DE69811360D1 - Diazepinoindolone als phophodiesterase 4 inhibitoren - Google Patents
Diazepinoindolone als phophodiesterase 4 inhibitorenInfo
- Publication number
- DE69811360D1 DE69811360D1 DE69811360T DE69811360T DE69811360D1 DE 69811360 D1 DE69811360 D1 DE 69811360D1 DE 69811360 T DE69811360 T DE 69811360T DE 69811360 T DE69811360 T DE 69811360T DE 69811360 D1 DE69811360 D1 DE 69811360D1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- compounds
- present
- diazepinoindolone
- phophodiesterase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- ZWOMUDQWODQGQH-UHFFFAOYSA-N 1H-pyrrolo[2,3-g][1,2]benzodiazepin-2-one Chemical compound C1=CC2=NN=CC=CC2=C2C1=CC(=O)N2 ZWOMUDQWODQGQH-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 abstract 1
- 206010065687 Bone loss Diseases 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 206010067125 Liver injury Diseases 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 abstract 1
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 231100000753 hepatic injury Toxicity 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000002815 pulmonary hypertension Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9705422A FR2762841B1 (fr) | 1997-04-30 | 1997-04-30 | Diazepino-indolones inhibitrices de phosphodiesterases iv |
| PCT/EP1998/002827 WO1998049169A1 (en) | 1997-04-30 | 1998-04-30 | Phosphodiesterase 4-inhibiting diazepinoindolones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69811360D1 true DE69811360D1 (de) | 2003-03-20 |
| DE69811360T2 DE69811360T2 (de) | 2003-10-09 |
Family
ID=9506517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69811360T Expired - Fee Related DE69811360T2 (de) | 1997-04-30 | 1998-04-30 | Diazepinoindolone als phophodiesterase 4 inhibitoren |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6239130B1 (de) |
| EP (1) | EP0980374B1 (de) |
| JP (1) | JP2001522367A (de) |
| KR (1) | KR20010020386A (de) |
| AT (1) | ATE232534T1 (de) |
| AU (1) | AU729495B2 (de) |
| BR (1) | BR9809429A (de) |
| CA (1) | CA2278217A1 (de) |
| DE (1) | DE69811360T2 (de) |
| DK (1) | DK0980374T3 (de) |
| ES (1) | ES2190083T3 (de) |
| FR (1) | FR2762841B1 (de) |
| HR (1) | HRP980231B1 (de) |
| MX (1) | MXPA99006979A (de) |
| NZ (1) | NZ337589A (de) |
| WO (1) | WO1998049169A1 (de) |
| ZA (1) | ZA983704B (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2795731B1 (fr) | 1999-07-02 | 2001-09-07 | Warner Lambert Co | PROCEDE DE PREPARATION DE [1,4] DIAZEPINO [6,7,1-hi] INDOL-4-ONES SUBSTITUEES |
| MXPA02008627A (es) * | 2000-03-03 | 2003-02-24 | Pfizer Prod Inc | Derivados de eteres de pirazol como agentes antiinflamatorios/analgesicos. |
| EP1161949A1 (de) | 2000-06-09 | 2001-12-12 | Warner-Lambert Company | Verwendung von diazepinoindolen zur behandlung von chronisch obstruktiver lungenkrankheiten |
| EP1199074A1 (de) * | 2000-09-15 | 2002-04-24 | Warner-Lambert Company | Pharmazeutische Zusammensetzungen zur Vorbeugung oder Behandlung von mit IL-12 Überproduktion assozierten Erkrankungen |
| EP1188438A1 (de) * | 2000-09-15 | 2002-03-20 | Warner-Lambert Company | Pharmazeutische Zusammensetzungen zur Vorbeugung oder Behandlung von mit IL-12 Überproduktion assozierten Erkrankungen |
| KR20040007596A (ko) * | 2001-05-23 | 2004-01-24 | 다나베 세이야꾸 가부시키가이샤 | 골절 치료 촉진용 조성물 |
| MXPA03010672A (es) | 2001-05-23 | 2004-03-02 | Tanabe Seiyaku Co | Composicion para el tratamiento regenerativo de enfermedades del cartilago. |
| WO2003007955A2 (en) * | 2001-07-20 | 2003-01-30 | Cancer Research Technology Limited | Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer |
