MXPA06002035A - Composicion farmaceutica para la prevencion y el tratamiento de adicciones en mamiferos. - Google Patents
Composicion farmaceutica para la prevencion y el tratamiento de adicciones en mamiferos.Info
- Publication number
- MXPA06002035A MXPA06002035A MXPA06002035A MXPA06002035A MXPA06002035A MX PA06002035 A MXPA06002035 A MX PA06002035A MX PA06002035 A MXPA06002035 A MX PA06002035A MX PA06002035 A MXPA06002035 A MX PA06002035A MX PA06002035 A MXPA06002035 A MX PA06002035A
- Authority
- MX
- Mexico
- Prior art keywords
- chlorophenyl
- methyl
- aza
- hydroxy
- bicyclo
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 25
- 206010012335 Dependence Diseases 0.000 title claims abstract description 18
- 241000124008 Mammalia Species 0.000 title claims description 8
- 230000002265 prevention Effects 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 73
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 34
- 229940123257 Opioid receptor antagonist Drugs 0.000 claims abstract description 25
- 239000003401 opiate antagonist Substances 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 18
- 229940123158 Cannabinoid CB1 receptor antagonist Drugs 0.000 claims abstract description 17
- 239000003555 cannabinoid 1 receptor antagonist Substances 0.000 claims abstract description 17
- 208000011117 substance-related disease Diseases 0.000 claims abstract description 16
- 201000009032 substance abuse Diseases 0.000 claims abstract description 14
- 231100000736 substance abuse Toxicity 0.000 claims abstract description 13
- 230000003542 behavioural effect Effects 0.000 claims abstract description 11
- 208000007848 Alcoholism Diseases 0.000 claims abstract description 10
- 208000001613 Gambling Diseases 0.000 claims abstract description 6
- 239000003937 drug carrier Substances 0.000 claims abstract description 6
- 230000009467 reduction Effects 0.000 claims abstract description 6
- 208000024891 symptom Diseases 0.000 claims abstract description 6
- 208000029650 alcohol withdrawal Diseases 0.000 claims abstract description 5
- 208000025569 Tobacco Use disease Diseases 0.000 claims abstract description 4
- 206010013663 drug dependence Diseases 0.000 claims abstract description 3
- 208000022497 Cocaine-Related disease Diseases 0.000 claims abstract 2
- 201000006145 cocaine dependence Diseases 0.000 claims abstract 2
- -1 1- [9- (4-chlorophenyl) -8- (2-chlorophenyl) -9H-purin-6-yl] -3-isopropyl-amino-azetidine-3-carboxylic acid amide Chemical compound 0.000 claims description 152
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims description 80
