MXPA04011679A - Sistema de expresion eucariotico inducible. - Google Patents
Sistema de expresion eucariotico inducible.Info
- Publication number
- MXPA04011679A MXPA04011679A MXPA04011679A MXPA04011679A MXPA04011679A MX PA04011679 A MXPA04011679 A MX PA04011679A MX PA04011679 A MXPA04011679 A MX PA04011679A MX PA04011679 A MXPA04011679 A MX PA04011679A MX PA04011679 A MXPA04011679 A MX PA04011679A
- Authority
- MX
- Mexico
- Prior art keywords
- leu
- nucleotide sequence
- interest
- expression
- ligand
- Prior art date
Links
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- VCHVSKNMTXWIIP-SRVKXCTJSA-N Leu-Lys-Ser Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O VCHVSKNMTXWIIP-SRVKXCTJSA-N 0.000 claims 2
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- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 108091006107 transcriptional repressors Proteins 0.000 description 1
- 101150006320 trpR gene Proteins 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38400402P | 2002-05-29 | 2002-05-29 | |
| PCT/US2003/016676 WO2003101189A1 (en) | 2002-05-29 | 2003-05-28 | Inducible eukaryotic expression system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04011679A true MXPA04011679A (es) | 2005-03-07 |
Family
ID=29711966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04011679A MXPA04011679A (es) | 2002-05-29 | 2003-05-28 | Sistema de expresion eucariotico inducible. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7455988B2 (enExample) |
| EP (1) | EP1531666B1 (enExample) |
| JP (2) | JP4817657B2 (enExample) |
| AU (1) | AU2003237259B2 (enExample) |
| BR (1) | BRPI0311201B1 (enExample) |
| CA (1) | CA2485939C (enExample) |
| DK (1) | DK1531666T3 (enExample) |
| ES (1) | ES2439874T3 (enExample) |
| MX (1) | MXPA04011679A (enExample) |
| WO (1) | WO2003101189A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001293798B2 (en) * | 2000-09-09 | 2006-12-21 | Basf Plant Science Gmbh | Modified tet-inducible system for regulation of gene expression in plants |
| US8673589B2 (en) * | 2002-05-29 | 2014-03-18 | Regeneron Pharmaceuticals, Inc. | Inducible eukaryotic expression system |
| US20090123468A1 (en) | 2003-10-24 | 2009-05-14 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
| US8062891B2 (en) | 2003-10-24 | 2011-11-22 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to plants |
| CA2543257C (en) | 2003-10-24 | 2013-12-31 | Gencia Corporation | Methods and compositions for delivering polynucleotides |
| US8133733B2 (en) | 2003-10-24 | 2012-03-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to target tissues |
| US8507277B2 (en) | 2003-10-24 | 2013-08-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides |
| GB0418651D0 (en) * | 2004-08-20 | 2004-09-22 | Medical Res Council | Method |
| ATE491022T1 (de) * | 2005-10-18 | 2010-12-15 | Nat Jewish Health | Konditionell immortalisierte adulte langzeit- stammzellen und verfahren zur herstellung und verwendung von solchen zellen |
| EP2393927B1 (en) | 2009-02-09 | 2014-12-31 | MorphoSys AG | Production of oligoclonal mixtures of immunoglobulins in single cells |
| TW201823460A (zh) | 2012-05-29 | 2018-07-01 | 美商再生元醫藥公司 | 生產細胞株增強子 |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| US9388243B2 (en) | 2013-05-29 | 2016-07-12 | Samsung Electronics Co., Ltd. | Method of target membrane protein depletion |
| TWI797060B (zh) | 2015-08-04 | 2023-04-01 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| EP3411483B1 (en) * | 2016-02-05 | 2022-07-06 | PolyGene AG | Glucocorticoid-based gene regulation system |
| CA3015371A1 (en) | 2016-04-20 | 2017-10-26 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for making antibodies based on use of an expression-enhancing locus |
| SG10202010155YA (en) | 2016-04-20 | 2020-11-27 | Regeneron Pharma | Compositions and methods for making antibodies based on use of expression-enhancing loci |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| KR20240004433A (ko) * | 2021-04-06 | 2024-01-11 | 센티 바이오사이언시스, 인코포레이티드 | Ert2 돌연변이체 및 이의 용도 |
| WO2022216825A1 (en) * | 2021-04-06 | 2022-10-13 | Senti Biosciences, Inc. | Ert2 mutants and uses thereof |
| CA3235563A1 (en) * | 2021-10-18 | 2023-04-27 | Regeneron Pharmaceuticals, Inc. | Controlled transcription of polynucleotides |
| US12234472B2 (en) | 2021-10-18 | 2025-02-25 | Regeneron Pharmaceuticals, Inc. | Eukaryotic cells comprising adenovirus-associated virus polynucleotides |
