MXPA05001585A - Nuevo uso de derivados de benzotiazol. - Google Patents
Nuevo uso de derivados de benzotiazol.Info
- Publication number
- MXPA05001585A MXPA05001585A MXPA05001585A MXPA05001585A MXPA05001585A MX PA05001585 A MXPA05001585 A MX PA05001585A MX PA05001585 A MXPA05001585 A MX PA05001585A MX PA05001585 A MXPA05001585 A MX PA05001585A MX PA05001585 A MXPA05001585 A MX PA05001585A
- Authority
- MX
- Mexico
- Prior art keywords
- novel use
- benzothiazole derivatives
- formula
- disclosed
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion se refiere al uso de compuestos de formula (1), en donde X, A, B, D, R1 y R2 son como se definen en la especificacion y sales del los mismos farmaceuticamente aceptables, en la manufactura de un medicamento para el tratamiento o profilaxis de enfermedades o condiciones en las cuales la inhibicion de la actividad de cinasa Itk es benefica. Tambien se describen ciertos nuevos compuestos de formula (I), junto con los procesos para su preparacion, composiciones que los contienen y su uso en terapia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0202429A SE0202429D0 (sv) | 2002-08-14 | 2002-08-14 | Novel Compounds |
PCT/SE2003/001271 WO2004016600A1 (en) | 2002-08-14 | 2003-08-13 | Novel use of benzothiazole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05001585A true MXPA05001585A (es) | 2005-04-25 |
Family
ID=20288724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05001585A MXPA05001585A (es) | 2002-08-14 | 2003-08-13 | Nuevo uso de derivados de benzotiazol. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20060106015A1 (es) |
EP (1) | EP1539723B1 (es) |
JP (1) | JP2006504672A (es) |
KR (1) | KR20060002728A (es) |
CN (1) | CN1675189A (es) |
AT (1) | ATE327225T1 (es) |
AU (1) | AU2003248587A1 (es) |
BR (1) | BR0313407A (es) |
CA (1) | CA2495492A1 (es) |
DE (1) | DE60305514D1 (es) |
IL (1) | IL166412A0 (es) |
MX (1) | MXPA05001585A (es) |
NO (1) | NO20051263L (es) |
SE (1) | SE0202429D0 (es) |
WO (1) | WO2004016600A1 (es) |
ZA (1) | ZA200501098B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2007105232A (ru) * | 2004-08-26 | 2008-10-20 | Вайет (Us) | Пролекарственные замещенные бензоксазолы как эстрогенные агенты |
KR20070114748A (ko) | 2005-02-17 | 2007-12-04 | 에이엠알 테크놀로지, 인크. | Cinv 및 ibsd를 치료하기 위한 벤족사졸카복스아미드 |
EP2388263A1 (en) | 2005-08-04 | 2011-11-23 | Sirtris Pharmaceuticals, Inc. | Imidazo[2,1-b]thiazole derivatives as sirtuin modulators |
US8093401B2 (en) | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US7855289B2 (en) | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US8088928B2 (en) | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
DK1990330T3 (da) * | 2007-05-07 | 2011-09-26 | Siemens Ag | Keramisk pulver, keramisk lag og lagsystem med pyrochlorfase og oxider |
CL2008001822A1 (es) | 2007-06-20 | 2009-03-13 | Sirtris Pharmaceuticals Inc | Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras. |
CN101910158A (zh) * | 2007-10-25 | 2010-12-08 | 阿斯利康(瑞典)有限公司 | 可用于治疗细胞增殖性病症的吡啶衍生物和吡嗪衍生物 |
BRPI0922435A2 (pt) | 2008-12-19 | 2018-09-11 | Sirtris Pharmaceuticals Inc | "composto de tiazolopiridina moduladores de sirtuina, composição farmacêutica compreendendo o mesmo e seu uso." |