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 73
- 150000003839 salts Chemical class 0.000 claims description 45
- KBPHGUKTJKPERJ-UHFFFAOYSA-N 2-methoxyethanesulfonic acid Chemical compound COCCS(O)(=O)=O KBPHGUKTJKPERJ-UHFFFAOYSA-N 0.000 claims description 25
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims description 24
- 239000000126 substance Substances 0.000 claims description 18
- 239000012453 solvate Substances 0.000 claims description 16
- CYAYCOCJAVHQSD-UHFFFAOYSA-N 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid Chemical compound CC=1C(C(O)=O)=NN(C=2C(=CC(Cl)=CC=2)Cl)C=1C1=CC=C(Cl)C=C1 CYAYCOCJAVHQSD-UHFFFAOYSA-N 0.000 claims description 12
- 229960003920 cocaine Drugs 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 11
- XYSDEMQLXPUMBO-UHFFFAOYSA-N [3-[6-ethyl-3-[(2-hydroxy-3,4-dihydro-1h-naphthalen-2-yl)methyl]-3-azabicyclo[3.1.0]hexan-6-yl]phenyl]methanesulfonamide Chemical compound C12CN(CC3(O)CC4=CC=CC=C4CC3)CC2C1(CC)C1=CC=CC(CS(N)(=O)=O)=C1 XYSDEMQLXPUMBO-UHFFFAOYSA-N 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- KJJLEOOLZLWLSS-UHFFFAOYSA-N 3-[6-ethyl-3-[(1-hydroxy-3-phenylcyclobutyl)methyl]-3-azabicyclo[3.1.0]hexan-6-yl]benzamide Chemical compound C1C2C(CC)(C=3C=C(C=CC=3)C(N)=O)C2CN1CC(C1)(O)CC1C1=CC=CC=C1 KJJLEOOLZLWLSS-UHFFFAOYSA-N 0.000 claims description 7
- RZRVHGLZBLICCS-UHFFFAOYSA-N COC1(C2CN(CCCC3(CCCCC3)O)CC1CC2)C(C=CC=C1)=C1C(N)=O Chemical compound COC1(C2CN(CCCC3(CCCCC3)O)CC1CC2)C(C=CC=C1)=C1C(N)=O RZRVHGLZBLICCS-UHFFFAOYSA-N 0.000 claims description 7
- 150000001408 amides Chemical class 0.000 claims description 7
- VLJHXPKDNBNFPN-UHFFFAOYSA-N 3-[1-[(2-hydroxy-1,3-dihydroinden-2-yl)methyl]-3,4-dimethylpiperidin-4-yl]benzamide Chemical compound CC1CN(CC2(O)CC3=CC=CC=C3C2)CCC1(C)C1=CC=CC(C(N)=O)=C1 VLJHXPKDNBNFPN-UHFFFAOYSA-N 0.000 claims description 6
- SCNSHBHEDUUZDM-UHFFFAOYSA-N 3-[6-ethyl-3-[(2-hydroxy-1,3-dihydroinden-2-yl)methyl]-3-azabicyclo[3.1.0]hexan-6-yl]benzamide Chemical compound C12CN(CC3(O)CC4=CC=CC=C4C3)CC2C1(CC)C1=CC=CC(C(N)=O)=C1 SCNSHBHEDUUZDM-UHFFFAOYSA-N 0.000 claims description 6
- BVBIKNOVWWMBBP-UHFFFAOYSA-N C1N(CC2(O)CC3=CC=CC=C3C2)CC2CCC1C2(OC)C1=CC=CC(CS(N)(=O)=O)=C1 Chemical compound C1N(CC2(O)CC3=CC=CC=C3C2)CC2CCC1C2(OC)C1=CC=CC(CS(N)(=O)=O)=C1 BVBIKNOVWWMBBP-UHFFFAOYSA-N 0.000 claims description 6
- UUIGGJWRCKHZBN-UHFFFAOYSA-N COCC(C1=CC(C2(CCC3)CC3N(CC3(CC4=CC=CC=C4CC3)O)CC2)=CC=C1)S(N)(=O)=O Chemical compound COCC(C1=CC(C2(CCC3)CC3N(CC3(CC4=CC=CC=C4CC3)O)CC2)=CC=C1)S(N)(=O)=O UUIGGJWRCKHZBN-UHFFFAOYSA-N 0.000 claims description 6
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims description 6
