MXPA06004043A - 2h-[1,2,4]triazolo[4,3-a]pirazinas sustituidas como inhibidores de la glucogeno sintetasa cinasa 3. - Google Patents

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Publication number

MXPA06004043A

MXPA06004043A MXPA06004043A MXPA06004043A MXPA06004043A MX PA06004043 A MXPA06004043 A MX PA06004043A MX PA06004043 A MXPA06004043 A MX PA06004043A MX PA06004043 A MXPA06004043 A MX PA06004043A MX PA06004043 A MXPA06004043 A MX PA06004043A

Authority

MX

Mexico

Prior art keywords

independently

optionally substituted

tert

butyl

pyrazin

Prior art date

2003-10-10

Links

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• 239000003112 inhibitor Substances 0.000 title claims description 28
• SETPVHMQKAXDMY-UHFFFAOYSA-N 2,3-dihydro-[1,2,4]triazolo[4,3-a]pyrazine Chemical class C1=NC=CN2CNN=C21 SETPVHMQKAXDMY-UHFFFAOYSA-N 0.000 title 1
• 101150090422 gsk-3 gene Proteins 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 134
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• 229940002612 prodrug Drugs 0.000 claims abstract description 51
• 150000003839 salts Chemical class 0.000 claims abstract description 30
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 12
• -1 methylenedioxy Chemical group 0.000 claims description 109
• 125000000217 alkyl group Chemical group 0.000 claims description 90
• 239000000203 mixture Substances 0.000 claims description 75
• 125000003118 aryl group Chemical group 0.000 claims description 57
• 229910052736 halogen Inorganic materials 0.000 claims description 56
• 150000002367 halogens Chemical class 0.000 claims description 52
• 125000003545 alkoxy group Chemical group 0.000 claims description 45
• 125000001072 heteroaryl group Chemical group 0.000 claims description 42
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 36
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 30
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 24
• 229910052739 hydrogen Inorganic materials 0.000 claims description 24
• 239000001257 hydrogen Substances 0.000 claims description 24
• LAQJGAKLLZAETL-UHFFFAOYSA-N 2h-pyrazin-3-one Chemical compound O=C1CN=CC=N1 LAQJGAKLLZAETL-UHFFFAOYSA-N 0.000 claims description 23
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 19
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 18
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• 229910052757 nitrogen Inorganic materials 0.000 claims description 16
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