野義製薬株式会社 ラクタムまたはベンゼンスルホンアミド化合物を含有する医薬
US20110028624A1 (en) * 2009-07-30 2011-02-03 Genovique Specialties Holdings Corporation Polymer Compositions That Include High Solvating Plasticizer And Surfactant
EP2740726A1 (en) * 2012-12-07 2014-06-11 3B Pharmaceuticals GmbH Neurotensin receptor ligands
WO2015148465A1 (en) * 2014-03-25 2015-10-01 Research Triangle Institute Pyrazole compounds selective for neurotensin 2 receptor
MX387055B (es) 2014-06-06 2025-03-19 Res Triangle Inst Agonistas del receptor de apelina (apj) y usos de los mismos.
EP2954933A1 (en) 2014-06-10 2015-12-16 3B Pharmaceuticals GmbH Conjugate comprising a neurotensin receptor ligand
US10799605B2 (en) 2014-06-10 2020-10-13 3B Pharmaceuticals Gmbh Conjugate comprising a neurotensin receptor ligand and use thereof
EP2954934A1 (en) 2014-06-11 2015-12-16 3B Pharmaceuticals GmbH Conjugate comprising a neurotensin receptor ligand and use thereof
RU2021133849A (ru) 2015-12-09 2022-03-21 Рисерч Трайэнгл Инститьют Улучшенные агонисты апелинового рецептора (apj) и их использование
EP3279197A1 (en) 2016-08-03 2018-02-07 Friedrich-Alexander-Universität Erlangen-Nürnberg Diagnosis, treatment and prevention of neurotensin receptor-related conditions
GB201815696D0 (en) * 2018-09-26 2018-11-07 Mereo Biopharma 1 Ltd Synthetic method
GB201815695D0 (en) 2018-09-26 2018-11-07 Mereo Biopharma 1 Ltd Synthetic method
IL314786A (en) * 2022-02-18 2024-10-01 Full Life Tech Hk Limited Compounds and radioligands for targeting neurotensin receptor and uses thereof
US12091454B2 (en) 2022-12-28 2024-09-17 Development Center For Biotechnology Humanized anti-human neurotensin receptor 1 antibodies and their uses
WO2025146126A1 (en) * 2024-01-04 2025-07-10 Full-Life Technologies Hk Limited Preparation method of compounds targeting neurotensin receptor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE258017C (OSRAM) *
DE404647C (de) * 1922-11-18 1924-10-20 Chemische Ind Ges Verfahren zur Herstellung von Pyrazolonfarbstoffen
US3520926A (en) * 1966-11-14 1970-07-21 Hoffmann La Roche Methylhydrazinomethyl-substituted benzoic acid amides
US4105766A (en) * 1977-08-19 1978-08-08 Sterling Drug Inc. 4,5-Dihydro-5-oxopyrazolo[1,5-a]quinazoline-3-carboxylic acid derivatives
GB9004435D0 (en) * 1990-02-28 1990-04-25 Marconi Co Ltd Geostationary satellite
FR2665898B1 (fr) * 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2711140B1 (fr) * 1993-10-12 1996-01-05 Sanofi Sa 1-Naphtylpyrazole-3-carboxamides substitués actifs sur la neurotensine, leur préparation, les compositions pharmaceutiques en contenant.
FR2732967B1 (fr) 1995-04-11 1997-07-04 Sanofi Sa 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant

