FR2762841B1 - Diazepino-indolones inhibitrices de phosphodiesterases iv - Google Patents

Diazepino-indolones inhibitrices de phosphodiesterases iv

Info

Publication number
FR2762841B1
FR2762841B1 FR9705422A FR9705422A FR2762841B1 FR 2762841 B1 FR2762841 B1 FR 2762841B1 FR 9705422 A FR9705422 A FR 9705422A FR 9705422 A FR9705422 A FR 9705422A FR 2762841 B1 FR2762841 B1 FR 2762841B1
Authority
FR
France
Prior art keywords
formula
compounds
indolones
diazepino
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9705422A
Other languages
English (en)
French (fr)
Other versions
FR2762841A1 (fr
Inventor
Yves Pascal
Catherine Burnouf
Bernard Gaudilliere
Alain Calvet
Adrian Payne
Svein G Dahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut de Recherche Jouveinal
Original Assignee
Institut de Recherche Jouveinal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut de Recherche Jouveinal filed Critical Institut de Recherche Jouveinal
Priority to FR9705422A priority Critical patent/FR2762841B1/fr
Priority to HR980231A priority patent/HRP980231B1/xx
Priority to JP54662498A priority patent/JP2001522367A/ja
Priority to DE69811360T priority patent/DE69811360T2/de
Priority to DK98925598T priority patent/DK0980374T3/da
Priority to AT98925598T priority patent/ATE232534T1/de
Priority to MXPA99006979A priority patent/MXPA99006979A/es
Priority to ZA9803704A priority patent/ZA983704B/xx
Priority to CA002278217A priority patent/CA2278217A1/en
Priority to ES98925598T priority patent/ES2190083T3/es
Priority to NZ337589A priority patent/NZ337589A/xx
Priority to KR1019997010008A priority patent/KR20010020386A/ko
Priority to EP98925598A priority patent/EP0980374B1/en
Priority to PCT/EP1998/002827 priority patent/WO1998049169A1/en
Priority to AU77652/98A priority patent/AU729495B2/en
Priority to BR9809429-7A priority patent/BR9809429A/pt
Priority to US09/380,883 priority patent/US6239130B1/en
Publication of FR2762841A1 publication Critical patent/FR2762841A1/fr
Application granted granted Critical
Publication of FR2762841B1 publication Critical patent/FR2762841B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FR9705422A 1997-04-30 1997-04-30 Diazepino-indolones inhibitrices de phosphodiesterases iv Expired - Fee Related FR2762841B1 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
FR9705422A FR2762841B1 (fr) 1997-04-30 1997-04-30 Diazepino-indolones inhibitrices de phosphodiesterases iv
HR980231A HRP980231B1 (en) 1997-04-30 1998-04-29 Phosphodiesterase 4 - inhibiting diazepinoindolones
KR1019997010008A KR20010020386A (ko) 1997-04-30 1998-04-30 포스포디에스테라제 4를 억제하는 디아제피노인돌론
DK98925598T DK0980374T3 (da) 1997-04-30 1998-04-30 Phosphodiesterase 4-inhiberende diazepinoindoloner.
AT98925598T ATE232534T1 (de) 1997-04-30 1998-04-30 Diazepinoindolone als phophodiesterase 4 inhibitoren
MXPA99006979A MXPA99006979A (es) 1997-04-30 1998-04-30 Diazepinoindolonas que inhiben la fosfodiesterasa4.
ZA9803704A ZA983704B (en) 1997-04-30 1998-04-30 Phosphodiesterase 4-inhibiting diazepinoindolones.
CA002278217A CA2278217A1 (en) 1997-04-30 1998-04-30 Phosphodiesterase 4-inhibiting diazepinoindolones
JP54662498A JP2001522367A (ja) 1997-04-30 1998-04-30 ホスホジエステラーゼ４−阻害ジアゼピノインドロン
NZ337589A NZ337589A (en) 1997-04-30 1998-04-30 [1,4]diazepino[6,7,1-hi]indol-4-ones and there use in treating inflammatory diseases
DE69811360T DE69811360T2 (de) 1997-04-30 1998-04-30 Diazepinoindolone als phophodiesterase 4 inhibitoren
EP98925598A EP0980374B1 (en) 1997-04-30 1998-04-30 Phosphodiesterase 4-inhibiting diazepinoindolones
PCT/EP1998/002827 WO1998049169A1 (en) 1997-04-30 1998-04-30 Phosphodiesterase 4-inhibiting diazepinoindolones
AU77652/98A AU729495B2 (en) 1997-04-30 1998-04-30 Phosphodiesterase 4-inhibiting diazepinoindolones
BR9809429-7A BR9809429A (pt) 1997-04-30 1998-04-30 Diazepinoindolonas inibidoras de fosfodiesterase 4
US09/380,883 US6239130B1 (en) 1997-04-30 1998-04-30 Phosphodiesterase 4-inhibiting diazepinoindolones
ES98925598T ES2190083T3 (es) 1997-04-30 1998-04-30 Diazepinoindoles inhibidores de fosfodiesterasa 4'.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9705422A FR2762841B1 (fr) 1997-04-30 1997-04-30 Diazepino-indolones inhibitrices de phosphodiesterases iv

