MXPA04004059A - Metodo para tratar la depresion con compuestos agonistas receptores delta. - Google Patents
Metodo para tratar la depresion con compuestos agonistas receptores delta.Info
- Publication number
- MXPA04004059A MXPA04004059A MXPA04004059A MXPA04004059A MXPA04004059A MX PA04004059 A MXPA04004059 A MX PA04004059A MX PA04004059 A MXPA04004059 A MX PA04004059A MX PA04004059 A MXPA04004059 A MX PA04004059A MX PA04004059 A MXPA04004059 A MX PA04004059A
- Authority
- MX
- Mexico
- Prior art keywords
- mood disorder
- group
- formula
- therapeutic composition
- alkyl
- Prior art date
Links
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- -1 Ci-C6 alkyl Inorganic materials 0.000 claims description 54
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- 125000001424 substituent group Chemical group 0.000 claims description 25
- 150000002367 halogens Chemical class 0.000 claims description 23
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- 239000006199 nebulizer Substances 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000003401 opiate antagonist Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 125000005489 p-toluenesulfonic acid group Chemical class 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- CBPYOHALYYGNOE-UHFFFAOYSA-M potassium;3,5-dinitrobenzoate Chemical compound [K+].[O-]C(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1 CBPYOHALYYGNOE-UHFFFAOYSA-M 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- XTUSEBKMEQERQV-UHFFFAOYSA-N propan-2-ol;hydrate Chemical compound O.CC(C)O XTUSEBKMEQERQV-UHFFFAOYSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229940035613 prozac Drugs 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000011808 rodent model Methods 0.000 description 1
- 229960002073 sertraline Drugs 0.000 description 1
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 description 1
- 231100000872 sexual dysfunction Toxicity 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 235000011044 succinic acid Nutrition 0.000 description 1
- 150000003444 succinic acids Chemical class 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid group Chemical class S(N)(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 125000004417 unsaturated alkyl group Chemical group 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34008401P | 2001-10-29 | 2001-10-29 | |
| US33788701P | 2001-11-02 | 2001-11-02 | |
| PCT/US2002/034421 WO2003037342A1 (en) | 2001-10-29 | 2002-10-29 | Method of treating depression with delta receptor agonist compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04004059A true MXPA04004059A (es) | 2005-03-31 |
Family
ID=26990913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04004059A MXPA04004059A (es) | 2001-10-29 | 2002-10-29 | Metodo para tratar la depresion con compuestos agonistas receptores delta. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7030124B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1450807B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4892654B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1596113B (cg-RX-API-DMAC7.html) |
| CA (1) | CA2464471C (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA04004059A (cg-RX-API-DMAC7.html) |
| NO (1) | NO20042257L (cg-RX-API-DMAC7.html) |
| PL (1) | PL371297A1 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2314809C2 (cg-RX-API-DMAC7.html) |
| TW (1) | TW200300089A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2003037342A1 (cg-RX-API-DMAC7.html) |
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| CN1269805C (zh) * | 2001-05-18 | 2006-08-16 | 阿斯特拉曾尼卡有限公司 | 4－(苯基－哌嗪基－甲基)－苯甲酰胺衍生物及其在治疗疼痛、焦虑症或胃肠病中的应用 |
| US8476280B2 (en) * | 2002-05-09 | 2013-07-02 | Versi Group, Llc | Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists |
| SE0203300D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203303D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| US7314880B2 (en) * | 2003-01-02 | 2008-01-01 | Mount Cook Biosciences, Inc. | Cardioprotective delta opioid receptor agonists and methods of using same |
| NZ593444A (en) | 2003-10-01 | 2012-12-21 | Adolor Corp | 4-[(2-N,N-diethylaminocarbonyl)pyrid-5-yl]-spiro[1,2-dihydronaphthalene-2,4'-piperidine] and methods of its use |
