WO2004022769A3 - Moyens de detection des processus neurodegeneratifs et leurs applications - Google Patents

Moyens de detection des processus neurodegeneratifs et leurs applications Download PDF

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Publication number
WO2004022769A3
WO2004022769A3 PCT/FR2003/002667 FR0302667W WO2004022769A3 WO 2004022769 A3 WO2004022769 A3 WO 2004022769A3 FR 0302667 W FR0302667 W FR 0302667W WO 2004022769 A3 WO2004022769 A3 WO 2004022769A3
Authority
WO
WIPO (PCT)
Prior art keywords
applications
same
neurodegenerative processes
detecting neurodegenerative
detecting
Prior art date
Application number
PCT/FR2003/002667
Other languages
English (en)
Other versions
WO2004022769A2 (fr
Inventor
Andre Delacourte
Nicolas Sergeant
Annick Wattez
Original Assignee
Inst Nat Sante Rech Med
Andre Delacourte
Nicolas Sergeant
Annick Wattez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med, Andre Delacourte, Nicolas Sergeant, Annick Wattez filed Critical Inst Nat Sante Rech Med
Priority to AU2003278281A priority Critical patent/AU2003278281A1/en
Priority to US10/526,899 priority patent/US20060166283A1/en
Priority to EP03769589A priority patent/EP1551994A2/fr
Publication of WO2004022769A2 publication Critical patent/WO2004022769A2/fr
Publication of WO2004022769A3 publication Critical patent/WO2004022769A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention se rapporte à de nouveaux marqueurs du processus neurodégénératif, consititués par la chaîne α de l'ATP synthase ayant subi des modifications. L'invention vise également des méthodes de détection, de diagnostic, des anticorps, des kits et leurs applications.
PCT/FR2003/002667 2002-09-06 2003-09-08 Moyens de detection des processus neurodegeneratifs et leurs applications WO2004022769A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2003278281A AU2003278281A1 (en) 2002-09-06 2003-09-08 Means of detecting neurodegenerative processes and applications of same
US10/526,899 US20060166283A1 (en) 2002-09-06 2003-09-08 Means for detecting neurodegenerative processes and applications of same
EP03769589A EP1551994A2 (fr) 2002-09-06 2003-09-08 Moyens de detection des processus neurodegeneratifs et leurs applications

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0211100A FR2844279A1 (fr) 2002-09-06 2002-09-06 Moyens de detection des processus neurodegeneratifs et leurs applications
FR0211100 2002-09-06

Publications (2)

Publication Number Publication Date
WO2004022769A2 WO2004022769A2 (fr) 2004-03-18
WO2004022769A3 true WO2004022769A3 (fr) 2004-05-21

Family

ID=31725916

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2003/002667 WO2004022769A2 (fr) 2002-09-06 2003-09-08 Moyens de detection des processus neurodegeneratifs et leurs applications

Country Status (5)

Country Link
US (1) US20060166283A1 (fr)
EP (1) EP1551994A2 (fr)
AU (1) AU2003278281A1 (fr)
FR (1) FR2844279A1 (fr)
WO (1) WO2004022769A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR122018069446B8 (pt) 2008-01-18 2021-07-27 Harvard College método in vitro para detectar a presença de um célula de câncer em um indivíduo
AU2011280997A1 (en) 2010-07-23 2013-02-28 President And Fellows Of Harvard College Methods of detecting autoimmune or immune-related diseases or conditions
KR20130041962A (ko) 2010-07-23 2013-04-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 식작용 세포를 사용하여 질환 또는 상태를 검출하는 방법
KR20130041961A (ko) 2010-07-23 2013-04-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 체액에서 질환 또는 상태의 특징을 검출하는 방법
WO2012012717A1 (fr) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Méthodes de dépistage de maladies ou d'affections prénatales ou liées à la grossesse
KR101240207B1 (ko) 2010-08-27 2013-03-06 고려대학교 산학협력단 알츠하이머병 조기진단용 단백질성 마커
MX2014015425A (es) 2012-06-15 2015-07-14 Harry Stylli Metodos para detectar enfermedades o condiciones.
KR20150035818A (ko) 2012-06-15 2015-04-07 해리 스타일리 순환 병든 세포를 사용하여 질환 또는 병태를 검출하는 방법
EP2965086A4 (fr) 2013-03-09 2017-02-08 Harry Stylli Procédés de détection du cancer de la prostate
EP4202441A3 (fr) 2013-03-09 2023-07-26 Immunis.AI, Inc. Profil d'expression génétique dans les macrophages pour le diagnostic du cancer
WO2016040843A1 (fr) 2014-09-11 2016-03-17 Harry Stylli Procédés pour détecter le cancer de la prostate
CN111918875A (zh) * 2018-03-11 2020-11-10 库罗什·沙帕桑 构象-特异性的抗神经毒性tau蛋白的抗体

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6444431B1 (en) * 1998-05-19 2002-09-03 Duke University Angiostatin receptor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6444431B1 (en) * 1998-05-19 2002-09-03 Duke University Angiostatin receptor

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHANG SUN YOUNG ET AL: "Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 10, 8 March 2002 (2002-03-08), March 8, 2002, pages 8388 - 8394, XP002240871, ISSN: 0021-9258 *
KAGAWA Y ET AL: "REGULATION OF MITOCHONDRIAL ATP SYNTHESIS IN MAMMALIAN CELLS BY TRANSCRIPTIONAL CONTROL", INTERNATIONAL JOURNAL OF BIOCHEMISTRY, vol. 22, no. 3, 1990, pages 219 - 230, XP009010733, ISSN: 0020-711X *
KIM S H ET AL: "Decreased levels of complex III core protein 1 and complex V beta chain in brains from patients with Alzheimer's diseases and Down syndrome.", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 57, no. 12, November 2000 (2000-11-01), pages 1810 - 1816, XP002240872, ISSN: 1420-682X *
LEFEBVRE-LEGENDRE LINNKA ET AL: "Identification of a nuclear gene (FMC1) required for the assembly/stability of yeast mitochondrial F1-ATPase in heat stress conditions.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 9, 2 March 2001 (2001-03-02), pages 6789 - 6796, XP002240870, ISSN: 0021-9258 *
MOSER T EL AL: "Angiostatin binds ATP synthase on the surface of human endothelial cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, no. 6, 16 March 1999 (1999-03-16), pages 2811 - 2816, XP002121371, ISSN: 0027-8424 *
SCHÄGGER H ET AL: "Human diseases with defects in oxidative phosphorylation. 2. F1F0 ATP-synthase defects in Alzheimer disease revealed by blue native polyacrylamide gel electrophoresis.", EUROPEAN JOURNAL OF BIOCHEMISTRY / FEBS. GERMANY 1 FEB 1995, vol. 227, no. 3, 1 February 1995 (1995-02-01), pages 916 - 921, XP001157497, ISSN: 0014-2956 *

Also Published As

Publication number Publication date
FR2844279A1 (fr) 2004-03-12
WO2004022769A2 (fr) 2004-03-18
EP1551994A2 (fr) 2005-07-13
US20060166283A1 (en) 2006-07-27
AU2003278281A1 (en) 2004-03-29
AU2003278281A8 (en) 2004-03-29

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