- 206010034158 Pathological gambling Diseases 0.000 claims description 6
- CFEHQSDWANWIDE-UHFFFAOYSA-N [3-[2-[(1-hydroxy-3-phenylcyclobutyl)methyl]-2-azabicyclo[3.3.1]nonan-5-yl]phenyl]methanesulfonamide Chemical compound NS(=O)(=O)CC1=CC=CC(C23CC(CCC2)N(CC2(O)CC(C2)C=2C=CC=CC=2)CC3)=C1 CFEHQSDWANWIDE-UHFFFAOYSA-N 0.000 claims description 6
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 5
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims description 5
- CMXNJCYHOYIGPE-UHFFFAOYSA-N 3-[1-[(1-hydroxy-3-phenylcyclobutyl)methyl]-3,4-dimethylpiperidin-4-yl]benzamide Chemical compound C1CC(C=2C=C(C=CC=2)C(N)=O)(C)C(C)CN1CC(C1)(O)CC1C1=CC=CC=C1 CMXNJCYHOYIGPE-UHFFFAOYSA-N 0.000 claims description 5
- ZCDWSEYWBPLIPE-UHFFFAOYSA-N 3-[2-[(2-hydroxy-3,4-dihydro-1h-naphthalen-2-yl)methyl]-2-azabicyclo[3.3.1]nonan-5-yl]benzamide Chemical compound NC(=O)C1=CC=CC(C23CC(CCC2)N(CC2(O)CC4=CC=CC=C4CC2)CC3)=C1 ZCDWSEYWBPLIPE-UHFFFAOYSA-N 0.000 claims description 5
- CQMGDWUBLFGSDQ-UHFFFAOYSA-N 3-[3-[(1-hydroxy-3-phenylcyclobutyl)methyl]-8-methoxy-3-azabicyclo[3.2.1]octan-8-yl]benzamide Chemical compound C=1C=CC(C(N)=O)=CC=1C1(OC)C(C2)CCC1CN2CC(C1)(O)CC1C1=CC=CC=C1 CQMGDWUBLFGSDQ-UHFFFAOYSA-N 0.000 claims description 5
- WXNZTHHGJRFXKQ-UHFFFAOYSA-N 4-chlorophenol Chemical compound OC1=CC=C(Cl)C=C1 WXNZTHHGJRFXKQ-UHFFFAOYSA-N 0.000 claims description 5
- JVUOJEOSXJAJGS-UHFFFAOYSA-N CC(CN(CCCC1(CCCCC1)O)CC1)C1(C)C(C=CC=C1)=C1C(N)=O Chemical compound CC(CN(CCCC1(CCCCC1)O)CC1)C1(C)C(C=CC=C1)=C1C(N)=O JVUOJEOSXJAJGS-UHFFFAOYSA-N 0.000 claims description 5
- RYBMKDVAGXFMHB-UHFFFAOYSA-N CCC1(C2C1CN(CC1(CC3=CC=CC=C3CC1)O)C2)C1=CC=CC(C(COC)S(N)(=O)=O)=C1 Chemical compound CCC1(C2C1CN(CC1(CC3=CC=CC=C3CC1)O)C2)C1=CC=CC(C(COC)S(N)(=O)=O)=C1 RYBMKDVAGXFMHB-UHFFFAOYSA-N 0.000 claims description 5
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims description 5
- 229960002715 nicotine Drugs 0.000 claims description 5
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 5
- UNAZAADNBYXMIV-UHFFFAOYSA-N otenabant Chemical compound C1CC(NCC)(C(N)=O)CCN1C1=NC=NC2=C1N=C(C=1C(=CC=CC=1)Cl)N2C1=CC=C(Cl)C=C1 UNAZAADNBYXMIV-UHFFFAOYSA-N 0.000 claims description 5
- SQSZXZKMVHUPRD-UHFFFAOYSA-N 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]-4-(propan-2-ylamino)piperidine-4-carboxamide Chemical compound C1CC(NC(C)C)(C(N)=O)CCN1C1=NC=NC2=C1N=C(C=1C(=CC=CC=1)Cl)N2C1=CC=C(Cl)C=C1 SQSZXZKMVHUPRD-UHFFFAOYSA-N 0.000 claims description 4
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims description 4