| MX2007001240A (es) * | 2004-08-02 | 2007-03-23 | Astrazeneca Ab | Derivados de diarilmetil-piperazina, preparaciones y usos de las mismas. |
| SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7683168B2 (en) * | 2005-04-14 | 2010-03-23 | Mount Cook Bio Sciences, Inc. | Compositions of novel opioid compounds and method of use thereof |
| TW200803856A (en) | 2005-09-02 | 2008-01-16 | Mount Cook Biosciences Inc | Method of treating parkinson's disease with diarylmethylpiperazine compounds exhibiting delta receptor agonist activity |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| NZ590041A (en) * | 2008-05-20 | 2012-11-30 | Astrazeneca Ab | Method of treating anxious major depressive disorder |
| CN103467460A (zh) * | 2013-09-23 | 2013-12-25 | 昆明理工大学 | 一类含噻吩环和苄基的二芳基甲基哌嗪化合物及其应用 |
| CN105646151B (zh) * | 2016-02-26 | 2018-06-29 | 山西大学 | 一种炔类化合物及其制备方法和该化合物的用途 |
| WO2017173067A1 (en) | 2016-03-31 | 2017-10-05 | Versi Group, Llc | Delta opioid agonist, mu opioid antagonist compositions and methods for treating parkinson's disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5A (en) * | 1836-08-10 | Thomas Blanchard | Machine for mortising solid wooden shells of ships' tackle-blocks | |
| US5807858A (en) * | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
| US5681830A (en) * | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
| US5574159A (en) * | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| US5985880A (en) * | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
| US20020052007A1 (en) * | 1992-02-03 | 2002-05-02 | Chang Kwen Jen | Diarylmethylbenzylpiperazines and corresponding halobenzyl derivatives |
| AU692788B2 (en) * | 1993-07-30 | 1998-06-18 | Ardent Pharmaceuticals, Inc. | Piperazine compounds used in therapy |
| US6046200A (en) * | 1994-09-09 | 2000-04-04 | The United States Of America As Represented By The Secretary Of The Army | Compositions having neuroprotective and analgesic activity |
| SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| GB9709972D0 (en) * | 1997-05-19 | 1997-07-09 | Pfizer Ltd | Tetrazoles |
| GB9804734D0 (en) * | 1998-03-05 | 1998-04-29 | Pfizer Ltd | Compounds |
| ATE273970T1 (de) * | 1998-04-16 | 2004-09-15 | Pfizer Prod Inc | N-acyl und n-aroyl aralkylamide |
| SE9904673D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE9904674D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE9904675D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| GB0017256D0 (en) * | 2000-07-13 | 2000-08-30 | Merck Sharp & Dohme | Therapeutic agents |
| CN1269805C (zh) | 2001-05-18 | 2006-08-16 | 阿斯特拉曾尼卡有限公司 | 4－(苯基－哌嗪基－甲基)－苯甲酰胺衍生物及其在治疗疼痛、焦虑症或胃肠病中的应用 |
-
2002
- 2002-10-29 CN CN028237099A patent/CN1596113B/zh not_active Expired - Fee Related
- 2002-10-29 WO PCT/US2002/034421 patent/WO2003037342A1/en not_active Ceased
- 2002-10-29 RU RU2004115748/14A patent/RU2314809C2/ru not_active IP Right Cessation
- 2002-10-29 PL PL02371297A patent/PL371297A1/xx unknown
- 2002-10-29 EP EP02789294.2A patent/EP1450807B1/en not_active Expired - Lifetime
- 2002-10-29 JP JP2003539685A patent/JP4892654B2/ja not_active Expired - Fee Related
- 2002-10-29 CA CA2464471A patent/CA2464471C/en not_active Expired - Fee Related
- 2002-10-29 US US10/282,411 patent/US7030124B2/en not_active Expired - Fee Related
- 2002-10-29 MX MXPA04004059A patent/MXPA04004059A/es unknown
- 2002-10-29 TW TW091132060A patent/TW200300089A/zh unknown
-
2004
- 2004-06-01 NO NO20042257A patent/NO20042257L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003037342A1 (en) | 2003-05-08 |
| CN1596113B (zh) | 2010-05-26 |
| TW200300089A (en) | 2003-05-16 |
| US7030124B2 (en) | 2006-04-18 |
| CA2464471C (en) | 2012-05-15 |
| EP1450807B1 (en) | 2013-12-25 |
| CN1596113A (zh) | 2005-03-16 |
| US20030144299A1 (en) | 2003-07-31 |
| CA2464471A1 (en) | 2003-05-08 |
| RU2314809C2 (ru) | 2008-01-20 |
| EP1450807A4 (en) | 2008-06-25 |
| JP2005508363A (ja) | 2005-03-31 |
| EP1450807A1 (en) | 2004-09-01 |
| NO20042257L (no) | 2004-06-24 |
| RU2004115748A (ru) | 2005-03-27 |
| JP4892654B2 (ja) | 2012-03-07 |
| PL371297A1 (en) | 2005-06-13 |
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| GB | Transfer or rights |