MXPA04000310A - Procedimiento para la preparacion de 2,4-didesoxihexosas y 2,4,6-tridesoxihexosas. - Google Patents

Procedimiento para la preparacion de 2,4-didesoxihexosas y 2,4,6-tridesoxihexosas.

Info

Publication number
MXPA04000310A
MXPA04000310A MXPA04000310A MXPA04000310A MXPA04000310A MX PA04000310 A MXPA04000310 A MX PA04000310A MX PA04000310 A MXPA04000310 A MX PA04000310A MX PA04000310 A MXPA04000310 A MX PA04000310A MX PA04000310 A MXPA04000310 A MX PA04000310A
Authority
MX
Mexico
Prior art keywords
preparation
substituted
trideoxyhexose
dideoxyhexose
unsubstituted
Prior art date
Application number
MXPA04000310A
Other languages
English (en)
Inventor
Mink Daniel
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NL1018525A external-priority patent/NL1018525C2/nl
Priority claimed from NL1019622A external-priority patent/NL1019622C2/nl
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of MXPA04000310A publication Critical patent/MXPA04000310A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/02—Monosaccharides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invencion se refiere a un procedimiento para la preparacion de una 2,4-didesoxihexosa o una 2,4,6-tridesoxihexosa a partir de un compuesto carbonilo sustituido o no sustituido con al menos dos atomos de carbono y al menos un atomo de hidrogeno a y un aldehido sustituido o no sustituido, en presencia de una aldolasa y agua, llevandose a cabo la reaccion entre el compuesto carbonilo sustituido o no sustituido con al menos dos atomos de carbono y al menos un atomo de hidrogeno a y el aldehido sustituido o no sustituido, a una concentracion de carbonilo de cuando mucho 6 moles/l de mezcla de reaccion, y la concentracion final de la 2,4-didesoxihexosa o la 2,4,6-tridesoxihexosa es de al menos 2% en masa de la mezcla de reaccion; la invencion tambien se refiere al uso de una didesoxihexosa o una 2,4,6-tridesoxihexosa obtenida por medio de un procedimiento de acuerdo con la invencion, en la preparacion de un medicamento, particularmente en la preparacion de una estatina.
MXPA04000310A 2001-07-12 2002-07-09 Procedimiento para la preparacion de 2,4-didesoxihexosas y 2,4,6-tridesoxihexosas. MXPA04000310A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL1018525A NL1018525C2 (nl) 2001-07-12 2001-07-12 Werkwijze voor de bereiding van 2,4-dideoxyhexosen en 2,4,6-trideoxyhexosen.
NL1019622A NL1019622C2 (nl) 2001-12-20 2001-12-20 Werkwijze voor de bereiding van 2,4-dideoxyhexosen en 2,4,6-trideoxyhexosen.
PCT/NL2002/000450 WO2003006656A2 (en) 2001-07-12 2002-07-09 Process for the preparation of 2,4-dideoxyhexoses and 2,4,6-trideoxyhexoses

Publications (1)

Publication Number Publication Date
MXPA04000310A true MXPA04000310A (es) 2004-05-04

Family

ID=26643375

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04000310A MXPA04000310A (es) 2001-07-12 2002-07-09 Procedimiento para la preparacion de 2,4-didesoxihexosas y 2,4,6-tridesoxihexosas.

Country Status (12)

Country Link
US (2) US6964863B2 (es)
EP (1) EP1404844B1 (es)
JP (1) JP4248392B2 (es)
CN (1) CN1300132C (es)
AT (1) ATE356215T1 (es)
CA (1) CA2448517A1 (es)
DE (1) DE60218678T2 (es)
DK (1) DK1404844T3 (es)
ES (1) ES2282433T3 (es)
HU (1) HU228734B1 (es)
MX (1) MXPA04000310A (es)
WO (1) WO2003006656A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7414119B2 (en) 2002-09-20 2008-08-19 Verenium Corporation Aldolases, nucleic acids encoding them and methods for making and using them
US7402710B2 (en) 2004-03-29 2008-07-22 Mitsui Chemicals, Inc. Process for producing chiral hydroxyaldehyde compounds
KR100807523B1 (ko) 2004-12-31 2008-02-26 주식회사유한양행 광학 활성 디올 유도체의 신규 제조방법
WO2007137816A1 (en) * 2006-05-30 2007-12-06 Dsm Ip Assets B.V. Process for the preparation of epoxide intermediates for pharmaceutical compounds such as statins
EP2532660B1 (en) 2007-08-03 2014-09-10 Pfizer Products Inc. Process for preparing chiral compounds
WO2009092702A2 (en) * 2008-01-23 2009-07-30 Lek Pharmaceuticals D.D. ((2s,4r)-4,6-dihydroxytetrahydro-2h-pyran-2-yl)methyl carboxylate and process for the production thereof
WO2013083719A1 (en) 2011-12-09 2013-06-13 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of a thioprecursor for statins
EP2788342B1 (en) 2011-12-09 2018-01-24 DSM Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of a statin precursor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
US5795749A (en) 1995-04-05 1998-08-18 The Scripps Research Institution Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives
EP1619191B1 (en) 1998-08-05 2010-10-27 Kaneka Corporation Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl] acetic acid derivatives

Also Published As

Publication number Publication date
DK1404844T3 (da) 2007-06-04
EP1404844A2 (en) 2004-04-07
DE60218678D1 (de) 2007-04-19
US6964863B2 (en) 2005-11-15
CA2448517A1 (en) 2003-01-23
ES2282433T3 (es) 2007-10-16
CN1526019A (zh) 2004-09-01
JP4248392B2 (ja) 2009-04-02
US20050287650A1 (en) 2005-12-29
HUP0401577A2 (hu) 2004-11-29
HU228734B1 (hu) 2013-05-28
HUP0401577A3 (en) 2010-03-29
WO2003006656A2 (en) 2003-01-23
EP1404844B1 (en) 2007-03-07
JP2005500838A (ja) 2005-01-13
WO2003006656A3 (en) 2003-12-11
US7439046B2 (en) 2008-10-21
US20040171125A1 (en) 2004-09-02
DE60218678T2 (de) 2008-02-14
ATE356215T1 (de) 2007-03-15
CN1300132C (zh) 2007-02-14

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Legal Events

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GB Transfer or rights
HC Change of company name or juridical status