- YZMRJTFTIRSULG-UHFFFAOYSA-N 3-[2-[(1-hydroxy-3-phenylcyclobutyl)methyl]-2-azabicyclo[3.3.1]nonan-5-yl]benzamide Chemical compound NC(=O)C1=CC=CC(C23CC(CCC2)N(CC2(O)CC(C2)C=2C=CC=CC=2)CC3)=C1 YZMRJTFTIRSULG-UHFFFAOYSA-N 0.000 claims description 4
- PNUIAAYEYHRGJI-UHFFFAOYSA-N 3-[3-[(2-hydroxy-1,3-dihydroinden-2-yl)methyl]-8-methoxy-3-azabicyclo[3.2.1]octan-8-yl]benzamide Chemical compound C1N(CC2(O)CC3=CC=CC=C3C2)CC2CCC1C2(OC)C1=CC=CC(C(N)=O)=C1 PNUIAAYEYHRGJI-UHFFFAOYSA-N 0.000 claims description 4
- YBQGLTGAHBCMME-UHFFFAOYSA-N 4-amino-1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]piperidine-4-carboxamide Chemical compound C1CC(C(=O)N)(N)CCN1C1=NC=NC2=C1N=C(C=1C(=CC=CC=1)Cl)N2C1=CC=C(Cl)C=C1 YBQGLTGAHBCMME-UHFFFAOYSA-N 0.000 claims description 4
- YJDQIHXWBXWGGO-UHFFFAOYSA-N C(C)C1(C2CN(CC12)CCCC1(CCCCC1)O)C1=C(C(=O)N)C=CC=C1 Chemical compound C(C)C1(C2CN(CC12)CCCC1(CCCCC1)O)C1=C(C(=O)N)C=CC=C1 YJDQIHXWBXWGGO-UHFFFAOYSA-N 0.000 claims description 4
- FDRLWIIAPQXTMO-UHFFFAOYSA-N COCC(C1=CC(C2(CCC3)CC3N(CC(C3)(CC3C3=CC=CC=C3)O)CC2)=CC=C1)S(N)(=O)=O Chemical compound COCC(C1=CC(C2(CCC3)CC3N(CC(C3)(CC3C3=CC=CC=C3)O)CC2)=CC=C1)S(N)(=O)=O FDRLWIIAPQXTMO-UHFFFAOYSA-N 0.000 claims description 4
- IKMIFKMETPRUBK-UHFFFAOYSA-N COCC(C1=CC(C2(CCC3)CC3N(CC3(CC4=CC=CC=C4C3)O)CC2)=CC=C1)S(N)(=O)=O Chemical compound COCC(C1=CC(C2(CCC3)CC3N(CC3(CC4=CC=CC=C4C3)O)CC2)=CC=C1)S(N)(=O)=O IKMIFKMETPRUBK-UHFFFAOYSA-N 0.000 claims description 4
- OPXPEHGRRFTOHD-UHFFFAOYSA-N NC(C1=C(C2(CCC3)CC3N(CCCC3(CCCCC3)O)CC2)C=CC=C1)=O Chemical compound NC(C1=C(C2(CCC3)CC3N(CCCC3(CCCCC3)O)CC2)C=CC=C1)=O OPXPEHGRRFTOHD-UHFFFAOYSA-N 0.000 claims description 4
- HJUAYCORBOWWGO-UHFFFAOYSA-N [3-[6-ethyl-3-[(2-hydroxy-1,3-dihydroinden-2-yl)methyl]-3-azabicyclo[3.1.0]hexan-6-yl]phenyl]methanesulfonamide Chemical compound C12CN(CC3(O)CC4=CC=CC=C4C3)CC2C1(CC)C1=CC=CC(CS(N)(=O)=O)=C1 HJUAYCORBOWWGO-UHFFFAOYSA-N 0.000 claims description 4
- JIHQDMXYYFUGFV-UHFFFAOYSA-N 1,3,5-triazine Chemical compound C1=NC=NC=N1 JIHQDMXYYFUGFV-UHFFFAOYSA-N 0.000 claims description 3
- BMVXCPBXGZKUPN-UHFFFAOYSA-N 1-hexanamine Chemical compound CCCCCCN BMVXCPBXGZKUPN-UHFFFAOYSA-N 0.000 claims description 3
- XWJBBHRGYQANKK-UHFFFAOYSA-N 3-[2-[(2-hydroxy-1,3-dihydroinden-2-yl)methyl]-2-azabicyclo[3.3.1]nonan-5-yl]benzamide Chemical compound NC(=O)C1=CC=CC(C23CC(CCC2)N(CC2(O)CC4=CC=CC=C4C2)CC3)=C1 XWJBBHRGYQANKK-UHFFFAOYSA-N 0.000 claims description 3
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 3
- MGXWXNOHTWTTFC-UHFFFAOYSA-N 8-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]-1-propan-2-yl-1,3,8-triazaspiro[4.5]decan-4-one Chemical compound CC(C)N1CNC(=O)C11CCN(C=2C=3N=C(N(C=3N=CN=2)C=2C=CC(Cl)=CC=2)C=2C(=CC=CC=2)Cl)CC1 MGXWXNOHTWTTFC-UHFFFAOYSA-N 0.000 claims description 3