Publications (2)

Publication Number Publication Date
FR2762841A1 FR2762841A1 (fr) 1998-11-06
FR2762841B1 true FR2762841B1 (fr) 1999-07-02

Family

ID=9506517

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9705422A Expired - Fee Related FR2762841B1 (fr) 1997-04-30 1997-04-30 Diazepino-indolones inhibitrices de phosphodiesterases iv

Country Status (17)

Country Link
US (1) US6239130B1 (enExample)
EP (1) EP0980374B1 (enExample)
JP (1) JP2001522367A (enExample)
KR (1) KR20010020386A (enExample)
AT (1) ATE232534T1 (enExample)
AU (1) AU729495B2 (enExample)
BR (1) BR9809429A (enExample)
CA (1) CA2278217A1 (enExample)
DE (1) DE69811360T2 (enExample)
DK (1) DK0980374T3 (enExample)
ES (1) ES2190083T3 (enExample)
FR (1) FR2762841B1 (enExample)
HR (1) HRP980231B1 (enExample)
MX (1) MXPA99006979A (enExample)
NZ (1) NZ337589A (enExample)
WO (1) WO1998049169A1 (enExample)
ZA (1) ZA983704B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2795731B1 (fr) * 1999-07-02 2001-09-07 Warner Lambert Co PROCEDE DE PREPARATION DE [1,4] DIAZEPINO [6,7,1-hi] INDOL-4-ONES SUBSTITUEES
BR0108908A (pt) * 2000-03-03 2002-12-24 Pfizer Prod Inc Derivados de éteres de pirazol como agentes antiinflamatórios/analgésicos
EP1161949A1 (en) 2000-06-09 2001-12-12 Warner-Lambert Company Use od diazepinoindoles for the treatment of chronic obstructive pulmonary disease
EP1188438A1 (en) * 2000-09-15 2002-03-20 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production
EP1199074A1 (en) * 2000-09-15 2002-04-24 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production
CN1520313A (zh) * 2001-05-23 2004-08-11 ������ҩ��ʽ���� 一种加速骨折愈合的组合物
ES2427930T3 (es) 2001-05-23 2013-11-04 Mitsubishi Tanabe Pharma Corporation Composición terapéutica para el tratamiento regenerativo de enfermedades de los cartílagos
WO2003007955A2 (en) * 2001-07-20 2003-01-30 Cancer Research Technology Limited Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
US20090042951A1 (en) * 2004-02-20 2009-02-12 Robert Danziger Blood Pressure Reduction in Salt-Sensitive Hypertension
CN1972684A (zh) * 2004-04-23 2007-05-30 细胞基因公司 用于治疗和控制肺高血压的含有pde4调节剂的组合物以及其使用方法
AU2006237300B2 (en) * 2005-04-19 2011-10-13 Takeda Gmbh Roflumilast for the treatment of pulmonary hypertension
WO2008041118A2 (en) * 2006-10-04 2008-04-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
US20080254029A1 (en) * 2007-04-11 2008-10-16 Alcon Research, Ltd. Use of an Inhibitor of TNFa Plus an Antihistamine to Treat Allergic Rhinitis and Allergic Conjunctivitis
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
KR20100037047A (ko) * 2007-06-26 2010-04-08 렉시컨 파마슈티컬스 인코퍼레이티드 세로토닌-매개 질환 및 장애의 치료 방법
CN102548536A (zh) * 2009-10-01 2012-07-04 爱尔康研究有限公司 奥洛他定组合物及其用途
AU2019417718A1 (en) 2018-12-28 2021-07-08 Regeneron Pharmaceuticals, Inc. Treatment of respiratory disorders with Arachidonate 15-Lipoxygenase (ALOX15) inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2725719B1 (fr) * 1994-10-14 1996-12-06 Jouveinal Inst Rech Diazepino-indoles inhibiteurs de phosphodiesterases iv

Also Published As

Publication number Publication date
MXPA99006979A (es) 2005-04-19
HRP980231B1 (en) 2002-06-30
ATE232534T1 (de) 2003-02-15
US6239130B1 (en) 2001-05-29
ES2190083T3 (es) 2003-07-16
WO1998049169A1 (en) 1998-11-05
EP0980374B1 (en) 2003-02-12
KR20010020386A (ko) 2001-03-15
FR2762841A1 (fr) 1998-11-06
AU729495B2 (en) 2001-02-01
ZA983704B (en) 1999-10-25
DK0980374T3 (da) 2003-05-05
DE69811360D1 (de) 2003-03-20
NZ337589A (en) 2000-10-27
DE69811360T2 (de) 2003-10-09
JP2001522367A (ja) 2001-11-13
AU7765298A (en) 1998-11-24
CA2278217A1 (en) 1998-11-05
HRP980231A2 (en) 2000-04-30
EP0980374A1 (en) 2000-02-23
BR9809429A (pt) 2000-06-13

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20061230