MXPA99006979A - Diazepinoindolonas que inhiben la fosfodiesterasa4. - Google Patents

Diazepinoindolonas que inhiben la fosfodiesterasa4.

Info

Publication number
MXPA99006979A
MXPA99006979A MXPA99006979A MX9906979A MXPA99006979A MX PA99006979 A MXPA99006979 A MX PA99006979A MX PA99006979 A MXPA99006979 A MX PA99006979A MX 9906979 A MX9906979 A MX 9906979A MX PA99006979 A MXPA99006979 A MX PA99006979A
Authority
MX
Mexico
Prior art keywords
oxo
methyl
diazepino
phenyl
dihydro
Prior art date
Application number
MXPA99006979A
Other languages
English (en)
Spanish (es)
Inventor
Adrian Payne
Original Assignee
Parke Davis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis filed Critical Parke Davis
Publication of MXPA99006979A publication Critical patent/MXPA99006979A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
MXPA99006979A 1997-04-30 1998-04-30 Diazepinoindolonas que inhiben la fosfodiesterasa4. MXPA99006979A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9705422A FR2762841B1 (fr) 1997-04-30 1997-04-30 Diazepino-indolones inhibitrices de phosphodiesterases iv
PCT/EP1998/002827 WO1998049169A1 (en) 1997-04-30 1998-04-30 Phosphodiesterase 4-inhibiting diazepinoindolones

Publications (1)

Publication Number Publication Date
MXPA99006979A true MXPA99006979A (es) 2005-04-19

Family

ID=9506517

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA99006979A MXPA99006979A (es) 1997-04-30 1998-04-30 Diazepinoindolonas que inhiben la fosfodiesterasa4.

Country Status (17)

Country Link
US (1) US6239130B1 (enExample)
EP (1) EP0980374B1 (enExample)
JP (1) JP2001522367A (enExample)
KR (1) KR20010020386A (enExample)
AT (1) ATE232534T1 (enExample)
AU (1) AU729495B2 (enExample)
BR (1) BR9809429A (enExample)
CA (1) CA2278217A1 (enExample)
DE (1) DE69811360T2 (enExample)
DK (1) DK0980374T3 (enExample)
ES (1) ES2190083T3 (enExample)
FR (1) FR2762841B1 (enExample)
HR (1) HRP980231B1 (enExample)
MX (1) MXPA99006979A (enExample)
NZ (1) NZ337589A (enExample)
WO (1) WO1998049169A1 (enExample)
ZA (1) ZA983704B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2795731B1 (fr) * 1999-07-02 2001-09-07 Warner Lambert Co PROCEDE DE PREPARATION DE [1,4] DIAZEPINO [6,7,1-hi] INDOL-4-ONES SUBSTITUEES
BR0108908A (pt) * 2000-03-03 2002-12-24 Pfizer Prod Inc Derivados de éteres de pirazol como agentes antiinflamatórios/analgésicos
EP1161949A1 (en) 2000-06-09 2001-12-12 Warner-Lambert Company Use od diazepinoindoles for the treatment of chronic obstructive pulmonary disease
EP1188438A1 (en) * 2000-09-15 2002-03-20 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production
EP1199074A1 (en) * 2000-09-15 2002-04-24 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production
CN1520313A (zh) * 2001-05-23 2004-08-11 ������ҩ��ʽ���� 一种加速骨折愈合的组合物
ES2427930T3 (es) 2001-05-23 2013-11-04 Mitsubishi Tanabe Pharma Corporation Composición terapéutica para el tratamiento regenerativo de enfermedades de los cartílagos
WO2003007955A2 (en) * 2001-07-20 2003-01-30 Cancer Research Technology Limited Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
US20090042951A1 (en) * 2004-02-20 2009-02-12 Robert Danziger Blood Pressure Reduction in Salt-Sensitive Hypertension
CN1972684A (zh) * 2004-04-23 2007-05-30 细胞基因公司 用于治疗和控制肺高血压的含有pde4调节剂的组合物以及其使用方法
AU2006237300B2 (en) * 2005-04-19 2011-10-13 Takeda Gmbh Roflumilast for the treatment of pulmonary hypertension
WO2008041118A2 (en) * 2006-10-04 2008-04-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
US20080254029A1 (en) * 2007-04-11 2008-10-16 Alcon Research, Ltd. Use of an Inhibitor of TNFa Plus an Antihistamine to Treat Allergic Rhinitis and Allergic Conjunctivitis
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
KR20100037047A (ko) * 2007-06-26 2010-04-08 렉시컨 파마슈티컬스 인코퍼레이티드 세로토닌-매개 질환 및 장애의 치료 방법
CN102548536A (zh) * 2009-10-01 2012-07-04 爱尔康研究有限公司 奥洛他定组合物及其用途
AU2019417718A1 (en) 2018-12-28 2021-07-08 Regeneron Pharmaceuticals, Inc. Treatment of respiratory disorders with Arachidonate 15-Lipoxygenase (ALOX15) inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2725719B1 (fr) * 1994-10-14 1996-12-06 Jouveinal Inst Rech Diazepino-indoles inhibiteurs de phosphodiesterases iv