- NVEWRUMMUBKWLP-UHFFFAOYSA-N 9-(4-chlorophenyl)-6-(1-cyclohexylazetidin-3-yl)oxy-8-(2,4-dichlorophenyl)purine Chemical compound C1=CC(Cl)=CC=C1N1C2=NC=NC(OC3CN(C3)C3CCCCC3)=C2N=C1C1=CC=C(Cl)C=C1Cl NVEWRUMMUBKWLP-UHFFFAOYSA-N 0.000 claims description 3
- 206010057852 Nicotine dependence Diseases 0.000 claims description 3
- 239000013543 active substance Substances 0.000 claims description 3
- NUJGJRNETVAIRJ-UHFFFAOYSA-N octanal Chemical compound CCCCCCCC=O NUJGJRNETVAIRJ-UHFFFAOYSA-N 0.000 claims description 3
- RSHRLSNTSNPHBI-UHFFFAOYSA-N 1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methyl-3-[1-(1-phenylethyl)imidazol-4-yl]pyrazole Chemical compound C1=NC(C=2C(=C(N(N=2)C=2C(=CC=CC=2)Cl)C=2C=CC(Cl)=CC=2)C)=CN1C(C)C1=CC=CC=C1 RSHRLSNTSNPHBI-UHFFFAOYSA-N 0.000 claims description 2
- CTSFSQZYEGEKNJ-UHFFFAOYSA-N 1-(oxazepan-4-yl)ethanone Chemical compound O1NCC(CCC1)C(C)=O CTSFSQZYEGEKNJ-UHFFFAOYSA-N 0.000 claims description 2
- KGJHVABFBBJFIG-UHFFFAOYSA-N 1-[1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methylpyrazol-3-yl]-2-(3,3-dimethylpiperidin-1-yl)ethanol Chemical compound CC=1C(C(O)CN2CC(C)(C)CCC2)=NN(C=2C(=CC=CC=2)Cl)C=1C1=CC=C(Cl)C=C1 KGJHVABFBBJFIG-UHFFFAOYSA-N 0.000 claims description 2
- MJKOCBMDVCJJOQ-UHFFFAOYSA-N 1-[1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methylpyrazol-3-yl]-2-[4-(1-methylpyrrole-2-carbonyl)piperazin-1-yl]ethanone Chemical compound CC=1C(C(=O)CN2CCN(CC2)C(=O)C=2N(C=CC=2)C)=NN(C=2C(=CC=CC=2)Cl)C=1C1=CC=C(Cl)C=C1 MJKOCBMDVCJJOQ-UHFFFAOYSA-N 0.000 claims description 2
- JBCFDMJWDPFMLH-UHFFFAOYSA-N 1-[1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methylpyrazol-3-yl]-2-morpholin-4-ylethanone Chemical compound CC=1C(C(=O)CN2CCOCC2)=NN(C=2C(=CC=CC=2)Cl)C=1C1=CC=C(Cl)C=C1 JBCFDMJWDPFMLH-UHFFFAOYSA-N 0.000 claims description 2
- LBBWUMREEVVZRO-UHFFFAOYSA-N 1-[1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-methylimidazol-4-yl]-2-morpholin-4-ylethanone Chemical compound C=1C=C(Cl)C=CC=1N1C(C)=C(C(=O)CN2CCOCC2)N=C1C1=CC=C(Cl)C=C1Cl LBBWUMREEVVZRO-UHFFFAOYSA-N 0.000 claims description 2
- HUKVRWGDXWJBMB-UHFFFAOYSA-N 1-[1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-methylimidazol-4-yl]-2-piperidin-1-ylethanone Chemical compound C=1C=C(Cl)C=CC=1N1C(C)=C(C(=O)CN2CCCCC2)N=C1C1=CC=C(Cl)C=C1Cl HUKVRWGDXWJBMB-UHFFFAOYSA-N 0.000 claims description 2
- HVXLAPMGPSSUAP-UHFFFAOYSA-N 1-[2-(2-chlorophenyl)-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl]-3-(methylamino)azetidine-3-carboxamide Chemical compound C1C(NC)(C(N)=O)CN1C1=CC=NC2=C(C=3C=CC(Cl)=CC=3)C(C=3C(=CC=CC=3)Cl)=NN12 HVXLAPMGPSSUAP-UHFFFAOYSA-N 0.000 claims description 2
