MXPA05006766A - Procedimiento de deteccion de prp utilizando un ligando adyuvante macrociclico. - Google Patents

Procedimiento de deteccion de prp utilizando un ligando adyuvante macrociclico.

Info

Publication number
MXPA05006766A
MXPA05006766A MXPA05006766A MXPA05006766A MXPA05006766A MX PA05006766 A MXPA05006766 A MX PA05006766A MX PA05006766 A MXPA05006766 A MX PA05006766A MX PA05006766 A MXPA05006766 A MX PA05006766A MX PA05006766 A MXPA05006766 A MX PA05006766A
Authority
MX
Mexico
Prior art keywords
ancillary
macrocyclic ligand
detection method
prp
prpsc
Prior art date
Application number
MXPA05006766A
Other languages
English (en)
Inventor
Marilyne Dupin
Original Assignee
Afssa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Afssa filed Critical Afssa
Publication of MXPA05006766A publication Critical patent/MXPA05006766A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/823—Immunogenic carrier or carrier per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/807—Hapten conjugated with peptide or protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transmission And Conversion Of Sensor Element Output (AREA)

Abstract

La presente invencion se refiere a un procedimiento de deteccion de las formas de prion patogenas responsables de enfecefalopatias espongiformes transmisibles subagudas, caracterizado porque se agrega en una muestra biologica susceptible de contener PrPSC, un ligando adyuvante macrociclico (AML) libre o unido a un soporte, despues se hace reaccionar la suspension resultante con un anticuerpo anti-PrPsc, y se detecta la presencia de PrP.
MXPA05006766A 2002-12-20 2003-12-19 Procedimiento de deteccion de prp utilizando un ligando adyuvante macrociclico. MXPA05006766A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0216383A FR2849205B1 (fr) 2002-12-20 2002-12-20 Procede d'amplification de la detection de la prpsc et utilisation d'un ligand adjuvant macrocyclique pour une telle amplification
PCT/FR2003/003857 WO2004059322A1 (fr) 2002-12-20 2003-12-19 Procede de detection de la prp utilisant un ligand adjuvant macrocyclique.

Publications (1)

Publication Number Publication Date
MXPA05006766A true MXPA05006766A (es) 2006-02-17

Family

ID=32406305

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05006766A MXPA05006766A (es) 2002-12-20 2003-12-19 Procedimiento de deteccion de prp utilizando un ligando adyuvante macrociclico.

Country Status (14)

