BR9809429A - Diazepinoindolonas inibidoras de fosfodiesterase 4 - Google Patents

Diazepinoindolonas inibidoras de fosfodiesterase 4

Info

Publication number
BR9809429A
BR9809429A BR9809429-7A BR9809429A BR9809429A BR 9809429 A BR9809429 A BR 9809429A BR 9809429 A BR9809429 A BR 9809429A BR 9809429 A BR9809429 A BR 9809429A
Authority
BR
Brazil
Prior art keywords
formula
compounds
phosphodiesterase
diazepinoindolones
inhibiting
Prior art date
Application number
BR9809429-7A
Other languages
English (en)
Inventor
Yves Pascal
Catharine Burnouf
Bernard Gaudilliere
Henri Jacobelli
Alain Calvet
Adrian Payne
Svein Gunwald Dahl
Original Assignee
Parke Davis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis filed Critical Parke Davis
Publication of BR9809429A publication Critical patent/BR9809429A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Patente de Invenção: <B>"DIAZEPINOINDOLONAS INIBIDORAS DE FOSFODIESTERASE 4"<D>. A presente invenção apresenta compostos que inibem a fosfodiesterase 4 tendo fórmula (l). A presente invenção também fornece métodos para uso dos compostos de fórmula (l) para prevenir ou tratar asma, dermatite atópica, artrite reumatóide, doenças inflamatórias do intestino, hipertensão pulmonar, lesão do fígado, perda óssea, choque séptico ou esclerose múltipla, e a composições farmacêuticas que contêm os compostos de fórmula (l).
BR9809429-7A 1997-04-30 1998-04-30 Diazepinoindolonas inibidoras de fosfodiesterase 4 BR9809429A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9705422A FR2762841B1 (fr) 1997-04-30 1997-04-30 Diazepino-indolones inhibitrices de phosphodiesterases iv
PCT/EP1998/002827 WO1998049169A1 (en) 1997-04-30 1998-04-30 Phosphodiesterase 4-inhibiting diazepinoindolones

Publications (1)

Publication Number Publication Date
BR9809429A true BR9809429A (pt) 2000-06-13

Family

ID=9506517

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9809429-7A BR9809429A (pt) 1997-04-30 1998-04-30 Diazepinoindolonas inibidoras de fosfodiesterase 4

Country Status (17)

Country Link
US (1) US6239130B1 (pt)
EP (1) EP0980374B1 (pt)
JP (1) JP2001522367A (pt)
KR (1) KR20010020386A (pt)
AT (1) ATE232534T1 (pt)
AU (1) AU729495B2 (pt)
BR (1) BR9809429A (pt)
CA (1) CA2278217A1 (pt)
DE (1) DE69811360T2 (pt)
DK (1) DK0980374T3 (pt)
ES (1) ES2190083T3 (pt)
FR (1) FR2762841B1 (pt)
HR (1) HRP980231B1 (pt)
MX (1) MXPA99006979A (pt)
NZ (1) NZ337589A (pt)
WO (1) WO1998049169A1 (pt)
ZA (1) ZA983704B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2795731B1 (fr) * 1999-07-02 2001-09-07 Warner Lambert Co PROCEDE DE PREPARATION DE [1,4] DIAZEPINO [6,7,1-hi] INDOL-4-ONES SUBSTITUEES
WO2001064669A1 (en) * 2000-03-03 2001-09-07 Pfizer Products Inc. Pyrazole ether derivatives as anti-inflammatory/analgesic agents
EP1161949A1 (en) 2000-06-09 2001-12-12 Warner-Lambert Company Use od diazepinoindoles for the treatment of chronic obstructive pulmonary disease
EP1199074A1 (en) * 2000-09-15 2002-04-24 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production
EP1188438A1 (en) * 2000-09-15 2002-03-20 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production
ES2427930T3 (es) 2001-05-23 2013-11-04 Mitsubishi Tanabe Pharma Corporation Composición terapéutica para el tratamiento regenerativo de enfermedades de los cartílagos
WO2002094321A1 (fr) 2001-05-23 2002-11-28 Tanabe Seiyaku Co., Ltd. Compositions favorisant la guérison d'une fracture osseuse
AU2002317377A1 (en) * 2001-07-20 2003-03-03 Cancer Research Technology Limited Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
WO2006073413A1 (en) * 2004-02-20 2006-07-13 The Board Of Trustees Of The University Of Illinois Blood pressure reduction in salt-sensitive
WO2005102317A1 (en) * 2004-04-23 2005-11-03 Celgene Corporation Methods of using and compositions comprising pde4 modulators for the treatment and management of pulmonary hypertension
MX2007012711A (es) * 2005-04-19 2008-01-11 Nycomed Gmbh Roflumilast para el tratamiento de hipertension pulmonar.
WO2008041118A2 (en) * 2006-10-04 2008-04-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
CA2682730A1 (en) * 2007-04-11 2008-10-23 Alcon Research, Ltd. Use of an inhibitor of tnf.alpha. plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis
MX2009013990A (es) * 2007-06-26 2010-03-30 Lexicon Pharmaceuticals Inc Metodos para tratar enfermedades y trastornos mediados por serotonina.
BR112012007091A2 (pt) * 2009-10-01 2016-04-19 Alcon Res Ltd composições de olopatadina e seus usos
CN113423435A (zh) 2018-12-28 2021-09-21 雷杰纳荣制药公司 使用花生四烯酸15-脂氧合酶(alox15)抑制剂治疗呼吸系统病症

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2725719B1 (fr) * 1994-10-14 1996-12-06 Jouveinal Inst Rech Diazepino-indoles inhibiteurs de phosphodiesterases iv

Also Published As

Publication number Publication date
FR2762841B1 (fr) 1999-07-02
US6239130B1 (en) 2001-05-29
NZ337589A (en) 2000-10-27
HRP980231B1 (en) 2002-06-30
FR2762841A1 (fr) 1998-11-06
AU7765298A (en) 1998-11-24
EP0980374A1 (en) 2000-02-23
CA2278217A1 (en) 1998-11-05
AU729495B2 (en) 2001-02-01
DE69811360D1 (de) 2003-03-20
EP0980374B1 (en) 2003-02-12
ZA983704B (en) 1999-10-25
ATE232534T1 (de) 2003-02-15
KR20010020386A (ko) 2001-03-15
DE69811360T2 (de) 2003-10-09
ES2190083T3 (es) 2003-07-16
DK0980374T3 (da) 2003-05-05
MXPA99006979A (es) 2005-04-19
JP2001522367A (ja) 2001-11-13
HRP980231A2 (en) 2000-04-30
WO1998049169A1 (en) 1998-11-05

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1908 DE 31/07/2007.