- IKIJBYVYJILIOG-UHFFFAOYSA-N 1-[2-(2-chlorophenyl)-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl]-3-(propan-2-ylamino)azetidine-3-carboxamide Chemical compound C1C(NC(C)C)(C(N)=O)CN1C1=CC=NC2=C(C=3C=CC(Cl)=CC=3)C(C=3C(=CC=CC=3)Cl)=NN12 IKIJBYVYJILIOG-UHFFFAOYSA-N 0.000 claims description 2
- ZNNPDKATJWCFJB-UHFFFAOYSA-N 1-[2-(2-chlorophenyl)-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl]-4-(ethylamino)piperidine-4-carboxamide Chemical compound C1CC(NCC)(C(N)=O)CCN1C1=CC=NC2=C(C=3C=CC(Cl)=CC=3)C(C=3C(=CC=CC=3)Cl)=NN12 ZNNPDKATJWCFJB-UHFFFAOYSA-N 0.000 claims description 2
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- GVPQEAGKQZOLCM-UHFFFAOYSA-N 1-[7-(2-chlorophenyl)-8-(4-chlorophenyl)-2-methylpyrazolo[1,5-a][1,3,5]triazin-4-yl]-4-(ethylamino)piperidine-4-carboxylic acid Chemical compound CCNC1(CCN(CC1)C2=NC(=NC3=C(C(=NN32)C4=CC=CC=C4Cl)C5=CC=C(C=C5)Cl)C)C(=O)O GVPQEAGKQZOLCM-UHFFFAOYSA-N 0.000 claims description 2
- RSSDYHXNXTWNJY-UHFFFAOYSA-N 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]-4-(propylamino)piperidine-4-carboxamide Chemical compound C1CC(NCCC)(C(N)=O)CCN1C1=NC=NC2=C1N=C(C=1C(=CC=CC=1)Cl)N2C1=CC=C(Cl)C=C1 RSSDYHXNXTWNJY-UHFFFAOYSA-N 0.000 claims description 2
- SKJBKOGUSSCGFF-UHFFFAOYSA-N 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]-4-phenylpiperidin-4-ol Chemical compound C1CC(O)(C=2C=CC=CC=2)CCN1C(C=1N=2)=NC=NC=1N(C=1C=CC(Cl)=CC=1)C=2C1=CC=CC=C1Cl SKJBKOGUSSCGFF-UHFFFAOYSA-N 0.000 claims description 2
- XGMUXVHFGMMZJM-UHFFFAOYSA-N 1-[9-(4-chlorophenyl)-8-(2,4-dichlorophenyl)purin-6-yl]-4-(propylamino)piperidine-4-carboxamide Chemical compound C1CC(NCCC)(C(N)=O)CCN1C1=NC=NC2=C1N=C(C=1C(=CC(Cl)=CC=1)Cl)N2C1=CC=C(Cl)C=C1 XGMUXVHFGMMZJM-UHFFFAOYSA-N 0.000 claims description 2
- LGRHTFQDJMGCCC-UHFFFAOYSA-N 1-[9-(4-chlorophenyl)-8-(2-fluorophenyl)-2-methylpurin-6-yl]-4-(propan-2-ylamino)piperidine-4-carboxamide Chemical compound C1CC(NC(C)C)(C(N)=O)CCN1C1=NC(C)=NC2=C1N=C(C=1C(=CC=CC=1)F)N2C1=CC=C(Cl)C=C1 LGRHTFQDJMGCCC-UHFFFAOYSA-N 0.000 claims description 2
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Landscapes
- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49680303P | 2003-08-21 | 2003-08-21 | |
| PCT/IB2004/002596 WO2005018645A1 (en) | 2003-08-21 | 2004-08-09 | A pharmaceutical composition for the prevention and treatment of addiction in a mammal |
Publications (1)
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|---|---|
| MXPA06002035A true MXPA06002035A (es) | 2006-05-17 |
Family
