MXPA05009348A - Esterilizacion de particulas de farmaco de beclometasona para distribucion pulmonar. - Google Patents
Esterilizacion de particulas de farmaco de beclometasona para distribucion pulmonar.Info
- Publication number
- MXPA05009348A MXPA05009348A MXPA05009348A MXPA05009348A MXPA05009348A MX PA05009348 A MXPA05009348 A MX PA05009348A MX PA05009348 A MXPA05009348 A MX PA05009348A MX PA05009348 A MXPA05009348 A MX PA05009348A MX PA05009348 A MXPA05009348 A MX PA05009348A
- Authority
- MX
- Mexico
- Prior art keywords
- beclomethasone
- sterilization
- pulmonary delivery
- drug particles
- formulations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0023—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
- A61L2/06—Hot gas
- A61L2/07—Steam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
Se describe un proceso para la esterilizacion de sustancias medicinales solidas insolubles en agua. El proceso proporciona la esterilizacion de beclometasona, que es adecuada para administracion pulmonar. En particular, el proceso se usa en plantas industriales para la produccion de formulaciones de beclometasona esteril para distribucion por inhalacion, para evitar cualquier modificacion en la distribucion del tamano de particulas y en el perfil de impurezas del farmaco. El proceso se lleva a cabo al calentar una mezcla de beclometasona micronizada y agua purificada unicamente, de manera preferente a una temperatura de aproximadamente 120degree C durante 20 minutos. El proceso es particularmente eficiente y economico para la esterilizacion con vapor de dipropionato de beclometasona en formulaciones para distribucion pulmonar.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03004726A EP1454636A1 (en) | 2003-03-04 | 2003-03-04 | Sterilization of glucocorticoid drug particles for pulmonary delivery |
PCT/EP2004/050235 WO2004078102A2 (en) | 2003-03-04 | 2004-03-02 | Sterilization of beclomethasone drug particles for pulmonary delivery |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05009348A true MXPA05009348A (es) | 2005-11-04 |
Family
ID=32798759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05009348A MXPA05009348A (es) | 2003-03-04 | 2004-03-02 | Esterilizacion de particulas de farmaco de beclometasona para distribucion pulmonar. |
Country Status (15)
Country | Link |
---|---|
US (1) | US20060140816A1 (es) |
EP (2) | EP1454636A1 (es) |
JP (1) | JP4712689B2 (es) |
AT (1) | ATE360443T1 (es) |
BR (1) | BRPI0408022B1 (es) |
CY (1) | CY1106732T1 (es) |
DE (1) | DE602004006089T2 (es) |
DK (1) | DK1599233T3 (es) |
ES (1) | ES2285436T3 (es) |
MX (1) | MXPA05009348A (es) |
PL (1) | PL1599233T3 (es) |
PT (1) | PT1599233E (es) |
RU (1) | RU2336905C2 (es) |
SI (1) | SI1599233T1 (es) |
WO (1) | WO2004078102A2 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2523035C (en) | 2003-05-22 | 2011-04-26 | Elan Pharma International Ltd. | Sterilization of dispersions of nanoparticulate active agents with gamma radiation |
PE20050941A1 (es) | 2003-12-16 | 2005-11-08 | Nycomed Gmbh | Suspensiones acuosas de ciclesonida para nebulizacion |
GB0410995D0 (en) | 2004-05-17 | 2004-06-23 | Norton Healthcare Ltd | Heat sterilization of glucocorticosteroids |
GB0425266D0 (en) * | 2004-11-16 | 2004-12-15 | Norton Healthcare Ltd | Pharmaceutical manufacturing process |
EP2704724B1 (en) | 2011-05-03 | 2016-10-26 | Chiesi Farmaceutici S.p.A. | Improved suspension formulation of beclometasone dipropionate for administration by inhalation |
JP5792240B2 (ja) * | 2012-08-27 | 2015-10-07 | 武夫 西 | 注射シミュレータ用模擬剤及びその製造方法と製造装置 |
CA3006251A1 (en) * | 2015-12-07 | 2017-06-15 | Emcure Pharmaceuticals Limited | Sterile parenteral suspensions |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3962430A (en) * | 1974-08-07 | 1976-06-08 | Merck & Co., Inc. | Sterilization of solid non-electrolyte medicinal agents employing sodium chloride |
GB9410222D0 (en) * | 1994-05-21 | 1994-07-06 | Glaxo Wellcome Australia Ltd | Medicaments |