Country Link
US (2) US7217530B2 (es)
EP (1) EP1573337B1 (es)
JP (1) JP2006510914A (es)
CN (1) CN100380125C (es)
AT (1) ATE354095T1 (es)
AU (1) AU2003299390B2 (es)
BR (1) BR0317080A (es)
DE (1) DE60311871T2 (es)
DK (1) DK1573337T3 (es)
ES (1) ES2282733T3 (es)
FR (1) FR2849205B1 (es)
MX (1) MXPA05006766A (es)
PT (1) PT1573337E (es)
WO (1) WO2004059322A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2849205B1 (fr) * 2002-12-20 2005-02-11 Afssa Procede d'amplification de la detection de la prpsc et utilisation d'un ligand adjuvant macrocyclique pour une telle amplification
DE10328125A1 (de) * 2003-06-23 2005-01-13 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach spontaner Transformationsreaktion
FR2865279A1 (fr) * 2004-01-20 2005-07-22 Biomerieux Sa Procede de detection de la prp utilisant une molecule ayant au moins une charge positive et/ou au moins une liaison osidique et un ligand autre qu'un ligand proteique
FR2865280B1 (fr) * 2004-01-20 2007-01-12 Biomerieux Sa Procede de detection de la prp utilisant une molecule ayant au moins une charge positive et/ou au moins une liaison osidique et un ligand autre qu'un ligand proteique
FR2888937B1 (fr) 2005-07-21 2012-10-26 Biomerieux Sa Procede de detection des fcpa utilisant un agent d'agregation des fcpa et un agent de capture des agregats formes
EP3062104A1 (en) * 2008-07-04 2016-08-31 Sekisui Medical Co., Ltd. Method for enhancing sensitivity or method for avoiding influence of hemoglobin in immunological measurement
WO2013091074A1 (en) 2011-12-21 2013-06-27 Uvic Industry Partnerships Inc. Method and array for identifying histone-code-related analytes
US10338037B2 (en) 2015-08-18 2019-07-02 Uvic Industry Partnerships Inc. Compounds and conjugates for identifying and separating post-translationally modified analytes
CA3084887A1 (en) 2019-06-25 2020-12-25 Uvic Industry Partnerships Inc. Compound and dimer complex embodiments for supramolecular sensing
CN113876760B (zh) * 2021-10-26 2022-12-23 南开大学 杯芳烃和/或杯芳烃的衍生物在制备治疗创伤性脑损伤的药物中的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5312837A (en) * 1991-01-29 1994-05-17 Genelabs Technologies, Inc. Method of treating viral infections with aryl macrocyclic compounds
US5342934A (en) * 1992-06-19 1994-08-30 The Trustees Of Columbia University In The City Of New York Enantioselective receptor for amino acid derivatives, and other compounds
JP2000511880A (ja) * 1996-04-05 2000-09-12 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム カリックスピロール、カリックスピリジノピロールおよびカリックスピリジン
WO1997041856A1 (en) * 1996-05-08 1997-11-13 Massachusetts Institute Of Technology ORGANOMETALLIC LIGANDS FOR THE LOCALIZATION AND QUANTIFICATION OF AMYLOID IN VIVO AND $i(IN VITRO)
US5891641A (en) * 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
US6150172A (en) * 1999-01-08 2000-11-21 The United States Of America As Represented By The Secretary Of Agriculture Method and kit for extracting prion protein
EP1216258A1 (en) * 1999-09-28 2002-06-26 Universität Zürich Factors having prion-binding activity in serum and plasma and agents to detect transmissible spongiform encephalopathitis
EP1272509A2 (en) * 2000-04-05 2003-01-08 V.I. Technologies, Inc. Prion-binding peptidic ligands and methods of using same
DE10107083C2 (de) * 2001-02-13 2003-02-20 Abdulgabar Salama Pentosan Polysulfat als Ligand zum Nachweis von Prionen
DE10119713A1 (de) * 2001-04-21 2002-10-24 Prionics Ag Zuerich Verfahren zur Untersuchung von Prion-Protein enthaltenden Proben auf das eventuelle Vorliegen der PrPSc-Form
FR2849205B1 (fr) * 2002-12-20 2005-02-11 Afssa Procede d'amplification de la detection de la prpsc et utilisation d'un ligand adjuvant macrocyclique pour une telle amplification

Also Published As

Publication number Publication date
AU2003299390A1 (en) 2004-07-22
EP1573337B1 (fr) 2007-02-14
EP1573337A1 (fr) 2005-09-14
FR2849205B1 (fr) 2005-02-11
ES2282733T3 (es) 2007-10-16
WO2004059322A1 (fr) 2004-07-15
US20070154885A1 (en) 2007-07-05
ATE354095T1 (de) 2007-03-15
AU2003299390B2 (en) 2007-11-01
US20060019311A1 (en) 2006-01-26
DE60311871T2 (de) 2007-10-31
AU2003299390A8 (en) 2004-07-22
DE60311871D1 (de) 2007-03-29
BR0317080A (pt) 2005-10-25
US7217530B2 (en) 2007-05-15
PT1573337E (pt) 2007-05-31
CN1729397A (zh) 2006-02-01
DK1573337T3 (da) 2007-06-11
JP2006510914A (ja) 2006-03-30
WO2004059322A8 (fr) 2005-07-14
FR2849205A1 (fr) 2004-06-25
CN100380125C (zh) 2008-04-09

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