MXPA03006402A - Sintesis de temozolomida y analogos. - Google Patents

Sintesis de temozolomida y analogos.

Info

Publication number
MXPA03006402A
MXPA03006402A MXPA03006402A MXPA03006402A MXPA03006402A MX PA03006402 A MXPA03006402 A MX PA03006402A MX PA03006402 A MXPA03006402 A MX PA03006402A MX PA03006402 A MXPA03006402 A MX PA03006402A MX PA03006402 A MXPA03006402 A MX PA03006402A
Authority
MX
Mexico
Prior art keywords
temozolomide
analogs
synthesis
Prior art date
Application number
MXPA03006402A
Other languages
English (en)
Inventor
Shen-Chun Kuo
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MXPA03006402A publication Critical patent/MXPA03006402A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
MXPA03006402A 2001-01-18 2002-01-16 Sintesis de temozolomida y analogos. MXPA03006402A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26246401P 2001-01-18 2001-01-18
PCT/US2002/001092 WO2002057268A1 (en) 2001-01-18 2002-01-16 Synthesis of temozolomide and analogs

Publications (1)

Publication Number Publication Date
MXPA03006402A true MXPA03006402A (es) 2003-10-15

Family

ID=22997625

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03006402A MXPA03006402A (es) 2001-01-18 2002-01-16 Sintesis de temozolomida y analogos.

Country Status (9)

Country Link
US (1) US6844434B2 (es)
EP (1) EP1363911A1 (es)
JP (2) JP4441176B2 (es)
CN (1) CN1294132C (es)
AR (1) AR035420A1 (es)
CA (1) CA2434300A1 (es)
MX (1) MXPA03006402A (es)
SG (1) SG143062A1 (es)
WO (1) WO2002057268A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7615632B2 (en) * 2003-12-30 2009-11-10 Chemagis Ltd. Crystalline forms of temozolomide
CN100453543C (zh) * 2004-08-04 2009-01-21 天津天士力集团有限公司 一种替莫唑胺合成方法
DE102006007309B4 (de) * 2005-02-17 2012-11-29 Chemagis Ltd. Verbessertes Verfahren zur Herstellung von Temozolomid
CN1300143C (zh) * 2005-04-08 2007-02-14 江苏天士力帝益药业有限公司 替莫唑胺的精制方法
US20060257317A1 (en) * 2005-05-04 2006-11-16 Duke University Combination therapy in the treatment of cancer
US20060222792A1 (en) * 2006-04-21 2006-10-05 Chemagis Ltd. Temozolomide storage system
WO2008038031A1 (en) 2006-09-29 2008-04-03 Cipla Limited An improved process for the preparation of temozolomide and analogs
CN101190917B (zh) * 2006-11-30 2011-07-13 天津天士力集团有限公司 3,4-二氢-3-甲基-4-氧代咪唑[5,1-d]并1,2,3,5-四嗪-8-甲酸苯磺酰基呋咱氮氧基酯类化合物,制备方法及其用途
EP2151442A3 (en) 2008-08-07 2011-04-06 Chemi SPA Process for preparing temozolomide
US8236862B2 (en) 2009-02-06 2012-08-07 University Of Southern California Therapeutic compositions comprising monoterpenes
CN102178676B (zh) * 2011-04-29 2012-07-25 山东大学 一种治疗脑胶质瘤的药物组合物
CN103626772B (zh) * 2012-08-24 2016-08-17 国药一心制药有限公司 一种替莫唑胺及中间体的合成方法
CN110177792B (zh) 2016-12-20 2022-03-04 克里斯泰利亚化学药物产品有限公司 制备替莫唑胺和中间体的方法
US11597731B2 (en) 2021-07-17 2023-03-07 Shivalik Rasayan Limited Process for preparing highly pure temozolomide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260291A (en) * 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
GB2125402B (en) * 1982-08-17 1985-11-13 May & Baker Ltd New tetrazine derivatives
IE56381B1 (en) * 1982-12-20 1991-07-17 Merck & Co Inc 5-(amino or substituted amino)imidazoles
GB8616125D0 (en) 1986-07-02 1986-08-06 May & Baker Ltd Compositions of matter

Also Published As

Publication number Publication date
US6844434B2 (en) 2005-01-18
JP2004517897A (ja) 2004-06-17
CN1294132C (zh) 2007-01-10
SG143062A1 (en) 2008-06-27
AR035420A1 (es) 2004-05-26
EP1363911A1 (en) 2003-11-26
JP2009215316A (ja) 2009-09-24
JP4441176B2 (ja) 2010-03-31
CA2434300A1 (en) 2002-07-25
CN1486319A (zh) 2004-03-31
WO2002057268A1 (en) 2002-07-25
US20020133006A1 (en) 2002-09-19

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Legal Events

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FG Grant or registration
HC Change of company name or juridical status