WO2013153539A1 (en) | 2012-04-13 | 2013-10-17 | Glenmark Pharmaceuticals S.A. | Tricyclic compounds as tec kinase inhibitors |
US9795604B2 (en) | 2013-10-25 | 2017-10-24 | Pharmacyclics Llc | Methods of treating and preventing graft versus host disease |
EP3265090A4 (en) | 2015-03-06 | 2018-08-01 | Beyondspring Pharmaceuticals Inc. | Method of treating cancer associated with a ras mutation |
WO2017040617A1 (en) | 2015-08-31 | 2017-03-09 | Pharmacyclics Llc | Btk inhibitor combinations for treating multiple myeloma |
MY192703A (en) | 2016-02-08 | 2022-09-02 | Beyondspring Pharmaceuticals Inc | Compositions containing tucaresol or its analogs |
CN110139669A (zh) | 2016-11-03 | 2019-08-16 | 朱诺治疗学股份有限公司 | T细胞疗法和btk抑制剂的组合疗法 |
WO2018111049A1 (ko) * | 2016-12-15 | 2018-06-21 | 한국생명공학연구원 | 피리딘계 화합물을 유효성분으로 함유하는 dyrk 관련 질환의 예방 또는 치료용 약학적 조성물 |
KR102279347B1 (ko) | 2016-12-15 | 2021-07-21 | 한국생명공학연구원 | 피리딘계 화합물을 유효성분으로 함유하는 dyrk 관련 질환의 예방 또는 치료용 약학적 조성물 |
JP2020503363A (ja) | 2017-01-06 | 2020-01-30 | ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド | チューブリン結合化合物およびその治療的使用 |
KR20200112881A (ko) | 2018-01-24 | 2020-10-05 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법 |
UA128288C2 (uk) | 2018-03-08 | 2024-05-29 | Інсайт Корпорейшн | СПОЛУКИ АМІНОПІРАЗИНДІОЛУ ЯК ІНГІБІТОРИ PI3K-<font face="Symbol">g</font> |
CA3098497A1 (en) | 2018-05-03 | 2019-11-07 | Juno Therapeutics, Inc. | Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor |
US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
CN112778155B (zh) * | 2019-11-11 | 2023-08-11 | 大连万春布林医药有限公司 | 妥卡雷琐衍生物及其用途 |
WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU37546A1 (es) * | 1958-08-22 | |||
DE2145178C3 (de) * | 1970-09-11 | 1975-12-11 | Tokyo Tanabe Co., Ltd., Tokio | 2-Phenyl-5-oder -6-benzothiazolylessigsäure-Verblndungen |
JPS4932855B1 (es) * | 1971-08-03 | 1974-09-03 | ||
DD150059A1 (de) * | 1980-04-07 | 1981-08-12 | Horst Hartmann | Verfahren zur herstellung von hydroxyarylazolen |
JPS62221679A (ja) * | 1986-03-19 | 1987-09-29 | Santen Pharmaceut Co Ltd | ベンゾチアゾリン誘導体 |
DE4030511A1 (de) * | 1990-09-27 | 1992-04-02 | Basf Ag | Hochtemperaturbestaendige, benzthiazolhaltige polyarylether |
US5296486A (en) * | 1991-09-24 | 1994-03-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Leukotriene biosynthesis inhibitors |
CA2309319A1 (en) * | 1997-11-10 | 1999-05-20 | Bristol-Myers Squibb Company | Benzothiazole protein tyrosine kinase inhibitors |
WO2001074810A2 (en) * | 2000-03-31 | 2001-10-11 | Ortho Mcneil Pharmaceutical, Inc. | Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as h3 antagonists |
JP2004524289A (ja) * | 2000-12-22 | 2004-08-12 | アストラゼネカ・アクチエボラーグ | 治療化合物 |
JP2002306916A (ja) * | 2001-01-26 | 2002-10-22 | Toray Ind Inc | エアフィルタユニット |
-
2002
- 2002-08-14 SE SE0202429A patent/SE0202429D0/xx unknown
-
2003
- 2003-08-13 EP EP03788208A patent/EP1539723B1/en not_active Expired - Lifetime
- 2003-08-13 AU AU2003248587A patent/AU2003248587A1/en not_active Abandoned
- 2003-08-13 CN CNA038191393A patent/CN1675189A/zh active Pending