| KR20240167715A (ko) | 2022-03-02 | 2024-11-27 | 리제너론 파아마슈티컬스, 인크. | 고역가 항체의 제조 방법 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4833080A (en) | 1985-12-12 | 1989-05-23 | President And Fellows Of Harvard College | Regulation of eucaryotic gene expression |
| US4981784A (en) | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
| US5096815A (en) * | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| US5756448A (en) * | 1992-02-26 | 1998-05-26 | The General Hospital Corporation | Constitute activator of retinoid (CAR) receptor polypeptides |
| US5866755A (en) * | 1993-06-14 | 1999-02-02 | Basf Aktiengellschaft | Animals transgenic for a tetracycline-regulated transcriptional inhibitor |
| US5814618A (en) * | 1993-06-14 | 1998-09-29 | Basf Aktiengesellschaft | Methods for regulating gene expression |
| JPH09500526A (ja) * | 1993-06-14 | 1997-01-21 | ベーアーエスエフ アクツィエンゲゼルシャフト | テトラサイクリン反応性プロモーターによる真核細胞の遺伝子発現の厳密な制御 |
| GB2301991B (en) * | 1995-06-06 | 1999-06-30 | Plessey Telecomm | SDH Network |
| US5739018A (en) * | 1996-08-07 | 1998-04-14 | The Regents Of The University Of California | Packaging cell lines for pseudotyped retroviral vectors |
| US6133027A (en) * | 1996-08-07 | 2000-10-17 | City Of Hope | Inducible expression system |
| US5972650A (en) * | 1997-06-26 | 1999-10-26 | Brigham And Women's Hospital | Tetracycline repressor regulated mammalian cell transcription and viral replication switch |
| JP2003524368A (ja) * | 1997-08-26 | 2003-08-19 | アリアド ジーン セラピューティクス インコーポレイテッド | ニ量化ドメイン、三量化ドメインまたは四量化ドメインおよび補足的非相同転写活性化ドメイン、転写抑制ドメイン、ｄｎａ結合ドメインまたはリガンド結合ドメインを含む融合蛋白 |
| US6153383A (en) | 1997-12-09 | 2000-11-28 | Verdine; Gregory L. | Synthetic transcriptional modulators and uses thereof |
| FR2782732A1 (fr) * | 1998-08-28 | 2000-03-03 | Transgene Sa | Systeme d'expression inductible |
| US7329728B1 (en) | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
| FR2814642B1 (fr) | 2000-10-03 | 2005-07-01 | Ass Pour Le Dev De La Rech En | Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee |
| CA2440367A1 (en) * | 2000-10-20 | 2002-08-15 | Canji, Inc. | Aptamer-mediated regulation of gene expression |
| US20040102367A1 (en) | 2001-02-23 | 2004-05-27 | Gage Fred H | Gene expression system based on chimeric receptors |
| US7153685B2 (en) | 2002-03-11 | 2006-12-26 | The Board Of Trustees Of The University Of Illinois | Tamoxifen and 4-hydroxytamoxifen-activated system for regulated production of proteins in eukaryotic cells |
-
2003
- 2003-05-28 JP JP2004508560A patent/JP4817657B2/ja not_active Expired - Lifetime
- 2003-05-28 CA CA2485939A patent/CA2485939C/en not_active Expired - Lifetime
- 2003-05-28 US US10/447,243 patent/US7455988B2/en not_active Expired - Lifetime
- 2003-05-28 AU AU2003237259A patent/AU2003237259B2/en not_active Expired
- 2003-05-28 MX MXPA04011679A patent/MXPA04011679A/es active IP Right Grant
- 2003-05-28 BR BRPI0311201-2A patent/BRPI0311201B1/pt not_active IP Right Cessation
- 2003-05-28 EP EP03736725.7A patent/EP1531666B1/en not_active Expired - Lifetime
- 2003-05-28 ES ES03736725.7T patent/ES2439874T3/es not_active Expired - Lifetime
- 2003-05-28 WO PCT/US2003/016676 patent/WO2003101189A1/en not_active Ceased
- 2003-05-28 DK DK03736725.7T patent/DK1531666T3/da active
-
2006
- 2006-01-13 US US11/332,431 patent/US7514545B2/en not_active Expired - Lifetime
-
2011
- 2011-05-17 JP JP2011110860A patent/JP2011152152A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1531666A4 (en) | 2006-05-24 |
| EP1531666A1 (en) | 2005-05-25 |
| CA2485939C (en) | 2013-10-29 |
| BRPI0311201B8 (enExample) | 2021-05-25 |
| JP2005527227A (ja) | 2005-09-15 |
| BRPI0311201B1 (pt) | 2017-08-08 |
| EP1531666B1 (en) | 2013-10-23 |
| AU2003237259B2 (en) | 2008-01-24 |
| US20060107341A1 (en) | 2006-05-18 |
| BR0311201A (pt) | 2005-02-22 |
| JP4817657B2 (ja) | 2011-11-16 |
| HK1075364A1 (en) | 2005-12-16 |
| AU2003237259A1 (en) | 2003-12-19 |
| US7455988B2 (en) | 2008-11-25 |
| US20030235886A1 (en) | 2003-12-25 |
| DK1531666T3 (da) | 2014-01-13 |
| WO2003101189A1 (en) | 2003-12-11 |
| JP2011152152A (ja) | 2011-08-11 |
| CA2485939A1 (en) | 2003-12-11 |
| US7514545B2 (en) | 2009-04-07 |
| ES2439874T3 (es) | 2014-01-27 |
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Legal Events
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| FG | Grant or registration |