MXPA01001552A - Metodo de elaboracion de 1,3-oxatiolan-nucleosidos. - Google Patents

Metodo de elaboracion de 1,3-oxatiolan-nucleosidos.

Info

Publication number
MXPA01001552A
MXPA01001552A MXPA01001552A MXPA01001552A MXPA01001552A MX PA01001552 A MXPA01001552 A MX PA01001552A MX PA01001552 A MXPA01001552 A MX PA01001552A MX PA01001552 A MXPA01001552 A MX PA01001552A MX PA01001552 A MXPA01001552 A MX PA01001552A
Authority
MX
Mexico
Prior art keywords
oxathiolane
manufacture
oxathiolane nucleosides
preparation
nucleosides
Prior art date
Application number
MXPA01001552A
Other languages
English (en)
Inventor
Jose Soria
Original Assignee
Triangle Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Triangle Pharmaceuticals Inc filed Critical Triangle Pharmaceuticals Inc
Publication of MXPA01001552A publication Critical patent/MXPA01001552A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Se proporcionan procesos para la preparacion de 1,3-oxatiolan-nucleosidos, que incluyen metodos eficientes para la preparacion del anillo de 1,3-oxatiolano y la condensacion subsecuente del 1,3-oxatiolano con una base de pirimidina o purina. Usando los procesos descritos en la presente, se pueden proporcionar los compuestos como enantiomeros aislados.
MXPA01001552A 1998-08-12 1999-08-12 Metodo de elaboracion de 1,3-oxatiolan-nucleosidos. MXPA01001552A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9621498P 1998-08-12 1998-08-12
US12284199P 1999-03-04 1999-03-04
PCT/US1999/018584 WO2000009494A1 (en) 1998-08-12 1999-08-12 Method of manufacture of 1,3-oxathiolane nucleosides

Publications (1)

Publication Number Publication Date
MXPA01001552A true MXPA01001552A (es) 2004-08-23

Family

ID=26791450

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA01001552A MXPA01001552A (es) 1998-08-12 1999-08-12 Metodo de elaboracion de 1,3-oxatiolan-nucleosidos.

Country Status (17)

Country Link
US (4) US6215004B1 (es)
EP (4) EP1361223B1 (es)
JP (4) JP4249393B2 (es)
KR (3) KR100687194B1 (es)
CN (1) CN1141305C (es)
AT (2) ATE292631T1 (es)
AU (2) AU771779B2 (es)
BR (1) BR9912951B1 (es)
CA (3) CA2563022C (es)
DE (2) DE69924651D1 (es)
ES (2) ES2232169T3 (es)
HK (2) HK1038921A1 (es)
IL (4) IL141359A0 (es)
MX (1) MXPA01001552A (es)
PT (2) PT2322518E (es)
RU (2) RU2439069C2 (es)
WO (1) WO2000009494A1 (es)

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AU2008202336B2 (en) * 2001-03-01 2011-11-10 Abbvie Inc. Polymorphic and other crystalline forms of cis-FTC
ATE370945T1 (de) * 2001-06-15 2007-09-15 Shire Biochem Inc Stereoselektives verfahren zur herstellung von nukleosidderivaten
CA2351049C (en) 2001-06-18 2007-03-13 Brantford Chemicals Inc. Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers
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WO2011007367A1 (en) 2009-07-15 2011-01-20 Lupin Limited An improved process for preparation of efavirenz
WO2011141805A2 (en) 2010-05-14 2011-11-17 Lupin Limited An improved process for the manufacture of lamivudine
US20130296562A1 (en) 2011-08-05 2013-11-07 Lupin Limited Stereoselective process for preparation of 1,3-oxathiolane nucleosides
CN106478618A (zh) * 2016-10-14 2017-03-08 上海礼泰医药科技有限公司 恩曲他滨氢卤酸盐的制备方法
CN109553610B (zh) * 2018-12-21 2020-10-27 江西富祥药业股份有限公司 一种恩曲他滨异构体的制备方法
CN115043823A (zh) * 2022-06-28 2022-09-13 江苏普信制药有限公司 一种恩曲他滨的合成方法

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Also Published As

Publication number Publication date
PT2322518E (pt) 2015-06-08
KR101208429B1 (ko) 2012-12-05
ES2232169T3 (es) 2005-05-16
IL173745A0 (en) 2006-07-05
CA2563022A1 (en) 2000-02-24
BR9912951A (pt) 2001-10-02
KR100687194B1 (ko) 2007-02-27
JP4249393B2 (ja) 2009-04-02
IL141359A0 (en) 2002-03-10
EP1104415A1 (en) 2001-06-06
JP5956492B2 (ja) 2016-07-27
EP1104415B1 (en) 2004-11-10
EP1535921A1 (en) 2005-06-01
KR20070094667A (ko) 2007-09-20
US6215004B1 (en) 2001-04-10
ES2537540T3 (es) 2015-06-09
CA2563022C (en) 2010-11-23
DE69921829D1 (de) 2004-12-16
BR9912951B1 (pt) 2012-01-10
CN1141305C (zh) 2004-03-10
ATE282034T1 (de) 2004-11-15
IL201293A0 (en) 2010-05-31
JP2014132026A (ja) 2014-07-17
AU2004202930C1 (en) 2008-11-13
CA2340214C (en) 2007-10-30
AU2004202930B2 (en) 2008-05-08
US6518425B1 (en) 2003-02-11
JP2009108080A (ja) 2009-05-21
EP1361223A1 (en) 2003-11-12
CN1313858A (zh) 2001-09-19
CA2714085A1 (en) 2000-02-24
DE69921829T2 (de) 2005-10-27
JP5547772B2 (ja) 2014-07-16
RU2439069C2 (ru) 2012-01-10
IL141359A (en) 2006-07-05
AU2004202930A1 (en) 2004-07-29
AU771779B2 (en) 2004-04-01
PT1104415E (pt) 2005-03-31
CA2714085C (en) 2013-02-05
KR100856416B1 (ko) 2008-09-04
IL201293A (en) 2011-02-28
WO2000009494A1 (en) 2000-02-24
ATE292631T1 (de) 2005-04-15
JP2002522534A (ja) 2002-07-23
US6939965B2 (en) 2005-09-06
IL173745A (en) 2010-05-31
EP2322518A1 (en) 2011-05-18
JP5203897B2 (ja) 2013-06-05
US20030144532A1 (en) 2003-07-31
US6576776B1 (en) 2003-06-10
DE69924651D1 (de) 2005-05-12
RU2244712C2 (ru) 2005-01-20
EP1361223B1 (en) 2005-04-06
HK1038921A1 (en) 2002-04-04
JP2012176974A (ja) 2012-09-13
AU5675299A (en) 2000-03-06
KR20060063991A (ko) 2006-06-12
EP2322518B1 (en) 2015-02-25
HK1156604A1 (en) 2012-06-15
CA2340214A1 (en) 2000-02-24
RU2004125183A (ru) 2006-01-27
KR20010072428A (ko) 2001-07-31

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Legal Events

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