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Family Applications (1)
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|---|---|---|---|
| MXPA06002035A MXPA06002035A (es) | 2003-08-21 | 2004-08-09 | Composicion farmaceutica para la prevencion y el tratamiento de adicciones en mamiferos. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050043327A1 (https=) |
| EP (1) | EP1658082A1 (https=) |
| JP (1) | JP2007502808A (https=) |
| BR (1) | BRPI0413693A (https=) |
| CA (1) | CA2536280A1 (https=) |
| MX (1) | MXPA06002035A (https=) |
| WO (1) | WO2005018645A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1440059B1 (en) * | 2001-10-22 | 2008-04-16 | Pfizer Products Inc. | 3-azabicyclo(3.1.0)hexane derivatives as opioid receptor antagonists |
| CA2499994C (en) * | 2002-09-23 | 2012-07-10 | Verion, Inc. | Abuse-resistant pharmaceutical compositions |
| US7129239B2 (en) * | 2002-10-28 | 2006-10-31 | Pfizer Inc. | Purine compounds and uses thereof |
| MXPA05007485A (es) | 2003-01-14 | 2006-01-30 | Arena Pharm Inc | Derivados de arilo y heteroarilo 1,2,3-trisubstituidos como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con ello tales como diabetes e hiperglicemia. |
| US7132426B2 (en) * | 2003-07-14 | 2006-11-07 | Arena Pharmaceuticals, Inc. | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
| AU2006305104B2 (en) * | 2005-10-21 | 2009-10-22 | Mitsubishi Tanabe Pharma Corporation | Pyrazolo[1,5-a]pyrimidine compounds as cannabinoid receptor antagonists |
| AR061793A1 (es) | 2006-07-05 | 2008-09-24 | Mitsubishi Tanabe Pharma Corp | Compuesto de pirazolo[1,5-a] pirimidina y composicion farmaceutica |
| JP5269795B2 (ja) * | 2006-09-29 | 2013-08-21 | グリーン・クロス・コーポレイション | カンナビノイドｃｂ１受容体アンタゴニストとしてのヘテロアリール−ピラゾール誘導体 |
| WO2008044111A1 (en) * | 2006-10-13 | 2008-04-17 | Pfizer Products Inc. | Pharmaceutical formulation tablet |
| JP3145620U (ja) | 2008-07-30 | 2008-10-16 | 公二 平井 | 擬似嗜好物品 |
| US8252791B2 (en) * | 2008-08-13 | 2012-08-28 | Jenrin Discovery, Inc. | Purine compounds as cannabinoid receptor blockers |
| UA104010C2 (en) * | 2008-12-18 | 2013-12-25 | Эли Лилли Энд Компани | Purine compounds |
| GB0908394D0 (en) | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB0913636D0 (en) | 2009-08-05 | 2009-09-16 | Univ Leuven Kath | Novel viral replication inhibitors |
| PH12013500547A1 (en) | 2010-09-22 | 2013-06-10 | Arena Pharm Inc | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| JP2013542243A (ja) | 2010-11-15 | 2013-11-21 | カトリーケ ウニヴェルシテイト ルーヴェン | 新規な抗ウイルス性化合物 |
| US9663463B2 (en) | 2013-11-20 | 2017-05-30 | Sanwa Kagaku Kenkyusho Co., Ltd. | 3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purpose |
