BR0311201A - Método para induzir a expressão de uma sequência de nucleotìdeos de interesse em uma célula eucariótica, sequência de nucleotìdeos isolada, proteìna de fusão reguladora, célula eucariótica, animal transgênico, e, método para controlar a produção de um produto de uma sequência de nucleotìdeos de interesse em uma célula eucariótica - Google Patents
Método para induzir a expressão de uma sequência de nucleotìdeos de interesse em uma célula eucariótica, sequência de nucleotìdeos isolada, proteìna de fusão reguladora, célula eucariótica, animal transgênico, e, método para controlar a produção de um produto de uma sequência de nucleotìdeos de interesse em uma célula eucarióticaInfo
- Publication number
- BR0311201A BR0311201A BR0311201-2A BR0311201A BR0311201A BR 0311201 A BR0311201 A BR 0311201A BR 0311201 A BR0311201 A BR 0311201A BR 0311201 A BR0311201 A BR 0311201A
- Authority
- BR
- Brazil
- Prior art keywords
- interest
- nucleotide sequence
- eukaryotic cell
- sequence
- product
- Prior art date
Links
- 239000002773 nucleotide Substances 0.000 title abstract 7
- 210000003527 eukaryotic cell Anatomy 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- 125000003729 nucleotide group Chemical group 0.000 title abstract 5
- 230000014509 gene expression Effects 0.000 title abstract 4
- 230000001939 inductive effect Effects 0.000 title abstract 3
- 230000001105 regulatory effect Effects 0.000 title abstract 3
- 108020001507 fusion proteins Proteins 0.000 title abstract 2
- 102000037865 fusion proteins Human genes 0.000 title abstract 2
- 230000001276 controlling effect Effects 0.000 title 1
- 230000009261 transgenic effect Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 3
- 239000003446 ligand Substances 0.000 abstract 2
- 108020001756 ligand binding domains Proteins 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 230000000903 blocking effect Effects 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 230000002103 transcriptional effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
"MéTODO PARA INDUZIR A EXPRESSãO DE UMA SEQuêNCIA DE NUCLEOTìDEOS DE INTERESSE EM UMA CéLULA EUCARIóTICA, SEQuêNCIA DE NUCLEOTìDEOS ISOLADA, PROTEìNA DE FUSãO REGULADORA, CéLULA EUCARIóTICA, ANIMAL TRANSGêNICO, E, MéTODO PARA CONTROLAR A PRODUçãO DE UM PRODUTO DE UMA SEQuêNCIA DE NUCLEOTìDEOS DE INTERESSE EM UMA CéLULA EUCARIóTICA". Composições e métodos para a expressão indutível de genes em células eucarióticas. A expressão de uma seq³ência de interesse é controlada por uma proteína de fusão reguladora que consiste de um domínio de bloqueio da transcrição e um domínio de ligação por ligando. Quando o ligando cognato para o domínio de ligação por ligando está presente, a transcrição da seq³ência de nucleotídeos de interesse é bloqueada. Após a remoção do ligando cognato, a seq³ência de nucleotídeos de interesse é transcrita. O método é útil para a produção em larga escala de um produto desejado em células eucarióticas.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38400402P | 2002-05-29 | 2002-05-29 | |
| US60/384,004 | 2002-05-29 | ||
| PCT/US2003/016676 WO2003101189A1 (en) | 2002-05-29 | 2003-05-28 | Inducible eukaryotic expression system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0311201A true BR0311201A (pt) | 2005-02-22 |
| BRPI0311201B1 BRPI0311201B1 (pt) | 2017-08-08 |
| BRPI0311201B8 BRPI0311201B8 (pt) | 2021-05-25 |
Family
ID=29711966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0311201-2A BRPI0311201B1 (pt) | 2002-05-29 | 2003-05-28 | A method for inducing the expression of a nucleotide sequence of interest in a eukaryotic cell, a regulatory fusion protein, and a method for controlling the production of a product of a nucleotide sequence of interest in a eukaryotic cell |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7455988B2 (pt) |