Also Published As

Publication number Publication date
HUP9801435A3 (en) 1998-12-28
CN1072210C (zh) 2001-10-03
US5936123A (en) 1999-08-10
JP3061644B2 (ja) 2000-07-10
WO1996032382A1 (fr) 1996-10-17
US6172239B1 (en) 2001-01-09
RU2195455C2 (ru) 2002-12-27
NO974702L (no) 1997-12-10
HUP9801435A2 (hu) 1998-10-28
AU5651696A (en) 1996-10-30
SK136797A3 (en) 1998-07-08
CA2220827A1 (en) 1996-10-17
ZA962886B (en) 1996-10-15
FR2732967A1 (fr) 1996-10-18
AU709119B2 (en) 1999-08-19
EP0820444A1 (fr) 1998-01-28
EP1097921A1 (fr) 2001-05-09
US5939449A (en) 1999-08-17
US5925661A (en) 1999-07-20
CZ292255B6 (cs) 2003-08-13
IS4582A (is) 1997-10-09
PL322723A1 (en) 1998-02-16
NO974702D0 (no) 1997-10-10
TR199701146T1 (xx) 1998-02-21
CN1184469A (zh) 1998-06-10
EE9700264A (et) 1998-04-15
IL117860A0 (en) 1996-08-04
US5723483A (en) 1998-03-03
IN185700B (OSRAM) 2001-04-07
NO310071B1 (no) 2001-05-14
CZ323297A3 (cs) 1998-02-18
NZ307227A (en) 2000-01-28
US5965579A (en) 1999-10-12
PL188077B1 (pl) 2004-12-31
UA66750C2 (en) 2004-06-15
TW411332B (en) 2000-11-11
JPH11504624A (ja) 1999-04-27
AR003940A1 (es) 1998-09-30
KR100366118B1 (ko) 2003-03-15
FR2732967B1 (fr) 1997-07-04

Similar Documents

Publication Publication Date Title
MY114424A (en) Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors,their preparation and pharmaceutical compositions containing them
ES8800269A1 (es) Un procedimiento para la preparacion de peptidilaminodioles.
IL119729A0 (en) Heterocyclic compounds having tachykinin receptor antagonist activity pharmaceutical compositions containing the same and processes for the preparation thereof
DE69205327D1 (de) Harnstoffderivate, Verfahren zu ihrer Herstellung und diese enthaltende Medikamente.
AU1324595A (en) Cyclic polyamines
GB2346878B (en) Preparation of 3-substituted adenines
DE69837346D1 (de) Anilidderivate, deren herstellung und verwendung
PL354323A1 (en) Quinazoline derivatives and their use as pharmaceuticals
NZ505675A (en) N-alkylamide substituted hydroxamic acid derivatives are used as antibacterial agents
HUP9802426A2 (hu) 2,4-Diamino-1,3,5-triazin-származékok, eljárás előállításukra és ezeket tartalmazó herbicid és növekedésszabályozó készítmények
EP1245249A3 (fr) Utilisation d'un composé amphipathique cationique comme agent de transfection, comme adjuvant de vaccin, ou comme medicament
DE69120664D1 (de) Brennstoffzusammensetzungen welche hydroxyalkyl-substituierte amine enthalten
IL104567A0 (en) Ethanolamine derivatives,processes for the preparation thereof and a pharmaceutical composition containing the same
EP0775487A4 (en) TRIAZINE DERIVATIVE AND MEDICINE
ZA945157B (en) Imidazo [1,2-a] pyrazin-4-one derivatives, their preparation and medicaments containing them
BG106814A (en) Quaternary salts of n-substituted cyclic or acyclic amines as pharmaceuticals
DE69939602D1 (de) Verbindungen, aus der verbindung hergestelltes polymer und das polymer enthaltende mischung
FI951555A0 (fi) 5H,10H-imidatso[1,2-a]indeno[1,2-e]pyratsin-4-onijohdannaiset, niiden valmistus ja niitä sisältävät lääkkeet
GB9516929D0 (en) Pigment compositions
HUP9802568A2 (hu) Glutamát-receptor antagonista hatású szubsztituált-kinoxalin-2,3-dionok alkil-amin-származékai és ezeket tartalmazó gyógyszerkészítmények
NO963791L (no) Peptidderivater
HU9402509D0 (en) N,n'-disubstituted amine derivative
TW372963B (en) Substituted cycloalkylamino and cycloalkoxy heterocycles, processes for preparing them and their use as pesticides and fungicides
ZA945773B (en) Pharmaceuticals
BG103414A (en) N-(imidazolylbutyl)benzenesulphonamide derivatives, method for their prepraration and application as medicaments