| MX386419B (es) | 2015-01-06 | 2025-03-18 | Arena Pharm Inc | Metodos de condiciones de tratamiento relacionadas con el receptor s1p1. |
| KR20180004734A (ko) | 2015-05-20 | 2018-01-12 | 가부시키가이샤산와카가쿠켄큐쇼 | 신규 3-아자비시클로［3.1.0］헥산 유도체의 염의 결정 및 그의 의약 용도 |
| CA3036382A1 (en) * | 2016-12-21 | 2018-06-28 | Research Triangle Institute | Diaryl purine derivatives with improved bioavailability |
| CN110352055A (zh) * | 2017-03-02 | 2019-10-18 | 株式会社三和化学研究所 | 酒精使用障碍的治疗药物 |
| SG11202007422QA (en) * | 2018-02-05 | 2020-09-29 | Alkermes Inc | Compounds for the treatment of pain |
| WO2023064228A1 (en) * | 2021-10-11 | 2023-04-20 | Anebulo Pharmaceuticals, Inc. | Method of treating addiction |
| AU2022362107A1 (en) | 2021-10-11 | 2024-05-02 | Anebulo Pharmaceuticals, Inc. | Crystalline forms of a cannabinoid receptor type 1 (cb1) modulator and methods of use and preparation thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1440059B1 (en) * | 2001-10-22 | 2008-04-16 | Pfizer Products Inc. | 3-azabicyclo(3.1.0)hexane derivatives as opioid receptor antagonists |
| AU2003267728A1 (en) * | 2002-10-18 | 2004-05-04 | Pfizer Products Inc. | Cannabinoid receptor ligands and uses thereof |
| US7129239B2 (en) * | 2002-10-28 | 2006-10-31 | Pfizer Inc. | Purine compounds and uses thereof |
| US7247628B2 (en) * | 2002-12-12 | 2007-07-24 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
| US7329658B2 (en) * | 2003-02-06 | 2008-02-12 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
| US7176210B2 (en) * | 2003-02-10 | 2007-02-13 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
-
2004
- 2004-06-17 US US10/870,209 patent/US20050043327A1/en not_active Abandoned
- 2004-08-09 JP JP2006523697A patent/JP2007502808A/ja active Pending
- 2004-08-09 CA CA002536280A patent/CA2536280A1/en not_active Abandoned
- 2004-08-09 BR BRPI0413693-4A patent/BRPI0413693A/pt not_active IP Right Cessation
- 2004-08-09 WO PCT/IB2004/002596 patent/WO2005018645A1/en not_active Ceased
- 2004-08-09 MX MXPA06002035A patent/MXPA06002035A/es not_active Application Discontinuation
- 2004-08-09 EP EP04744231A patent/EP1658082A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2536280A1 (en) | 2005-03-03 |
| BRPI0413693A (pt) | 2006-10-24 |
| WO2005018645A1 (en) | 2005-03-03 |
| EP1658082A1 (en) | 2006-05-24 |
| JP2007502808A (ja) | 2007-02-15 |
| US20050043327A1 (en) | 2005-02-24 |
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Legal Events
| Date | Code | Title | Description |
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| FA | Abandonment or withdrawal |