| EP (1) | EP1531666B1 (pt) |
| JP (2) | JP4817657B2 (pt) |
| AU (1) | AU2003237259B2 (pt) |
| BR (1) | BRPI0311201B1 (pt) |
| CA (1) | CA2485939C (pt) |
| DK (1) | DK1531666T3 (pt) |
| ES (1) | ES2439874T3 (pt) |
| HK (1) | HK1075364A1 (pt) |
| MX (1) | MXPA04011679A (pt) |
| WO (1) | WO2003101189A1 (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1322771A2 (en) * | 2000-09-09 | 2003-07-02 | BASF Plant Science GmbH | MODIFIED i TET /i -INDUCIBLE SYSTEM FOR REGULATION OF GENE EXPRESSION IN PLANTS |
| US8673589B2 (en) | 2002-05-29 | 2014-03-18 | Regeneron Pharmaceuticals, Inc. | Inducible eukaryotic expression system |
| US8507277B2 (en) | 2003-10-24 | 2013-08-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides |
| US8062891B2 (en) | 2003-10-24 | 2011-11-22 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to plants |
| US20090123468A1 (en) | 2003-10-24 | 2009-05-14 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
| CA2543257C (en) | 2003-10-24 | 2013-12-31 | Gencia Corporation | Methods and compositions for delivering polynucleotides |
| US8133733B2 (en) | 2003-10-24 | 2012-03-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to target tissues |
| GB0418651D0 (en) * | 2004-08-20 | 2004-09-22 | Medical Res Council | Method |
| IN2014DN06624A (pt) * | 2005-10-18 | 2015-07-10 | Univ Colorado | |
| DK2393927T3 (en) | 2009-02-09 | 2015-03-30 | Morphosys Ag | Preparation of oligoclonal mixtures of antibodies in the individual cells |
| TWI641687B (zh) | 2012-05-29 | 2018-11-21 | 美商再生元醫藥公司 | 生產細胞株增強子 |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| CN104211814A (zh) | 2013-05-29 | 2014-12-17 | 三星电子株式会社 | 用于消耗靶膜蛋白的组合物 |
| TW202330904A (zh) | 2015-08-04 | 2023-08-01 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| EP3411483B1 (en) * | 2016-02-05 | 2022-07-06 | PolyGene AG | Glucocorticoid-based gene regulation system |
| SG10202010155YA (en) | 2016-04-20 | 2020-11-27 | Regeneron Pharma | Compositions and methods for making antibodies based on use of expression-enhancing loci |
| MX2018012866A (es) | 2016-04-20 | 2019-03-11 | Regeneron Pharma | Composiciones y metodos para generar anticuerpos basado en el uso de un locus potenciador de la expresion. |
| EP4320228A1 (en) * | 2021-04-06 | 2024-02-14 | Senti Biosciences, Inc. | Ert2 mutants and uses thereof |
| WO2022216825A1 (en) * | 2021-04-06 | 2022-10-13 | Senti Biosciences, Inc. | Ert2 mutants and uses thereof |
| MX2024004691A (es) * | 2021-10-18 | 2024-05-23 | Regeneron Pharma | Transcripcion controlada de polinucleotidos. |
| US20230287043A1 (en) | 2022-03-02 | 2023-09-14 | Regeneron Pharmaceuticals, Inc. | Cell culture methods for antibody production |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4833080A (en) * | 1985-12-12 | 1989-05-23 | President And Fellows Of Harvard College | Regulation of eucaryotic gene expression |
| US4981784A (en) * | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
| US5096815A (en) * | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| US5756448A (en) * | 1992-02-26 | 1998-05-26 | The General Hospital Corporation | Constitute activator of retinoid (CAR) receptor polypeptides |
| US5866755A (en) * | 1993-06-14 | 1999-02-02 | Basf Aktiengellschaft | Animals transgenic for a tetracycline-regulated transcriptional inhibitor |
| US5814618A (en) * | 1993-06-14 | 1998-09-29 | Basf Aktiengesellschaft | Methods for regulating gene expression |
| AU684524B2 (en) * | 1993-06-14 | 1997-12-18 | Tet Systems Holding Gmbh & Co. Kg | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
| GB2301991B (en) * | 1995-06-06 | 1999-06-30 | Plessey Telecomm | SDH Network |
| US6133027A (en) * | 1996-08-07 | 2000-10-17 | City Of Hope | Inducible expression system |
| US5739018A (en) * | 1996-08-07 | 1998-04-14 | The Regents Of The University Of California | Packaging cell lines for pseudotyped retroviral vectors |
| US5972650A (en) * | 1997-06-26 | 1999-10-26 | Brigham And Women's Hospital | Tetracycline repressor regulated mammalian cell transcription and viral replication switch |
| CA2300376A1 (en) * | 1997-08-26 | 1999-03-04 | Ariad Gene Therapeutics, Inc. | Fusion proteins comprising a dimerization, trimerization or tetramerization domain and an additional heterologous transcription activation, transcription repression, dna binding or ligand binding domain |
| US6153383A (en) * | 1997-12-09 | 2000-11-28 | Verdine; Gregory L. | Synthetic transcriptional modulators and uses thereof |
| FR2782732A1 (fr) * | 1998-08-28 | 2000-03-03 | Transgene Sa | Systeme d'expression inductible |
| US7329728B1 (en) | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
| FR2814642B1 (fr) * | 2000-10-03 | 2005-07-01 | Ass Pour Le Dev De La Rech En | Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee |
| AU2002253836A1 (en) * | 2000-10-20 | 2002-08-19 | Canji, Inc | Aptamer-mediated regulation of gene expression |
| US20040102367A1 (en) * | 2001-02-23 | 2004-05-27 | Gage Fred H | Gene expression system based on chimeric receptors |
| US7153685B2 (en) * | 2002-03-11 | 2006-12-26 | The Board Of Trustees Of The University Of Illinois | Tamoxifen and 4-hydroxytamoxifen-activated system for regulated production of proteins in eukaryotic cells |
-
2003
- 2003-05-28 ES ES03736725.7T patent/ES2439874T3/es not_active Expired - Lifetime
- 2003-05-28 BR BRPI0311201-2A patent/BRPI0311201B1/pt active IP Right Grant
- 2003-05-28 CA CA2485939A patent/CA2485939C/en not_active Expired - Lifetime
- 2003-05-28 AU AU2003237259A patent/AU2003237259B2/en not_active Expired
- 2003-05-28 DK DK03736725.7T patent/DK1531666T3/da active
- 2003-05-28 WO PCT/US2003/016676 patent/WO2003101189A1/en active Application Filing
- 2003-05-28 JP JP2004508560A patent/JP4817657B2/ja not_active Expired - Lifetime
- 2003-05-28 MX MXPA04011679A patent/MXPA04011679A/es active IP Right Grant
- 2003-05-28 US US10/447,243 patent/US7455988B2/en not_active Expired - Lifetime
- 2003-05-28 EP EP03736725.7A patent/EP1531666B1/en not_active Expired - Lifetime
-
2005
- 2005-07-19 HK HK05106115.2A patent/HK1075364A1/xx not_active IP Right Cessation
-
2006
- 2006-01-13 US US11/332,431 patent/US7514545B2/en not_active Expired - Lifetime
-
2011
- 2011-05-17 JP JP2011110860A patent/JP2011152152A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003101189A1 (en) | 2003-12-11 |
| JP2011152152A (ja) | 2011-08-11 |
| US7455988B2 (en) | 2008-11-25 |
| EP1531666A1 (en) | 2005-05-25 |
| DK1531666T3 (da) | 2014-01-13 |
| AU2003237259B2 (en) | 2008-01-24 |
| JP2005527227A (ja) | 2005-09-15 |
| US7514545B2 (en) | 2009-04-07 |
| BRPI0311201B1 (pt) | 2017-08-08 |
| ES2439874T3 (es) | 2014-01-27 |
| JP4817657B2 (ja) | 2011-11-16 |
| MXPA04011679A (es) | 2005-03-07 |
| CA2485939C (en) | 2013-10-29 |
| EP1531666B1 (en) | 2013-10-23 |
| AU2003237259A1 (en) | 2003-12-19 |
| US20030235886A1 (en) | 2003-12-25 |
| US20060107341A1 (en) | 2006-05-18 |
| EP1531666A4 (en) | 2006-05-24 |
| BRPI0311201B8 (pt) | 2021-05-25 |
| HK1075364A1 (en) | 2005-12-16 |
| CA2485939A1 (en) | 2003-12-11 |
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Legal Events
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: AS CLASSIFICACOES ANTERIORES ERAM: A01K 67/00 , C07K 19/00 , C12N 5/10 , C12N 15/79 , C12P 21/02 Ipc: C12N 5/10 (2006.01), C12N 5/07 (2010.01), C12N 15/ |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] | ||
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/05/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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