- 2003-08-13 AT AT03788208T patent/ATE327225T1/de not_active IP Right Cessation
- 2003-08-13 JP JP2004528996A patent/JP2006504672A/ja active Pending
- 2003-08-13 MX MXPA05001585A patent/MXPA05001585A/es unknown
- 2003-08-13 US US10/524,124 patent/US20060106015A1/en not_active Abandoned
- 2003-08-13 DE DE60305514T patent/DE60305514D1/de not_active Expired - Lifetime
- 2003-08-13 BR BR0313407-5A patent/BR0313407A/pt not_active Application Discontinuation
- 2003-08-13 WO PCT/SE2003/001271 patent/WO2004016600A1/en active IP Right Grant
- 2003-08-13 CA CA002495492A patent/CA2495492A1/en not_active Abandoned
- 2003-08-13 KR KR1020057002297A patent/KR20060002728A/ko not_active Application Discontinuation
-
2005
- 2005-01-20 IL IL16641205A patent/IL166412A0/xx unknown
- 2005-02-07 ZA ZA200501098A patent/ZA200501098B/xx unknown
- 2005-03-11 NO NO20051263A patent/NO20051263L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2495492A1 (en) | 2004-02-26 |
WO2004016600A1 (en) | 2004-02-26 |
AU2003248587A1 (en) | 2004-03-03 |
SE0202429D0 (sv) | 2002-08-14 |
EP1539723B1 (en) | 2006-05-24 |
JP2006504672A (ja) | 2006-02-09 |
EP1539723A1 (en) | 2005-06-15 |
IL166412A0 (en) | 2006-01-15 |
DE60305514D1 (de) | 2006-06-29 |
US20060106015A1 (en) | 2006-05-18 |
ATE327225T1 (de) | 2006-06-15 |
KR20060002728A (ko) | 2006-01-09 |
NO20051263L (no) | 2005-05-12 |
ZA200501098B (en) | 2006-12-27 |
BR0313407A (pt) | 2005-07-05 |
CN1675189A (zh) | 2005-09-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL166412A0 (en) | Novel use of benzothiazole derivatives | |
SE0202462D0 (sv) | Novel use | |
IL150635A0 (en) | Novel use of phenylheteroalkylamine derivatives | |
MY157949A (en) | Thioxanthine derivatives as myeloperoxidase inhibitors | |
SG170101A1 (en) | 2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial. | |
NO20055565L (no) | Anvendelse av derivater av 2,4-dihydro-[1,2,4]triazol-3-thion som inhibitorer av enzymet myeloperoksidase (MPO) | |
IL165264A (en) | Protein kinase inhibitors, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for treating protein kinase-associated diseases | |
MY140638A (en) | New heterocyclic compounds, which are active as inhibitors of beta-lactamases | |
GB0112348D0 (en) | Compounds | |
HK1091121A1 (en) | Substituted 2-aminotetralins for the treatment of depressions | |
MY133527A (en) | Isoquinoline derivatives | |
MX2007006744A (es) | Derivados de hidantoina utiles como inhibidores de metaloproteinasa. | |
MXPA05005790A (es) | Aminoalcoxiindoles como ligandos del receptor 5-ht6 para el tratamiento de enfermedades del sistema nervioso central. | |
IL150640A0 (en) | Novel use of phenylheteroalkylamine derivatives | |
NO20045353L (no) | Orto-substituerte benzosyrederivater for behandling av insulinresistens | |
BRPI0415546A (pt) | composto, composição farmacêutica, uso de um composto, e, métodos de tratamento ou profilaxia de doenças ou condições humanas, e de distúrbios | |
YU30602A (sh) | Primena 2-amino-3,4-dihidro-hinazolina za proizvodnju leka za lečenje ili profilaksu bolesti koje su prouzrokovane ishemičnim stanjima | |
SE0201193D0 (sv) | Novel use |