SE9704186D0 (sv) * | 1997-11-14 | 1997-11-14 | Astra Ab | New composition of matter |
US6066292A (en) * | 1997-12-19 | 2000-05-23 | Bayer Corporation | Sterilization process for pharmaceutical suspensions |
EP0938896A1 (en) * | 1998-01-15 | 1999-09-01 | Novartis AG | Autoclavable pharmaceutical compositions containing a chelating agent |
IT1303692B1 (it) * | 1998-11-03 | 2001-02-23 | Chiesi Farma Spa | Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione. |
EP1337279B1 (en) * | 2000-11-24 | 2006-06-21 | Breath Limited | Sterilisation of glucocorticosteriode suspensions |
JP4364486B2 (ja) * | 2002-07-02 | 2009-11-18 | 帝人株式会社 | 無菌水性懸濁製剤 |
-
2003
- 2003-03-04 EP EP03004726A patent/EP1454636A1/en not_active Withdrawn
-
2004
- 2004-03-02 PL PL04716254T patent/PL1599233T3/pl unknown
- 2004-03-02 SI SI200430337T patent/SI1599233T1/sl unknown
- 2004-03-02 RU RU2005130637/15A patent/RU2336905C2/ru not_active IP Right Cessation
- 2004-03-02 MX MXPA05009348A patent/MXPA05009348A/es active IP Right Grant
- 2004-03-02 JP JP2006505438A patent/JP4712689B2/ja not_active Expired - Fee Related
- 2004-03-02 ES ES04716254T patent/ES2285436T3/es not_active Expired - Lifetime
- 2004-03-02 DE DE602004006089T patent/DE602004006089T2/de not_active Expired - Lifetime
- 2004-03-02 DK DK04716254T patent/DK1599233T3/da active
- 2004-03-02 EP EP04716254A patent/EP1599233B1/en not_active Expired - Lifetime
- 2004-03-02 AT AT04716254T patent/ATE360443T1/de active
- 2004-03-02 PT PT04716254T patent/PT1599233E/pt unknown
- 2004-03-02 WO PCT/EP2004/050235 patent/WO2004078102A2/en active IP Right Grant
- 2004-03-02 US US10/544,832 patent/US20060140816A1/en not_active Abandoned
- 2004-03-02 BR BRPI0408022-0A patent/BRPI0408022B1/pt not_active IP Right Cessation
-
2007
- 2007-07-13 CY CY20071100942T patent/CY1106732T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE602004006089T2 (de) | 2008-01-10 |
EP1599233A2 (en) | 2005-11-30 |
DE602004006089D1 (de) | 2007-06-06 |
ATE360443T1 (de) | 2007-05-15 |
PL1599233T3 (pl) | 2007-10-31 |
EP1599233B1 (en) | 2007-04-25 |
DK1599233T3 (da) | 2007-09-17 |
PT1599233E (pt) | 2007-07-26 |
JP4712689B2 (ja) | 2011-06-29 |
ES2285436T3 (es) | 2007-11-16 |
BRPI0408022A (pt) | 2006-02-14 |
JP2007527364A (ja) | 2007-09-27 |
SI1599233T1 (sl) | 2007-10-31 |
EP1454636A1 (en) | 2004-09-08 |
RU2336905C2 (ru) | 2008-10-27 |
US20060140816A1 (en) | 2006-06-29 |
BRPI0408022B1 (pt) | 2018-01-23 |
RU2005130637A (ru) | 2006-01-27 |
WO2004078102A2 (en) | 2004-09-16 |
WO2004078102A3 (en) | 2004-11-18 |
CY1106732T1 (el) | 2012-05-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20063047L (no) | Vandige ciclesonidsuspensjoner for forstoving | |
CN104688648B (zh) | 一种口腔用组合物及其制备方法 | |
CY1106732T1 (el) | Αποστειρωση σωματιδιων του φαρμακου βεκλομεθαζονη για πνευμονικη χορηγηση | |
ITMI20022674A1 (it) | Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione. | |
CN104547991A (zh) | 一种足浴泡腾片及其制备方法 | |
EA016596B9 (ru) | Получение механоактивированных аморфной и аморфно-кристаллической кальциевых солей глюконовой кислоты | |
CN102488746B (zh) | 一种治疗猪传染性萎缩性鼻炎的复方蜂胶组合物及其制备方法 | |
CN102423498B (zh) | 一种卫生香的制备工艺 | |
CN111838212A (zh) | 一种防止气溶胶传播的中药空气消毒净化粉剂 | |
CN105542964A (zh) | 一种玫瑰复配茉莉提取物香精及其制备方法和含有该香精的牙膏 | |
CN1061242C (zh) | 一种治疗跌打损伤的药物及其制备方法 | |
CN106692755A (zh) | 一种具有止血消炎抗菌的中药组合物及其制备方法和应用 | |
CN106822191A (zh) | 一种灵芝冬虫夏草提取物的组合物及其纯片制备方法 | |
JP6710408B2 (ja) | 黒生姜抽出物含有組成物 | |
CN101549023B (zh) | 一种治疗脚气的中药散剂 | |
CN105412407A (zh) | 一种预防和治疗流感的中药组合物及其制备方法和应用 | |
CN1685855A (zh) | 一种黄连防疫杀菌制品 | |
CN105770002A (zh) | 一种喷鼻水及其制备方法 | |
CN100431558C (zh) | 一种治疗结核病的中药胶囊和其制备方法 | |
CN115089634A (zh) | 一种防治新冠肺炎的牛黄/精油组合物及制备方法与应用 | |
CN1475235A (zh) | 一种用于治疗牙齿和口腔疾病的中药复方剂 | |
CN1175883C (zh) | 一种使用全蝎制备的治疗银屑病的药物 | |
EP1632250A1 (en) | Sterilization process of a glucocorticosteroid | |
CN1615984A (zh) | 速效鼻炎康 | |
CN1685858A (zh) | 一种谷精草防疫杀菌制品 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |