CN1596113B - δ受体激动剂化合物在制备治疗抑郁症的药物中的应用 - Google Patents

δ受体激动剂化合物在制备治疗抑郁症的药物中的应用 Download PDF

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Publication number
CN1596113B
CN1596113B CN028237099A CN02823709A CN1596113B CN 1596113 B CN1596113 B CN 1596113B CN 028237099 A CN028237099 A CN 028237099A CN 02823709 A CN02823709 A CN 02823709A CN 1596113 B CN1596113 B CN 1596113B
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composition
formula
mood disorder
treating
alkyl
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Chinese (zh)
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CN1596113A (zh
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张宽仁
威廉·彭德格斯特
彼得·J·真戈
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Wersi Refco Group Ltd
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Mount Cook Biosciences Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN028237099A 2001-10-29 2002-10-29 δ受体激动剂化合物在制备治疗抑郁症的药物中的应用 Expired - Fee Related CN1596113B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US34008401P 2001-10-29 2001-10-29
US60/340,084 2001-10-29
US33788701P 2001-11-02 2001-11-02
US60/337,887 2001-11-02
PCT/US2002/034421 WO2003037342A1 (en) 2001-10-29 2002-10-29 Method of treating depression with delta receptor agonist compounds

Publications (2)

Publication Number Publication Date
CN1596113A CN1596113A (zh) 2005-03-16
CN1596113B true CN1596113B (zh) 2010-05-26

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CN028237099A Expired - Fee Related CN1596113B (zh) 2001-10-29 2002-10-29 δ受体激动剂化合物在制备治疗抑郁症的药物中的应用

Country Status (11)

Country Link
US (1) US7030124B2 (cg-RX-API-DMAC7.html)
EP (1) EP1450807B1 (cg-RX-API-DMAC7.html)
JP (1) JP4892654B2 (cg-RX-API-DMAC7.html)
CN (1) CN1596113B (cg-RX-API-DMAC7.html)
CA (1) CA2464471C (cg-RX-API-DMAC7.html)
MX (1) MXPA04004059A (cg-RX-API-DMAC7.html)
NO (1) NO20042257L (cg-RX-API-DMAC7.html)
PL (1) PL371297A1 (cg-RX-API-DMAC7.html)
RU (1) RU2314809C2 (cg-RX-API-DMAC7.html)
TW (1) TW200300089A (cg-RX-API-DMAC7.html)
WO (1) WO2003037342A1 (cg-RX-API-DMAC7.html)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1269805C (zh) * 2001-05-18 2006-08-16 阿斯特拉曾尼卡有限公司 4－(苯基－哌嗪基－甲基)－苯甲酰胺衍生物及其在治疗疼痛、焦虑症或胃肠病中的应用
US8476280B2 (en) * 2002-05-09 2013-07-02 Versi Group, Llc Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists
SE0203300D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
US7314880B2 (en) * 2003-01-02 2008-01-01 Mount Cook Biosciences, Inc. Cardioprotective delta opioid receptor agonists and methods of using same
NZ593444A (en) 2003-10-01 2012-12-21 Adolor Corp 4-[(2-N,N-diethylaminocarbonyl)pyrid-5-yl]-spiro[1,2-dihydronaphthalene-2,4'-piperidine] and methods of its use
MX2007001240A (es) * 2004-08-02 2007-03-23 Astrazeneca Ab Derivados de diarilmetil-piperazina, preparaciones y usos de las mismas.
SE0401968D0 (sv) * 2004-08-02 2004-08-02 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7683168B2 (en) * 2005-04-14 2010-03-23 Mount Cook Bio Sciences, Inc. Compositions of novel opioid compounds and method of use thereof
TW200803856A (en) 2005-09-02 2008-01-16 Mount Cook Biosciences Inc Method of treating parkinson's disease with diarylmethylpiperazine compounds exhibiting delta receptor agonist activity
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
NZ590041A (en) * 2008-05-20 2012-11-30 Astrazeneca Ab Method of treating anxious major depressive disorder
CN103467460A (zh) * 2013-09-23 2013-12-25 昆明理工大学 一类含噻吩环和苄基的二芳基甲基哌嗪化合物及其应用
CN105646151B (zh) * 2016-02-26 2018-06-29 山西大学 一种炔类化合物及其制备方法和该化合物的用途
WO2017173067A1 (en) 2016-03-31 2017-10-05 Versi Group, Llc Delta opioid agonist, mu opioid antagonist compositions and methods for treating parkinson's disease

Citations (1)

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US5658908A (en) * 1992-02-03 1997-08-19 Delta Pharmaceuticals, Inc. Opioid diarylmethylpiperazines and piperdines

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US5A (en) * 1836-08-10 Thomas Blanchard Machine for mortising solid wooden shells of ships' tackle-blocks
US5807858A (en) * 1996-06-05 1998-09-15 Delta Pharmaceutical, Inc. Compositions and methods for reducing respiratory depression
US5681830A (en) * 1992-02-03 1997-10-28 Delta Pharmaceuticals, Inc. Opioid compounds
US5574159A (en) * 1992-02-03 1996-11-12 Delta Pharmaceuticals, Inc. Opioid compounds and methods for making therefor
US5985880A (en) * 1996-06-05 1999-11-16 Delta Pharmaceuticals Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
US20020052007A1 (en) * 1992-02-03 2002-05-02 Chang Kwen Jen Diarylmethylbenzylpiperazines and corresponding halobenzyl derivatives
AU692788B2 (en) * 1993-07-30 1998-06-18 Ardent Pharmaceuticals, Inc. Piperazine compounds used in therapy
US6046200A (en) * 1994-09-09 2000-04-04 The United States Of America As Represented By The Secretary Of The Army Compositions having neuroprotective and analgesic activity
SE9504661D0 (sv) 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
GB9709972D0 (en) * 1997-05-19 1997-07-09 Pfizer Ltd Tetrazoles
GB9804734D0 (en) * 1998-03-05 1998-04-29 Pfizer Ltd Compounds
ATE273970T1 (de) * 1998-04-16 2004-09-15 Pfizer Prod Inc N-acyl und n-aroyl aralkylamide
SE9904673D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904674D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904675D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
GB0017256D0 (en) * 2000-07-13 2000-08-30 Merck Sharp & Dohme Therapeutic agents
CN1269805C (zh) 2001-05-18 2006-08-16 阿斯特拉曾尼卡有限公司 4－(苯基－哌嗪基－甲基)－苯甲酰胺衍生物及其在治疗疼痛、焦虑症或胃肠病中的应用

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
US5658908A (en) * 1992-02-03 1997-08-19 Delta Pharmaceuticals, Inc. Opioid diarylmethylpiperazines and piperdines

Also Published As

Publication number Publication date
WO2003037342A1 (en) 2003-05-08
TW200300089A (en) 2003-05-16
US7030124B2 (en) 2006-04-18
CA2464471C (en) 2012-05-15
MXPA04004059A (es) 2005-03-31
EP1450807B1 (en) 2013-12-25
CN1596113A (zh) 2005-03-16
US20030144299A1 (en) 2003-07-31
CA2464471A1 (en) 2003-05-08
RU2314809C2 (ru) 2008-01-20
EP1450807A4 (en) 2008-06-25
JP2005508363A (ja) 2005-03-31
EP1450807A1 (en) 2004-09-01
NO20042257L (no) 2004-06-24
RU2004115748A (ru) 2005-03-27
JP4892654B2 (ja) 2012-03-07
PL371297A1 (en) 2005-06-13

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