Also Published As

Publication number Publication date
HRP980231B1 (en) 2002-06-30
ATE232534T1 (de) 2003-02-15
US6239130B1 (en) 2001-05-29
ES2190083T3 (es) 2003-07-16
WO1998049169A1 (en) 1998-11-05
EP0980374B1 (en) 2003-02-12
KR20010020386A (ko) 2001-03-15
FR2762841A1 (fr) 1998-11-06
AU729495B2 (en) 2001-02-01
ZA983704B (en) 1999-10-25
DK0980374T3 (da) 2003-05-05
DE69811360D1 (de) 2003-03-20
NZ337589A (en) 2000-10-27
DE69811360T2 (de) 2003-10-09
JP2001522367A (ja) 2001-11-13
AU7765298A (en) 1998-11-24
CA2278217A1 (en) 1998-11-05
HRP980231A2 (en) 2000-04-30
FR2762841B1 (fr) 1999-07-02
EP0980374A1 (en) 2000-02-23
BR9809429A (pt) 2000-06-13

Similar Documents

Publication Publication Date Title
MXPA99006979A (es) Diazepinoindolonas que inhiben la fosfodiesterasa4.
AU735631B2 (en) Diazepino-indoles as phosphodiesterase IV inhibitors
HRP20030081A2 (en) Benzimidazole derivatives, preparation and therapeutic use thereof
US5852190A (en) Diazepinoindoles as phosphodiesterase IV inhibitors
CA3190745A1 (en) Substituted tricyclic compounds
WO1997023482A1 (en) 2,7-substituted octahydro-pyrrolo[1,2-a]pyrazine derivatives
US20170258807A1 (en) Substituted triazolobenzodiazepines
JPWO1993003031A1 (ja) ピロロアゼピン誘導体
JP2006515018A (ja) ピリド［２，３−ｄ］ピリミジン−７−カルボン酸誘導体類、それらの製造及び医薬剤としての使用
AU592551B2 (en) Imidazo-isoquinoline and imidazo-thienopyridine compounds
CN101014600A (zh) 用作蛋白激酶抑制剂的6－(2－烷基－苯基)－吡啶并[2,3－d]嘧啶类
SK133797A3 (en) 5h,10h-imidazo£1,2-a|indeno£1,2-e|pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives
SK19242001A3 (sk) Spôsob prípravy substituovaných [1,4]diazepino[6,7,1-hi]indol-4-ónov
MXPA97002637A (en) Diazepin-indoles, as inhibitors of phosphodysterase
AU4614801A (en) Diazepino-indoles as phosphodiesterase IV inhibitors
HK1153195A1 (en) Compound with serotoninergic activity, process for preparing it and pharmaceutical composition comprising it
HK1153195B (en) Compound with serotoninergic activity, process for preparing it and pharmaceutical composition comprising it
HK1028769A1 (en) 2-aryl-8-oxodihydropurine derivatives, process for producing the same, medicinal compositions containing the same, and intermediates thereof