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| US20050187278A1 (en) * | 2003-08-28 | 2005-08-25 | Pharmacia Corporation | Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors |
| WO2006073413A1 (en) * | 2004-02-20 | 2006-07-13 | The Board Of Trustees Of The University Of Illinois | Blood pressure reduction in salt-sensitive |
| EP1755589A4 (de) * | 2004-04-23 | 2007-11-07 | Celgene Corp | Verfahren zur verwendung von pde4-modulatoren und diese enthaltende zusammensetzungen zur behandlung und kontrolle von pulmonaler hypertonie |
| WO2006111495A1 (en) * | 2005-04-19 | 2006-10-26 | Nycomed Gmbh | Roflumilast for the treatment of pulmonary hypertension |
| KR101129868B1 (ko) * | 2006-10-04 | 2012-04-12 | 화이자 프로덕츠 인코포레이티드 | 칼슘 수용체 길항제로서의 피리도［4,3-ｄ］피리미딘-4(3Ｈ)-온 유도체 |
| US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
| KR20100014565A (ko) * | 2007-04-11 | 2010-02-10 | 알콘 리서치, 리미티드 | 알레르기성 비염 및 알레르기성 결막염을 치료하기 위한 ｔｎｆａ의 억제제 및 항히스타민의 용도 |
| JP2010531888A (ja) * | 2007-06-26 | 2010-09-30 | レクシコン ファーマシューティカルズ インコーポレイテッド | セロトニン媒介性の疾患及び障害を治療する方法 |
| MX2012003693A (es) * | 2009-10-01 | 2012-04-19 | Alcon Res Ltd | Composiciones de olopatadine y usos de las mismas. |
| MX2021007938A (es) | 2018-12-28 | 2022-01-24 | Regeneron Pharma | Tratamiento de trastornos respiratorios con inhibidores de la araquidonato 15-lipooxigenasa (alox15). |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2725719B1 (fr) * | 1994-10-14 | 1996-12-06 | Jouveinal Inst Rech | Diazepino-indoles inhibiteurs de phosphodiesterases iv |
-
1997
- 1997-04-30 FR FR9705422A patent/FR2762841B1/fr not_active Expired - Fee Related
-
1998
- 1998-04-29 HR HR980231A patent/HRP980231B1/xx not_active IP Right Cessation
- 1998-04-30 US US09/380,883 patent/US6239130B1/en not_active Expired - Fee Related
- 1998-04-30 ZA ZA9803704A patent/ZA983704B/xx unknown
- 1998-04-30 NZ NZ337589A patent/NZ337589A/xx unknown
- 1998-04-30 CA CA002278217A patent/CA2278217A1/en not_active Abandoned
- 1998-04-30 DE DE69811360T patent/DE69811360T2/de not_active Expired - Fee Related
- 1998-04-30 BR BR9809429-7A patent/BR9809429A/pt not_active IP Right Cessation
- 1998-04-30 WO PCT/EP1998/002827 patent/WO1998049169A1/en not_active Ceased
- 1998-04-30 JP JP54662498A patent/JP2001522367A/ja not_active Abandoned
- 1998-04-30 AT AT98925598T patent/ATE232534T1/de not_active IP Right Cessation
- 1998-04-30 ES ES98925598T patent/ES2190083T3/es not_active Expired - Lifetime
- 1998-04-30 AU AU77652/98A patent/AU729495B2/en not_active Ceased
- 1998-04-30 KR KR1019997010008A patent/KR20010020386A/ko not_active Ceased
- 1998-04-30 DK DK98925598T patent/DK0980374T3/da active
- 1998-04-30 MX MXPA99006979A patent/MXPA99006979A/es unknown
- 1998-04-30 EP EP98925598A patent/EP0980374B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0980374B1 (de) | 2003-02-12 |
| MXPA99006979A (es) | 2005-04-19 |
| ZA983704B (en) | 1999-10-25 |
| ES2190083T3 (es) | 2003-07-16 |
| FR2762841B1 (fr) | 1999-07-02 |
| FR2762841A1 (fr) | 1998-11-06 |
| EP0980374A1 (de) | 2000-02-23 |
| DK0980374T3 (da) | 2003-05-05 |
| US6239130B1 (en) | 2001-05-29 |
| CA2278217A1 (en) | 1998-11-05 |
| DE69811360T2 (de) | 2003-10-09 |
| BR9809429A (pt) | 2000-06-13 |
| AU7765298A (en) | 1998-11-24 |
| KR20010020386A (ko) | 2001-03-15 |
| ATE232534T1 (de) | 2003-02-15 |
| HRP980231A2 (en) | 2000-04-30 |
| AU729495B2 (en) | 2001-02-01 |
| JP2001522367A (ja) | 2001-11-13 |
| HRP980231B1 (en) | 2002-06-30 |
| WO1998049169A1 (en) | 1998-11-05 |
| NZ337589A (en) | 2000-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |