ZA983704B - Phosphodiesterase 4-inhibiting diazepinoindolones. - Google Patents

Phosphodiesterase 4-inhibiting diazepinoindolones.

Info

Publication number
ZA983704B
ZA983704B ZA9803704A ZA983704A ZA983704B ZA 983704 B ZA983704 B ZA 983704B ZA 9803704 A ZA9803704 A ZA 9803704A ZA 983704 A ZA983704 A ZA 983704A ZA 983704 B ZA983704 B ZA 983704B
Authority
ZA
South Africa
Prior art keywords
formula
compounds
phosphodiesterase
diazepinoindolones
inhibiting
Prior art date
Application number
ZA9803704A
Other languages
English (en)
Inventor
Yves Pascal
Catherine Burnouf
Bernard Gaudilliere
Henry Jacobelli
Alain Calvet
Adrian Payne
Svein Gunwald Dahl
Original Assignee
Parke Davis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis filed Critical Parke Davis
Publication of ZA983704B publication Critical patent/ZA983704B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA9803704A 1997-04-30 1998-04-30 Phosphodiesterase 4-inhibiting diazepinoindolones. ZA983704B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9705422A FR2762841B1 (fr) 1997-04-30 1997-04-30 Diazepino-indolones inhibitrices de phosphodiesterases iv

Publications (1)

Publication Number Publication Date
ZA983704B true ZA983704B (en) 1999-10-25

Family

ID=9506517

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9803704A ZA983704B (en) 1997-04-30 1998-04-30 Phosphodiesterase 4-inhibiting diazepinoindolones.

Country Status (17)

Country Link
US (1) US6239130B1 (enExample)
EP (1) EP0980374B1 (enExample)
JP (1) JP2001522367A (enExample)
KR (1) KR20010020386A (enExample)
AT (1) ATE232534T1 (enExample)
AU (1) AU729495B2 (enExample)
BR (1) BR9809429A (enExample)
CA (1) CA2278217A1 (enExample)
DE (1) DE69811360T2 (enExample)
DK (1) DK0980374T3 (enExample)
ES (1) ES2190083T3 (enExample)
FR (1) FR2762841B1 (enExample)
HR (1) HRP980231B1 (enExample)
MX (1) MXPA99006979A (enExample)
NZ (1) NZ337589A (enExample)
WO (1) WO1998049169A1 (enExample)
ZA (1) ZA983704B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2795731B1 (fr) * 1999-07-02 2001-09-07 Warner Lambert Co PROCEDE DE PREPARATION DE [1,4] DIAZEPINO [6,7,1-hi] INDOL-4-ONES SUBSTITUEES
BR0108908A (pt) * 2000-03-03 2002-12-24 Pfizer Prod Inc Derivados de éteres de pirazol como agentes antiinflamatórios/analgésicos
EP1161949A1 (en) 2000-06-09 2001-12-12 Warner-Lambert Company Use od diazepinoindoles for the treatment of chronic obstructive pulmonary disease
EP1188438A1 (en) * 2000-09-15 2002-03-20 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production
EP1199074A1 (en) * 2000-09-15 2002-04-24 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production
CN1520313A (zh) * 2001-05-23 2004-08-11 ������ҩ��ʽ���� 一种加速骨折愈合的组合物
ES2427930T3 (es) 2001-05-23 2013-11-04 Mitsubishi Tanabe Pharma Corporation Composición terapéutica para el tratamiento regenerativo de enfermedades de los cartílagos
WO2003007955A2 (en) * 2001-07-20 2003-01-30 Cancer Research Technology Limited Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
US20090042951A1 (en) * 2004-02-20 2009-02-12 Robert Danziger Blood Pressure Reduction in Salt-Sensitive Hypertension
CN1972684A (zh) * 2004-04-23 2007-05-30 细胞基因公司 用于治疗和控制肺高血压的含有pde4调节剂的组合物以及其使用方法
AU2006237300B2 (en) * 2005-04-19 2011-10-13 Takeda Gmbh Roflumilast for the treatment of pulmonary hypertension
WO2008041118A2 (en) * 2006-10-04 2008-04-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
US20080254029A1 (en) * 2007-04-11 2008-10-16 Alcon Research, Ltd. Use of an Inhibitor of TNFa Plus an Antihistamine to Treat Allergic Rhinitis and Allergic Conjunctivitis
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
KR20100037047A (ko) * 2007-06-26 2010-04-08 렉시컨 파마슈티컬스 인코퍼레이티드 세로토닌-매개 질환 및 장애의 치료 방법
CN102548536A (zh) * 2009-10-01 2012-07-04 爱尔康研究有限公司 奥洛他定组合物及其用途
AU2019417718A1 (en) 2018-12-28 2021-07-08 Regeneron Pharmaceuticals, Inc. Treatment of respiratory disorders with Arachidonate 15-Lipoxygenase (ALOX15) inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2725719B1 (fr) * 1994-10-14 1996-12-06 Jouveinal Inst Rech Diazepino-indoles inhibiteurs de phosphodiesterases iv

Also Published As

Publication number Publication date
MXPA99006979A (es) 2005-04-19
HRP980231B1 (en) 2002-06-30
ATE232534T1 (de) 2003-02-15
US6239130B1 (en) 2001-05-29
ES2190083T3 (es) 2003-07-16
WO1998049169A1 (en) 1998-11-05
EP0980374B1 (en) 2003-02-12
KR20010020386A (ko) 2001-03-15
FR2762841A1 (fr) 1998-11-06
AU729495B2 (en) 2001-02-01
DK0980374T3 (da) 2003-05-05
DE69811360D1 (de) 2003-03-20
NZ337589A (en) 2000-10-27
DE69811360T2 (de) 2003-10-09
JP2001522367A (ja) 2001-11-13
AU7765298A (en) 1998-11-24
CA2278217A1 (en) 1998-11-05
HRP980231A2 (en) 2000-04-30
FR2762841B1 (fr) 1999-07-02
EP0980374A1 (en) 2000-02-23
BR9809429A (pt) 2000-06-13

Similar Documents

Publication Publication Date Title
ZA983704B (en) Phosphodiesterase 4-inhibiting diazepinoindolones.
PL314605A1 (en) Isoxazolin compounds as anti-inflammatory agents
GR3032506T3 (en) 3-aryl-2-isoxazolines as antiinflammatory agents
MX9805016A (es) INHIBIDORES DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1 beta.
BG102872A (en) 6-phenylpyridyl-3-amine derivatives
WO2003041643A3 (en) Hsp90-inhibiting zearalanol compounds and methods of producing and using same
EP1034164A4 (en) BETA-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS
BG104138A (en) 2-aminopyridines containing substituents with condensed rings as nos inhibitors
WO2004054501A3 (en) Methods of usig and compositions comprising (-)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide
SI1480961T1 (sl) Inhibitorji dpiv na osnovi glutaminila
ZA951909B (en) Isoxazoline compounds as inhibitors of tnf release
WO2001035950A3 (en) Benzamide therapeutics and methods for treating inflammatory bowel disease
MY122278A (en) 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
AP2000001992A0 (en) Succinamide inhibitors of inteleukin-1B converting enzyme.
IL117209A (en) 1-aryl-2-acylamino-ethane compounds and pharmaceutical compositions containing them
BG104292A (en) Methods and compositions for the treatment of rheumatoid arthritis
BG104373A (en) Polymorphous forms of dofetilide
PL358552A1 (en) 2-aminoalkyl-thieno[2,3-d]pyrimidines
DE69929802D1 (en) Lta4 hydrolase-hemmer
MX9805015A (es) INHIBIDORES DE LA ENZIMA QUE CONVIERTE LA INTERLEUCINA-1 beta.
HK1073599A (en) Immunosuppressant compounds, methods and uses related thereto